Category: 2969-81-5

Related Products of 2969-81-5In 2019 ,《Functional Biointerfaces Based on Mixed Zwitterionic Self-Assembled Monolayers for Biosensing Applications》 was published in Langmuir. The article was written by Wang, Yu-Sin; Yau, Shuehlin; Chau, Lai-Kwan; Mohamed, Ameen; Huang, Chun-Jen. The article contains the following contents:

Surface modification for biosensors has focused attention for improvement of their sensitivity and specificity, particularly for the detection in complex medium. In this work, we have synthesized zwitterionic carboxybetaine-thiols (CB-thiols) and sulfobetaine-thiols (SB-thiols) for modification of gold substrates to form a functional self-assembled monolayer (SAM) for the immunoassay in a surface plasmon resonance (SPR) biosensor. XPS, contact angle goniometer, and cyclic voltammetry were applied for characterizations of elemental composition, surface wettability, and packing d., resp. The antifouling properties of the SAMs were accessed by quant. anal. of protein and bacterial adsorption. The results from the SAMs with a single component indicated that the SB-thiol SAM provides better surface hydrophilicity, fouling resistance, and packing d. as compared to the CB-thiol SAM, likely due to the ionic association of CB moieties. However, the CB-thiol with the functional carboxylate group plays a critical role in postmodification of biomols. via com. available amine coupling chem. Thus, the mixed SAMs were prepared to integrate the unique characteristics from CB- and SB-thiols to control compositions and surface properties. The immunoassay was performed in the SPR biosensor, showing that the zwitterionic mixed SAM enables immobilization of biorecognition elements (BREs), and improved sensitivity and specificity. Consequently, the work reveals excellent and attractive versatility, antifouling, and functionalizable properties of zwitterionic mixed SAMs comprising CB- and SB-thiols for biosensing applications. This surface chem. is expected to be applicable to monitor specific mol. recognition events. After reading the article, we found that the author used Ethyl 4-bromobutyrate(cas: 2969-81-5Related Products of 2969-81-5)

Ethyl 4-bromobutyrate(cas: 2969-81-5) belongs to bromides. One prominent application of synthetic organobromine compounds is the use of polybrominated diphenyl ethers as fire-retardants, and in fact fire-retardant manufacture is currently the major industrial use of the element bromine.Related Products of 2969-81-5

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

In 2019,Molecules included an article by Qin, Shu-Qin; Li, Lian-Chun; Song, Jing-Ru; Li, Hai-Yun; Li, Dian-Peng. Recommanded Product: 2969-81-5. The article was titled 《Structurally simple phenanthridine analogues based on nitidine and their antitumor activities》. The information in the text is summarized as follows:

A series of novel structurally simple analogs based on nitidine was designed and synthesized in search of potent anticancer agents. The antitumor activity against human cancer cell lines (HepG2, A549, NCI-H460, and CNE1) was performed by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide (MTT) assay in vitro. The results showed that some of them had good anticancer activities, especially derivatives with a [(dimethylamino)ethyl]amino side chain in the C-6 position. Planar conjugated compounds 15a, 15b, and 15c, with IC50 values of 1.20 μM, 1.87 μM, and 1.19 μM against CNE1 cells, resp., were more active than nitidine chloride. Compound 15b and compound 15c with IC50 values of 1.19 μM and 1.37 μM against HepG2 cells and A549 cells demonstrated superior activities to nitidine. Besides, compound 5e which had a phenanthridinone core displayed extraordinary cytotoxicity against all test cells, particularly against CNE1 cells with the IC50 value of 1.13 μM.Ethyl 4-bromobutyrate(cas: 2969-81-5Recommanded Product: 2969-81-5) was used in this study.

Ethyl 4-bromobutyrate(cas: 2969-81-5) belongs to bromides. Most organobromine compounds, like most organohalide compounds, are relatively nonpolar. Bromine is more electronegative than carbon (2.9 vs 2.5). Consequently, the carbon in a carbon–bromine bond is electrophilic, i.e. alkyl bromides are alkylating agents.Recommanded Product: 2969-81-5

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

COA of Formula: C6H11BrO2In 2020 ,《gamma-tocotrienol and a-tocopherol ether acetate enhance docetaxel activity in drug-resistant prostate cancer cells》 appeared in Molecules. The author of the article were Asay, Spencer; Graham, Andrew; Hollingsworth, Sydney; Barnes, Bradley; Oblad, Richard V.; Michaelis, David J.; Kenealey, Jason D.. The article conveys some information:

Prostate cancer is the second most commonly diagnosed cancer in men, and metastatic prostate cancer is currently incurable. Prostate cancer frequently becomes resistant to standard of care treatments, and the administration of chemotherapeutic drugs is often accompanied by toxic side effects. Combination therapy is one tool that can be used to combat therapeutic resistance and drug toxicity. Vitamin E (VE) compounds and analogs have been proposed as potential non-toxic chemotherapeutics. Here we modeled combination therapy using mixture design response surface methodol. (MDRSM), a statistical technique designed to optimize mixture compositions, to determine whether combinations of three chemotherapeutic agents: gamma-tocotrienol (gamma-T3), a-tocopherol ether acetate (a-TEA), and docetaxel (DOC), would prove more effective than docetaxel alone in the treatment of human prostate cancer cells. Response surfaces were generated for cell viability, and the optimal treatment combination for reducing cell viability was calculated We found that a combination of 20 uM gamma-T3, 30 uM a-TEA, and 25 nm DOC was most effective in the treatment of PC-3 cells. We also found that the combination of gamma-T3 and a-TEA with DOC decreased the amount of DOC required to reduce cell viability in PC-3 cells and ameliorated therapeutic resistance in DOC-resistant PC-3 cells. After reading the article, we found that the author used Ethyl 4-bromobutyrate(cas: 2969-81-5COA of Formula: C6H11BrO2)

Ethyl 4-bromobutyrate(cas: 2969-81-5) belongs to bromides. One prominent application of synthetic organobromine compounds is the use of polybrominated diphenyl ethers as fire-retardants, and in fact fire-retardant manufacture is currently the major industrial use of the element bromine.COA of Formula: C6H11BrO2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

In 2019,RSC Advances included an article by Tan, Xiaoyan; Zhou, Yanlin; Shen, Li; Jia, Han; Tan, Xiaorong. Application of 2969-81-5. The article was titled 《A mitochondria-targeted delivery system of doxorubicin and evodiamine for the treatment of metastatic breast cancer》. The information in the text is summarized as follows:

For mitochondria-targeted nano-drug delivery systems against cancer, effectively targeting and releasing the drug into mitochondria are the keys to improve the therapeutic effect. In this study, mitochondria-targeted and reduction-sensitive micelles were developed to co-deliver doxorubicin (DOX) and evodiamine (EVO) for the treatment of metastatic breast cancer. After entering cancer cells, the micelles first targeted mitochondria through triphenylphosphonium cations. Then, the disulfide bonds of the micelles were cleaved by GSH, and both DOX and EVO were released near the mitochondria. The released EVO subsequently destroyed the mitochondrial membrane, resulting in a large amount of DOX entering the mitochondria and improving the anti-tumor effect of DOX. These mitochondria-targeted and reduction-sensitive micelles loaded with doxorubicin and evodiamine showed significant inhibition of the tumor cell growth both in vitro and in vivo. In the experiment, the researchers used Ethyl 4-bromobutyrate(cas: 2969-81-5Application of 2969-81-5)

Ethyl 4-bromobutyrate(cas: 2969-81-5) belongs to bromides. A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals. Organobromine compounds have fallen under increased scrutiny for their environmental impact.Application of 2969-81-5

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

The author of 《Broad-spectrum monoclonal antibody and a sensitive multi-residue indirect competitive enzyme-linked immunosorbent assay for the antibacterial synergists in samples of animal origin》 were Han, Xiaoya; Sheng, Feng; Kong, Dexin; Wang, Yulian; Pan, Yuanhu; Chen, Mo; Tao, Yanfei; Liu, Zhenli; Ahmed, Saeed; Yuan, Zonghui; Peng, Dapeng. And the article was published in Food Chemistry in 2019. Application of 2969-81-5 The author mentioned the following in the article:

To monitor the abuse of antibacterial synergists, a hapten, trimethoprim carboxylic derivative (TMPCOOH), was designed by using mol. modeling technol. A broad-spectrum monoclonal antibody (mAb) TMP/2G1 was prepared, for which the IC50 values of trimethoprim, diaveridine, aditoprim, baquiloprim, ormetoprim, and brodimoprim were 0.232, 0.527, 1.479, 4.354, 0.965, and 0.119 μg L-1, resp. Based on the broad spectrum mAb, an indirect competitive ELISA (ic-ELISA) was developed to determine the residues of antibacterial synergists. The limit of detection regarding the developed ic-ELISA for antibacterial synergists ranged from 0.025 to 1.126 μg L-1 in milk, honey and edible animal tissues. The recoveries ranged from 81.4% to 107.7%, with a coefficient of variation less than 20%. A good correlation (R2 = 0.994) between the ic-ELISA and HPLC-MS/MS showed the reliability of the developed ic-ELISA. In the experiment, the researchers used many compounds, for example, Ethyl 4-bromobutyrate(cas: 2969-81-5Application of 2969-81-5)

Ethyl 4-bromobutyrate(cas: 2969-81-5) belongs to bromides. A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals. Organobromine compounds have fallen under increased scrutiny for their environmental impact.Application of 2969-81-5

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

In 2022,Wang, Rui; Liu, Wentao; Wang, Qian; Lu, Yang published an article in Analytical Methods. The title of the article was 《A paper-analytical device for detecting bisphenol-A in foods》.Electric Literature of C6H11BrO2 The author mentioned the following in the article:

Bisphenol A (BPA) is a plastic monomer that can leach into food and cause adverse health effects with long-term exposure. In this study, we developed simple paper-anal. devices (PADs) for detecting BPA in food. The PADs were designed with hydrophilic and hydrophobic areas via wax printing. The hydrophilic areas were designed as a detection zone and modified with CM-cellulose (CMC) for the immobilization of BPA-bovine serum albumin (BSA). The monoclonal antibodies against BPA were generated and modified with quantum dots (QDs) to synthesize QD-antibody (QD-Ab) probes. Detection conditions of the assay were optimized, with results of 0.1 μg of BPA-BSA and 30-fold diluted QD-Ab probes. The detection limit was 0.098 μg L-1 using ImageJ anal. Samples of drinking water, green tea beverage and peanut cooking oil were selected to conduct the matrix effect study. The recovery rates of BPA in different samples ranged from 78.77% to 118.96%, proving that the PADs were a simple and sensitive detection method for easy, low-cost anal. of real food samples. In addition to this study using Ethyl 4-bromobutyrate, there are many other studies that have used Ethyl 4-bromobutyrate(cas: 2969-81-5Electric Literature of C6H11BrO2) was used in this study.

Ethyl 4-bromobutyrate(cas: 2969-81-5) belongs to bromides. Most organobromine compounds, like most organohalide compounds, are relatively nonpolar. Bromine is more electronegative than carbon (2.9 vs 2.5). Consequently, the carbon in a carbon–bromine bond is electrophilic, i.e. alkyl bromides are alkylating agents.Electric Literature of C6H11BrO2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

The author of 《End-Chain Fluorescent Highly Branched Poly(L-lactide)s: Synthesis, Architecture-Dependence, and Fluorescent Visible Paclitaxel-Loaded Microspheres》 were Bian, Yufei; Leng, Xuefei; Wei, Zhiyong; Wang, Zefeng; Tu, Zhu; Wang, Yanshai; Li, Yang. And the article was published in Biomacromolecules in 2019. COA of Formula: C6H11BrO2 The author mentioned the following in the article:

A facile method in combination of “”grafting from”” and “”end-functionalization”” was developed for the synthesis of fluorescent highly branched poly(L-lactide)s (PLLA-COU) via ring opening polymerization (ROP) and esterification end-capping. These resulting PLLA-COU with four kinds of architectures, including linear, star, linear-comb, and star-comb structures, were subjected to characterization and application as fluorescent visible paclitaxel-loaded microspheres. The mutual effects of architecture and end-groups on thermal and fluorescence properties, enzymic degradation, and drug release behaviors were focused. Contrast to linear and star PLLA-COU, two comb-shaped analogs demonstrated higher fluorescence quantum yield, faster drug release, and lower enzymic degradation rate. All the fluorescent microspheres could maintain fluorescence traceability. The fluorescent PLLA-COU displayed negligible toxicity and good biocompatibility. This work highlights that the fluorescent highly branched poly(L-lactide)s are properties-tailored and used as fluorescent visible drug delivery systems (DDS) for potential theranostic applications. In addition to this study using Ethyl 4-bromobutyrate, there are many other studies that have used Ethyl 4-bromobutyrate(cas: 2969-81-5COA of Formula: C6H11BrO2) was used in this study.

Ethyl 4-bromobutyrate(cas: 2969-81-5) belongs to bromides. A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals. Organobromine compounds have fallen under increased scrutiny for their environmental impact.COA of Formula: C6H11BrO2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

《Exploring the Antiparasitic Activity of Tris-1,3,4-Thiadiazoles against Toxoplasma gondii-Infected Mice》 was written by Almutairi, Tahani M.; Rezki, Nadjet; Aouad, Mohamed Reda; Hagar, Mohamed; Bakr, Basant A.; Hamed, Moaaz T.; Hassen, Maha Khairy; Elwakil, Bassma H.; Moneer, Esraa Abdelhamid. Safety of Ethyl 4-bromobutyrateThis research focused onToxoplasma antiparasitic thiadiazoles antiinflammatory cytokines liver spleen brain; Toxoplasma gondii; antiparasite; docking studies; immunological studies; in vivo study; tris-1,3,4-thiadiazoles. The article conveys some information:

Nitrogen-containing atoms in their core structures have been exclusive building blocks in drug discovery and development. One of the most significant and well-known heterocycles is the 1,3,4-thidiazole nucleus, which is found in a wide range of natural products and therapeutic agents. In the present work, certain tris-1,3,4-thiadiazole derivatives (6, 7) were synthesized through a multi-step synthesis approach. All synthesized compounds were characterized using different spectroscopic tools. Previously, thiadiazole compounds as anti-Toxoplasma gondii agents have been conducted and reported in vitro. However, this is the first study to test the anti-Toxoplasma gondii activity of manufactured mol. hybrids thiadiazole in an infected mouse model with the acute RH strain of T. gondii. All the observed results demonstrated compound (7)′s powerful activity, with a considerable reduction in the parasite count reaching 82.6% in brain tissues, followed by liver and spleen tissues (65.35 and 64.81%, resp.). Inflammatory and anti-inflammatory cytokines assessments proved that Compound 7 possesses potent antiparasitic effect. Furthermore, docking tests against TgCDPK1 and ROP18 kinase (two major enzymes involved in parasite invasion and egression) demonstrated compound 7′s higher potency compared to compound 6 and megazol. According to the mentioned results, tris-1,3,4-thiadiazole derivatives under test can be employed as potent antiparasitic agents against the acute RH strain of T. gondii. In the part of experimental materials, we found many familiar compounds, such as Ethyl 4-bromobutyrate(cas: 2969-81-5Safety of Ethyl 4-bromobutyrate)

Ethyl 4-bromobutyrate(cas: 2969-81-5) belongs to bromides. One prominent application of synthetic organobromine compounds is the use of polybrominated diphenyl ethers as fire-retardants, and in fact fire-retardant manufacture is currently the major industrial use of the element bromine.Safety of Ethyl 4-bromobutyrate

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Li, Jiaguo; Xiao, Dian; Xie, Fei; Li, Wei; Zhao, Lei; Sun, Wei; Yang, Xiaohong; Zhou, Xinbo published an article in 2021. The article was titled 《Novel antibody-drug conjugate with UV-controlled cleavage mechanism for cytotoxin release》, and you may find the article in Bioorganic Chemistry.Application of 2969-81-5 The information in the text is summarized as follows:

Antibody-drug conjugates (ADCs) are being developed worldwide with the potential to revolutionize current cancer treatment strategies. However, off-target toxicity caused by the instability of linkers remains one of the main issues to be resolved. Developing a novel photocontrol-ADC with good stability and photocontrolled release seemed to be an attractive and practical solution In this study, we designed, for the first time, a novel UV light-controlled ADC by carefully integrating the UV-cleavable o-nitro-benzyl structure into the linker. Our preliminary work indicated that the ADC exhibited good stability and photocontrollability while maintaining a targeting effect similar to that of the naked antibody. Upon irradiation with UV light, the ADC rapidly released free cytotoxins and exerted significant cytotoxicity toward drug-resistant tumor cells. Compared to those of the unirradiated cells, the EC50 values of ADCs increased by up to 50-fold. Furthermore, our research confirmed that the degradation products of unirradiated ADC, Cys-1a, were relatively less toxic, thus potentially reducing the off-target toxicity caused by nonspecific uptake of ADCs. The novel design strategy of UV light-controlled ADCs may provide new perspectives for future research on ADCs and promote the development of photocontrol systems. The experimental part of the paper was very detailed, including the reaction process of Ethyl 4-bromobutyrate(cas: 2969-81-5Application of 2969-81-5)

Ethyl 4-bromobutyrate(cas: 2969-81-5) belongs to bromides. A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals. Organobromine compounds have fallen under increased scrutiny for their environmental impact.Application of 2969-81-5

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

In 2022,Feng, Rui; Wang, Mian; Qian, Jingqi; He, Qingqing; Zhang, Man; Zhang, Jiaqi; Zhao, Hongwei; Wang, Baomin published an article in Microchemical Journal. The title of the article was 《Monoclonal antibody-based enzyme-linked immunosorbent assay and lateral flow immunoassay for the rapid screening of paraquat in adulterated herbicides》.Formula: C6H11BrO2 The author mentioned the following in the article:

The use of the herbicide paraquat has been banned in many countries due to its high toxicity. However, there is an issue that illegal addition of paraquat in herbicide products. Therefore, a rapid, sensitive, and portable method will be useful to detect paraquat in adulterated herbicides for regulation purpose. In the present study, an indirect competition ELISA (icELISA) was developed with a new paraquat-specific monoclonal antibody (mAb) for paraquat detection. The icELISA results showed a 50% inhibitory concentration (IC50) of 7.63 ng/mL with a working range (IC20-IC80) of 1.68-33.1 ng/mL. In addition, a lateral flow immunoassay (LFIA) with a cut-off value of 20.0 ng/mL was also developed. The LFIA showed no detection of the herbicides diquat, glyphosate and glufosinate up to 50μg/mL. Nine herbicide samples were collected across Hainan province, China and analyzed by the LFIA dipsticks. One out of the nine samples was tested pos., which was confirmed with icELISA and HPLC. The accuracy of the LFIA was further verified through onsite tests in different places in China. Forty-seven com. herbicide products were tested via the LFIA dipsticks, of which 9 samples were pos. and confirmed with HPLC anal. The paraquat LFIA exhibited the most promising potential as the point of care (POC) device for the rapid screening of paraquat in adulterated herbicide products. The experimental part of the paper was very detailed, including the reaction process of Ethyl 4-bromobutyrate(cas: 2969-81-5Formula: C6H11BrO2)

Ethyl 4-bromobutyrate(cas: 2969-81-5) belongs to bromides. A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals. Organobromine compounds have fallen under increased scrutiny for their environmental impact.Formula: C6H11BrO2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary