Category: 2725-82-8

Wang, Yong; Cao, Xinyi; Zhao, Leyao; Pi, Chao; Ji, Jingfei; Cui, Xiuling; Wu, Yangjie published the artcile< Generalized Chemoselective Transfer Hydrogenation/Hydrodeuteration>, COA of Formula: C8H9Br, the main research area is unsaturated compound palladium catalyst chemoselective transfer hydrogenation.

A generalized, simple and efficient transfer hydrogenation of unsaturated bonds was developed using HBPin and various proton reagents as hydrogen sources. The substrates, including alkenes, alkynes, aromatic heterocycles, aldehydes, ketones, imines, azo, nitro, epoxy and nitrile compounds, were all applied to this catalytic system. Various groups, which cannot survive under the Pd/C/H2 combination, were tolerated. The activity of the reactants was studied and the trends were as follows: styrene>diphenylmethanimine>benzaldehyde>azobenzene>nitrobenzene>quinoline>acetophenone>benzonitrile. Substrates bearing two or more different unsaturated bonds were also investigated and transfer hydrogenation occurred with excellent chemoselectivity. Nano-palladium catalyst in situ generated from Pd(OAc)2 and HBPin extremely improved the TH efficiency. Furthermore, chemoselective anti-Markovnikov hydrodeuteration of terminal aromatic olefins was achieved using D2O and HBPin via in situ HD generation and discrimination.

Advanced Synthesis & Catalysis published new progress about Alkanes Role: RCT (Reactant), RACT (Reactant or Reagent). 2725-82-8 belongs to class bromides-buliding-blocks, and the molecular formula is C8H9Br, COA of Formula: C8H9Br.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Xia, Dong; Duan, Xin-Fang published the artcile< Tandem vinyl radical Minisci-type annulation on pyridines: one-pot expeditious access to azaindenones>, Product Details of C8H9Br, the main research area is azaindenone preparation regioselective; pyridine alkylative alkenylative tandem annulation.

A new regiospecific alkylative/alkenylative cascade annulation of pyridines e.g., I has been achieved while the corresponding classic Minisci alkylative annulation failed. This protocol provides a novel and expeditious access to azaindenones and related compounds e.g., II via cross-dehydrogenative coupling with the long-standing problem of C2/C4 regioselectivity of pyridines being well addressed.

Chemical Communications (Cambridge, United Kingdom) published new progress about Cyclization (alkylative, alkenylative, regioselective). 2725-82-8 belongs to class bromides-buliding-blocks, and the molecular formula is C8H9Br, Product Details of C8H9Br.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Wang, Bin; Yan, Zicong; Liu, Liyan; Wang, Jiawei; Zha, Zhenggen; Wang, Zhiyong published the artcile< TBN-mediated regio- and stereoselective sulfonylation & oximation (oximosulfonylation) of alkynes with sulfonyl hydrazines in EtOH/H2O>, Synthetic Route of 2725-82-8, the main research area is sulfonyl aryl ketoxime regioselective stereoselective preparation; tandem sulfonylation oximation terminal aryl alkyne arylsulfonylhydrazine butyl nitrite; byproduct radical inhibition tandem sulfonylation oximation alkyne arylsulfonylhydrazine; mechanism tandem sulfonylation oximation alkyne arylsulfonylhydrazine nitrite.

Terminal aryl alkynes such as phenylacetylene underwent regioselective and diastereoselective cascade sulfonylation and oximation reactions with arylsulfonyl hydrazides such as 4-MeC6H4SO2NHNH2 mediated by tert-Bu nitrite (TBN), hydrazine hydrate, and imidazole in 40:1 EtOH:H2O to yield (Z)-α-sulfonyl aryl Me ketoximes such as (Z)-4-MeC6H4SO2CH2C(:NOH)Ph. The mechanism was studied through identification of byproducts and radical inhibition and deuterium incorporation studies.

Green Chemistry published new progress about Alkynes, aryl Role: RCT (Reactant), RACT (Reactant or Reagent) (terminal). 2725-82-8 belongs to class bromides-buliding-blocks, and the molecular formula is C8H9Br, Synthetic Route of 2725-82-8.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Wan, Nan-Wei; Cui, Hai-Bo; Zhao, Ling; Shan, Jing; Chen, Ke; Wang, Zhong-Qiang; Zhou, Xiao-Jian; Cui, Bao-Dong; Han, Wen-Yong; Chen, Yong-Zheng published the artcile< Directed evolution of cytochrome P450DA hydroxylase activity for stereoselective biohydroxylation>, Formula: C8H9Br, the main research area is chiral alc preparation stereoselective biohydroxylation cytochrome P450DA hydroxylase.

Engineering of a hydroxylase for highly active and stereoselective biohydroxylation of C(sp3)-H bonds attracts keen interest in synthetic chem. Herein, we report the development of a colorimetric high throughput screening assay for the directed evolution of cytochrome P450DA hydroxylase. The best triple-mutant P450DA-M3 (N190F/V356L/A486E) was identified with improvements in the turnover frequency (TOF) and total turnover number (TTN). P450DA-M3 exhibited good catalytic efficiency (up to 6750 TTNs) and stereoselectivity (up to 98% ee) in the biohydroxylation of diverse substrates. The heme domain structure of the P450DA was also solved for understanding the possible influence of these pos. mutations.

Catalysis Science & Technology published new progress about Aralkyl alcohols Role: BPN (Biosynthetic Preparation), BIOL (Biological Study), PREP (Preparation). 2725-82-8 belongs to class bromides-buliding-blocks, and the molecular formula is C8H9Br, Formula: C8H9Br.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Guo, Le; Mao, Junjie; Guo, Shuangxi; Zhang, Qi; Cai, Shuangfei; He, Wei published the artcile< PtAu bimetallic nanocatalyst for selective hydrogenation of alkenes over aryl halides>, Application of C8H9Br, the main research area is platinum gold nanocatalyst hydrogenation chemoselectivity enantioselectivity.

Herein, we present a new strategy that for the first time achieved chemo- and enantio-selective hydrogenation of alkenes over arylhalides. Key to the success is that instead of using external poisons, we use the composition of the bimetallic nanocrystal catalysts to control chemoselectivity (hydrogenation of C=C bonds without cleavage of Ar-X bonds). We further show that this system combined with surface modifying chiral ligands can control the enantioselectivity. Thus, after synthesizing and screening a series of easily accessible MxAuy (M = Pd, Pt; x, y = 1, 3, 5) bimetallic nanocrystals (9-10 nm) supported on activated carbon, we identified that Pt1Au1/C is a recyclable and generally applicable catalyst for the chemoselective hydrogenation of alkenes without cleaving aryl halogen bonds. Furthermore, cinchonidine modified Pt1Au1/C is shown to be capable of enantioselective hydrogenation, as illustrated by the rapid and enantio-enriched synthesis of RIP1 inhibitor analog 7-Br-O-Nec1.

Nano Research published new progress about Binding energy. 2725-82-8 belongs to class bromides-buliding-blocks, and the molecular formula is C8H9Br, Application of C8H9Br.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Hu, Deqing; Jiang, Xuefeng published the artcile< Stepwise benzylic oxygenation via uranyl-photocatalysis>, Recommanded Product: 1-Bromo-3-ethylbenzene, the main research area is carboxylic acid ketone alc preparation photochem; benzylic mol stepwise oxygenation uranyl catalyst.

Stepwise oxygenation at the benzylic position (1°, 2°, 3°) of aromatic mols. was comprehensively established under ambient conditions via uranyl photocatalysis to produce carboxylic acids, ketones, and alcs., resp. The accuracy of the stepwise oxygenation was ensured by the tunability of catalytic activity in uranyl photocatalysis, which was adjusted by solvents and additives demonstrated through Stern-Volmer anal. Hydrogen atom transfer between the benzylic position and the uranyl catalyst facilitated oxygenation, further confirmed by kinetic studies. Considerably improved efficiency of flow operation demonstrated the potential for industrial synthetic application.

Green Chemistry published new progress about Alcohols Role: SPN (Synthetic Preparation), PREP (Preparation). 2725-82-8 belongs to class bromides-buliding-blocks, and the molecular formula is C8H9Br, Recommanded Product: 1-Bromo-3-ethylbenzene.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Li, Chuang; Xu, Rong; Song, Qingming; Mao, Zhipeng; Li, Junfeng; Yang, Hongjun; Chen, Jian published the artcile< Highly efficient photocatalytic oxidation of C-H bond based on microchannel reactor>, Computed Properties of 2725-82-8, the main research area is alkyl arene oxygen methylanthraquinone photooxidation green chem; aryl ketone preparation.

A mild photocatalytic C-H bond selective oxidation mediated by metal-free photocatalyst 2-Methylanthraquinone was reported. Glass microchannel reactor enhanced the absorption of photon energy and oxygen by the reaction mixture, so as to greatly improve the reaction efficiency of photocatalytic reaction in glass microchannel reactor. This reaction method can quickly oxidize alkyl aromatics into corresponding oxidation products to obtain aromatic ketones in high yield.

Tetrahedron Letters published new progress about Aromatic hydrocarbons Role: RCT (Reactant), RACT (Reactant or Reagent). 2725-82-8 belongs to class bromides-buliding-blocks, and the molecular formula is C8H9Br, Computed Properties of 2725-82-8.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Xu, Jitao; Li, Zhilong; Xu, Yumin; Shu, Xiaomin; Huo, Haohua published the artcile< Stereodivergent Synthesis of Both Z- and E-Alkenes by Photoinduced, Ni-Catalyzed Enantioselective C(sp3)-H Alkenylation>, Name: 1-Bromo-3-ethylbenzene, the main research area is alkylarene vinyl bromide nickel catalyst photoredox enantioselective diastereoselective alkenylation; aryl alkyl alkene preparation.

An enantioselective benzylic C(sp3)-H alkenylation of simple alkylarenes with vinyl bromides via photoinduced nickel catalysis was reported, which allowed the stereodivergent synthesis of both enantioenriched Z- and E-alkenes bearing aryl-substituted, allylic tertiary stereogenic centers. Interestingly, the tunable Z/E-selectivity was achieved by energy transfer catalysis via a judicious choice of the photocatalyst counteranion. This versatile strategy featured simple starting materials, mild reaction conditions, broad substrate scope, divergent Z- and E-selectivity and high enantioselectivities. Moreover, a formal asym. benzylic C(sp3)-H alkylation was also be achieved via a one-pot alkenylation/reduction sequence, providing a complementary strategy to address the notoriously challenging stereochem. control in C(sp3)-C(sp3) bond construction.

ACS Catalysis published new progress about Alkenes Role: PRP (Properties), RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 2725-82-8 belongs to class bromides-buliding-blocks, and the molecular formula is C8H9Br, Name: 1-Bromo-3-ethylbenzene.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Chacon-Huete, Franklin; Lasso, Juan David; Szavay, Paul; Covone, Jason; Forgione, Pat published the artcile< Synthesis of 2,5-diaryl nonsymmetric furans C6-platform chemicals via catalytic conversion of biomass and the formal synthesis of dantrolene>, Application In Synthesis of 2725-82-8, the main research area is diarylfuran preparation biomass furancarboxylic acid decarboxylation arylation aryl bromide.

Biomass-derived commodity chem. 5-hydroxymethyl furfural is an underutilized C6-platform chem. derived from cellulose that is ideal to prepare next-generation value-added products. We have developed an efficient synthetic strategy to access 2,5-diaryl nonsym. furans from 5-hydroxymethyl furfural utilizing decarboxylative cross-couplings. A key finding was that the presence of the hydroxymethyl handle enhances the yields of the palladium-catalyzed decarboxylative cross-coupling reaction. The method provides access to a broad-range nonsym. 2,5-diaryl furans where each arene can be systematically introduced as required. Addnl., this green synthetic strategy was employed for a formal synthesis of the muscle relaxant Dantrolene in excellent yields.

Journal of Organic Chemistry published new progress about Aryl bromides Role: RCT (Reactant), RACT (Reactant or Reagent). 2725-82-8 belongs to class bromides-buliding-blocks, and the molecular formula is C8H9Br, Application In Synthesis of 2725-82-8.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Shah, Akshara P.; Sharma, Anuj S.; Sharma, Vinay S.; Shimpi, Navinchandra G. published the artcile< Polyacrylonitrile Nanofibers Incorporating Silver-Decorated Graphitic Carbon Nitride for the Visible-Light-Activated Selective Oxidation of Styrene, Benzylic Methylene Groups, and Benzene>, Recommanded Product: 1-Bromo-3-ethylbenzene, the main research area is photooxidation catalyst nanofiber nanocomposite visible light.

A polyacrylonitrile nanofiber (PAN NF) supported silver nanoparticles-graphitic carbon nitride (Ag NPs/g-C3N4) nanoparticles catalyst was fabricated by electrospinning technique. Structural and morphol. studies indicate that the spherical Ag NPs present in the g-C3N4 material were well-dispersed on the surfaces of the PAN NFs or embedded in the PAN NFs without agglomerating. The catalytic potential of PAN/Ag NPs/g-C3N4 NFs was developed for oxidation of organic substrate such as styrene, -CH2 bonded mols., and benzene under visible light. The visible-light-mediated activity of the catalyst could be aided by the photoactive nature of the g-C3N4 surface. PAN/Ag NPs/g-C3N4 NFs show good selectivity toward epoxide with higher conversion (98%) in the case of styrene oxidation Further, ethylbenzene was oxidized to acetophenone with 99% conversion using H2O2. Addnl., the present material also shows excellent C-H oxidation of benzene (99%) into the desired phenol with higher selectivity. PAN/Ag NPs/g-C3N4 NFs possess mesoporous properties with excellent absorptive performance. This hybrid NFs exhibited enhanced activity, excellent stabilization, and recyclability.

ACS Applied Nano Materials published new progress about Electrospinning. 2725-82-8 belongs to class bromides-buliding-blocks, and the molecular formula is C8H9Br, Recommanded Product: 1-Bromo-3-ethylbenzene.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary