Category: 32863-30-2

Electric Literature of 32863-30-2,Some common heterocyclic compound, 32863-30-2, name is 4-(Bromomethyl)benzo[c][1,2,5]oxadiazole, molecular formula is C7H5BrN2O, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

4-bromomethylbenzimidazolium chloride (19. 7 g, 0.1 mol),DMSO 15 ml,Sodium bicarbonate (10 g, 0.12 mol) was added to the reaction flask. Heating to 100-150 C under nitrogen. After completion of the reaction, the mixture was cooled to room temperature and extracted with water and ethyl acetate. The organic layers were combined and washed with saturated brine. Dried over anhydrous sodium sulfate, and the solvent was evaporated under reduced pressure to give 10. 6 g of a pale yellow solid in 71.6% yield, mp 108-109 C.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 4-(Bromomethyl)benzo[c][1,2,5]oxadiazole, its application will become more common.

Reference:
Patent; Hefei Huafang Pharmaceutical Science & Technology Co., Ltd,; HE, YONG; WU, ZONGHAO; CHEN, SHIYUN; LI, JIAJIA; GAO, YONGHAO; (6 pag.)CN102285978; (2016); B;,
Bromide – Wikipedia,
bromide – Wiktionary

These common heterocyclic compound, 32863-30-2, name is 4-(Bromomethyl)benzo[c][1,2,5]oxadiazole, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Formula: C7H5BrN2O

Compound 9-2 (44.5 mg, 0.1 mmol) and 4-(bromomethyl)benzo[c][1,2,5]oxadiazole 14-1 (32 mg, 0.15 mmol) were dissolved in dry DMF Add cesium carbonate (65.2mg, 0.2mmol) and stir at room temperature for about two hours. The reaction is complete. the reaction solution was extracted with water and ethyl acetate. The organic phase was washed with saturated brine and dried over anhydrous sodium sulfate. PE: EA = 5: 1 to give 20 mg of compound 14-2.

The synthetic route of 4-(Bromomethyl)benzo[c][1,2,5]oxadiazole has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Chinese Academy Of Sciences Shanghai Pharmaceutical Institute; Zhang Ao; Geng Meiyu; Song Zilan; Ai Jing; Gu Wangting; Liu Bo; Ding Jian; (28 pag.)CN110240587; (2019); A;,
Bromide – Wikipedia,
bromide – Wiktionary