Category: 2675-79-8

In 2022,Singh, Bara; Bankar, Siddheshwar K.; Ramasastry, S. S. V. published an article in Organic Letters. The title of the article was 《Pd-Catalyzed Nazarov-Type Cyclization: Application in the Total Synthesis of β-Diasarone and Other Complex Cyclopentanoids》.HPLC of Formula: 2675-79-8 The author mentioned the following in the article:

Author describe the palladium-catalyzed Nazarov-type cyclization of easily accessible (hetero)arylallyl acetates to pentannulated (hetero)arenes. This method provides ready access to various types of bi-, tri-, tetra-, and pentacyclic cyclopentanoids under neutral conditions. The synthetic utility is further demonstrated in the first total synthesis of β-diasarone (I) and several other complex cyclopentanoids relevant to medicinal chem. and materials science. The experimental process involved the reaction of 1-Bromo-3,4,5-trimethoxybenzene(cas: 2675-79-8HPLC of Formula: 2675-79-8)

1-Bromo-3,4,5-trimethoxybenzene(cas: 2675-79-8) is an important raw material and intermediate used in organic synthesis, pharmaceuticals, agrochemicals and dyestuff.HPLC of Formula: 2675-79-81-Bromo-3,4,5-trimethoxybenzene can be used to synthesize N,N′-diarylated indolo[3,2-b]carbazole derivatives, which can find applications in electrophotography.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

In 2022,Guo, Jiawei; Liu, Song; Pang, Qinjiao; Zhang, Hongyun; Gao, Lu; Chen, Li; Song, Zhenlei published an article in Organic Letters. The title of the article was 《Synthesis of Silacyclohexanones from Divinylsilanes and Allylamines by a Rh-Catalyzed Cyclization》.Product Details of 2675-79-8 The author mentioned the following in the article:

An efficient synthesis of silacyclohexanones bearing a variety of silyl substituents was developed by a [Rh(coe)2Cl]2/PCy3-catalyzed cyclization of divinylsilanes with Jun’s allylamine. The silacyclohexanones can be oxidized with DDQ to give the corresponding silacyclohexadienones, which are further transformed into Si analog of 2-deoxystreptamine or exo-alkylidenesilacyclohexadienes.1-Bromo-3,4,5-trimethoxybenzene(cas: 2675-79-8Product Details of 2675-79-8) was used in this study.

1-Bromo-3,4,5-trimethoxybenzene(cas: 2675-79-8) is an important raw material and intermediate used in organic synthesis, pharmaceuticals, agrochemicals and dyestuff.Product Details of 2675-79-81-Bromo-3,4,5-trimethoxybenzene can be used to synthesize N,N′-diarylated indolo[3,2-b]carbazole derivatives, which can find applications in electrophotography.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Electric Literature of C9H11BrO3In 2021 ,《Synthesis and biological evaluation of 1-(diarylmethyl)-1H-1,2,4-triazoles and 1-(diarylmethyl)-1H-imidazoles as a novel class of anti-mitotic agent for activity in breast cancer》 appeared in Pharmaceuticals. The author of the article were Ana, Gloria; Kelly, Patrick M.; Malebari, Azizah M.; Noorani, Sara; Nathwani, Seema M.; Twamley, Brendan; Fayne, Darren; O’Boyle, Niamh M.; Zisterer, Daniela M.; Pimentel, Elisangela Flavia; Endringer, Denise Coutinho; Meegan, Mary J.. The article conveys some information:

Synthesis and biochem. evaluation of diaryl(heterocyclyl)methanes R1CH(X)R2 (I) [X = 1,2,4-triazol-1-yl, 1-imidazolyl, 1-pyrrolidinyl, 1-piperidinyl, N-R3-piperazin-1-yl, 1,2,3-triazol-2-yl; R1, R2 = Ph, 4-HOC6H4, 3-HO-4-MeOC6H3, 3,4,5-(MeO)3C6H2, etc.; R3 = H, Ph, PhCH2, etc.], that were designed as hybrids of the microtubule targeting benzophenone phenstatin and the aromatase inhibitor letrozole, are described. A preliminary screening in estrogen receptor (ER)-pos. MCF-7 breast cancer cells identified the compound I [X = 1,2,3-triazol-2-yl; R1 = 3,4,5-(MeO)3C6H2; R2 = 3-HO-4-MeOC6H3] as a potent antiproliferative compound with an IC50 value of 52 nM in MCF-7 breast cancer cells (ER+/PR+) and 74 nM in triple-neg. MDA-MB-231 breast cancer cells. The compounds I demonstrated significant G2/M phase cell cycle arrest and induction of apoptosis in the MCF-7 cell line, inhibited tubulin polymerization, and were selective for cancer cells when evaluated in non-tumorigenic MCF-10A breast cells. The immunofluorescence staining of MCF-7 cells confirmed that these compounds targeted tubulin and induced multinucleation, which was a recognized sign of mitotic catastrophe. Computational docking studies of compounds I [X = 1,2,4-triazol-1-yl, imidazol-1-yl, 1,2,3-triazol-2-yl; R1 = 3,4,5-(MeO)3C6H2; R2 = 3-OH-4-MeOC6H3] in the colchicine binding site of tubulin indicated potential binding conformations for the compounds The compounds I [X = 1,2,4-triazol-1-yl, imidazol-1-yl; R1 = 3,4,5-(MeO)3C6H2; R2 = 3-OH-4-MeOC6H3] were also shown to selectively inhibit aromatase. These compounds are promising candidates for development as antiproliferative, aromatase inhibitory, and microtubule-disrupting agents for breast cancer. The experimental process involved the reaction of 1-Bromo-3,4,5-trimethoxybenzene(cas: 2675-79-8Electric Literature of C9H11BrO3)

1-Bromo-3,4,5-trimethoxybenzene(cas: 2675-79-8) is an important raw material and intermediate used in organic synthesis, pharmaceuticals, agrochemicals and dyestuff.Electric Literature of C9H11BrO31-Bromo-3,4,5-trimethoxybenzene can be used to synthesize analogs of HA14-1, which shows promising anticancer properties.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Zuo, Hang-Dong; Zhu, Shan-Shan; Hao, Wen-Juan; Wang, Shi-Chao; Tu, Shu-Jiang; Jiang, Bo published their research in ACS Catalysis in 2021. The article was titled 《Copper-Catalyzed Asymmetric Deconstructive Alkynylation of Cyclic Oximes》.Recommanded Product: 1-Bromo-3,4,5-trimethoxybenzene The article contains the following contents:

A general asym. deconstructive alkynylation of cyclic oximes with terminal alkynes was reported using copper/chiral cinchona alkaloid-based N,N,P-ligand catalysts and used to produce more than 60 examples of enantioenriched γ- and δ-alkynyl nitriles in a highly functional group-compatible manner. A wide variety of low-cost terminal alkynes and easily available cyclic oximes with substituent diversity were found to be well tolerated with the current asym. transformation with good functional group tolerance. The resulting chiral alkynyl nitriles were intermediates, which could be converted into skeletally diverse chiral mols., including δ-alkynyl amides, ε-alkenyl carbamate, and ζ-keto nitrile, under suitable reaction conditions. After reading the article, we found that the author used 1-Bromo-3,4,5-trimethoxybenzene(cas: 2675-79-8Recommanded Product: 1-Bromo-3,4,5-trimethoxybenzene)

1-Bromo-3,4,5-trimethoxybenzene(cas: 2675-79-8) is an important raw material and intermediate used in organic synthesis, pharmaceuticals, agrochemicals and dyestuff.Recommanded Product: 1-Bromo-3,4,5-trimethoxybenzene1-Bromo-3,4,5-trimethoxybenzene can be used to synthesize N,N′-diarylated indolo[3,2-b]carbazole derivatives, which can find applications in electrophotography.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Huang, Binbin; Guo, Lin; Xia, Wujiong published an article in 2021. The article was titled 《A facile and versatile electro-reductive system for hydrodefunctionalization under ambient conditions》, and you may find the article in Green Chemistry.Safety of 1-Bromo-3,4,5-trimethoxybenzene The information in the text is summarized as follows:

A general electrochem. system for reductive hydrodefunctionalization is described, employing the inexpensive and easily available triethylamine (Et3N) as a sacrificial reductant. This protocol is characterized by facile operation, sustainable conditions, and exceptionally wide substrate e.g., 9-bromophenanthrene scope covering the cleavage of C-halogen, N-S, N-C, O-S, O-C, C-C and C-N bonds. Notably, the selectivity and capability of reduction can be conveniently switched by simple incorporation or removal of an ethanol. as a co-solvent. In the experimental materials used by the author, we found 1-Bromo-3,4,5-trimethoxybenzene(cas: 2675-79-8Safety of 1-Bromo-3,4,5-trimethoxybenzene)

1-Bromo-3,4,5-trimethoxybenzene(cas: 2675-79-8) is an important raw material and intermediate used in organic synthesis, pharmaceuticals, agrochemicals and dyestuff.Safety of 1-Bromo-3,4,5-trimethoxybenzene1-Bromo-3,4,5-trimethoxybenzene can be used to synthesize N,N′-diarylated indolo[3,2-b]carbazole derivatives, which can find applications in electrophotography.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

《Transition-Metal-Free Site-Selective γ-C(sp2)-H Monoiodination of Arenes Directed by an Aliphatic Keto Group》 was written by Bian, Hong-Li; Tang, Shi-Zhong; Chen, Meng-En; Zhang, Xiao-Ming; Lv, Jian-Wei; Chen, Xiao-Wei; Qi, Feng-Ming; Chen, Shi-Wu; Zhang, Fu-Min. Category: bromides-buliding-blocks And the article was included in Organic Letters in 2020. The article conveys some information:

A general γ-C(sp2)-H iodination method directed by an aliphatic keto group has been developed under transition-metal-free conditions for the first time, generating iodoarenes I (X = (CH2)n; n = 0, 1, 2; R = H, 5-bromo, 3,4,5-trimethoxy, etc.; R1 = H, 2-iodophenyl; R2 = H; R1R2 = -CH=CH-CH=CH-), R3C(O)CH(R4)R5 (R3 = Me, Ph, 4-chlorophenyl, etc.; R4 = H, ethyl; R5 = 2-iodophenyl, 2-iodo-4,5-dimethoxyphenyl, 5-chloro-2-iodophenyl, etc.) and 7-(2-iodophenyl)-1,4-dioxaspiro[4.5]decan-8-one in good to excellent yields with excellent site selectivity. This protocol features a wide range of aryl-substituted ketones II, R3C(O)CH(R4)R6 (R6 = Ph, 4-methylphenyl, 4-fluorophenyl, etc.) and 7-phenyl-1,4-dioxaspiro[4.5]decan-8-one, short reaction times, mild reaction conditions, and scalable synthetic procedures. A possible reaction mechanism was also proposed based on several control experiments In the experiment, the researchers used many compounds, for example, 1-Bromo-3,4,5-trimethoxybenzene(cas: 2675-79-8Category: bromides-buliding-blocks)

1-Bromo-3,4,5-trimethoxybenzene(cas: 2675-79-8) is an important raw material and intermediate used in organic synthesis, pharmaceuticals, agrochemicals and dyestuff.Category: bromides-buliding-blocks1-Bromo-3,4,5-trimethoxybenzene can be used to synthesize analogs of HA14-1, which shows promising anticancer properties.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

SDS of cas: 2675-79-8In 2022 ,《Tetratopic Terpyridine Building Unit as a Precursor to Wheel-Like Metallo-Supramolecules》 was published in Inorganic Chemistry. The article was written by Wang, Jun; Wang, Feng; Dong, Qiangqiang; Chen, Mingzhao; Jiang, Zhiyuan; Zhao, He; Liu, Die; Jiang, Zhilong; Su, Peiyang; Li, Yiming; Liu, Qianqian; Liu, Hui; Wang, Pingshan. The article contains the following contents:

In an effort to construct mols. with distinct shapes and functions, the design and synthesis of multitopic ligands are often able to play an important role. Here, the authors report the synthesis of a novel tetratopic organic ligand LA, which can be viewed as a bis-tenon with successive angular orientations in space. The particular ligand has been treated with different tailored metal-organic ligands to afford new members of the mol. wheel family (multi-rhomboidal-shaped wheel and bis-trapezium-shaped wheel) that show enhanced stability. Two-dimensional (2D) diffusion NMR (NMR) spectroscopy (DOSY), electrospray ionization (ESI) mass spectrometry, traveling wave ion mobility (TWIM), and gradient tandem mass spectrometry (gMS2) experiments, as well as mol. modeling, have been employed to provide structural information and differentiate the isomeric separation process. In addition, considering that LA has rotational properties, it is expected to open the door to functional supramols. and stimuli-responsive materials. In the part of experimental materials, we found many familiar compounds, such as 1-Bromo-3,4,5-trimethoxybenzene(cas: 2675-79-8SDS of cas: 2675-79-8)

1-Bromo-3,4,5-trimethoxybenzene(cas: 2675-79-8) is an important raw material and intermediate used in organic synthesis, pharmaceuticals, agrochemicals and dyestuff.SDS of cas: 2675-79-81-Bromo-3,4,5-trimethoxybenzene can be used to synthesize analogs of HA14-1, which shows promising anticancer properties.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Tsushima, Takumi; Tanaka, Hideya; Nakanishi, Kazuki; Nakamoto, Masaaki; Yoshida, Hiroto published an article in 2021. The article was titled 《Origins of Internal Regioselectivity in Copper-Catalyzed Borylation of Terminal Alkynes》, and you may find the article in ACS Catalysis.Safety of 1-Bromo-3,4,5-trimethoxybenzene The information in the text is summarized as follows:

Installation of a boron functionality into a more substituted carbon of terminal alkynes has been a challenging issue in chem. synthesis, since inherently Lewis acidic boron moieties, in principle, favor their attachment to a terminal carbon. Herein, we report on the highly internal-selective borylation of terminal alkynes under copper catalysis, wherein diminishment of boron-Lewis acidity and ligand-derived steric bulk around a copper center are the key to the success. In particular, the use of an anthranilamide-substituted boron moiety [B(aam)] is of high synthetic significance, because its properly diminished Lewis acidity enabled the internal regioselectivity and the Suzuki-Miyaura cross-coupling activity to be compatibly achieved. This method provided a direct and universal approach to variously substituted branched alkenylboron compounds, regardless of electronic and steric properties of a substituent on terminal alkynes. In the experiment, the researchers used many compounds, for example, 1-Bromo-3,4,5-trimethoxybenzene(cas: 2675-79-8Safety of 1-Bromo-3,4,5-trimethoxybenzene)

1-Bromo-3,4,5-trimethoxybenzene(cas: 2675-79-8) is an important raw material and intermediate used in organic synthesis, pharmaceuticals, agrochemicals and dyestuff.Safety of 1-Bromo-3,4,5-trimethoxybenzene1-Bromo-3,4,5-trimethoxybenzene can be used to synthesize N,N′-diarylated indolo[3,2-b]carbazole derivatives, which can find applications in electrophotography.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

SDS of cas: 2675-79-8In 2019 ,《Asymmetric synthesis of the allocolchicinoid natural product N-acetylcolchinol methyl ether (suhailamine), solid state and solution phase conformational analysis》 was published in Tetrahedron. The article was written by Davies, Stephen G.; Fletcher, Ai M.; Roberts, Paul M.; Thomson, James E.; Yeung, Angus. The article contains the following contents:

An asym. synthesis of the allocolchicinoid N-acetylcolchinol Me ether (NCME) from 3-methoxybenzaldehyde is reported. Comparison of 1H and 13C NMR spectroscopic data obtained for this sample of NCME provide further evidence for the assertion that this compound is congruous with the natural product that has been dubbed suhailamine, establishing NCME as a naturally-occurring allocolchicinoid. The single crystal X-ray diffraction structure of NCME is also reported for the first time, revealing a preference for adoption of the (7S,Ra,Z) form-i.e., describing the orientation of the biaryl axis and the amide N-CO bond as well as the configuration of the stereogenic center-in the solid state. A preference for the same form in DMSO-d6 solution is revealed upon anal. by a range of NMR spectroscopic techniques, while an interconverting 69:24:7 mixture of the (7S,Ra,Z), (7S,Sa,Z) and (7S,Ra,E) forms is observed in CDCl3. After reading the article, we found that the author used 1-Bromo-3,4,5-trimethoxybenzene(cas: 2675-79-8SDS of cas: 2675-79-8)

1-Bromo-3,4,5-trimethoxybenzene(cas: 2675-79-8) is an important raw material and intermediate used in organic synthesis, pharmaceuticals, agrochemicals and dyestuff.SDS of cas: 2675-79-81-Bromo-3,4,5-trimethoxybenzene can be used to synthesize analogs of HA14-1, which shows promising anticancer properties.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

《The influence of hypoxia and energy depletion on the response of endothelial cells to the vascular disrupting agent combretastatin A-4-phosphate》 was published in Scientific Reports in 2020. These research results belong to Holmes, Toby; Brown, Andrew W.; Suggitt, Marie; Shaw, Lucy A.; Simpson, Lucy; Harrity, Joseph P. A.; Tozer, Gillian M.; Kanthou, Chryso. Formula: C9H11BrO3 The article mentions the following:

Combretastatin A-4 phosphate (CA4P) is a microtubule-disrupting tumor-selective vascular disrupting agent (VDA). While hypoxia renders tumors resistant to many conventional therapies, little is known about its influence on VDA activity. Here, we found that active RhoA and ROCK effector phospho-myosin light chain (pMLC) were downregulated in endothelial cells by severe hypoxia. CA4P failed to activate RhoA/ROCK/pMLC but its activity was restored upon reoxygenation. Hypoxia also inhibited CA4P-mediated actinomyosin contractility, VE-cadherin junction disruption and permeability rise. Glucose withdrawal downregulated pMLC, and coupled with hypoxia, reduced pMLC faster and more profoundly than hypoxia alone. Concurrent inhibition of glycolysis (2-deoxy-D-glucose, 2DG) and mitochondrial respiration (rotenone) caused profound actin filament loss, blocked RhoA/ROCK signalling and rendered microtubules CA4P-resistant. Withdrawal of the metabolism inhibitors restored the cytoskeleton and CA4P activity. The AMP-activated kinase AMPK was investigated as a potential mediator of pMLC downregulation. Pharmacol. AMPK activators that generate AMP, unlike allosteric activators, downregulated pMLC but only when combined with 2DG and/or rotenone. Altogether, our results suggest that Rho/ROCK and actinomyosin contractility are regulated by AMP/ATP levels independently of AMPK, and point to hypoxia/energy depletion as potential modifiers of CA4P response. In the experiment, the researchers used 1-Bromo-3,4,5-trimethoxybenzene(cas: 2675-79-8Formula: C9H11BrO3)

1-Bromo-3,4,5-trimethoxybenzene(cas: 2675-79-8) is an important raw material and intermediate used in organic synthesis, pharmaceuticals, agrochemicals and dyestuff.Formula: C9H11BrO31-Bromo-3,4,5-trimethoxybenzene can be used to synthesize N,N′-diarylated indolo[3,2-b]carbazole derivatives, which can find applications in electrophotography.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary