Category: 28342-75-8

Electric Literature of 28342-75-8, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 28342-75-8, name is 1,5-Dibromo-2,4-difluorobenzene belongs to bromides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

Under a nitrogen atmosphere and at reflux temperature there was added 1,5-bromo-2,4-difluorobenzene (90.0 g), phenylboronic acid (which 88.6 g of), tripotassiumphosphate (154.0g), Pd-132 (Johnson Matthey (JohnsonMatthey)) (1.6g), toluene (900ml),isopropanol (300ml) and water (150ml) of the flask was heated for 1 hour. After stoppingthe reaction, the reaction solution was cooled until room temperature and water wasadded to carry out liquid separation. After the solvent was distilled off under reducedpressure, silica gel short column (eluent: heptane / toluene = 1/2 (volume ratio)) to bepurified, thereby obtaining 4 ‘, 6′-difluoro-1,1’: 3 ‘, 1’ – terphenyl (86.0g).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1,5-Dibromo-2,4-difluorobenzene, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Kwansei Gakuin School Corporation; Tian, Shanzuoci; Zhong, Zhongzongyiliang; Zhong, Daoguiyi; Ping, Jingdagui; Xiao, Yeyangping; Zhi, Lianyizhi; Ni, Jingping; Song, Xiawusi; Sheng, Tianlizhao; (405 pag.)CN105431439; (2016); A;,
Bromide – Wikipedia,
bromide – Wiktionary

Related Products of 28342-75-8,Some common heterocyclic compound, 28342-75-8, name is 1,5-Dibromo-2,4-difluorobenzene, molecular formula is C6H2Br2F2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

A 200-ml three-necked flask was replaced with nitrogen. 207 mmol (8.78 g) of lithium chloride and 1.6 mmol (1.13 g) of bistriphenylphosphine palladium dichloride were added, and the flask was replaced with nitrogen again. Next, 80 ml of toluene and 20.7 mmol (5.62 g) of the compound A were added. Further, 62.1 mmol (15.0 g) of trimethyl-2-pyridyl tin were dropped, and the whole was refluxed under heat for 3 days in a stream of nitrogen. After the resultant had been left standing to cool, 150 ml of a saturated aqueous solution of potassium fluoride were added, and the whole was stirred for 30 minutes. A solid was removed by filtration, and the remainder was extracted with methylene chloride and a 5percent aqueous solution of sodium hydrogen carbonate. After that, sodium sulfate was added to an organic layer for dehydration. The solvent was removed under reduced pressure, whereby a brown solid was obtained. Ether was added to the resultant solid, and the solvent was removed by filtration, whereby 4.35 g of a compound B were obtained (78.3percent yield).

The synthetic route of 28342-75-8 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Chuo University; Idemitsu Kosan Co., Ltd.; EP1961743; (2008); A1;,
Bromide – Wikipedia,
bromide – Wiktionary

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 28342-75-8, name is 1,5-Dibromo-2,4-difluorobenzene, A new synthetic method of this compound is introduced below., COA of Formula: C6H2Br2F2

Under a nitrogen atmosphere, 1,5-dibromo-2,4-difluorobenzene (600.0 g),carbazole (81.1 g), potassium carbonate (91.0 g of) and NMP (300ml) was heated to 155 and It was stirred for 4 hours. The reaction mixture was cooled until room temperature,water was added to make the inorganic salt is dissolved, and the organics were extractedby suction filtration. After washing with ethyl acetate, dissolved in heated odichlorobenzene,and the short silica gel column (eluent: o-dichlorobenzene) by. Afterthe solvent was distilled off under reduced pressure, and then washed with ethylacetate, to obtain 9,9 ‘- (4,6-dibromo-1,3-phenylene) bis (9H-carbazole) (108.0 g of) .

The synthetic route of 28342-75-8 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Kwansei Gakuin School Corporation; Tian, Shanzuoci; Zhong, Zhongzongyiliang; Zhong, Daoguiyi; Ping, Jingdagui; Xiao, Yeyangping; Zhi, Lianyizhi; Ni, Jingping; Song, Xiawusi; Sheng, Tianlizhao; (405 pag.)CN105431439; (2016); A;,
Bromide – Wikipedia,
bromide – Wiktionary

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 28342-75-8, name is 1,5-Dibromo-2,4-difluorobenzene, This compound has unique chemical properties. The synthetic route is as follows., Computed Properties of C6H2Br2F2

Step 1: Synthesis of (3aR,5R,7aS)-5-[(benzyloxy)methyl]-7a-(5-bromo-2,4-difluorophenyl)hexahydro-1H-pyrano[3,4-c][1,2]oxazole (C6) P1 (4.01 g, 16.5 mmol) was added to a three neck round-bottomed flask (oven dried) equipped with a thermocouple, a nitrogen inlet and mechanical overhead stirrer. Toluene:isopropyl ether (1:1, 160 mL) was added and the resulting solution was cooled to -74¡ã C. Boron trifluoride-diethyl etherate (46.5percent, 4.91 ml, 18.5 mmol) was added and the resulting solution was allowed to stir at -74¡ã C. for 30 minutes. 2,4-Difluoro-1,5-di-bromobenzene (5.01 g, 18.4 mmol) was added followed by a slow addition of n-butyllithium (2.5 M in hexanes, 6.96 mL, 17.4 mmol) ensuring the internal temperature did not rise >5¡ã C. The resulting solution was allowed to stir at -78¡ã C. for 90 minutes. Saturated aqueous ammonium chloride (100 mL) was added and the resulting mixture was allowed to warm to room temperature, at which point it was partitioned between ethyl acetate (1*200 mL) and water (1*600 mL). The organic layer was extracted and the aqueous was back extracted with ethyl acetate (3*200 mL). The combined organics were washed with brine (1*100 mL) and the organic layer was dried over sodium sulfate, filtered, and the filtrate concentrated in vacuo Silica gel chromatography (Gradient 10percent to 70percent ethyl acetate in heptane) provided the product as a clear oily residue. Yield: 3.11 g, 7.06 mmol, 43percent. 1H NMR (400 MHz, CD3OD), delta 8.09 (t, J=8.3 Hz, 1H), 7.31-7.36 (m, 4H), 7.25-7.29 (m, 1H), 7.12 (dd, J=11.5, 8.4 Hz, 1H), 4.55 (s, 2H), 4.06 (dd, J=12.6, 1.7 Hz, 1H), 3.78 (d, J=12.5 Hz, 1H), 3.73-3.8 (m, 1H), 3.69 (d, J=7.2 Hz, 1H), 3.53-3.57 (m, 2H), 3.49 (dd, J=7.3, 5.2 Hz, 1H), 3.05-3.11 (m, 1H), 1.82-1.87 (m, 1H), 1.52-1.61 (m, 1H).

According to the analysis of related databases, 28342-75-8, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Pfizer Inc.; Brodney, Michael Aaron; Beck, Elizabeth Mary; Butler, Christopher Ryan; Davoren, Jennifer Elizabeth; O’Neill, Brian Thomas; US2014/163015; (2014); A1;,
Bromide – Wikipedia,
bromide – Wiktionary

Electric Literature of 28342-75-8,Some common heterocyclic compound, 28342-75-8, name is 1,5-Dibromo-2,4-difluorobenzene, molecular formula is C6H2Br2F2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

To a stirred solution of 1,5-dibromo-2,4-difluorobenzene (20.0 g, 73.6 mmol) in diethyl ether (400 mL) in a dry ice bath was added n-butyl lithium in hexanes (31 ml, 2.5 M, 77 mmol) so that the temperature of the reaction mixture stayed between -65¡ã C and -70¡ã C and then the mixture was stirred at -70¡ã C for further 0.5 h. N,N-dimethylformamide (7.1 ml, 92 mmol) was slowly added so that the temperature of the reaction mixture stayed between -65¡ã C and -70¡ã C and then the mixture was stirred at -70¡ã C for fu rther 0.5 h. The dry ice bath was removed and the mixture was allowed to warm up to 0¡ã C. A m ixture of water (180 mL) and acetic acid (1 1 ml, 200 mmol) was added and the mixture was stirred for 15 min. The phases were separated and the aqueous phase was extracted with ethyl acetate. The organic phases were combined and washed with saturated sodium chloride solution, dried (sodium sulfate), filtered and the solvent was removed in vacuum. Silicagel chromatography gave 12.6 g (77 percent yield) of the title compound. LC-MS (Method 1 ): Rt = 1 .09 min; MS (ESIpos): m/z = 220 [M+H]+ 1H-NMR (400 MHz, DMSO-d6) d [ppm]: 2.518 (0.45), 7.716 (4.55), 7.738 (4.98), 7.742 (4.92), 7.765 (4.71 ), 8.141 (4.86), 8.159 (6.75), 8.179 (4.87), 10.079 (16.00).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 1,5-Dibromo-2,4-difluorobenzene, its application will become more common.

Reference:
Patent; BAYER PHARMA AKTIENGESELLSCHAFT; SCHULZE, Volker; HEINRICH, Tobias; CHRIST, Clara; BRIEM, Hans; FARIA ALVARES DE LEMOS, Adelaide, Clara; BADER, Benjamin; HOLTON, Simon; BOeMER, Ulf; LIENAU, Philip; KUHNKE, Lara, Patricia; (122 pag.)WO2019/185525; (2019); A1;,
Bromide – Wikipedia,
bromide – Wiktionary

Patent; Kwansei Gakuin Educational Foundation; JNC Corporation; HATAKEYAMA, Takuji; KONDO, Yasuhiro; NAKAMOTO, Keiichi; YANAI, Motoki; (190 pag.)US2018/94000; (2018); A1;,
Author tianliPosted on November 25, 2020Categories 28342-75-8, bromides-buliding-blocksTags M.W=200-300

28342-75-8, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 28342-75-8, name is 1,5-Dibromo-2,4-difluorobenzene, A new synthetic method of this compound is introduced below.

1. Add 1 mmol of 1,5-dibromo-2,4-difluorobenzene, 2.2 mmol of nitrogen-containing heterocyclic compound and 2.27 mmol of potassium carbonate to 5 mL of dimethyl sulfoxide.Then reacted for 6 h under an argon atmosphere at a temperature of 130 C.Obtaining a mixed solution I containing a reactant;The mixed solution I containing the reactant was extracted with a mixture of water and dichloromethane, and then the organic layer obtained after the extraction was dried using anhydrous sodium sulfate, and the solvent was evaporated under reduced pressure using a rotary evaporator to give a crude reaction. Product I; using solvent I as a rinse, the crude reaction product I is purified by column chromatography to obtain 1,5-dicarbazole-2,4-dibromobenzene;The nitrogen-containing heterocyclic compound described in the first step is oxazole;The solvent I described in the first step is a mixed solution of petroleum ether and dichloromethane, the volume ratio of petroleum ether to dichloromethane in the solvent I is 5:1;The volume ratio of water to dichloromethane in the mixture of water and dichloromethane described in the first step is 1:5;

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; Heilongjiang University; Xu Hui; Duan Chunbo; Han Chunmiao; Liang Qianqian; (46 pag.)CN107325811; (2019); B;,
Bromide – Wikipedia,
bromide – Wiktionary

28342-75-8,Some common heterocyclic compound, 28342-75-8, name is 1,5-Dibromo-2,4-difluorobenzene, molecular formula is C6H2Br2F2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

A mixture of 2-(2-methoxy-1-naphthalenyl)-boronic acid (3.24 g, 16 mmole), 1,5-dibromo-2,4-difluorobenzene (1.78 g, 6.55 mmole), Pd(PPh3)4 (0.33 g, 0.29 mmole) and potassium carbonate (4.53 g, 32.8 mmole) in 1,2-dimethoxyethane (120 ml) and water (30 ml) was stirred with heating at reflux temperature under nitrogen atmosphere for 4 hours. After that reaction mixture cooled down, precipitate collected by filtration to give 1.12 g of the product. Organic phase of the filtrate was evaporated further and the second precipitate collected by filtration, dried in vacuum to give 1.8 g of the product. Crude product as a mixture of diastereomers was used for the next step without further purification. Crude product can be purified by chromatography on silica gel column using gradient elution with mixtures of hexanes and dichlromethane to isolate pure isolated diastereomers. MS: MH+ = 427.1H-NMR of diastereomer 1 (CDCl3, 500 MHz): 3.95 (s, 6H), 7.14 (t, 1H, J = 9 Hz), 7.34-7.37 (m, 3H), 7.38 (d, 2H, J = 9 Hz), 7.43 (td, 2H, J1 = 1 Hz, J2 = 8 Hz), 7.68 (d, 2H, J = 9 Hz), 7.83 (d, 2H, J = 8 Hz), 7.92 (d , 2H, J = 9 Hz).1H-NMR of diastereomer 2 (CDCl3, 500 MHz): 3.91 (s, 6H), 7.14 (t, 1H, J = 9 Hz), 7.31-7.38 (m, 3H), 7.38 (d, 2H, J = 9 Hz), 7.44 (td, 2H, J1 = 1 Hz, J2 = 8 Hz), 7.64 (d, 2H, J = 9 Hz), 7.83 (d, 2H, J = 9 Hz), 7.92 (d, 2H, J = 9 Hz).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 28342-75-8, its application will become more common.

Reference:
Patent; E. I. DU PONT DE NEMOURS AND COMPANY; SKULASON, Hjalti; DIEV, Viacheslav V.; VO, Giang Dong; GAO, Weiying; WU, Weishi; HERRON, Norman; HOWARD, Michael Henry, Jr.; DOGRA, Kalindi; ZOU, Yunlong; (195 pag.)WO2018/97937; (2018); A1;,
Bromide – Wikipedia,
bromide – Wiktionary

Some common heterocyclic compound, 28342-75-8, name is 1,5-Dibromo-2,4-difluorobenzene, molecular formula is C6H2Br2F2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. 28342-75-8

100 g of intermediate 1-1, 186 g of intermediate 1-2, 203 g of potassium carbonate, 23.7 g of tetrabutylammonium bromide (TBAB) were added to a 2 L three-necked flask, and 800 ml of toluene, 200 ml of ethanol, and 200 ml of water were sequentially added. Nitrogen gas was introduced, stirred for 15 min, 2.1 g of tetrakis(triphenylphosphine)palladium was added, and the mixture was heated to 80 ¡ãC for refluxing for 8 h. TLC was used to monitor the reaction of the starting material to room temperature and filtered to remove insoluble.The impurities were separated, and the organic phase was washed with water until neutral. After drying over anhydrous sodium sulfate, the residue was purified by silica gel column to obtain 104.5 g of intermediate 1 in a yield of 89.3percent.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 28342-75-8, its application will become more common.

Reference:
Patent; Xi’an Ruilian New Materials Co., Ltd.; Sun Jun; Zhang Hongke; Liu Kaipeng; Yang Dandan; Tian Mi; He Haixiao; Li Jiangnan; Wang Xiaowei; Liu Qianfeng; Gao Renxiao; (33 pag.)CN109535131; (2019); A;,
Bromide – Wikipedia,
bromide – Wiktionary

The chemical industry reduces the impact on the environment during synthesis 28342-75-8, name is 1,5-Dibromo-2,4-difluorobenzene, I believe this compound will play a more active role in future production and life. 28342-75-8

l,5-Dibromo-2,4-difluorobenzene (1, 1.36 g, 5.00 mmol) was dissolved in dry diethyl ether ( 15 mL) and cooled down to -78C. 2.35 M n-Butyllithium in hexane (2.20 mL, 5.25 mmol) was added drop-wise with stirring . After 15 minutes, dry N,N- dimethylformamide (0.77 mL, 10.0 mmol) was added and the resulting mixture was stirred at for 15 minutes and then allowed to warm to ambient temperature. After one hour, the reaction mixture was quenched with 1.0 M aqueous solution of hydrochloric acid ( 15 mL) . Layers were separated and the organic layer was washed with brine ( 15 mL), dried over anhydrous magnesium sulfate and evaporated . The residue was purified by flash column chromatography (Silicagel 60, 0.063-0.200 mm ; eluent: cyclohexane/ ethyl acetate 20 : 1) 5-bromo-2,4-difluorobenzaldehyde (2) as colorless oil which solidified on storage in freezer. Yield : 780 mg (70%) . JH NM R spectrum (300 MHz, CDCI3, deltaEta) : 10.26 (s, 1 H) ; 8.14 (dd, J =9.6 and 8.0 Hz, 1 H) ; 7.05 (d, J = 8.0 Hz, 1 H) .

The chemical industry reduces the impact on the environment during synthesis 28342-75-8. I believe this compound will play a more active role in future production and life.

Reference:
Patent; NOVO NORDISK A/S; KRUSE, Thomas; HANSEN, Mikael, Kofoed; MUeNZEL, Martin, Werner, Borchsenius; TH?GERSEN, Henning; SAUERBERG, Per; RASMUSSEN, Jakob, Ewald; BEHRENS, Carsten; H?EG-JENSEN, Thomas; BAL?ANEK, Vojtech; DROBNAKOVA, Zuzana; DRO?, Ladislav; HAVRANEK, Miroslav; KOTEK, Vladislav; ?TENGL, Milan; ?NAJDR, Ivan; VANOVA, Hana; (202 pag.)WO2019/92125; (2019); A1;,
Bromide – Wikipedia,
bromide – Wiktionary