Category: 291536-01-1

The chemical properties of alicyclic heterocycles are similar to those of the corresponding chain compounds. Compound: (2S)-1-[(4R)-4,5-dihydro-4-phenyl-2-oxazolyl]-2-(diphenylphosphino)ferrocene, is researched, Molecular C31H26FeNOP, CAS is 291536-01-1, about Catalytic Enantioselective Formal Synthesis of MDM2 Antagonist RG7388 and Its Analogues, the main research direction is arylimino acetate enantioselective diastereoselective dipolar cycloaddition cyanostilbene copper catalyst; cyano triaryl pyrrolidine carboxylate asym synthesis; MDM2 antagonist RG7388 formal synthesis.Name: (2S)-1-[(4R)-4,5-dihydro-4-phenyl-2-oxazolyl]-2-(diphenylphosphino)ferrocene.

The catalytic asym. 1,3-dipolar [3 + 2] cycloaddition of azomethine ylides, generated in-situ from imino esters ArCH:NCH2CO2Me (Ar = 4-ClC6H4, 4-BrC6H4, 4-MeC6H4, 2-thienyl, 2-naphthyl), with cyanostilbenes R1C(CN):CHR2 (R1 = Ph, 4-ClC6H4; R2 = Ph, 4-MeC6H4, 3-BrC6H4, etc.) was established, affording structurally diverse pyrrolidines I (and their enantiomers) bearing four contiguous stereocenters with stereo-diversity in generally high yields and good to excellent stereoselectivities (up to 98% yield, 99:1 dr, >99% ee). This strategy allowed the formal synthesis of antitumor drug RG7388 (phase III clin. study) and its analogs in high efficiency.

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Reference:
Bromide – Wikipedia,
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Zhu, Minghui; Zhang, Qinglong; Zi, Weiwei published the article 《Diastereodivergent Synthesis of β-Amino Alcohols by Dual-Metal-Catalyzed Coupling of Alkoxyallenes with Aldimine Esters》. Keywords: diastereodivergent synthesis beta amino alc; dual metal catalyst coupling alkoxyallene aldimine ester; total synthesis mycestericins F G; amino alcohols; asymmetric catalysis; palladium; stereodivergence; synergistic catalysis.They researched the compound: (2S)-1-[(4R)-4,5-dihydro-4-phenyl-2-oxazolyl]-2-(diphenylphosphino)ferrocene( cas:291536-01-1 ).Related Products of 291536-01-1. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:291536-01-1) here.

Both syn- and anti-β-amino alcs. are common structural motifs in natural products, drug mols., chiral ligands and catalysts. However, the currently available methods for synthesizing these motifs are limited to generate only one diastereoisomer. Therefore, development of a unified method for stereoselective access to complementary diastereomers would be highly desirable. Herein, we report a method for dual-metal-catalyzed diastereodivergent coupling of alkoxyallenes with aldimine esters. By carefully selecting the two metals and appropriate chiral ligands, we could synthesize both syn- and anti-β-amino alc. motifs with high enantioselectivity and diastereoselectivity from the same set of starting materials. Furthermore, stereodivergent syntheses of all four stereoisomers of β-amino alcs. could be achieved. We demonstrated the synthetic utility of this method by concisely synthesizing two β-amino alc. natural products, mycestericins F and G.

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Bromide – Wikipedia,
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The three-dimensional configuration of the ester heterocycle is basically the same as that of the carbocycle. Compound: (2S)-1-[(4R)-4,5-dihydro-4-phenyl-2-oxazolyl]-2-(diphenylphosphino)ferrocene(SMILESS: [H]C12=C3([H])[Fe+2]145678(C3=C94C%10=N[C@H](C%11=CC=CC=C%11)CO%10)([C-]%12C5=C6C7=C8%12)[C-]92P(C%13=CC=CC=C%13)C%14=CC=CC=C%14,cas:291536-01-1) is researched.Reference of 7-Chloro-4-(piperazin-1-yl)quinoline. The article 《Chiral phosphine Lewis bases in catalytic, asymmetric aza-Morita-Baylis-Hillman reaction》 in relation to this compound, is published in Pure and Applied Chemistry. Let’s take a look at the latest research on this compound (cas:291536-01-1).

In the aza-Morita-Baylis-Hillman reaction of N-sulfonated imines with Me vinyl ketone (MVK) promoted by chiral phosphine Lewis base: (R)-2′-diphenylphosphanyl[1,1′]binaphthalenyl-2-ol (LB1) (10 mol %), the aza-Morita-Baylis-Hillman adducts were obtained in good yields with high ee (70-94 % ee) at -30 °C in THF. The scope and limitations of this reaction have been disclosed.

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Bromide – Wikipedia,
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The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: (2S)-1-[(4R)-4,5-dihydro-4-phenyl-2-oxazolyl]-2-(diphenylphosphino)ferrocene( cas:291536-01-1 ) is researched.Safety of (2S)-1-[(4R)-4,5-dihydro-4-phenyl-2-oxazolyl]-2-(diphenylphosphino)ferrocene.Zhang, Dan-Jie; Xie, Ming-Sheng; Qu, Gui-Rong; Gao, Yao-Wei; Guo, Hai-Ming published the article 《Synthesis of Azacyclic Nucleoside Analogs via Asymmetric [3+2] Cycloaddition of 9-(2-Tosylvinyl)-9H-purines》 about this compound( cas:291536-01-1 ) in Organic Letters. Keywords: azacyclic nucleoside synthesis asym stereoselective cycloaddition tosylvinylpurine copper catalyst. Let’s learn more about this compound (cas:291536-01-1).

With 9-(2-tosylvinyl)-9H-purines as the dipolarophiles, a series of chiral azacyclic nucleosides with four continuous stereo-centers were obtained in 86-99% yields, >20:1 dr, and 94 → 99% ee via the Cu(I)-catalyzed asym. [3+2] cycloaddition Both (E)- and (Z)-9-(2-tosylvinyl)-9H-purines were suitable dipolarophiles, enriching the structure diversity of azacyclic nucleosides. Furthermore, when α-Me imino ester was explored, the corresponding azacyclic nucleoside with a chiral quaternary stereo-center could also be afforded with excellent results.

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Bromide – Wikipedia,
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So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Lautens, Mark; Hiebert, Sheldon; Renaud, Jean-Luc researched the compound: (2S)-1-[(4R)-4,5-dihydro-4-phenyl-2-oxazolyl]-2-(diphenylphosphino)ferrocene( cas:291536-01-1 ).Safety of (2S)-1-[(4R)-4,5-dihydro-4-phenyl-2-oxazolyl]-2-(diphenylphosphino)ferrocene.They published the article 《Enantioselective Ring Opening of Aza and Oxabicyclic Alkenes with Dimethylzinc》 about this compound( cas:291536-01-1 ) in Organic Letters. Keywords: azabenzonorbornadiene methyl zinc stereoselective alkylative ring opening; oxabicyclic alkene methyl zinc stereoselective ring opening; alkylative ring opening catalyst palladium chiral phosphinooxazoline ligand; hydronaphthalene methyl stereoselective preparation; methylcyclohexenol stereoselective preparation; methylcycloheptenol stereoselective preparation. We’ll tell you more about this compound (cas:291536-01-1).

A system for efficient, asym. alkylative ring opening of azabenzonorbornadienes and [2.2.1] and [3.2.1] oxabicyclic alkenes was developed. The use of Pd(CH3CN)2Cl2 and chiral phosphinooxazoline ligands gave the corresponding dihydronaphthalenes, cyclohexenols, and cycloheptenols in excellent yields and enantiomeric excesses.

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Bromide – Wikipedia,
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In general, if the atoms that make up the ring contain heteroatoms, such rings become heterocycles, and organic compounds containing heterocycles are called heterocyclic compounds. An article called Enantioselective Inverse Electron Demand (3 + 2) Cycloaddition of Palladium-Oxyallyl Enabled by a Hydrogen-Bond-Donating Ligand, published in 2021-01-20, which mentions a compound: 291536-01-1, Name is (2S)-1-[(4R)-4,5-dihydro-4-phenyl-2-oxazolyl]-2-(diphenylphosphino)ferrocene, Molecular C31H26FeNOP, Electric Literature of C31H26FeNOP.

A method for enantioselective (3 + 2) cycloaddition reactions between palladium-oxyallyl species and electron-deficient nitroalkenes has been reported. This transformation is enabled by a rationally designed hydrogen-bond-donating ligand (FeUrPhos) and proceeds via an inverse electron demand pathway. Using this method, cyclopentanones I (R = n-Bu, Ph, PhCH2CH2, 4-MeC6H4, 3-ClC6H4, 2-naphthyl, etc.; R1 = H, R2 = H, 2-O2NC6H4, 4-FC6H4, 2-naphthyl, etc; R1 = Me, R2 = H) with up to three contiguous stereocenters were assembled with high enantioselectivity and good to excellent diastereoselectivity from cyclic carbonates II and nitroalkenes O2NCR1:CHR2.

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Bromide – Wikipedia,
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HPLC of Formula: 291536-01-1. The reaction of aromatic heterocyclic molecules with protons is called protonation. Aromatic heterocycles are more basic than benzene due to the participation of heteroatoms. Compound: (2S)-1-[(4R)-4,5-dihydro-4-phenyl-2-oxazolyl]-2-(diphenylphosphino)ferrocene, is researched, Molecular C31H26FeNOP, CAS is 291536-01-1, about Stereodivergent Coupling of 1,3-Dienes with Aldimine Esters Enabled by Synergistic Pd and Cu Catalysis. Author is Zhang, Qinglong; Yu, Huimin; Shen, Lulu; Tang, Tianhua; Dong, Dongfang; Chai, Weiwei; Zi, Weiwei.

Herein we describe the use of synergistic Pd and Cu catalysis for stereodivergent coupling reactions between 1,3-dienes and aldimine esters. By using different enantiomers of the two metal catalysts, all four stereoisomers of the coupling products, which have two vicinal stereocenters, could be accessed with high diastereo- and enantioselectivity [e.g., I + II → III (99%, 88% isolated; >20:1 dr, >99% ee)]. This atom-economical cross-coupling reaction has a wide substrate scope and good functional group tolerance. Our work highlights the power of synergistic catalysis for asym. coupling reactions involving Pd-hydride catalysts.

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Bromide – Wikipedia,
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