Category: 2789-89-1

Electric Literature of 2789-89-1,Some common heterocyclic compound, 2789-89-1, name is 1,2-Bis(4-bromophenyl)ethyne, molecular formula is C14H8Br2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

In 25mL dry pressure reaction tube, was added 58mg of 1-octyl-4- (p-chlorophenyl) -1,2,3-triazole, 134mg of 1-phenyl-1-propyne, 6mg of dichloro (pentamethylcyclopentadienyl yl) rhodium dimer, 80mg of copper acetate monohydrate, 32mg 1.5mL sodium peroxide and 1,2-dichloroethane.100 stirred for 24 hours.After the reaction was cooled to room temperature, directly on a silica gel column (ethyl acetate and petroleum ether, the volume ratio of 1: 3) to give product 48mg, 39% yield,

The synthetic route of 2789-89-1 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Zhejiang University; Chen, Wanzhi; (11 pag.)CN104725375; (2016); B;,
Bromide – Wikipedia,
bromide – Wiktionary

Some common heterocyclic compound, 2789-89-1, name is 1,2-Bis(4-bromophenyl)ethyne, molecular formula is C14H8Br2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Recommanded Product: 2789-89-1

A solution of bis(4-bromophenyl)acetylene (1.500 g, 4.46 mmol, 1 equiv), and iodine(566 mg, 2.23 mmol, 0.5 equiv) in DMSO (7.5 mL) was stirred at 155 00 for 6 h. Thereaction mixture was then cooled down to room temperature and a 1% aqueoussolution of Na2S2O4 (100 mL) was added. The resulting yellow crystals were filtratedand washed with water. Recrystallisation from dioxane afforded 101 as yellow crystals(1.06 g, 65%).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 2789-89-1, its application will become more common.

Reference:
Patent; THE UNIVERSITY OF BIRMINGHAM; BARANOFF, Etienne David; HERBAUT, Antoine Joel Maurice; (37 pag.)WO2016/193748; (2016); A1;,
Bromide – Wikipedia,
bromide – Wiktionary

In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 2789-89-1 as follows. COA of Formula: C14H8Br2

General procedure: The photocatalyst [Ir(dF-CF3-ppy)2(dtbpy)]PF6 (PC-1) (11.2 mg, 0.01 mmol, 2.0 mol%) wasadded to an oven-dried Schlenk tube containing a magnetic stirring bar and anhydrous ethylacetate (2.5 mL, 0.2 M) was added under argon. In the absence of light, the enone (0.5 mmol,1.0 equiv) and the alkyne (1.0 mmol, 2.0 equiv) were added under an argon stream. Theresulting solution was degassed using three freeze-pump-thaw cycles and the tube was finallybackfilled with argon. The reaction mixture was allowed to stir at room temperature for 24 hunder irradiation with visible light from two 30 W Kessil LEDs (lambdamax = 455 nm, see chapter 1.2).The solvent was evaporated and the crude reaction products were purified by columnchromatography over silica gel (dry load of crude material, pentane/EtOAc or pentane/diethylether mixtures as eluent) to afford products 6a-6e, 9a-9e and 10.

According to the analysis of related databases, 2789-89-1, the application of this compound in the production field has become more and more popular.

Reference:
Article; Strieth-Kalthoff; Henkel, Christian; Teders, Michael; Kahnt, Axel; Knolle, Wolfgang; Gomez-Suarez, Adrian; Dirian, Konstantin; Alex, Wiebke; Bergander; Daniliuc, Constantin G.; Abel; Guldi, Dirk M.; Glorius; Chem; vol. 5; 8; (2019); p. 2183 – 2194;,
Bromide – Wikipedia,
bromide – Wiktionary

Electric Literature of 2789-89-1, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 2789-89-1, name is 1,2-Bis(4-bromophenyl)ethyne belongs to bromides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

General procedure: A 7 ml screw-cap tube, containing a magnetic stirring bar, was flame-dried undervacuum and filled with nitrogen after cooling to room temperature. To this tube wereadded tetraarylthiophene S-oxide 6 (0.03 mmol, 1.0 equiv.), diarylethyne 7 (0.06 mmol,2.0 equiv.) and mesitylene (200 mul) under a stream of nitrogen. The flask was heatedat 160 C for 48 h. After cooling the reaction mixture to room temperature, themixture was concentrated in vacuo and the residue was purified by preparativethin-layer chromatography to afford the corresponding HAB 9.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1,2-Bis(4-bromophenyl)ethyne, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Suzuki, Shin; Segawa, Yasutomo; Itami, Kenichiro; Yamaguchi, Junichiro; Nature Chemistry; vol. 7; 3; (2015); p. 227 – 233;,
Bromide – Wikipedia,
bromide – Wiktionary

Related Products of 2789-89-1, The chemical industry reduces the impact on the environment during synthesis 2789-89-1, name is 1,2-Bis(4-bromophenyl)ethyne, I believe this compound will play a more active role in future production and life.

Synthesis route a) 1 ,2-bis(4-bromophenyl)-3,4,5,6-tetraphenylbenzene A mixture of tetraphenylcydopentadienone (5.0 mmol), and bis(p-promophenyl) acetylene (5.0 mmol) in diphenyl ether (20 ml) was heated to 260 C overnight. Then the temperature was raised to 270 C. After 69 h, the reaction mixture was cooled, and methanol (100 ml) was added. After stirring for 1 h, the product was filtered off, washed with methanol, and finally dried in vaccuo overnight. Yield: Quantitative.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1,2-Bis(4-bromophenyl)ethyne, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; SINVENT AS; PAUCHARD, Vincent Olivier; WO2013/162381; (2013); A1;,
Bromide – Wikipedia,
bromide – Wiktionary

Electric Literature of 2789-89-1,Some common heterocyclic compound, 2789-89-1, name is 1,2-Bis(4-bromophenyl)ethyne, molecular formula is C14H8Br2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

The starting material 2-aminobenzamide (0.3 mmol, 1 equiv),4,4′-dibromodiphenylacetylene (0.9 mmol,3equiv), catalyst palladium trifluoroacetate (Pd(TFA) 2, 0.03 mmol, 10%) and ligand 2,2′-bipyridine (bpy,0.06mmol, 20%) was added to the reaction vessel, and the reaction vessel was continuously subjected to three pumping-oxygenation operations, and then continued.The reaction solvent 1,4-dioxane (1,4-dioxane, 0.4 mL) was added to the reaction vessel, followed by reaction at 100 C in an oil bath.Stir at temperature until the end of the reaction (about 12h), then spin off the reaction solvent and pass column chromatography (filled with 300 mesh in column)400 mesh silica gel, separated by dichloromethane and ethyl acetate in a volume ratio of 10:1 as an eluent), after separation and purification, whiteSolid, yield 79%.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 1,2-Bis(4-bromophenyl)ethyne, its application will become more common.

Reference:
Patent; Wenzhou University; Liu Miaochang; Liu Wei; Bi Kang; Zhu Xiaobin; Gao Wenxia; Huang Xiaobo; Wu Huayue; (11 pag.)CN108129402; (2018); A;,
Bromide – Wikipedia,
bromide – Wiktionary

Electric Literature of 2789-89-1, A common heterocyclic compound, 2789-89-1, name is 1,2-Bis(4-bromophenyl)ethyne, molecular formula is C14H8Br2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

To a solution of di(4-bromophenyl)acetylene (719 mg, 2.14 mmol, 1 equiv) in dry THF (60 mL) was added the fresh solution (Ca. 0.4 mol/L) of (4-dodecylphenyl)magnesium bromide (20 mL, 8.57 mmol, 4 equiv) in a flame-dried apparatus. PdCI2(dppf) (138 mg,0.17 mmol, 8 mol%) was then added and the reaction mixture was stirred at reflux under argon overnight. The solution was then cooled down to room temperature. The obtained white precipitate was filtered and washed with methanol and petroleum ether. 044 was obtained as an off-white solid (1.1672 mg, 82%).

The synthetic route of 2789-89-1 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; THE UNIVERSITY OF BIRMINGHAM; BARANOFF, Etienne David; HERBAUT, Antoine Joel Maurice; (37 pag.)WO2016/193748; (2016); A1;,
Bromide – Wikipedia,
bromide – Wiktionary

Related Products of 2789-89-1, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 2789-89-1, name is 1,2-Bis(4-bromophenyl)ethyne belongs to bromides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

A small molecule luminescent material (P37) based on 1,2-diphenylacetylene as the acceptor unit,The specific steps are:Under nitrogen protection,To a three-necked flask was added 100 ml of toluene,1 g of intermediate 1 (2.99 mmol),2.14 g of 9-phenyl-3-carbazole boronic acid (7.45 mmol, 2.5 equ)Under stirring, 3.47 g of sodium tert-butyl alcohol was added,Then add 230 mg of palladium acetate,0.5 mL of tri-tert-butylphosphine,90 & lt; 0 & gt; C overnight.Cooling, extraction of organic phase with methylene chloride, spin dry,Column. To give 1.48 g of product as a yellow solid in 75% yield.

The synthetic route of 1,2-Bis(4-bromophenyl)ethyne has been constantly updated, and we look forward to future research findings.

Reference:
Patent; South China University of Technology; Su Shijian; He Zuozheng; Ma Wuguang; Peng Junbiao; Cao Yong; (30 pag.)CN106242976; (2016); A;,
Bromide – Wikipedia,
bromide – Wiktionary

Application of 2789-89-1,Some common heterocyclic compound, 2789-89-1, name is 1,2-Bis(4-bromophenyl)ethyne, molecular formula is C14H8Br2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: A glass tube equipped with a magnetic stir bar was charged with isoxazole 1 (0.2 mmol), alkyne 2 (0.62 mmol, 3.1 equiv),[Cp*Rh(MeCN)3](SbF6)2 (0.008 mmol, 4.0 mol%), and Cu(OAc)2 (0.8mmol, 4.0 equiv). The tube was evacuated and backfilled with N2 (3 ×)followed by addition of 1,4-dioxane (4.0 mL) via syringe. The resulting mixture was heated at 100 C for 12 h. After cooling to r.t., the mixture was poured into water and extracted with EtOAc (3 ×). The combined organic extracts were washed with brine, dried (Na2SO4), andc oncentrated under reduced pressure. The residue was subjected to column chromatography (silica gel) to afford the corresponding product .Further purification was performed by GPC if required. Note: the coupling products 3 exhibit broadened and split peaks inNMR spectra owing to the presence of rotamers, and the following data are reported as appeared in the spectra.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 1,2-Bis(4-bromophenyl)ethyne, its application will become more common.

Reference:
Article; Noguchi, Teppei; Nishii, Yuji; Miura, Masahiro; Synthesis; vol. 51; 1; (2019); p. 258 – 270;,
Bromide – Wikipedia,
bromide – Wiktionary

2789-89-1, name is 1,2-Bis(4-bromophenyl)ethyne, belongs to bromides-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Safety of 1,2-Bis(4-bromophenyl)ethyne

General procedure: A 25 mL Schlenk-type tube (with a Teflon high pressure valve and side arm) was charged withcompound 1a (34.6 mg, 0.10 mmol), alkynes (0.20 mmol), Cu(OAc)2.H2O (5.0 mg, 0.025 mmol),[RuCl2(p-cymene)]2 (6.1 mg, 0.01 mmol), AgSbF6 (13.7 mg, 0.04 mmol) and THF (1 mL). Thereaction tube was evacuated and back-filled with N2 (3 times, ballon). After the reaction mixturewas stirred at 120 oC for 12 h, it was allowed to cool down to room temperature. The reactionmixture was diluted with ethyl acetate (20 mL), and then filtered through a pad of Celite. Thefiltrate was washed with brine (10 mL), dried over Na2SO4, and concentrated in vacuo. Theresidue was purified by silica gel preparative TLC to give the corresponding products

The synthetic route of 2789-89-1 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Pan, Shulei; Jiang, Hang; Zhang, Yu; Chen, Dushen; Zhang, Yanghui; Synlett; vol. 27; 13; (2016); p. 1997 – 2002;,
Bromide – Wikipedia,
bromide – Wiktionary