Category: 2969-81-5

《Hapten Synthesis and the Development of an Ultrasensitive Indirect Competitive ELISA for the Determination of Diethylstilbestrol in Food Samples》 was written by Yang, Xingdong; Wang, Yinbiao; Song, Chunmei; Hu, Xiaofei; Wang, Fangyu; Zeng, Xianyin. Recommanded Product: 2969-81-5 And the article was included in Scientific Reports in 2020. The article conveys some information:

An ultrasensitive indirect competitive ELISA (ic ELISA) using monoclonal antibodies (mAbs) was developed for the specific detection of diethylstilbestrol (DES) residues. To establish an ELISA based on mAbs, hapten diethylstilbestrol mono-carboxypropyl-ether (DES-MCPE) was chem. synthesized and then conjugated to bovine serum albumin (BSA) for immunization in mice. This ic ELISA was further optimized for DES determination The sensitivity of the ic ELISA was found to be 0.49μg/kg and the limit of detection was 0.075μg/kg. DES residues in salmon meat and pork were tested with the recovery range from 74.0 to 85.2% and the coefficient of variation (CV) was less than 10%. Parallel anal. of DES samples from salmon meat showed comparable results from the ic ELISA with high-performance liquid chromatog. The ic ELISA provides a useful screening method for the quant. detection of DES residues in animal-derived food. In the experiment, the researchers used Ethyl 4-bromobutyrate(cas: 2969-81-5Recommanded Product: 2969-81-5)

Ethyl 4-bromobutyrate(cas: 2969-81-5) belongs to bromides. A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals. Organobromine compounds have fallen under increased scrutiny for their environmental impact.Recommanded Product: 2969-81-5

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Wu, Sisi; Shi, Weijia; Zou, Gang published an article in 2021. The article was titled 《Mechanical metal activation for Ni-catalyzed, Mn-mediated cross-electrophile coupling between aryl and alkyl bromides》, and you may find the article in New Journal of Chemistry.SDS of cas: 2969-81-5 The information in the text is summarized as follows:

Liquid-assisted grinding was successfully applied to eliminate the requirements of chem. activators and anhydrous solvents in nickel-catalyzed, manganese-mediated cross-electrophile coupling between aryl and alkyl bromides. In addition to the traditional reaction parameters, mech. ones, e.g. the rotational speed of mill, the filling degree of jar and ball size, was found to affect the catalytic efficiency remarkably, implying the involvement of the regeneration of nickel(0) species in the rate-determining steps. A combined evaluation of the reaction and mech. parameters led to an optimal condition under which a variety of n-alky aromatics with various functional groups was readily obtained in good yields with a 1 mol% catalyst loading. The practical application of liquid-assisted grinding-enabled aryl/alkyl cross-electrophile coupling was demonstrated in the gram-scale synthesis of 6-methoxytetralone. The experimental process involved the reaction of Ethyl 4-bromobutyrate(cas: 2969-81-5SDS of cas: 2969-81-5)

Ethyl 4-bromobutyrate(cas: 2969-81-5) belongs to bromides. A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals. Organobromine compounds have fallen under increased scrutiny for their environmental impact.SDS of cas: 2969-81-5

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

《A Widely Applicable Dual Catalytic System for Cross-Electrophile Coupling Enabled by Mechanistic Studies》 was published in ACS Catalysis in 2020. These research results belong to Charboneau, David J.; Barth, Emily L.; Hazari, Nilay; Uehling, Mycah R.; Zultanski, Susan L.. COA of Formula: C6H11BrO2 The article mentions the following:

A dual catalytic system for cross-electrophile coupling reactions between aryl halides and alkyl halides that features a Ni catalyst, a Co cocatalyst, and a mild homogeneous reductant is described. Mechanistic studies indicate that the Ni catalyst activates the aryl halide, while the Co cocatalyst activates the alkyl halide. This allows the system to be rationally optimized for a variety of substrate classes by simply modifying the loadings of the Ni and Co catalysts based on the reaction product profile. For example, the coupling of aryl bromides and aryl iodides with alkyl bromides, alkyl iodides, and benzyl chlorides is demonstrated using the same Ni and Co catalysts under similar reaction conditions but with different optimal catalyst loadings in each case. Our system is tolerant of numerous functional groups and is capable of coupling heteroaryl halides, di-ortho-substituted aryl halides, pharmaceutically relevant druglike aryl halides, and a diverse range of alkyl halides. Addnl., the dual catalytic platform facilitates a series of selective one-pot three-component cross-electrophile coupling reactions of bromo(iodo)arenes with two distinct alkyl halides. This demonstrates the unique level of control that the platform provides and enables the rapid generation of mol. complexity. The system can be readily utilized for a wide range of applications as all reaction components are com. available, the reaction is scalable, and toxic amide-based solvents are not required. It is anticipated that this strategy, as well as the underlying mechanistic framework, will be generalizable to other cross-electrophile coupling reactions. In the experiment, the researchers used Ethyl 4-bromobutyrate(cas: 2969-81-5COA of Formula: C6H11BrO2)

Ethyl 4-bromobutyrate(cas: 2969-81-5) belongs to bromides. A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals. Organobromine compounds have fallen under increased scrutiny for their environmental impact.COA of Formula: C6H11BrO2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

The author of 《Sustainable strategies based on glycine-betaine analogue ionic liquids for the recovery of monoclonal antibodies from cell culture supernatants》 were Capela, Emanuel V.; Santiago, Alexandre E.; Rufino, Ana F. C. S.; Tavares, Ana P. M.; Pereira, Matheus M.; Mohamadou, Aminou; Aires-Barros, M. Raquel; Coutinho, Joao A. P.; Azevedo, Ana M.; Freire, Mara G.. And the article was published in Green Chemistry in 2019. Product Details of 2969-81-5 The author mentioned the following in the article:

Monoclonal antibodies (mAbs) are of crucial interest for therapeutic purposes, particularly in vaccination and immunization, and in the treatment of life-threatening diseases. However, their downstream processing from the complex cell culture media in which they are produced still requires multiple steps, making mAbs extremely high-cost products. Therefore, the development of cost-effective, sustainable and biocompatible purification strategies for mAbs is in high demand to decrease the associated economic, environmental and health burdens. Herein, novel aqueous biphasic systems (ABS) composed of glycine-betaine analog ionic liquids (AGB-ILs) and K2HPO4/KH2PO4 at pH 7.0, the resp. three-phase partitioning (TPP) systems, and hybrid processes combined with ultrafiltration were investigated and compared in terms of performance as alternative strategies for the purification and recovery of anti-human interleukin-8 (anti-IL-8) mAbs, which are specific therapeutics in the treatment of inflammatory diseases, from Chinese Hamster Ovary (CHO) cell culture supernatants. With the studied ABS, mAbs preferentially partition to the IL-rich phase, with recovery yields up to 100% and purification factors up to 1.6. The best systems were optimized in what concerns the IL concentration, allowing to take advantage of IL-based three-phase partitioning approaches where a precipitate enriched in mAbs is obtained at the ABS interface, yielding 41.0% of IgG with a purification factor of 2.7 (purity of 60.9%). Hybrid processes combining the two previous techniques and an ultrafiltration step were finally applied, allowing the recovery of mAbs from the different fractions in an appropriate buffer solution for further biopharmaceutical formulations, while allowing the simultaneous IL removal and reuse. The best results were obtained with the hybrid process combining TPP and ultrafiltration, allowing to obtain mAbs with a purity higher than 60%. The recyclability of the IL was addnl. demonstrated, revealing no losses in the purification and recovery performance of these systems for mAbs. The biol. activity of anti-IL-8 mAbs is maintained after the several purification and recovery steps, indicating that the novel ABS, three-phase partitioning and hybrid processes comprising AGB-ILs are promising and sustainable strategies in mAbs downstream processing. The experimental process involved the reaction of Ethyl 4-bromobutyrate(cas: 2969-81-5Product Details of 2969-81-5)

Ethyl 4-bromobutyrate(cas: 2969-81-5) belongs to bromides. A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals. Organobromine compounds have fallen under increased scrutiny for their environmental impact.Product Details of 2969-81-5

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

The author of 《The development of unimolecular conjugated polymeric micelles for the highly selective detection and recovery of gold from electronic waste》 were Liu, Jilin; Yang, Ting; Hu, Zhiru; Feng, Guodong. And the article was published in New Journal of Chemistry in 2019. Recommanded Product: 2969-81-5 The author mentioned the following in the article:

Gold is a widely used precious metal. In this paper, a novel conjugated polymer is designed and synthesized that can be used to detect and sep. gold from electronic waste with satisfactory sensitivity and selectivity. Therefore, this strategy is of great significance for the recycling of gold resources. In the part of experimental materials, we found many familiar compounds, such as Ethyl 4-bromobutyrate(cas: 2969-81-5Recommanded Product: 2969-81-5)

Ethyl 4-bromobutyrate(cas: 2969-81-5) belongs to bromides. A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals. Organobromine compounds have fallen under increased scrutiny for their environmental impact.Recommanded Product: 2969-81-5

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Petruncio, Greg; Elahi-Mohassel, Synah; Girgis, Michael; Paige, Mikell published their research in Tetrahedron Letters in 2021. The article was titled 《Copper-catalyzed sp3-sp3 cross-coupling of turbo grignards with benzyl halides》.Recommanded Product: Ethyl 4-bromobutyrate The article contains the following contents:

The aromatic ring in benzyl halides and sulfonates imparts unique reactivity at the benzylic carbon atom. Photoredox sp3-sp3 cross-coupling proved ineffective for coupling p-methoxybenzyl chloride (PMBCl), leading to a new strategy for the sp3-sp3 cross-coupling of benzyl halides and sulfonates. This strategy involved LiCl-accelerated synthesis of a Grignard reagent followed by a copper-catalyzed cross-coupling. The conditions worked well for PMBCl due to its exceptional reactivity but other benzyl bromides or sulfonates reacted poorly. In the part of experimental materials, we found many familiar compounds, such as Ethyl 4-bromobutyrate(cas: 2969-81-5Recommanded Product: Ethyl 4-bromobutyrate)

Ethyl 4-bromobutyrate(cas: 2969-81-5) belongs to bromides. Most organobromine compounds, like most organohalide compounds, are relatively nonpolar. Bromine is more electronegative than carbon (2.9 vs 2.5). Consequently, the carbon in a carbon–bromine bond is electrophilic, i.e. alkyl bromides are alkylating agents.Recommanded Product: Ethyl 4-bromobutyrate

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

In 2022,Zhang, Can; Hu, Jinnuo; Song, Jingya; Wu, Maotong; Zhang, Zhen published an article in ACS Food Science & Technology. The title of the article was 《Development of ic-ELISAs for the Detection of Bisphenol A Diglycidyl Ether and Its Derivatives in Canned Luncheon Meats》.Name: Ethyl 4-bromobutyrate The author mentioned the following in the article:

Canned foods are widely consumed because of their convenience, hygiene, and nutrition. Bisphenol A diglycidyl ether (BADGE), an industrial product of epichlorohydrin and bisphenol A, widely exists in the inner coating of canned foods. A hydrolysis or chlorination reaction of BADGE can occur in the process of storage, forming a variety of derivatives such as bisphenol A (2,3-dihydroxypropyl) glycidyl ether (BADGE·H2O), bisphenol A (3-chloro-2-hydroxypropyl) glycidyl ether (BADGE·HCl), and bisphenol A (3-chloro-2-hydroxypropyl) (2,3-dihydroxypropyl) glycidyl ether (BADGE·HCl·H2O), which seriously threaten consumer′s health. In this research, two haptens were successfully synthesized, and antibodies were obtained by the s.c. immunization of New Zealand rabbits. Indirect competitive enzyme-linked immunosorbent assays (ic-ELISAs) were established for the detection of BADGE, BADGE·H2O, BADGE·HCl, and BADGE·HCl·H2O, and the IC15 values (concentrations at an inhibition rate of 15%) were determined as 0.73, 0.39, 0.78, and 1.45 ng/mL, resp. The recovery of BADGE and its derivatives at various spiking levels in canned luncheon meat samples ranged from 76.70 to 98.35%. The results detected by the proposed ic-ELISAs were also validated by HPLC anal., which showed a good agreement (R2 = 0.9861). In the experiment, the researchers used Ethyl 4-bromobutyrate(cas: 2969-81-5Name: Ethyl 4-bromobutyrate)

Ethyl 4-bromobutyrate(cas: 2969-81-5) belongs to bromides. Most organobromine compounds, like most organohalide compounds, are relatively nonpolar. Bromine is more electronegative than carbon (2.9 vs 2.5). Consequently, the carbon in a carbon–bromine bond is electrophilic, i.e. alkyl bromides are alkylating agents.Name: Ethyl 4-bromobutyrate

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

《Visible-light reversible photopolymerization: insights via online photoflow – electrospray ionization – mass spectrometry》 was written by Van De Walle, Matthias; Petit, Charlotte; Blinco, James P.; Barner-Kowollik, Christopher. Reference of Ethyl 4-bromobutyrateThis research focused onvisible light reversible photopolymerization electrospray ionization mass spectrometry. The article conveys some information:

Light as a non-invasive and clean external stimulus provides a facile route towards macromol. design. Herein, we demonstrate the scalable synthesis of catalyst-free, visible-light mediated photo-oligomers and -polymers via a step-growth mechanism. Both a batch approach and a continuous photoflow setup are employed to investigate the degree of polymerization and scalability. Violet blue light at 415 nm triggers [2 + 2]-cycloadditions of a pyrene-chalcone derivative to grow linear step-growth polymers, while subsequent UV-B light irradiation triggers the depolymerization The process was monitored online via a photoflow – high resolution electrospray ionization mass spectrometry setup (ESI-MS). Size exclusion chromatog. provides addnl. off-line anal. of both the polymerization and photodegradation over time. By changing the color of light, photopolymers can be recycled and reshaped, allowing these macromol. precursors to be applied to reversible and photodegradable material design. In addition to this study using Ethyl 4-bromobutyrate, there are many other studies that have used Ethyl 4-bromobutyrate(cas: 2969-81-5Reference of Ethyl 4-bromobutyrate) was used in this study.

Ethyl 4-bromobutyrate(cas: 2969-81-5) belongs to bromides. One prominent application of synthetic organobromine compounds is the use of polybrominated diphenyl ethers as fire-retardants, and in fact fire-retardant manufacture is currently the major industrial use of the element bromine.Reference of Ethyl 4-bromobutyrate

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

In 2019,Monatshefte fuer Chemie included an article by Anschuber, Martin; Pollice, Robert; Schnuerch, Michael. Electric Literature of C6H11BrO2. The article was titled 《Rhodium-catalyzed direct alkylation of benzylic amines using alkyl bromides》. The information in the text is summarized as follows:

The development and substrate scope evaluation of a direct alkylation protocol of the C(sp3)-H bond of benzylic amines using alkyl bromides was reported. This pyridine-directed method was initiated by elimination of the alkyl bromide to a terminal olefin, which was then the true alkylating agent. In the experiment, the researchers used many compounds, for example, Ethyl 4-bromobutyrate(cas: 2969-81-5Electric Literature of C6H11BrO2)

Ethyl 4-bromobutyrate(cas: 2969-81-5) belongs to bromides. Most organobromine compounds, like most organohalide compounds, are relatively nonpolar. Bromine is more electronegative than carbon (2.9 vs 2.5). Consequently, the carbon in a carbon–bromine bond is electrophilic, i.e. alkyl bromides are alkylating agents.Electric Literature of C6H11BrO2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

In 2022,Liu, Jie; Xu, Xinxin; Wu, Aihong; Song, Shanshan; Xu, Liguang; Xu, Chuanlai; Kuang, Hua; Liu, Liqiang published an article in LWT–Food Science and Technology. The title of the article was 《Immunochromatographic assay for the rapid and sensitive detection of etoxazole in orange and grape samples》.Name: Ethyl 4-bromobutyrate The author mentioned the following in the article:

Etoxazole, a novel organofluorine pesticide, has been widely used against various mites in fruits and vegetables. In this study, we designed an etoxazole-hapten and produced a highly sensitive monoclonal antibody (mAb) against etoxazole with a half-maximal inhibitory concentration of 4.04 ng/mL. Based on the mAb, we developed an immunochromatog. assay (ICA) for the detection of etoxazole in orange and grape samples. In the qual. detection, the visible limit of detection (vLOD) and cut-off value were 10 and 100 ng/g (fresh weight), resp. In the quant. detection, the LOD value was 2.03 ng/g (fresh weight) in orange and 2.52 ng/g (fresh weight) in grape samples. The recovery rates ranged from 94.7 ± 4.0% to 103.3 ± 3.8%, with CVs of 3.7-4.2% and 96.4 ± 3.4% to 106.1 ± 5.5%, with CVs of 3.5-5.2% for etoxazole in grape and orange samples, resp. The ICA results were similar to those of LC-MS/MS. Therefore, our developed ICA is a rapid, sensitive, and simple tool for screening etoxazole residues in fruits and vegetables. In addition to this study using Ethyl 4-bromobutyrate, there are many other studies that have used Ethyl 4-bromobutyrate(cas: 2969-81-5Name: Ethyl 4-bromobutyrate) was used in this study.

Ethyl 4-bromobutyrate(cas: 2969-81-5) belongs to bromides. A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals. Organobromine compounds have fallen under increased scrutiny for their environmental impact.Name: Ethyl 4-bromobutyrate

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary