Application of 31543-75-6, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 31543-75-6, name is 2,4-Dibromo-1-methylbenzene belongs to bromides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.
2,4-Dibromotoluene (1.000 g, 4.00 mmol) and freshly purifiedNBS (0.925 g, 5.20 mmol) were solubilized in 12 mL of 1,2-dichloroethane under inert atmosphere. The solution wasrefluxed during 10 min and azobisisobuthyronitrile AIBN, 0.328 g,2.00 mmol) was added. The resulting suspension was stirred andrefluxed during 6 h. The reaction was monitored by TLC cyclohexane100%. Then, the reaction mixture was evaporated and asolution of cold cyclohexane/dichloromethane 1:1 was added toprecipitate side products (white solid). After the filtration andevaporation, the crude product (1.476 g, 4.49 mmol) was directlyused without purification.
The synthetic route of 2,4-Dibromo-1-methylbenzene has been constantly updated, and we look forward to future research findings.
Reference:
Article; Roussel, Emile; Tran-Nguyen, Viet-Khoa; Bouhedjar, Khalid; Dems, Mohamed Abdesselem; Belaidi, Amine; Matougui, Brahim; Peres, Basile; Azioune, Ammar; Renaudet, Olivier; Falson, Pierre; Boumendjel, Ahcene; European Journal of Medicinal Chemistry; vol. 184; (2019);,
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