Category: 2675-79-8

Application of 2675-79-8In 2020 ,《Tellurides Bearing Sulfonamides as Novel Inhibitors of Leishmanial Carbonic Anhydrase with Potent Antileishmanial Activity》 appeared in Journal of Medicinal Chemistry. The author of the article were Angeli, Andrea; Etxebeste-Mitxeltorena, Mikel; Sanmartin, Carmen; Espuelas, Socorro; Moreno, Esther; Azqueta, Amaya; Parkkila, Seppo; Carta, Fabrizio; Supuran, Claudiu T.. The article conveys some information:

A novel series of tellurides bearing sulfonamide has been reported for the first time as selective and potent inhibitors of the β-class carbonic anhydrase (CA; EC 4.2.1.1) enzyme expressed in Leishmania donovani protozoa. Such derivatives showed high activity against axenic amastigotes, and among them, 4-(((3,4,5-trimethoxyphenyl)tellanyl)methyl)benzenesulfonamide showed an IC50 of 0.02μM being highly selective for the parasites over THP-1 cells with a selectivity index of 300. The in vitro and in vivo toxicity experiments showed this compound to possess a safe profile thus paving the way for tellurium-containing compounds as novel drug entities.1-Bromo-3,4,5-trimethoxybenzene(cas: 2675-79-8Application of 2675-79-8) was used in this study.

1-Bromo-3,4,5-trimethoxybenzene(cas: 2675-79-8) is an important raw material and intermediate used in organic synthesis, pharmaceuticals, agrochemicals and dyestuff.Application of 2675-79-81-Bromo-3,4,5-trimethoxybenzene can be used to synthesize analogs of HA14-1, which shows promising anticancer properties.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

《Palladium-Catalyzed Olefination of N-Tosylhydrazones as β-Diazo Phosphonate Precursors with Arylhalides》 was written by He, Jing; Feng, Yijiao; Yang, Fang; Dai, Bin; Liu, Ping. Product Details of 2675-79-8 And the article was included in European Journal of Organic Chemistry in 2020. The article conveys some information:

Palladium-catalyzed reaction of β-ketophosphonate hydrazones R1C(:NNTs)CH2P(O)R22 with halides RX (R1, R = aryl, alkyl; X = halo) affording vinylphosphonates R1RC:CHP(O)R22 as a (Z/E)-mixtures An efficient palladium-catalyzed olefination of N-tosylhydrazones as β-diazo phosphonate precursors with aryl halides has been developed. 2,2-Disubstituted vinylphosphonates bearing versatile functional groups were easily accessed in moderate to excellent yields. Various aryl halides could be employed as the coupling partners, such as (hetero)aryl bromides, aryl iodides, and even aryl chlorides. Moreover, with a similar strategy (2,2-diphenylvinyl)diarylphosphine oxides can also be attained by the reaction of N-tosylhydrazones and aryl bromides. This protocol features easily available raw materials, simple reaction conditions, broad substrate scope as well as scale-up ability. Moreover, the potential application of this product was exemplified by further transformations. After reading the article, we found that the author used 1-Bromo-3,4,5-trimethoxybenzene(cas: 2675-79-8Product Details of 2675-79-8)

1-Bromo-3,4,5-trimethoxybenzene(cas: 2675-79-8) is an important raw material and intermediate used in organic synthesis, pharmaceuticals, agrochemicals and dyestuff.Product Details of 2675-79-81-Bromo-3,4,5-trimethoxybenzene can be used to synthesize analogs of HA14-1, which shows promising anticancer properties.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Computed Properties of C9H11BrO3In 2021 ,《Tuning the Molecular Packing of Self-Assembled Amphiphilic PtII Complexes by Varying the Hydrophilic Side-Chain Length》 appeared in Chemistry – A European Journal. The author of the article were Herkert, Lorena; Selter, Philipp; Daniliuc, Constantin G.; Baeumer, Nils; Palakkal, Jasnamol P.; Fernandez, Gustavo; Hansen, Michael Ryan. The article conveys some information:

Understanding the relation between mol. design and packing modes constitutes one of the major challenges in self-assembly and is essential for the preparation of functional materials. Herein, the authors have achieved high precision control over the supramol. packing of amphiphilic PtII complexes by systematic variation of the hydrophilic side-chain length. A novel approach of general applicability based on complementary x-ray diffraction and solid-state NMR spectroscopy has allowed the authors to establish a clear correlation between mol. features and supramol. ordering. Systematically increasing the side-chain length gradually increases the steric demand and reduces the extent of aromatic interactions, thereby inducing a gradual shift in the mol. packing from parallel to a long-slipped organization. Notably, the authors’ findings highlight the necessity of advanced solid-state NMR techniques to gain structural information for supramol. systems where single-crystal growth is not possible. The authors’ work further demonstrates a new mol. design strategy to modulate aromatic interaction strengths and packing arrangements that could be useful for the engineering of functional materials based on PtII and aromatic mols. In the experiment, the researchers used many compounds, for example, 1-Bromo-3,4,5-trimethoxybenzene(cas: 2675-79-8Computed Properties of C9H11BrO3)

1-Bromo-3,4,5-trimethoxybenzene(cas: 2675-79-8) is an important raw material and intermediate used in organic synthesis, pharmaceuticals, agrochemicals and dyestuff.Computed Properties of C9H11BrO31-Bromo-3,4,5-trimethoxybenzene can be used to synthesize analogs of HA14-1, which shows promising anticancer properties.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Javorskis, Tomas; Jurys, Arminas; Bagdziunas, Gintautas; Orentas, Edvinas published their research in Advanced Synthesis & Catalysis in 2021. The article was titled 《Synthesis of C- and N-Substituted 1,5,2,6-Dithiadiazocanes -Electrophilic-Nucleophilic Thioamination (ENTA) Reagents》.COA of Formula: C9H11BrO3 The article contains the following contents:

A synthetic method is presented for S-N bond formation starting from cheap and affordable materials. Its show that (un)substituted N-protected cyclic eight-membered C2-sym. sulfenamides e.g, I have been prepared in a few steps using this procedure. The synthetic utility of these ambipolar derivatives e.g. I was demonstrated in a variety of synthetic transformations affording different S,N-heterocycles e.g. II of pharmaceutical relevance in one or two steps from simple starting materials. The experimental part of the paper was very detailed, including the reaction process of 1-Bromo-3,4,5-trimethoxybenzene(cas: 2675-79-8COA of Formula: C9H11BrO3)

1-Bromo-3,4,5-trimethoxybenzene(cas: 2675-79-8) is an important raw material and intermediate used in organic synthesis, pharmaceuticals, agrochemicals and dyestuff.COA of Formula: C9H11BrO31-Bromo-3,4,5-trimethoxybenzene can be used to synthesize N,N′-diarylated indolo[3,2-b]carbazole derivatives, which can find applications in electrophotography.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Vankova, Karolina; Rahm, Michal; Choutka, Jan; Pohl, Radek; Parkan, Kamil published their research in Chemistry – A European Journal in 2021. The article was titled 《Facile Approach to C-Glucosides by Using a Protecting-Group-Free Hiyama Cross-Coupling Reaction: High-Yielding Dapagliflozin Synthesis》.Recommanded Product: 1-Bromo-3,4,5-trimethoxybenzene The article contains the following contents:

Access to unprotected (hetero)aryl pseudo-C-glucosides via a mild Pd-catalyzed Hiyama cross-coupling reaction of protecting-group-free 1-diisopropylsilyl-D-glucal with various (hetero)aryl halides has been developed. In addition, selected unprotected pseudo-C-glucosides were stereoselectively converted into the corresponding α- and β-C-glucosides, as well as 2-deoxy-β-C-glucosides. This methodol. was applied to the efficient and high-yielding synthesis of dapagliflozin, a medicament used to treat type 2 diabetes mellitus. Finally, the versatility of our methodol. was proved by the synthesis of other analogs of dapagliflozin. In addition to this study using 1-Bromo-3,4,5-trimethoxybenzene, there are many other studies that have used 1-Bromo-3,4,5-trimethoxybenzene(cas: 2675-79-8Recommanded Product: 1-Bromo-3,4,5-trimethoxybenzene) was used in this study.

1-Bromo-3,4,5-trimethoxybenzene(cas: 2675-79-8) is an important raw material and intermediate used in organic synthesis, pharmaceuticals, agrochemicals and dyestuff.Recommanded Product: 1-Bromo-3,4,5-trimethoxybenzene1-Bromo-3,4,5-trimethoxybenzene can be used to synthesize N,N′-diarylated indolo[3,2-b]carbazole derivatives, which can find applications in electrophotography.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

《Ligand-Free Iron-Catalyzed Homo-Coupling of Aryllithium Reagents》 was published in Asian Journal of Organic Chemistry in 2020. These research results belong to Wang, Zhi-Yong; Peng, Xiao-Shui; Wong, Henry N. C.. Safety of 1-Bromo-3,4,5-trimethoxybenzene The article mentions the following:

The synthesis of sym. biaryls via the iron-catalyzed homo-coupling of aryllithium reagents was developed under a mild condition, in the absence of ligand, with wide range of scope, and in good yields. Investigation on reaction concentration and practical utility of this environmentally friendly procedure also indicates a promising application outlook. The experimental process involved the reaction of 1-Bromo-3,4,5-trimethoxybenzene(cas: 2675-79-8Safety of 1-Bromo-3,4,5-trimethoxybenzene)

1-Bromo-3,4,5-trimethoxybenzene(cas: 2675-79-8) is an important raw material and intermediate used in organic synthesis, pharmaceuticals, agrochemicals and dyestuff.Safety of 1-Bromo-3,4,5-trimethoxybenzene1-Bromo-3,4,5-trimethoxybenzene can be used to synthesize symmetric 3,3′,4,4′,5,5′-hexamethoxydiphenylacetylene via Stille-type coupling with bis-(tributylstannyl)acetylene.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

《Synthesis, biological evaluation, and modeling studies of 1,3-disubstituted cyclobutane-containing analogs of combretastatin A4》 was published in Journal of Molecular Structure in 2020. These research results belong to Malashchuk, Andrii; Chernykh, Anton V.; Hurmach, Vasyl V.; Platonov, Maxim O.; Onopchenko, Oleksandra; Zozulya, Sergey; Daniliuc, Constantin G.; Dobrydnev, Alexey V.; Kondratov, Ivan S.; Moroz, Yuriy S.; Grygorenko, Oleksandr O.. Computed Properties of C9H11BrO3 The article mentions the following:

With the aim of circumventing the adverse cis/trans-isomerization of combretastatin A4 (CA4), a naturally occurring tumor-vascular disrupting agent, novel CA4 analogs, e.g., I, bearing 1,3-disubstituted cyclobutane moiety instead of the cis-stilbene unit of the parent compd was designed. The corresponding cis and trans cyclobutane-containing derivatives were prepared as pure diastereomers. The structure of the target compounds was confirmed by X-ray diffraction study. The title compounds were evaluated for their cytotoxic properties in human cancer cell lines HepG2 (hepatocarcinoma) and SK-N-DZ (neuroblastoma), and the overall activity was found in micromolar range. Mol. docking studies and mol. dynamics simulation within the colchicine binding site of tubulin were in good agreement with the obtained cytotoxicity data.1-Bromo-3,4,5-trimethoxybenzene(cas: 2675-79-8Computed Properties of C9H11BrO3) was used in this study.

1-Bromo-3,4,5-trimethoxybenzene(cas: 2675-79-8) is an important raw material and intermediate used in organic synthesis, pharmaceuticals, agrochemicals and dyestuff.Computed Properties of C9H11BrO31-Bromo-3,4,5-trimethoxybenzene can be used to synthesize N,N′-diarylated indolo[3,2-b]carbazole derivatives, which can find applications in electrophotography.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

《Renewable Solvents for Palladium-Catalyzed Carbonylation Reactions》 was published in Organic Process Research & Development in 2020. These research results belong to Ismael, Aya; Gevorgyan, Ashot; Skrydstrup, Troels; Bayer, Annette. Recommanded Product: 1-Bromo-3,4,5-trimethoxybenzene The article mentions the following:

Solvents constitute the largest component for many chem. processes and substitution of nonrenewable solvents is a longstanding goal for green chem. Here, we show that Pd-catalyzed carbonylative couplings, such as carbonylative cross-couplings, aminocarbonylations, and alkoxycarbonylations, can be successfully realized using renewable solvents. The present research covers not only well-established renewable solvents, such as 2-methyltetrahydrofuran (2MeTHF), limonene, and di-Me carbonate, but also recently introduced biomass-derived 1,1-diethoxyethane, isosorbide di-Me ether, eucalyptol, rose oxide, γ-terpinene, and α-pinene. The carbonylative coupling of boronic acids and aryl bromides works well in limonene. Aminocarbonylation gave excellent results in di-Me carbonate, α-pinene, and limonene, while alkoxycarbonylation was successful in 2MeTHF, α-pinene, γ-terpinene, and di-Me carbonate. The developed methods based on renewable solvents can be used for the synthesis of com. drug Trimetozine and an analog of Itopride. After reading the article, we found that the author used 1-Bromo-3,4,5-trimethoxybenzene(cas: 2675-79-8Recommanded Product: 1-Bromo-3,4,5-trimethoxybenzene)

1-Bromo-3,4,5-trimethoxybenzene(cas: 2675-79-8) is an important raw material and intermediate used in organic synthesis, pharmaceuticals, agrochemicals and dyestuff.Recommanded Product: 1-Bromo-3,4,5-trimethoxybenzene1-Bromo-3,4,5-trimethoxybenzene can be used to synthesize symmetric 3,3′,4,4′,5,5′-hexamethoxydiphenylacetylene via Stille-type coupling with bis-(tributylstannyl)acetylene.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Zhang, Qingyang; Barrett, Brandon; Lee, Taein; Mukhopadhyaya, Tushita; Lu, Chengchangfeng; Plunkett, Evan C.; Kale, Tejaswini; Chi, Chen; Livi, Kenneth J. T.; McGuiggan, Patricia; Reich, Daniel H.; Thon, Susanna; Bragg, Arthur E.; Katz, Howard E. published an article in 2021. The article was titled 《Maximized Hole Trapping in a Polystyrene Transistor Dielectric from a Highly Branched Iminobis(aminoarene) Side Chain》, and you may find the article in ACS Applied Materials & Interfaces.Computed Properties of C9H11BrO3 The information in the text is summarized as follows:

We synthesized highly branched and electron-donating side chain subunits and attached them to polystyrene (PS) used as a dielec. layer in a pentacene field-effect transistor. The influence of these groups on dielec. function, charge retention, and threshold voltage shifts (ΔVth) depending on their positions in dielec. multilayers was determined We compared the observations made on an N-perphenylated iminobisaniline side chain with those from the same side chains modified with ZnO nanoparticles and with an adduct formed from tetracyanoethylene (TCNE). We also synthesized an analog in which six methoxy groups are present instead of two amine nitrogens. At 6 mol % side chain, hopping transport was sufficient to cause shorting of the gate, while at 2 mol %, charge trapping was observable as transistor threshold voltage shifts (ΔVth). We created three types of devices: with the substituted PS layer as single-layer dielec., on top of a cross-linked PS layer but in contact with the pentacene (bilayers), and sandwiched between two PS layers in trilayers. Especially large bias stress effects and ΔVth, larger than those in the case of the hexamethoxy and previously studied dimethoxy analogs, were observed in the second case, and the effects increased with the increasing electron-donating properties of the modified side chains. The highest ΔVth was consistent with a majority of the side chains stabilizing the trapped charge. Trilayer devices showed decreased charge storage capability compared to previous work in which we used less donating side chains but in higher concentrations The ZnO and TCNE modifications resulted in slightly more and less neg. ΔVth, resp., when the side chain polystyrene was not in contact with the pentacene and isolated from the gate electrode. The results indicate a likely maximum combination of mol. charge stabilizing activity and side chain concentration that still allows gate dielec. function. The experimental part of the paper was very detailed, including the reaction process of 1-Bromo-3,4,5-trimethoxybenzene(cas: 2675-79-8Computed Properties of C9H11BrO3)

1-Bromo-3,4,5-trimethoxybenzene(cas: 2675-79-8) is an important raw material and intermediate used in organic synthesis, pharmaceuticals, agrochemicals and dyestuff.Computed Properties of C9H11BrO31-Bromo-3,4,5-trimethoxybenzene can be used to synthesize analogs of HA14-1, which shows promising anticancer properties.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

《Identification and optimization of biphenyl derivatives as novel tubulin inhibitors targeting colchicine-binding site overcoming multidrug resistance》 was written by Cheng, Bao; Zhu, Guirong; Meng, Linghua; Wu, Guolin; Chen, Qin; Ma, Shengming. Reference of 1-Bromo-3,4,5-trimethoxybenzeneThis research focused ontubulin optimization biphenyl colchicine multidrug resistance; Anticancer activity; Biphenyl derivatives; Multidrug resistance; Tubulin inhibitors. The article conveys some information:

Microtubule targeting agents (MTAs) are among the most successful chemotherapeutic drugs, but their efficacy is often limited by the development of multidrug resistance (MDR). Therefore, the development of novel MTAs with the ability to overcome MDR is urgently needed. In this contribution, through modification of the unsym. biaryl compounds, we discovered a novel compound dxy-1-175 with potent anti-proliferative activity against cancer cells. Mechanistic study revealed that dxy-1-175 inhibited tubulin polymerization by interacting with the colchicine-binding site of tubulin, which caused cell cycle arrest at G2/M phase. Based on the predicted binding model of dxy-1-175 with tubulin, a series of new 4-benzoylbiphenyl analogs were designed and synthesized. Among them, the hydrochloride compound 12e with improved solubility and good stability in human liver microsome, exhibited the most potent anti-proliferative activity with IC50 value in the low nanomolar range, and markedly inhibited the growth of breast cancer 4T1 xenograft in vivo. Notably, 12e effectively overcame P-gp-mediated MDR and our preliminary data suggested that 12e may not be a substrate of P-glycoprotein (P-gp). Taken together, our study reveals a novel MTA 12e targeting the colchicine-binding site with potent anticancer activity and the ability to circumvent MDR. In addition to this study using 1-Bromo-3,4,5-trimethoxybenzene, there are many other studies that have used 1-Bromo-3,4,5-trimethoxybenzene(cas: 2675-79-8Reference of 1-Bromo-3,4,5-trimethoxybenzene) was used in this study.

1-Bromo-3,4,5-trimethoxybenzene(cas: 2675-79-8) is an important raw material and intermediate used in organic synthesis, pharmaceuticals, agrochemicals and dyestuff.Reference of 1-Bromo-3,4,5-trimethoxybenzene1-Bromo-3,4,5-trimethoxybenzene can be used to synthesize analogs of HA14-1, which shows promising anticancer properties.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary