Category: 29086-41-7

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 29086-41-7, name is 1,1-Bis(bromomethyl)cyclopropane, A new synthetic method of this compound is introduced below., Product Details of 29086-41-7

Example 1271: 5-(5-Chloro-6-(2,2,2-trifluoroethoxy)-4′-(trifluoromethyl)biphenyl-3-yl)- spiro[2,3]hexane-5-carboxylic acidStep lEthyl 5-(5-chloro-6-(2,2,2-trifluoroethoxy)-4′-(trifluoromethyl)biphenyl-3-yl)- spiro[2,3]hexane-5-carboxylateEthyl 2-(5-chloro-6-(2,2,2-trifluoroethoxy)-4′-(trifluoromethyl)biphenyl-3-yl)acetate (0.6 g, 1.36 mmol) was dissolved in anhydrous DMF (3OmL), NaH (60% wt. in paraffin oil, 0.136 g, 3.4 mmol) was added at 00C. The reaction mixture was stirred for 30 min at room temperature and l,l-bis(bromomethyl)cyclopropane (0.482 g, 1.4 mmol, for preparation see J. Org. Chem 1993, 58, 4122-26) was added drop wise at 0 0C. The reaction mixture was stirred an additional Ih at 0 0C and saturated NH4CI solution (1OmL) was added. The reaction mixture was extracted with EtOAc (3x20mL) and the combined organic phases were washed with water (3x20mL) and brine (2OmL), and dried over MgSO4. The volatiles were removed under reduced pressure and the residue was purified by flash column chromatography to yield compound ethyl 5-(5-chloro-6-(2,2,2- trifluoroethoxy)-4′-(trifluoromethyl)biphenyl-3-yl)- spiro[2,3]hexane-5-carboxylate (150 mg) as a low melting solid.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; ENVIVO PHARMACEUTICALS, INC.; WO2009/86277; (2009); A1;,
Bromide – Wikipedia,
bromide – Wiktionary

Related Products of 29086-41-7,Some common heterocyclic compound, 29086-41-7, name is 1,1-Bis(bromomethyl)cyclopropane, molecular formula is C5H8Br2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

To a stirred solution of 1 .78 g (4.80 mmol) of compound 2-1 and 2.2 g (9.7 mmol) of 1 ,1 -bis(bromomethyl)cyclopropane in 20 mL of DMSO was added 3.2 g (9.7 mmol) of CS2CO3. The mixture was stirred at rt for 3 h under argon atmosphere, then diluted with 50 mL of water and extracted with four 100 mL portions of ethyl acetate. The combined organic layers were washed with brine and dried over anhydrous Na2S04. After filtration, the filtrate was concentrated under reduced pressure to afford a residue, which was purified by silica gel column chromatography eluting with 0 to 15 % gradient of EtOAc in PE to afford compound 6-1. LC-MS: m/e = 324 [M+H]+.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 1,1-Bis(bromomethyl)cyclopropane, its application will become more common.

Reference:
Patent; ANGEX PHARMACEUTICAL, INC.; WU, Wen-Lian; YANG, Zhiqiang; LEE, Francis; TAN, John Qiang; (112 pag.)WO2019/94143; (2019); A1;,
Bromide – Wikipedia,
bromide – Wiktionary

Electric Literature of 29086-41-7, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 29086-41-7, name is 1,1-Bis(bromomethyl)cyclopropane belongs to bromides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

Ethyl 2-(5-chioro-6-(2,2,2-trifluoroethoxy)-4′-(trifluoromethyl)biphenyl-3- yl)acetate (0.6 g, 1.36 mmol) was dissolved in anhydrous DMF (30mL), NaH (60% wt. in paraffin oil, 0.136 g, 3,4 mmol) was added at 0C. The reaction mixture was stirred for 30 rmn at room temperature and 1 , 1 -bis(bromomethyl)cyclopropane (0.482 g, 1 .4 mmol, for preparation see J. Org. Chem 1993, 58, 4122-26) was added drop wise at 0 C. The reaction mixture was stirred an additional Ih at 0 C and saturated NH4CI solution (lOmL) was added. The reaction mixture was extracted with EtOAc (3x20mL) and the combined organic phases were washed with water (3x20mL) and brine (20mL), and dried over MgS04. The volatiles were removed under reduced pressure and the residue was purified by flash column chromatograplivto yield compound ethyl 5-(5-chloro-6-(2,2,2- trifluoroethoxy)-4′-(trifluoromethyl)biphenyl-3-yl)- spiro[2,3]hexane-5-carboxylate (150 mg) as a low melting solid.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1,1-Bis(bromomethyl)cyclopropane, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; ENVIVO PHARMACEUTICALS, INC.; KOENIG, Gerhard; BLAIN, Jean-francois; WO2013/106328; (2013); A1;,
Bromide – Wikipedia,
bromide – Wiktionary