Category: 314084-61-2

Related Products of 314084-61-2, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 314084-61-2, name is 2-Bromo-1,3-diethyl-5-methylbenzene belongs to bromides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

To a solution at -78C of 25g (110 mmol) of 2,6-diethyl-4-methylbromobenzene (preparation described in WO 2000078712) in 240 ml of tetrahydrofuran is added a -1.6 M solution of butyllithium in hexanes (75 ml, 120 mmol) dropwise over 10 minutes. The mixture is stirred for 10 minutes at -78cC, then trimethylborate (24.6 ml, 22.9g; 220 mmol) is added at once and stirring is continued at -780C for 30 minutes. The cooling bath is removed and the solution is allowed to warm up to room temperature over 1 hour and quenched with 2N aqueous hydrochloric acid (140 ml).The organic layer is separated, and the aqueous phase is extracted three times with diethyl ether : hexane 1 :1. The organic extracts are combined, dried over anhydrous sodium sulfate, filtered and the filtrate concentrated in vacuo. The oily residue is taken up in hexane under stirring, and the white solid is collected by filtration to give 2,6-diethyl-4-methylphenylboronic acid. The filtrate is concentrated and purified by column chromatography on silica gel give a further quantity of desired product. A combined yield of 16.6g (78%) of 2,6-diethyl-4-methylphenylboronic acid is obtained.

The synthetic route of 2-Bromo-1,3-diethyl-5-methylbenzene has been constantly updated, and we look forward to future research findings.

Reference:
Patent; SYNGENTA PARTICIPATIONS AG; WO2008/110307; (2008); A1;,
Bromide – Wikipedia,
bromide – Wiktionary

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 314084-61-2, name is 2-Bromo-1,3-diethyl-5-methylbenzene, A new synthetic method of this compound is introduced below., Application In Synthesis of 2-Bromo-1,3-diethyl-5-methylbenzene

Into an oven-dried 35 ml_ carousel reaction tube fitted with a magnetic stirrer bar was added the palladium source, APhos (4-di-ferf-butylphoshanyl-N,N-dimethyl-aniline, 0 – 20 mol%), 1 ,2,4,5- tetrahydropyrazolo[1 ,2-d][1 ,4,5]oxadiazepine-7,9-dione (1.2 equiv.) and K3PO4 (2.1 equiv.) under an atmosphere of N2 gas. A solution of 2-bromo-1 ,3-diethyl-5-methyl-benzene (DEMBB, 1 equiv.) and mesitylene (0.25 equiv. as an internal standard) in 1 ,4-dioxane (1 – 3 ml) was purged of oxygen by bubbling with N2 gas for 20 mins and then transferred to the reaction tube which was then placed immediately into the pre-heated carousel at 1 10 C and stirred for 6 h. Sampling procedure: A small aliquot of the reaction mixture was quenched with HCI (aq, 1 M) and extracted into EtOAc. The conversion was determined by NMR spectroscopy and/or GC analysis against mesitylene as an internal standard, or 1 , 3, 5-trimethoxybenzene as an external standard. The above general procedure (example 3) was used to obtain the results referred to in Table 2 below. (0136) Table 2 – Summary of results comparing differing palladium catalysts with the APhos ligand

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; SYNGENTA PARTICIPATIONS AG; MORRIS, James, Alan; SALE, David, Alexander; SHAFIR, Alexandr; GONU, Mallikharjuna; BILAL, Iffat; (27 pag.)WO2019/110613; (2019); A1;,
Bromide – Wikipedia,
bromide – Wiktionary

Adding a certain compound to certain chemical reactions, such as: 314084-61-2, name is 2-Bromo-1,3-diethyl-5-methylbenzene, belongs to bromides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 314084-61-2, Safety of 2-Bromo-1,3-diethyl-5-methylbenzene

1,39 g Tetrahydro-pyrazolo[1,2-.a.]pyridazine-1,3-dion und 2,68 g Natriumtertiaerbutylat werden in 20 ml Dimethylformamid bei 20 geloest und mit 2,66 g 2,6-Diethyl-4-methylbrombenzol sowie 0.82 g Pd (TPP)2 Cl2 versetzt. Nun wird waehrend 2,5 Stunden bei 125 geruehrt. Nach dem Abkuehlen auf Raumtemperatur wird mit 200 ml Essigester und 200 ml Ether versetzt und die Reaktionsmischung auf einen Saugfilter gegeben. Der Filterrueckstand wird mit je 100 ml Wasser und Methylenchlorid versetzt und mit Salzsaeure angesaeuert. Die organische Phase wird abgetrennt, getrocknet und eingedampft. Der Rueckstand (1.4 g) wird an Kieselgel chromatographiert (Essigester/Hexan 3:1). Man erhaelt 2-(2,6-Diethyl-4-methyl-phenyl)-tetrahydro-pyrazolo[1,2-.a.]pyridazine-1,3-dion in Form beiger Kristalle mit einem Schmelzpunkt von 174-175.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2-Bromo-1,3-diethyl-5-methylbenzene, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Syngenta Participations AG; EP1210333; (2004); B1;,
Bromide – Wikipedia,
bromide – Wiktionary