Category: 2969-81-5

《Systematic Investigation into the Formation of Significant Amounts of Unknown Impurity during Scale-up of NaBH4-I2 Mediated Reduction of Nitro-Amide Intermediate of Mirabegron》 was written by Deshmukh, Dattatray G.; Bangal, Mukund N.; Kalawade, Kaustubh A.; Mathad, Vijayavitthal T.. Synthetic Route of C6H11BrO2 And the article was included in Organic Process Research & Development in 2020. The article conveys some information:

After successful development of a manufacturing process for the Mirabegron (I) at the laboratory scale, a muddled situation was aroused during the scale-up batches, wherein sodium borohydride-iodine (NaBH4-I2) mediated reduction of nitro-amide II ended up with substantial amounts (∼10%) of unspecified impurity in the nitro-amine intermediate III. On the basis of the structure elucidation and meticulous investigation, a reaction path for its genesis during the process was identified and an efficient mechanism proposed to arrest its formation. In-situ generated nickel boride (Ni2B) due to reaction of NiI2 (corrosion product) with NaBH4 followed by electrophilic attack of THF (solvent) was found to be the reason for the formation of impurity (IV). Execution of subsequent batches with proper controls arrested this impurity and successfully provided the Mirabegron with the desired quality. In the experiment, the researchers used Ethyl 4-bromobutyrate(cas: 2969-81-5Synthetic Route of C6H11BrO2)

Ethyl 4-bromobutyrate(cas: 2969-81-5) belongs to bromides. A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals. Organobromine compounds have fallen under increased scrutiny for their environmental impact.Synthetic Route of C6H11BrO2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

《Pharmacological characterisation of small molecule C5aR1 inhibitors in human cells reveals biased activities for signalling and function》 was published in Biochemical Pharmacology (Amsterdam, Netherlands) in 2020. These research results belong to Li, Xaria X.; Lee, John D.; Massey, Nicholas L.; Guan, Carolyn; Robertson, Avril A. B.; Clark, Richard J.; Woodruff, Trent M.. Reference of Ethyl 4-bromobutyrate The article mentions the following:

The complement fragment C5a is a core effector of complement activation. C5a, acting through its major receptor C5aR1, exerts powerful pro-inflammatory and immunomodulatory functions. Dysregulation of the C5a-C5aR1 axis has been implicated in numerous immune disorders, and the therapeutic inhibition of this axis is therefore imperative for the treatment of these diseases. A myriad of small-mol. C5aR1 inhibitors have been developed and independently characterised over the past two decades, however the pharmacol. properties of these compounds has been difficult to directly compare due to the wide discrepancies in the model, read-out, ligand dose and instrumentation implemented across individual studies. Here, we performed a systematic characterization of the most commonly reported and clin. advanced small-mol. C5aR1 inhibitors (peptidic: PMX53, PMX205 and JPE1375; non-peptide: W545011, NDT9513727, DF2593A and CCX168). Through signalling assays measuring C5aR1-mediated cAMP and ERK1/2 signalling, and β-arrestin 2 recruitment, this study highlighted the signalling-pathway dependence of the rank order of potencies of the C5aR1 inhibitors. Functional experiments performed in primary human macrophages demonstrated the high insurmountable antagonistic potencies for the peptidic inhibitors as compared to the non-peptide compounds Finally, wash-out studies provided novel insights into the duration of inhibition of the C5aR1 inhibitors, and confirmed the long-lasting antagonistic properties of PMX53 and CCX168. Overall, this study revealed the potent and prolonged antagonistic activities of selected peptidic C5aR1 inhibitors and the unique pharmacol. profile of CCX168, which thus represent ideal candidates to fulfil diverse C5aR1 research and clin. therapeutic needs. In addition to this study using Ethyl 4-bromobutyrate, there are many other studies that have used Ethyl 4-bromobutyrate(cas: 2969-81-5Reference of Ethyl 4-bromobutyrate) was used in this study.

Ethyl 4-bromobutyrate(cas: 2969-81-5) belongs to bromides. Most organobromine compounds, like most organohalide compounds, are relatively nonpolar. Bromine is more electronegative than carbon (2.9 vs 2.5). Consequently, the carbon in a carbon–bromine bond is electrophilic, i.e. alkyl bromides are alkylating agents.Reference of Ethyl 4-bromobutyrate

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

《Two color photoflow chemistry for macromolecular design》 was written by Van De Walle, Matthias; De Bruycker, Kevin; Blinco, James P.; Barner-Kowollik, Christopher. Safety of Ethyl 4-bromobutyrate And the article was included in Angewandte Chemie, International Edition in 2020. The article conveys some information:

We report a photochem. flow setup that exploits λ-orthogonal reactions using two different colors of light (λ1=350 nm and λ2=410 nm) in sequential online irradiation steps. Critically, both photochem. reactive units (a visible-light reactive chalcone and a UV-activated photo-caged diene) are present in the reaction mixture We demonstrate the power of two color photoflow by the wavelength-selective end group modification of photo-caged polymer end groups and the subsequent polymer ring closure driven by a [2+2] cycloaddition Importantly, we evidence that the high energy gate does not induce the visible light reaction of the chalcone, which attests the true λ-orthogonal nature of the flow reaction system. For the first time, this study opens the realm of photoflow reactions to λ-orthogonal photochem. In the part of experimental materials, we found many familiar compounds, such as Ethyl 4-bromobutyrate(cas: 2969-81-5Safety of Ethyl 4-bromobutyrate)

Ethyl 4-bromobutyrate(cas: 2969-81-5) belongs to bromides. A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals. Organobromine compounds have fallen under increased scrutiny for their environmental impact.Safety of Ethyl 4-bromobutyrate

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Recommanded Product: Ethyl 4-bromobutyrateIn 2022 ,《Solvatochromic spiropyran – a facile method for visualized, sensitive and selective response of lead (Pb2+) ions in aqueous solution》 was published in Journal of Photochemistry and Photobiology, A: Chemistry. The article was written by Liu, Guojie; Li, Yiwei; Cui, Congcong; Wang, Min; Gao, He; Gao, Jun; Wang, Jingbo. The article contains the following contents:

1′-(4′-carboxybutyl) -3′, 3′-dimethyl-6-nitro-8-hydroxylspiro [chromene-2, 2′-indoline] (SPC) is a visual, selective, and sensitive detector to lead (Pb2+) ions. The presence of 8 -hydroxyl in pyran ring makes SPC have a remarkable solvatochromism in polar solvents (SPC can isomerize to the ring-opening body (Mcc) spontaneously under visible light conditions), ascribed to the formation of intramol. hydrogen bonds. The color and spectrum of the Mcc solution could be changed instantly and significantly by addition of Pb2+, and Mcc showed excellent selectivity to Pb2+ in the simulated lead-zinc ore leachate. The complex Mcc – Pb2+, with a stoichiometry ratio of 1:1, can stably exist under visible light conditions, which is attributed to the interaction between Pb2+ and the deprotonated carboxy (-COO-), phenolic oxygen atom and 8-hydroxyl of the Mcc, and the whole process does not need UV irradiation, avoiding the serious photo-degradation of spiropyran derivatives The low limit of detection (0.61 μM) and the established test strips indicate that SPC has the potential to be applied in the quant. detection of Pb2+ in real samples.Ethyl 4-bromobutyrate(cas: 2969-81-5Recommanded Product: Ethyl 4-bromobutyrate) was used in this study.

Ethyl 4-bromobutyrate(cas: 2969-81-5) belongs to bromides. One prominent application of synthetic organobromine compounds is the use of polybrominated diphenyl ethers as fire-retardants, and in fact fire-retardant manufacture is currently the major industrial use of the element bromine.Recommanded Product: Ethyl 4-bromobutyrate

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

In 2019,Spectrochimica Acta, Part A: Molecular and Biomolecular Spectroscopy included an article by Liu, Ji-lin; Xu, Chun-ling; Yang, Ting; Hu, Zhi-ru; Zhang, Zhi-quan; Feng, Guo-dong. Reference of Ethyl 4-bromobutyrate. The article was titled 《Developed a novel sensor based on fluorescent graft conjugated polymer for the determination of aristolochic acid in traditional Chinese medicine》. The information in the text is summarized as follows:

A novel fluorescent graft conjugated polymer (poly (2, 5-bis (Polyethylene glycol oxybutyrate)-1, 4-phenylethynylene-alt-1, 4-phenyleneethynylene, PPE-OB-PEG)) has been designed and synthesized for the determination of aristolochic acid (AA). The detection conditions and detection characters of PPE-OB-PEG were systematically explored in this work. The fluorescence intensity of PPE-OB-PEG changes with the different concentration of AA. PPE-OB-PEG has a good linear range towards AA from 1.00×10-7 to 8.00×10-5 mol L-1 and the limit of detection (LOD) is 3.00×10-8 mol L-1 (S/N = 3). PPE-OB-PEG have been applied to detect AA in traditional Chinese medicine samples and the results are satisfactory. The exptl. results show that PPE-OB-PEG can be used as a fluorescence probe for rapid and sensitive detection of AA. In addition to this study using Ethyl 4-bromobutyrate, there are many other studies that have used Ethyl 4-bromobutyrate(cas: 2969-81-5Reference of Ethyl 4-bromobutyrate) was used in this study.

Ethyl 4-bromobutyrate(cas: 2969-81-5) belongs to bromides. Most organobromine compounds, like most organohalide compounds, are relatively nonpolar. Bromine is more electronegative than carbon (2.9 vs 2.5). Consequently, the carbon in a carbon–bromine bond is electrophilic, i.e. alkyl bromides are alkylating agents.Reference of Ethyl 4-bromobutyrate

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Recommanded Product: Ethyl 4-bromobutyrateIn 2022 ,《Mineralization of calcium phosphate on two-dimensional polymer films with controllable density of carboxyl groups》 appeared in Journal of Materials Chemistry B: Materials for Biology and Medicine. The author of the article were Zhang, Xinyu; Wu, Lingli; Feng, Guangyuan; Lei, Shengbin. The article conveys some information:

Two-dimensional polymers functionalized with controllable d. of carboxyl groups were constructed with the Langmuir-Blodgett method. Mineralization of calcium phosphate shows significantly different characteristics on these films, which clearly indicates that the d. of carboxy groups plays a determining role in controlling the nucleation and orientated growth of calcium phosphate. In the experimental materials used by the author, we found Ethyl 4-bromobutyrate(cas: 2969-81-5Recommanded Product: Ethyl 4-bromobutyrate)

Ethyl 4-bromobutyrate(cas: 2969-81-5) belongs to bromides. One prominent application of synthetic organobromine compounds is the use of polybrominated diphenyl ethers as fire-retardants, and in fact fire-retardant manufacture is currently the major industrial use of the element bromine.Recommanded Product: Ethyl 4-bromobutyrate

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

《Highly Regioselective Preparation and Characterization of New 6-O-Substituted Dieckol Derivatives》 was published in Journal of Industrial and Engineering Chemistry (Amsterdam, Netherlands) in 2020. These research results belong to Kim, Yongkyun; Shin, Jooseok; Kang, Su Min; Song, Jinyoung; Shin, Hyeon-Cheol; Keum, Young-Sam; Hwang, Hye Jeong; Park, Kwangyong. Recommanded Product: Ethyl 4-bromobutyrate The article mentions the following:

Dieckol is a brown algae-derived polyphenol that has broad bioactivity and low toxicity. Therefore, it is a promising lead compound for the development of therapeutic agents to treat various pathol. conditions, including viral infections, allergies, diabetes, skin ageing, cancers, and neurodegenerative conditions. To exploit the pharmacol. potential of dieckol, its stability, solubility, pharmacokinetics, and drug delivery must be improved. This can be achieved by the controlled modification of the hydroxyl groups, but the presence of eleven nearly equivalent hydroxyl groups makes the task highly challenging. In this study, the regioselectivities in five substitution reactions of the hydroxyl groups of dieckol under various SN2 reaction conditions were investigated. After reaction optimization, five substituents (Me, benzyl, methoxymethyl, 3-hydroxypropyl, and 3-(ethoxycarbonyl)propyl) could be introduced at the 6-Oposition of dieckol with surprisingly high regioselectivity, as confirmed by 2D-NMR spectroscopic analyses. The prepared dieckol derivatives showed antioxidant and anticancer activities analogous to those of unmodified dieckol, indicating that the mono-O-substitutions did not affect the biochem. and biol. characteristics of dieckol. Therefore, the proposed methodol. for the mono-O-substitution of a specific oxygen of dieckol is a powerful tool to add various pharmaceutical attributes to dieckol, thus contributing to the development of various dieckol-based drug candidates. In addition to this study using Ethyl 4-bromobutyrate, there are many other studies that have used Ethyl 4-bromobutyrate(cas: 2969-81-5Recommanded Product: Ethyl 4-bromobutyrate) was used in this study.

Ethyl 4-bromobutyrate(cas: 2969-81-5) belongs to bromides. Most organobromine compounds, like most organohalide compounds, are relatively nonpolar. Bromine is more electronegative than carbon (2.9 vs 2.5). Consequently, the carbon in a carbon–bromine bond is electrophilic, i.e. alkyl bromides are alkylating agents.Recommanded Product: Ethyl 4-bromobutyrate

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary