Category: 2675-79-8

In 2019,Angewandte Chemie, International Edition included an article by Wang, Wang; Ding, Chao; Li, Yangyang; Li, Zheqi; Li, Yuqiang; Peng, Long; Yin, Guoyin. Safety of 1-Bromo-3,4,5-trimethoxybenzene. The article was titled 《Migratory Arylboration of Unactivated Alkenes Enabled by Nickel Catalysis》. The information in the text is summarized as follows:

An unprecedented arylboration of unactivated terminal alkenes, featuring 1,n-regioselectivity, has been achieved by nickel catalysis. The nitrogen-based ligand plays an essential role in the success of this three-component reaction. This transformation displays good regioselectivity and excellent functional-group tolerance. In addition, the incorporation of a boron group into the products provides substantial opportunities for further transformations. Also demonstrated is that the products can be readily transformed into pharmaceutically relevant mols. Unexpectedly, preliminary mechanistic studies indicate that although the metal migration favors the α-position of boron, selective and decisive bond formation is favored at the benzylic position. In the experiment, the researchers used 1-Bromo-3,4,5-trimethoxybenzene(cas: 2675-79-8Safety of 1-Bromo-3,4,5-trimethoxybenzene)

1-Bromo-3,4,5-trimethoxybenzene(cas: 2675-79-8) is an important raw material and intermediate used in organic synthesis, pharmaceuticals, agrochemicals and dyestuff.Safety of 1-Bromo-3,4,5-trimethoxybenzene1-Bromo-3,4,5-trimethoxybenzene can be used to synthesize symmetric 3,3′,4,4′,5,5′-hexamethoxydiphenylacetylene via Stille-type coupling with bis-(tributylstannyl)acetylene.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

In 2019,Bioorganic & Medicinal Chemistry included an article by Nowikow, Christina; Fuerst, Rita; Kauderer, Maria; Dank, Christian; Schmid, Walther; Hajduch, Marian; Rehulka, Jiri; Gurska, Sona; Mokshyna, Olena; Polishchuk, Pavel; Zupko, Istvan; Dzubak, Petr; Rinner, Uwe. Quality Control of 1-Bromo-3,4,5-trimethoxybenzene. The article was titled 《Synthesis and biological evaluation of cis-restrained carbocyclic combretastatin A-4 analogs: Influence of the ring size and saturation on cytotoxic properties》. The information in the text is summarized as follows:

Combretastatin A-4 (CA-4) is a highly cytotoxic natural product and several derivatives have been prepared which underwent clin. trial. These investigations revealed that the cis-stilbene moiety of the natural product is prone to undergo cis/trans isomerization under physiol. conditions, reducing the overall activity of the drug candidates. Herein, we report the preparation of cis-restrained carbocyclic analogs of CA-4. The compounds, which differ by the size and hybridization of the carbocyclic ring have been evaluated for their cytotoxic properties and their ability to inhibit tubulin polymerization Biol. data, supported by mol. docking studies, identified cyclobutenyl and cyclobutyl derivatives of the natural product as highly promising drug candidates. In addition to this study using 1-Bromo-3,4,5-trimethoxybenzene, there are many other studies that have used 1-Bromo-3,4,5-trimethoxybenzene(cas: 2675-79-8Quality Control of 1-Bromo-3,4,5-trimethoxybenzene) was used in this study.

1-Bromo-3,4,5-trimethoxybenzene(cas: 2675-79-8) is an important raw material and intermediate used in organic synthesis, pharmaceuticals, agrochemicals and dyestuff.Quality Control of 1-Bromo-3,4,5-trimethoxybenzene1-Bromo-3,4,5-trimethoxybenzene can be used to synthesize N,N′-diarylated indolo[3,2-b]carbazole derivatives, which can find applications in electrophotography.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

《Membrane-Anchoring Photosensitizer with Aggregation-Induced Emission Characteristics for Combating Multidrug-Resistant Bacteria》 was written by Chen, Huan; Li, Shengliang; Wu, Min; Kenry; Huang, Zhongming; Lee, Chun-Sing; Liu, Bin. Recommanded Product: 1-Bromo-3,4,5-trimethoxybenzene And the article was included in Angewandte Chemie, International Edition in 2020. The article conveys some information:

Traditional photosensitizers (PSs) show reduced singlet oxygen (1O2) production and quenched fluorescence upon aggregation in aqueous media, which greatly affect their efficiency in photodynamic therapy (PDT). Meanwhile, non-targeting PSs generally yield low efficiency in antibacterial performance due to their short lifetimes and small effective working radii. Herein, a water-dispersible membrane anchor (TBD-anchor) PS with aggregation-induced emission is designed and synthesized to generate 1O2 on the bacterial membrane. TBD-anchor showed efficient antibacterial performance towards both Gram-neg. (Escherichia coli) and Gram-pos. bacteria (Staphylococcus aureus). Over 99.8% killing efficiency was obtained for methicillin-resistant S. aureus (MRSA) when they were exposed to 0.8μm of TBD-anchor at a low white light dose (25 mW cm-2) for 10 min. TBD-anchor thus shows great promise as an effective antimicrobial agent to combat the menace of multidrug-resistant bacteria. In the experiment, the researchers used 1-Bromo-3,4,5-trimethoxybenzene(cas: 2675-79-8Recommanded Product: 1-Bromo-3,4,5-trimethoxybenzene)

1-Bromo-3,4,5-trimethoxybenzene(cas: 2675-79-8) is an important raw material and intermediate used in organic synthesis, pharmaceuticals, agrochemicals and dyestuff.Recommanded Product: 1-Bromo-3,4,5-trimethoxybenzene1-Bromo-3,4,5-trimethoxybenzene can be used to synthesize analogs of HA14-1, which shows promising anticancer properties.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

In 2022,Liu, Xinyu; Wang, Zhifan; Wang, Qiwei; Wang, Yuanhua published an article in Angewandte Chemie, International Edition. The title of the article was 《Rhodium(II)-Catalyzed C(sp3)-H Diamination of Arylcyclobutanes》.COA of Formula: C9H11BrO3 The author mentioned the following in the article:

Activated by multiple consecutive oxidative radical-polar crossover and desaturation processes, the selective diamination of arylcyclobutanes, which is difficult to perform by classical metallonitrene C-H insertion, was achieved in a short time by rhodium(II) catalysis using N-fluorobenzenesulfonimide (NFSI) as the oxidant and nitrogen source.1-Bromo-3,4,5-trimethoxybenzene(cas: 2675-79-8COA of Formula: C9H11BrO3) was used in this study.

1-Bromo-3,4,5-trimethoxybenzene(cas: 2675-79-8) is an important raw material and intermediate used in organic synthesis, pharmaceuticals, agrochemicals and dyestuff.COA of Formula: C9H11BrO31-Bromo-3,4,5-trimethoxybenzene can be used to synthesize symmetric 3,3′,4,4′,5,5′-hexamethoxydiphenylacetylene via Stille-type coupling with bis-(tributylstannyl)acetylene.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

《Oxidative Deconstruction of Azetidinols to α-Amino Ketones》 was written by Raclea, Robert-Cristian; Natho, Philipp; Allen, Lewis A. T.; White, Andrew J. P.; Parsons, Philip J.. Application of 2675-79-8 And the article was included in Journal of Organic Chemistry in 2020. The article conveys some information:

A silver-mediated synthesis of α-amino ketones via the oxidative deconstruction of azetidinols has been developed using a readily scalable protocol with isolated yields up to 80%. The azetidinols are easily synthesized in one step and can act as protecting groups for these pharmaceutically relevant synthons. Furthermore, mechanistic insights are presented and these data have revealed that the transformation is likely to proceed through the β-scission of an alkoxy radical, followed by oxidation and C-N cleavage of the resulting α-amido radical. The results came from multiple reactions, including the reaction of 1-Bromo-3,4,5-trimethoxybenzene(cas: 2675-79-8Application of 2675-79-8)

1-Bromo-3,4,5-trimethoxybenzene(cas: 2675-79-8) is an important raw material and intermediate used in organic synthesis, pharmaceuticals, agrochemicals and dyestuff.Application of 2675-79-81-Bromo-3,4,5-trimethoxybenzene can be used to synthesize analogs of HA14-1, which shows promising anticancer properties.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

In 2019,Macromolecules (Washington, DC, United States) included an article by Su, Xin; Jessop, Philip G.; Cunningham, Michael F.. Related Products of 2675-79-8. The article was titled 《Versatility of Organocatalyzed Atom Transfer Radical Polymerization and CO2-Switching for Preparing Both Hydrophobic and Hydrophilic Polymers with the Recycling of a Photocatalyst》. The information in the text is summarized as follows:

A new approach was designed to prepare both hydrophobic and hydrophilic polymers by organocatalyzed atom transfer radical polymerization (O-ATRP). The method is based on using a recoverable photocatalyst whose properties can be switched using only CO2 addition and removal as triggers. The effectiveness of the CO2-switching approach in O-ATRP is demonstrated using a new CO2-switchable photoinitiated catalyst, which can be extracted from the polymer and reused. The residual catalyst in the polymer is reduced to less than 15 ppb. The feasibility of recovering and reusing the photoinitiated catalyst for subsequent polymerizations is also established. The experimental part of the paper was very detailed, including the reaction process of 1-Bromo-3,4,5-trimethoxybenzene(cas: 2675-79-8Related Products of 2675-79-8)

1-Bromo-3,4,5-trimethoxybenzene(cas: 2675-79-8) is an important raw material and intermediate used in organic synthesis, pharmaceuticals, agrochemicals and dyestuff.Related Products of 2675-79-81-Bromo-3,4,5-trimethoxybenzene can be used to synthesize symmetric 3,3′,4,4′,5,5′-hexamethoxydiphenylacetylene via Stille-type coupling with bis-(tributylstannyl)acetylene.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Percec, Virgil; Wang, Shitao; Huang, Ning; Partridge, Benjamin E.; Wang, Xuefeng; Sahoo, Dipankar; Hoffman, David J.; Malineni, Jagadeesh; Peterca, Mihai; Jezorek, Ryan L.; Zhang, Na; Daud, Hina; Sung, Paul D.; McClure, Emily R.; Song, Se Lin published their research in Journal of the American Chemical Society in 2021. The article was titled 《An Accelerated Modular-Orthogonal Ni-Catalyzed Methodology to Symmetric and Nonsymmetric Constitutional Isomeric AB2 to AB9 Dendrons Exhibiting Unprecedented Self-Organizing Principles》.Application of 2675-79-8 The article contains the following contents:

Three libraries consisting of 30 sym. and nonsym. constitutional isomeric phenolic acids with unprecedented sequenced patterns, including two AB2, three AB3, eight AB4, five AB5, six AB6, three AB7, two AB8, and one AB9 synthesized by accelerated modular-orthogonal Ni-catalyzed borylation and cross-coupling were reported. A single etherification step with 4-(n-dodecyloxy)benzyl chloride transformed all these phenolic acids, of interest also for other applications, into self-assembling dendrons. Despite this synthetic simplicity, they led to a diversity of unprecedented self-organizing principles: lamellar structures of interest for biol. membrane mimics, helical columnar assemblies from rigid-solid angle dendrons forming Tobacco Mosaic Virus-like assemblies, columnar organizations from adaptable-solid angle dendrons forming disordered micellar-like nonhelical columns, columns from supramol. spheres, five body-centered cubic phases displaying supramol. orientational memory, rarely encountered in previous libraries forming predominantly Frank-Kasper phases, and two Frank-Kasper phases. Lessons from these self-organizing principles, discovered within a single generation of self-assembling dendrons, might help elaborate design principles for complex helical and nonhelical organizations of synthetic and biol. matter. In the part of experimental materials, we found many familiar compounds, such as 1-Bromo-3,4,5-trimethoxybenzene(cas: 2675-79-8Application of 2675-79-8)

1-Bromo-3,4,5-trimethoxybenzene(cas: 2675-79-8) is an important raw material and intermediate used in organic synthesis, pharmaceuticals, agrochemicals and dyestuff.Application of 2675-79-81-Bromo-3,4,5-trimethoxybenzene can be used to synthesize N,N′-diarylated indolo[3,2-b]carbazole derivatives, which can find applications in electrophotography.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

《6,7-Benzotropolone Syntheses Based on Ring-Closing Metatheses and Four-Electron Oxidations》 was written by Kreibich, Michael; Gemander, Manuel; Peter, David; Yadav, Dharmendra B.; de Koning, Charles B.; Fernandes, Manuel A.; Green, Ivan R.; van Otterlo, Willem A. L.; Brueckner, Reinhard. Computed Properties of C9H11BrO3This research focused onvinylaryl ketone ring closing metathesis oxidation selenium Grubbs catalyst; benzotropolone preparation. The article conveys some information:

Four homoallyl ortho-vinylaryl ketones, e. g., I – 1,8-dienes of sorts – were prepared by several approaches. In the presence of 1-2 mol-% Grubbs-II catalyst, they ring-closed to give 6,7-dihydrobenzocyclohepten-5-ones, e.g., II, in 90-96% yield. With SeO2 the parent compound delivered benzocyclohepten-5-one (III) and/or selenium-containing compounds, e.g., IV, but no more than traces of 6,7-benzotropolone (V). However, V was accessible from compound II via the sodium enolate and allowing it to react with a stream of oxygen (43% yield). The sodium enolates of the substituted 6,7-dihydrobenzocyclohepten-5-ones and oxygen underwent analogous 4-electron oxidations This furnished the substituted 6,7-benzotropolones. In contrast, the corresponding lithium enolates were inert towards oxygen. The 6,7-dihydrobenzocyclohepten-5-one was also accessed differently, namely by a Grubbs-II catalyst-mediated RCM/C=C migration tandem reaction of the allyl ortho-allylaryl ketone VI – another 1,8-diene of sorts (90% yield). The experimental process involved the reaction of 1-Bromo-3,4,5-trimethoxybenzene(cas: 2675-79-8Computed Properties of C9H11BrO3)

1-Bromo-3,4,5-trimethoxybenzene(cas: 2675-79-8) is an important raw material and intermediate used in organic synthesis, pharmaceuticals, agrochemicals and dyestuff.Computed Properties of C9H11BrO31-Bromo-3,4,5-trimethoxybenzene can be used to synthesize analogs of HA14-1, which shows promising anticancer properties.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Pecnard, Shannon; Provot, Olivier; Levaique, Helene; Bignon, Jerome; Askenatzis, Laurie; Saller, Francois; Borgel, Delphine; Michallet, Sophie; Laisne, Marie-Catherine; Lafanechere, Laurence; Alami, Mouad; Hamze, Abdallah published an article in 2021. The article was titled 《Cyclic bridged analogs of isoCA-4: Design, synthesis and biological evaluation》, and you may find the article in European Journal of Medicinal Chemistry.Related Products of 2675-79-8 The information in the text is summarized as follows:

In this work, a series of cyclic bridged analogs of isocombretastatin A-4 (isoCA-4) with Ph or pyridine linkers were designed and synthesized. The synthesis of the desired analogs was performed by the formation of nitro-vinyl intermediates, followed by a Cadogan cyclization. Structure activity relationship (SAR) study demonstrates the critical role of the combination of quinaldine as ring A, pyridine as the linker, and indole as ring B in the same mol., for the cytotoxic activity. Among all tested compounds, compound I showed the highest antiproliferative activity against a panel of cancer cell lines with average IC50 values of 5.6 nM. Also, compound I showed high antiproliferative activity against the MDR1-overexpressing K562R cell line; thus, it was 1.5- and 12-fold more active than the reference compounds, isoCA-4 and CA-4, resp. Moreover, I displayed a strong antiproliferative activity against the colon-carcinoma cells (HT-29), which are resistant to combretastatin A-4 and isoCA-4, and it was found to be 8000-fold more active than natural CA-4. Compound I also effectively inhibited tubulin polymerization both in vitro and in cells, and induced cell cycle arrest in G2/M phase. Next, we demonstrated that compound I dose-dependently caused caspase-induced apoptosis of K562 cells through mitochondrial dysfunction. Finally, we evaluated the effect of compound I in human no cancer cells compared to the reference compound We demonstrated that I was 73 times less cytotoxic than isoCA-4 in quiescent peripheral blood lymphocytes (PBLs). In summary, these results suggest that compound I represents a promising tubulin inhibitor worthy of further investigation. In the experiment, the researchers used 1-Bromo-3,4,5-trimethoxybenzene(cas: 2675-79-8Related Products of 2675-79-8)

1-Bromo-3,4,5-trimethoxybenzene(cas: 2675-79-8) is an important raw material and intermediate used in organic synthesis, pharmaceuticals, agrochemicals and dyestuff.Related Products of 2675-79-81-Bromo-3,4,5-trimethoxybenzene can be used to synthesize analogs of HA14-1, which shows promising anticancer properties.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

《Orthogonal Stability and Reactivity of Aryl Germanes Enables Rapid and Selective (Multi)Halogenations》 was written by Fricke, Christoph; Deckers, Kristina; Schoenebeck, Franziska. Related Products of 2675-79-8 And the article was included in Angewandte Chemie, International Edition in 2020. The article conveys some information:

While halogenation is of key importance in synthesis and radio-imaging, the currently available repertoire is largely designed to introduce a single halogen per mol. This report makes the selective introduction of several different halogens accessible. Showcased here is the privileged stability of nontoxic aryl germanes under harsh fluorination conditions (that allow selective fluorination in their presence), while displaying superior reactivity and functional-group tolerance in electrophilic iodinations and brominations, out-competing silanes or boronic esters under rapid and additive-free conditions. Mechanistic experiments and computational studies suggest a concerted electrophilic aromatic substitution as the underlying mechanism. The results came from multiple reactions, including the reaction of 1-Bromo-3,4,5-trimethoxybenzene(cas: 2675-79-8Related Products of 2675-79-8)

1-Bromo-3,4,5-trimethoxybenzene(cas: 2675-79-8) is an important raw material and intermediate used in organic synthesis, pharmaceuticals, agrochemicals and dyestuff.Related Products of 2675-79-81-Bromo-3,4,5-trimethoxybenzene can be used to synthesize N,N′-diarylated indolo[3,2-b]carbazole derivatives, which can find applications in electrophotography.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary