Category: 327-51-5

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 327-51-5, name is 1,4-Dibromo-2,5-difluorobenzene, This compound has unique chemical properties. The synthetic route is as follows., 327-51-5

Into a three-necked flask, to 1,4-dibromo-2,5-difluoro-benzene (5.4g, 20.0mmol), compound 16 (12.8g, 42.0mmol), 2M Na2CO3 aqueous solution (40mL, 80.0mmol), DME (40mL), toluene (40mL), Pd[PPh3]4 (1.2g, 1.0mmol) was added, this mixture was refluxed for 8 hr under Ar atmosphere. After the reaction was cooled to room temperature. The sample was transferred to a separatory funnel, added water (100mL), and extracted with CH2Cl2. After drying with MgSO4, filtered, and concentrated. Purification of a sample was purified by silica gel column chromatography to give a white solid. Yield 8.8g, 70% yield.

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Reference:
Patent; Idemitsu Kosan Corporation; Kato, Tomoki; Numata, Masaki; Yoshida, K.; Nishimura, Kazuki; Eiwakuma, Toshihiro; Hosokawa, Chisio; (108 pag.)KR101500796; (2015); B1;,
Bromide – Wikipedia,
bromide – Wiktionary

327-51-5, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 327-51-5, name is 1,4-Dibromo-2,5-difluorobenzene belongs to bromides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

To a 1.0 M solution (tetrahydrofuran 1:1 toluene) of 2,2,6,6-tetramethylpiperidinylmagnesium chloride lithium chloride complex (200 cm3, 200 mmol) at -30 C. under inert atmosphere is added drop-wise a solution of 1,4-dibromo-2,5-difluoro-benzene (23.6 g, 86.8 mmol) in anhydrous tetrahydrofuran (150 cm3) over 30 minutes. After addition, the reaction mixture is stirred at -30 C. for 7 hours before ethyl chloroformate (22.6 g, 208 mmol) is added in one go. The mixture is then allowed to warm to 23 C. over 17 hours. Aqueous hydrochloric acid (1.0 M, 500 cm3) is added and the mixture stirred at 23 C. for 30 minutes. The product is extracted with diethyl ether (3*100 cm3). The combined organics are dried over anhydrous magnesium sulfate, filtered and the solvent removed in vacuo. The crude product is triturated with n-pentane to form a suspension. The product is filtered and washed with cold acetone, collected and dried under vacuum to give 2,5-dibromo-3,6-difluoro-terephthalic acid diethyl ester (12.0 g, 33%) as a white solid. 1H-NMR (300 MHz, CDCl3) 1.42 (6H, m, CH3), 4.49 (4H, q, CH3) 19F-NMR 108.72 (2F, s, CF).

The synthetic route of 1,4-Dibromo-2,5-difluorobenzene has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Merck Patent GmbH; D’LAVARI, Mansoor; MITCHELL, William; WANG, Changsheng; SPARROWE, David; (67 pag.)US2017/117477; (2017); A1;,
Bromide – Wikipedia,
bromide – Wiktionary

A common heterocyclic compound, 327-51-5, name is 1,4-Dibromo-2,5-difluorobenzene, molecular formula is C6H2Br2F2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. 327-51-5.

A solution of l,4-dibromo-2,5-difluorobenzene (640 mg, 2.35 mmol) in dry diethyl ether (10 mL) cooled in a dry ice-acetone bath was treated dropwise with 2.5 M n- butyllithium in hexanes (1.04 mL, 2.59 mmol). The solution was stirred at -78 C for 30 min, then was treated with a piece of dry ice. The cooling bath was removed after 5 min and the mixture was stirred for another 30 min while warming to room temperature. The mixture was diluted with EtOAc and water. The organic phase was separated and washed twice with saturated aqueous NaHCC . The combined aqueous phases were acidified with 1 M aqueous HCI, extracted twice with DCM, and the combined organic phases were dried and concentrated to give 4-bromo-2,5-difluorobenzoic acid as a white solid (297 mg, 53% yield).

The synthetic route of 1,4-Dibromo-2,5-difluorobenzene has been constantly updated, and we look forward to future research findings.

Reference:
Patent; BRISTOL-MYERS SQUIBB COMPANY; WATTERSON, Scott Hunter; TEBBEN, Andrew J.; AHMAD, Saleem; (95 pag.)WO2016/65222; (2016); A1;,
Bromide – Wikipedia,
bromide – Wiktionary