Category: 32046-62-1

Reference of 32046-62-1, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 32046-62-1, name is 5-Bromo-1H-benzotriazole belongs to bromides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

A flask equipped with a stirring bar and flushed with Ar is loaded with 5- bromo-1 – -benzotriazole (200 mg; 1.01 mmol; 1 eq.), potassium iodide (17 mg; 0.10 mmol; 0.10 eq.), potassium carbonate (698 mg; 5.05 mmol; 5 eq.) and acetone (20 ml_). The mixture is cooled in an ice bath and iodomethane (0.08 mL; 1.11 mmol; 1.10 eq.) is added via syringe. After 15 minutes, the bath is removed and the mixture is stirred for 48 h at room temperature. The reaction mixture is then filtered, and the filtrate is evaporated in vacuo. The residue is purified by FCC (0-30% EtOAc gradient in hexane) to provide two regioisomers: 5-bromo-1 -methyl-1 H-1 ,2,3-benzotriazole (79, 63 mg, 0.30 mmol, 29%; UPLC purity: 100%). 6-bromo-1 -methyl-1 H-1 ,2,3-benzotriazole (80, 57 mg, 0.27 mmol, 27%; UPLC purity: 100%).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 5-Bromo-1H-benzotriazole, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; SELVITA S.A.; FABRITIUS, Charles-Henry Robert Yves; NOWAK, Mateusz Oktawian; WIKLIK, Katarzyna Anna; SABINIARZ, Aleksandra Barbara; BIE?, Marcin Dominik; BUDA, Anna Malgorzata; GUZIK, Pawel Szczepan; BIA?AS, Arkadiusz Kacper; PAWLIK, Henryk Edward; BOUTARD, Nicolas Felix Pierre; (439 pag.)WO2016/180537; (2016); A1;,
Bromide – Wikipedia,
bromide – Wiktionary

32046-62-1, name is 5-Bromo-1H-benzotriazole, belongs to bromides-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. COA of Formula: C6H4BrN3

Example 2008 Compound 2008A (200 mg, 1.02 mmol) was dissolved in 1OmL of CH2CI2 and reacted with DIPEA (0.53 ml, 3.03 mmol), followed by addition of MEMCI (0.15 mL, 1.31 mmol). The reaction mixture was stirred for 16 hours at room temp, then it was added to CH2CI2 and sodium bicarbonate aqueous solution. The organic layers were extracted with CH2CI2, combined and dried over sodium sulfate. The solvent was removed by rotary evaporator to yield compound 2008B (210 mg, 72% yield).

The synthetic route of 32046-62-1 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; SCHERING CORPORATION; WO2007/84451; (2007); A1;,
Bromide – Wikipedia,
bromide – Wiktionary