These common heterocyclic compound, 30273-22-4, name is 4-Bromo-2-ethylaniline hydrochloride, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. HPLC of Formula: C8H11BrClN
Example 27 8-Bromo-6-ethyl-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indole hydrochloride Step A.; A solution of sodium nitrite (0.70 g, 10.2 mmol) and H2O (2.1 mL) was added dropwise at 0 C. to a solution of 4-bromo-2-ethylbenzenamine hydrochloride (2.0 g, 8.45 mmol) in 12N HCl (20.1 mL) and TFA (2.6 ml). The reaction mixture was stirred at 0 C. for 1 h followed by the dropwise addition of a solution of tin(II)chloride (3.53 g, 18.6 mmol) in 12N HCl (5.0 mL) and H2O (0.7 mL) at 0 C. The reaction mixture stirred for 15 h at 20 C. and was filtered to give 1-(4-bromo-2-ethylphenyl)hydrazine hydrochloride as an off-white solid (2.9 g, 11.5 mmol).
The synthetic route of 4-Bromo-2-ethylaniline hydrochloride has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Bristol-Myers Squibb Company; US2007/27178; (2007); A1;,
Bromide – Wikipedia,
bromide – Wiktionary