Category: 27976-27-8

27976-27-8, name is (6-Bromohexyl)benzene, belongs to bromides-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Computed Properties of C12H17Br

(1) 2-(4-Benzyloxyphenyl)-5-methyl-1-{2-[4-(6-phenylhexyloxy)phenyl]ethyl}-1H-pyrrole A solution of 4-{2-[2-(4-benzyloxyphenyl)-5-methyl-1H-pyrrol-1-yl]ethyl}phenol (1.50 g, 3.91 mmol), 1-bromo-6-phenylhexane (1.42 g, 5.87 mmol) and potassium carbonate (811 mg, 5.87 mmol) in DMF (15 ml) was stirred at 80 C. for 12 hours. The reaction solution was poured into water and the mixture was extracted with ethyl acetate. The extract was washed with water and dried over magnesium sulfate anhydride, and solvent was removed under reduced pressure. The residue was purified by silica gel column chromatography (hexane:ethyl acetate=30:1) to give the object compound as an oily substance. 1.43 g (yield: 67.1%) 1H-NMR (CDCl3) delta; 1.22-1.79 (8H, m), 2.24 (3H, s), 2.57-2.72 (4H, m), 3.86-4.03 (4H, m), 5.11 (2H, s), 5.91 (1H, d, J=3.2 Hz), 6.03 (1H, d, J=3.2 Hz), 6.73 (2H, d, J=8.4 Hz), 6.82 (2H, d, J=8.4 Hz), 7.00 (2H, d, J=8.0 Hz),7.15-7.49 (12H, m). IR (KBr) cm-1; 1611, 1524, 1512, 1244, 1175, 752, 689.

The synthetic route of 27976-27-8 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Matsumoto, Takahiro; Katayama, Nozomi; Mabuchi, Hiroshi; US2003/144338; (2003); A1;,
Bromide – Wikipedia,
bromide – Wiktionary

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 27976-27-8, name is (6-Bromohexyl)benzene, A new synthetic method of this compound is introduced below., Safety of (6-Bromohexyl)benzene

8.7 g (45%) 95 was obtained analogously to the preparation of 67 (example 15) as a colourless oil with a boiling point of 168 C./0.15 mbar from 14.96 g (55 mmol) dibromooctane, 15.5 g (64.2 mmol) 1-bromo-6-phenyl-hexane, 1.7 g (70 mmol) magnesium and 10 ml cuprate solution after distillation. 1.55 g (20%) 44 was obtained with a melting point of 58-59 C. from 7.1 g (20 mmol) 95 and 10.3 g (80 mmol) dichloroacetic acid as in example 9. The sodium salt obtained from 44 and pulverized NaOH in ethanol melted at 166 C. (decomp.).

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; Roche Diagnostics GmbH; US5968982; (1999); A;,
Bromide – Wikipedia,
bromide – Wiktionary

Adding a certain compound to certain chemical reactions, such as: 27976-27-8, name is (6-Bromohexyl)benzene, belongs to bromides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 27976-27-8, Computed Properties of C12H17Br

(1) 2-(4-Benzyloxyphenyl)-5-methyl-1-[4-(6-phenylhexyloxy)-phenyl]-1H-pyrrole A solution of 4-[2-(4-benzyloxyphenyl)-5-methyl-1H-pyrrol-1-yl]phenol (1.50 g, 4.22 mmol), 1-bromo-6-phenylhexane (1.53 g, 6.33 mmol) and potassium carbonate (874 mg, 6.33 mmol) in DMF (15 ml) was stirred at 80 C. for 12 hours. The reaction solution was poured into water and the mixture was extracted with ethyl acetate. The extract was washed with water, dried over magnesium sulfate anhydride and solvent was removed under reduced pressure. The residue was purified by silica gel column chromatography (hexane:ethyl acetate=20:1) to give the object compound as an oily substance. 1.74 g (yield: 79.4%) 1H-NMR (CDCl3) delta; 1.22-1.83 (8H, m), 2.10 (3H, s), 2.63 (2H, t, J=7.4 Hz), 3.94 (2H, t, J=6.2 Hz), 4.98 (2H, s), 6.04 (1H, d, J=3.2 Hz), 6.25 (1H, d, J=3.2 Hz), 6.74-7.42 (18H, m). IR (KBr) cm-1; 1607, 1514, 1289, 1244, 1177, 1026, 835, 750, 698.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, (6-Bromohexyl)benzene, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Matsumoto, Takahiro; Katayama, Nozomi; Mabuchi, Hiroshi; US2003/144338; (2003); A1;,
Bromide – Wikipedia,
bromide – Wiktionary