Category: 28148-04-1

28148-04-1, name is 1,3-Dibromo-2-methylpropane, belongs to bromides-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. HPLC of Formula: C4H8Br2

General procedure: Kinetic parameters were determined using a halide release assay. Assays were done at room temperature in 200 muL 50 mM Tris-SO4, pH 8.2. For compound 1e, 20% of DMSO was added to enhance the solubility to 0.5 mM. Samples were taken at different times and after adding mercuric thiocyanate and ferric ammonium sulfate the absorption was measured at 460 nm. [27] and [53] The initial rates of halide release at different substrate concentrations were plotted in a Michaelis-Menten graph in order to determine the kinetic parameters.Time-course experiments were done as follows. To 10 mL of a solution of compound 1 in 50 mM Tris-SO4, pH 8.2, enzyme was added and the mixture was incubated at 30 C (for details, see Table 5). At various times, 1 mL samples were taken and extracted with a solvent containing dodecane as internal standard. The samples were dried with MgSO4. The enantiomeric excess values for haloalcohols 2a-2c were determined by Chiral GC and for 2d and 2c by chiral HPLC, as described above. For the reactions with compounds 1a, 1b and 1c, the conversion was determined with the same GC program, whereas for 1d and 1e a different GC program was used. For 1d: AT5 GC column (80 C?130 C (10 C/min), 130 C for 1 min, 130 C?80 C (20 C/min), retention times 3.8 min (2d) and 4.4 min (1d)). For 1e: AT5 GC column (80 C?180 C (10 C/min), 180 C for 1 min, 180 C?80 C (20 C/min), retention times: 10.9 min (2e); 11.9 min (1e)).

The synthetic route of 28148-04-1 has been constantly updated, and we look forward to future research findings.

Reference:
Conference Paper; Westerbeek, Alja; Van Leeuwen, Jan G.E.; Szyma?ski, Wiktor; Feringa, Ben L.; Janssen, Dick B.; Tetrahedron; vol. 68; 37; (2012); p. 7645 – 7650;,
Bromide – Wikipedia,
bromide – Wiktionary

Adding a certain compound to certain chemical reactions, such as: 28148-04-1, name is 1,3-Dibromo-2-methylpropane, belongs to bromides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 28148-04-1, Recommanded Product: 1,3-Dibromo-2-methylpropane

The beta- lactam carbonyl compound of the formula shown CH3CH2COCH2CONHC6H51.0mmol added 50 ml round-bottomed flask, followed by adding further Cs2CO32.2mmol, eighteen crown six 0.05mmol, acetic 1.2mmol, 1,3- dibromo – 2-methyl propane 1.15mmol and 35mL of deionized water and mix well. The reaction was continued stirring at 40 deg C 5.0 hours, the reaction was stopped by filtration, dried and purified by recrystallization to give 6-anilino after -5- propionyl-3-methyl-3,4-dihydropyran, products yield 87%.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1,3-Dibromo-2-methylpropane, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Huaihua University; Xiang, Dexuan; Liang, Chunhua; Liu, Yilin; Xiang, Bailin; Zhang, Li; (9 pag.)CN105541770; (2016); A;,
Bromide – Wikipedia,
bromide – Wiktionary

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 28148-04-1, name is 1,3-Dibromo-2-methylpropane, This compound has unique chemical properties. The synthetic route is as follows., Recommanded Product: 28148-04-1

(a) 1,3-Dimethylphosphetane borane I-73 Prepared according to a procedure similar to that described for 1-ethylphosphetane borane I-64 starting from dimethyl methylphosphonate I-59 (1.2 g, 9.4 mmol) and 1,3- dibromo-2-methylpropane (2.1 g, 9.4 mmol) to provide the title compound as a colourless oil (274 mg, 2.4 mmol, 25%) which was isolated as an ca. 1 :1 mixture of cis/trans isomers.

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 28148-04-1.

Reference:
Patent; AUSPHERIX LIMITED; KING, Nigel Paul; POWELL, Jonathan Raymond; NEGOITA-GIRAS, Gabriel; WATTS, Joseph Michael; ALVAREZ, Alicia Galvan; GUETZOYAN, Lucie Juliette; FREEM, Joshua Robert; CLARKE, Philip Graham; NAYLOR, Alan; (264 pag.)WO2018/220171; (2018); A1;,
Bromide – Wikipedia,
bromide – Wiktionary

Reference of 28148-04-1, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 28148-04-1, name is 1,3-Dibromo-2-methylpropane belongs to bromides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

The beta- lactam carbonyl compound of the formula shown in C6H5-COCH2CONH-CH31.0mmol added 50 ml round bottomFlask, and then followed by adding K2CO32.4mmol, tetrabutylammonium bromide 0.07mmol, ammonium acetate 1.2mmol, 1,3- dibromo-2-Methyl propane 1.2mmol and 30mL of deionized water and mix well. The reaction was continued stirring at 30 deg C 8.0 hours, stoppedThe reaction, was filtered, dried, purified by recrystallization methanamine obtained after 5-benzoyl-6- methyl-3,4-dihydro-pyran-3, 87% yield of product.

The synthetic route of 1,3-Dibromo-2-methylpropane has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Huaihua University; Xiang, Dexuan; Liang, Chunhua; Liu, Yilin; Xiang, Bailin; Zhang, Li; (9 pag.)CN105541770; (2016); A;,
Bromide – Wikipedia,
bromide – Wiktionary

Related Products of 28148-04-1, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 28148-04-1, name is 1,3-Dibromo-2-methylpropane belongs to bromides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

General procedure: Kinetic parameters were determined using a halide release assay. Assays were done at room temperature in 200 muL 50 mM Tris-SO4, pH 8.2. For compound 1e, 20% of DMSO was added to enhance the solubility to 0.5 mM. Samples were taken at different times and after adding mercuric thiocyanate and ferric ammonium sulfate the absorption was measured at 460 nm. [27] and [53] The initial rates of halide release at different substrate concentrations were plotted in a Michaelis-Menten graph in order to determine the kinetic parameters.Time-course experiments were done as follows. To 10 mL of a solution of compound 1 in 50 mM Tris-SO4, pH 8.2, enzyme was added and the mixture was incubated at 30 C (for details, see Table 5). At various times, 1 mL samples were taken and extracted with a solvent containing dodecane as internal standard. The samples were dried with MgSO4. The enantiomeric excess values for haloalcohols 2a-2c were determined by Chiral GC and for 2d and 2c by chiral HPLC, as described above. For the reactions with compounds 1a, 1b and 1c, the conversion was determined with the same GC program, whereas for 1d and 1e a different GC program was used. For 1d: AT5 GC column (80 C?130 C (10 C/min), 130 C for 1 min, 130 C?80 C (20 C/min), retention times 3.8 min (2d) and 4.4 min (1d)). For 1e: AT5 GC column (80 C?180 C (10 C/min), 180 C for 1 min, 180 C?80 C (20 C/min), retention times: 10.9 min (2e); 11.9 min (1e)).

The synthetic route of 1,3-Dibromo-2-methylpropane has been constantly updated, and we look forward to future research findings.

Reference:
Conference Paper; Westerbeek, Alja; Van Leeuwen, Jan G.E.; Szyma?ski, Wiktor; Feringa, Ben L.; Janssen, Dick B.; Tetrahedron; vol. 68; 37; (2012); p. 7645 – 7650;,
Bromide – Wikipedia,
bromide – Wiktionary