Category: 2862-39-7

In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 2862-39-7 as follows. name: 2-Bromo-N,N-dimethylethanamine hydrobromide

A mixture of tert- butyl 5-{N-[(4-methoxyphenyl)methyl]3-fluoro-4-[2-(1H-imidazol-1-yl)acetamido]benzenesulfonamido}-1,3-thiazole-4-carboxylate (Example 20a) (250 mg, 0.4 mmol), dimethylaminoethyl bromide hydrobromide salt (Sigma Aldrich) (120 mg, 2.07 mmol) and DIPEA (0.61 mL, 3.3 mmol) in acetonitrile (30 mL) was heated at 80 C for 72 hours. The mixture was evaporated and the residue triturated with methanol-ether affording a brown solid (300 mg).

According to the analysis of related databases, 2862-39-7, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Antabio SAS; DAVIES, David; LEIRIS, Simon; (56 pag.)EP3572411; (2019); A1;,
Bromide – Wikipedia,
bromide – Wiktionary

Adding a certain compound to certain chemical reactions, such as: 2862-39-7, name is 2-Bromo-N,N-dimethylethanamine hydrobromide, belongs to bromides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 2862-39-7, Formula: C4H11Br2N

A mixture of 4- (4, 4, 5, 5-tetramethyl-1, 3, 2-dioxaborolan-2-yl) -1H-pyrazole (1.5 g, 7.7 mmol) , 2-bromo-N, N-dimethylethanamine hydrobromide (4 g, 20 mmol) and Cs2CO3(9 g, 17.6 mmol) in DMF (15 mL) was stirred at 70 overnight. The reaction mixture was concentrated to remove DMF. The residue was diluted with water (20 mL) . The resulting mixture was extracted with DCM (30 mL ¡Á 3) . The combined organic layers were dried over anhydrous Na2SO4and concentrated in vacuo. The residue was purified by silica gel column chromatography eluted with DCM/MeOH (v/v) 25/1 to give a white solid product (0.5 g, 20) .[1634]MS (ESI, pos. ion) m/z: 266.1 [M+1]+.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2-Bromo-N,N-dimethylethanamine hydrobromide, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; SUNSHINE LAKE PHARMA CO., LTD.; LIU, Bing; ZHANG, Yingjun; CHENG, Changchung; HUANG, Jiuzhong; BAI, Shun; REN, Xingye; LI, Zhi; ZHOU, Youbai; (368 pag.)WO2016/615; (2016); A1;,
Bromide – Wikipedia,
bromide – Wiktionary

Related Products of 2862-39-7, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 2862-39-7, name is 2-Bromo-N,N-dimethylethanamine hydrobromide belongs to bromides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

General procedure: To a stirred solution of 6-(4-chlorophenyl)-5-(3, 8-dimethyl-[1 ,2,4]triazolo[4, 3-a]pyridin-6-yl)-3-methyl-5,6-dihydropyrrolo[3,4-b]pyrrol-4(1H)-one (Step 10 of Example 3, 100 mg, 0.255 mmol)in DMF (4 mL) was added NaH (13.27 mg, 0.332 mmol) under Ar. After 30 mm at rt, 3-bromo-1- methypyrrolidin-2-one (54.5 mg, 0.306 mmol) was added. The reaction mixture stirred for 1 h at rt, quenched with a saturated aqueous solution of NaHCO3 (75 mL) and extracted with EtOAc (2 x 75 mL). The organic layers were combined, washed with a saturated aqueous solution of NaHCO3 (75 mL), dried on Na2504 and evaporated. The residue was purified by silica gelchromatography on Combiflash Isco (eluent: DCM/MeOH; gradient: 0-10% MeOH in 12 mm, 2 mm 10% MeOH; flow: 18 mL/min) and subsequent SF0 to afford 12 mg of diastereomerA and 25 mg of diastereomer B. The title compound was prepared using an analogous procedure to that described in Example 126 but using dimethylaminoethyl bromide hydrobromide (71.3 mg, 0.306 mmol, 1.2 eq) and 3eq of NaH. The crude product was purified by silica gel chromatography on Combiflash Isco (eluent: DCM/MeOH; gradient: 0-10% MeOH in 12 mm, 3.6 mm 10% MeOH; flow: 18 mL/min) and subsequent trituration of the resulting material in diethyl ether to afford (65 mg) of the title compound as a colorless solid. Rt: 0.62 mm (LC-MS 1); ESI-MS mlz: 463.2 [M+H] (LC-MS 1); 1H NMR (400 MHz, DMSO-d6) O 8.31 (d, J = 1.7 Hz, 1H), 7.42- 7.26 (m, 5H), 6.71 (5, 1H), 6.42(5, 1H), 3.72-3.57 (m, 1H), 3.57-3.44 (m, 1H), 2.59 (5, 3H), 2.41 (5, 3H), 2.29-2.18 (m, 1H),2.14 (5, 3H), 2.08- 1.91 (m, 7H).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2-Bromo-N,N-dimethylethanamine hydrobromide, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; NOVARTIS AG; BLANK, Jutta; BOLD, Guido; BORDAS, Vincent; COTESTA, Simona; GUAGNANO, Vito; RUeEGER, Heinrich; VAUPEL, Andrea; WO2015/75665; (2015); A1;,
Bromide – Wikipedia,
bromide – Wiktionary

Application of 2862-39-7, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 2862-39-7, name is 2-Bromo-N,N-dimethylethanamine hydrobromide belongs to bromides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

A mixture of intermediate 252 (0.76 g, 4.17 mmol), K2CO3 (1.10 g, 7.96 mmol) and 2- bromo-N,N-dimethylethylamine hydrobromide (1.13 g, 4.61 mmol) in DMF (8 mL) was stirred in a sealed tube at 120 C using one single mode microwave (Biotage Initiator EXP 60) with a power output ranging from 0 to 400 W for 60 min. [fixed hold time]. This reaction was performed at 150 C for 15 min then K2CO3 added 150 C for 70 min. Water was added and this mixture was extracted twice with EtOAc. The organic layer was decanted and the solvent was evaporated until dryness. This residue was purified by column chromatography on silica gel (Irregular SiOH, 40 muiotaeta, 40 g, mobile phase: heptane/EtOAc, gradient from 80:20 to 60:40). The pure fractions were collected and the solvent was evaporated until dryness to give 240 mg of a mixture of intermediates 253 & 254 (29% yield) used as it in the next step. This purification was performed with 95% DCM, 5% MeOH (+10% NH4OH) to 85% DCM, 15% MeOH (+10% NH4OH). The pure fractions were collected and the solvent was evaporated until dryness to give 450 mg of a mixture of intermediates 261 & 262 (42% yield) directly used as it in the next step and a mixture of intermediates 253 & 254 also directly used in the next step.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2-Bromo-N,N-dimethylethanamine hydrobromide, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; JANSSEN PHARMACEUTICA NV; STANSFIELD, Ian; QUEROLLE, Olivier, Alexis, Georges; LIGNY, Yannick, Aime, Eddy; GROSS, Gerhard, Max; JACOBY, Edgar; MEERPOEL, Lieven; GREEN, Simon, Richard; HYND, George; KULAGOWSKI, Janusz, Jozef; MACLEOD, Calum; MANN, Samuel, Edward; (472 pag.)WO2018/2217; (2018); A1;,
Bromide – Wikipedia,
bromide – Wiktionary

Related Products of 2862-39-7, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 2862-39-7, name is 2-Bromo-N,N-dimethylethanamine hydrobromide, This compound has unique chemical properties. The synthetic route is as follows.

A stirred mixture of 3,3-bis(4-hydroxyphenyl)-2-(thiophen-2-yl)acrylonitrile (11; 30 mg, 0.1 mmol), 2-bromo-N,N-dimethylethylamine hydrobromide (328 mg, 1.4 mmol), cesium carbonate (612 mg, 1.9 mmol), and acetonitrile (3 mL) was heated at reflux for 18 h. The mixture was diluted with water and extracted with ethyl acetate (3x). The combined extracts were washed successively with water and sat. brine, dried and concentrated to a syrup that was purified by flash silica gel chromatography, eluting first with 4-5 column volumes of 3:1 dichloromethane/methanol and then with 95:5 methanol/conc. ammonium hydroxide to elute the product. Combined product fractions were concentrated to leave 12 (18 mg, 42%) as an amber gum. HPLC: rt 5.1 min (89% purity). 1H NMR (400 MHz, DMSO-d6): delta 7.46 (d, J = 5.2 Hz, 1H), 7.32 (d, J = 8.9 Hz, 2H), 7.17 (d, J = 2.5 Hz, 1H), 7.08 (d, J = 8.8 Hz, 2H), 7.03-6.87 (m, 5H), 4.15-3.97 (m, 4H), 2.65-2.53 (m, 4H), 2.20 (s, 12H). MS TOFES+: m/z 462.1 (M+H)+.

The chemical industry reduces the impact on the environment during synthesis 2-Bromo-N,N-dimethylethanamine hydrobromide. I believe this compound will play a more active role in future production and life.

Reference:
Article; Carpenter, Colleen; Sorenson, Roderick J.; Jin, Yafei; Klossowski, Szymon; Cierpicki, Tomasz; Gnegy, Margaret; Showalter, Hollis D.; Bioorganic and Medicinal Chemistry; vol. 24; 21; (2016); p. 5495 – 5504;,
Bromide – Wikipedia,
bromide – Wiktionary

Adding a certain compound to certain chemical reactions, such as: 2862-39-7, name is 2-Bromo-N,N-dimethylethanamine hydrobromide, belongs to bromides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 2862-39-7, category: bromides-buliding-blocks

(A) (cis)-3-(Hydroxy)-1-[2-(dimethylamino)ethyl]-1,3,4,5-tetrahydro-4-(4-methoxyphenyl)-7-(trifluoromethyl)-2H-1-benzazepin-2-one A vigorously stirred suspension of 7.0 g (0.020 mol) of (cis)-7-(trifluoromethyl)-1,3,4,5-tetrahydro-3-hydroxy-4-(4-methoxyphenyl)-2H-1-benzazepin-2-one (see Example 28, part E) in 140 ml of dichloromethane (500 ml recovery flask fitted with magnetic stirrer) was treated with 25 ml of water, followed by 13.3 g (0.042 mol) of pulverized barium hydroxide and 0.8 g of benzyltrimethylammonium chloride. A solution of 10.5 g (0.045 mol) of 2-dimethylaminoethyl bromide hydrobromide in 12 ml of water was then added portionwise. The flask was stoppered and the mixture was vigorously stirred at room temperature and stirring was continued overnight. Some solids were filtered off, washed with dichloromethane, and the layers in the filtrate separated. The dichloromethane layer was washed with water (2*75 ml), then shaken with 750 ml of water containing 42 ml of N hydrochloric acid. A stubborn emulsion was encountered at this point. Some dichloromethane was drawn off but then the mixture was extracted with 600 ml of ether. The aqueous phase was layered over with 250 ml of ethyl acetate, basified with 56 ml of N sodium hydroxide, shaken, and separated. The aqueous phase was extracted with ethyl acetate (three times 150 ml), the combined organic layers washed with brine (100 ml), dried (magnesium sulfate), and the solvent evaporated to give a colorless solid which was pump-dried; yield 7.87 g; melting point 136-138 C. TLC:Rf 0.42 (90:10 dichloromethane-methanol).

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.

Reference:
Patent; E. R. Squibb & Sons, Inc.; US4748239; (1988); A;,
Bromide – Wikipedia,
bromide – Wiktionary

Synthetic Route of 2862-39-7, The chemical industry reduces the impact on the environment during synthesis 2862-39-7, name is 2-Bromo-N,N-dimethylethanamine hydrobromide, I believe this compound will play a more active role in future production and life.

50 ml of N,N-dimethylformamide and 7.37 g of dimethylaminobromoethane hydrobromide were added to the reaction vessel.(0 ¡¤ 0318 mol), adding 5 g of potassium carbonate, stirring at room temperature for 15 min, adding 4.5 g of 2-benzylpyridine (0.0265 mol), heating to 80 C for 5 h, monitoring by TLC, filtering while hot, adding 150 ml of water and 150 ml of filtrate. Extracted with ethyl acetate and extracted with 100 ml of ethyl acetate.The ethyl acetate phases were combined and concentrated to give 6 g of Pheniramine.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2-Bromo-N,N-dimethylethanamine hydrobromide, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Guangdong Zhongsheng Pharmaceutical Co., Ltd.; Guangdong Xian Qiang Pharmaceutical Co., Ltd.; Tan Zhenyou; Deng Jun; CN108164455; (2018); A;,
Bromide – Wikipedia,
bromide – Wiktionary

Related Products of 2862-39-7, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 2862-39-7 as follows.

A solution of 5-(2-hydroxyphenyl)-9-[(2R)-3,3,3-trifluoro-2-methoxy-2-phenylpropanoyl]-3,9- diazaspiro[5.5]undecan-2-one (stereoisomer 1) (50.0 mg, 105 pmol) (Example 175) and caesium carbonate (68.4 mg, 210 pmol) in DMF (1 ml_) was was stirred for 10 min at room temperature. Then 2-bromo-N,N-dimethylethan-1 -amine hydrogen bromide (1/1) (24.4 mg, 105 pmol) was added. The mixture was stirred at 80 for 12 hours. The reaction mixture was concentrated in vacuo. The residue was purified via preparative HPLC (method 6) to give the title compound 15.3 mg (95 % purity, 25 % yield).LC-MS (Method 2): Rt= 1.20 min; MS (ESIpos): m/z = 548 [M+H]+Optical rotation (method OR1): +71.1?(methanol).1H-NMR (400 MHz, DMSO-d6) delta [ppm]: 0.390 (0.18), 0.421 (0.34), 0.444 (0.20), 0.763 (0.46), 0.797 (0.44), 0.851 (0.16), 0.894 (0.24), 0.917 (0.40), 0.927 (0.40), 0.950 (0.26), 1.107(1.85), 1.163 (0.62), 1.232 (0.84), 1.269 (0.32), 1.481 (0.62), 1.515 (0.50), 1.899 (0.42), 1.942(0.52), 2.003 (0.64), 2.046 (0.68), 2.121 (0.54), 2.170 (11.10), 2.191 (0.44), 2.225 (16.00), 2.284 (0.58), 2.518 (5.23), 2.522 (3.58), 2.544 (0.50), 2.556 (0.64), 2.570 (0.50), 2.586 (0.54),2.602 (1.49), 2.615 (0.94), 2.629 (1.11), 2.664 (1.15), 2.668 (1.31), 2.673 (1.01), 2.841 (0.30), 2.869 (0.54), 2.908 (0.36), 2.945 (0.58), 2.954 (0.48), 2.967 (0.46), 3.096 (0.30), 3.130 (0.46),3.163 (0.26), 3.244 (0.50), 3.273 (1.15), 3.289 (2.55), 3.367 (0.36), 3.398 (0.24), 3.419 (0.52),3.431 (0.58), 3.446 (0.42), 3.459 (0.36), 3.494 (0.32), 3.513 (0.52), 3.527 (0.60), 3.566 (5.03),3.966 (0.32), 3.976 (0.66), 3.991 (1.39), 4.006 (1 .39), 4.021 (0.72), 4.034 (0.48), 4.050 (0.34), 4.063 (0.18), 4.102 (0.38), 4.135 (0.58), 4.167 (0.24), 4.191 (0.18), 6.716 (0.66), 6.734 (0.76),6.894 (0.30), 6.912 (0.58), 6.931 (0.34), 6.965 (0.54), 6.984 (0.96), 7.004 (1 .75), 7.026 (1 .51 ),7.172 (1 .35), 7.191 (1 .85), 7.219 (1.00), 7.237 (0.76), 7.267 (0.58), 7.285 (1 .93), 7.304 (2.15),7.324 (1 .00), 7.340 (0.66), 7.350 (0.80), 7.358 (0.78), 7.434 (1.97), 7.441 (1 .63), 7.451 (1 .13),7.477 (0.60), 7.495 (0.90), 7.514 (0.40), 7.549 (0.98), 7.554 (1.00), 7.629 (0.66).

According to the analysis of related databases, 2862-39-7, the application of this compound in the production field has become more and more popular.

Reference:
Patent; BAYER AKTIENGESELLSCHAFT; BAYER PHARMA AKTIENGESELLSCHAFT; GRAHAM, Keith; BUCHGRABER, Philipp; AIGUABELLA FONT, Nuria; WITTROCK, Sven; HEINRICH, Tobias; BRAeUER, Nico; KUHNKE, Lara, Patricia; LANGE, Martin; BADER, Benjamin; PRECHTL, Stefan; LIENAU, Philip; KOPITZ, Charlotte, Christine; NOWAK-REPPEL, Katrin; POTZE, Lisette; STEUBER, Holger; (754 pag.)WO2020/48831; (2020); A1;,
Bromide – Wikipedia,
bromide – Wiktionary

Synthetic Route of 2862-39-7, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 2862-39-7 name is 2-Bromo-N,N-dimethylethanamine hydrobromide, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

General procedure: Example 54A 3-Ethyl-5-methyl-1-(2,2,2-trifluoroethyl)thieno[2,3-d]pyrimidine-2,4(1H,3H)-dione 1.0 g (4.76 mmol) of the compound from Ex. 42A and 2.32 g (7.13 mmol) of caesium carbonate were stirred in 12 ml of anhydrous DMF at RT for 10 min, before 700 mul (7.13 mmol) of 1,1,1-trifluoro-2-iodoethane were added. Then the reaction mixture was heated in a microwave oven (Biotage Initiator with dynamic control of irradiation power) to 120 C. for 4 h. After cooling to RT, the mixture was diluted with ethyl acetate and washed successively with water and saturated sodium chloride solution. After drying over anhydrous magnesium sulphate, the mixture was filtered and concentrated to dryness. The residue obtained was purified by MPLC (Biotage cartridge, 100 g of silica gel, cyclohexane/ethyl acetate 3:1). After combination of the product fractions, concentration and drying under high vacuum, 592 mg (42% of theory) of the title compound were obtained. 1H-NMR (400 MHz, DMSO-d6, delta/ppm): 10.09 (s, 1H), 4.00 (t, 2H), 3.91 (q, 2H), 2.79 (s, 3H), 2.58 (t, 2H), 2.20 (s, 6H), 1.13 (t, 3H). LC/MS (Method 1, ESIpos): Rt=0.39 min, m/z=310 [M+H]+.

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 2-Bromo-N,N-dimethylethanamine hydrobromide, and friends who are interested can also refer to it.

Reference:
Patent; BAYER PHARMA AKTIENGESELLSCHAFT; HAeRTER, Michael; KOSEMUND, Dirk; DELBECK, Martina; KALTHOF, Bernd; WASNAIRE, Pierre; SUessMEIER, Frank; LUSTIG, Klemens; (369 pag.)US2018/65981; (2018); A1;,
Bromide – Wikipedia,
bromide – Wiktionary