Category: 2645-22-9

Yi, Seungjoo; Lee, Won Kyu; Park, Ji-Ho; Lee, Jae-Seung; Seo, Ji-Hun published an article about the compound: 4,4-Dipyridyl Disulfide( cas:2645-22-9,SMILESS:C1(SSC2=CC=NC=C2)=CC=NC=C1 ).Safety of 4,4-Dipyridyl Disulfide. Aromatic heterocyclic compounds can be classified according to the number of heteroatoms or the size of the ring. The authors also want to convey more information about this compound (cas:2645-22-9) through the article.

The goal of this study is to develop a simple one-pot method for the synthesis of a zwitterionic small mol. bearing disulfide moiety, which can effectively inhibit nonspecific protein adsorption on macroscopic and nanoscopic gold surfaces. To this end, the optimal mol. structure of a pyridine disulfide derivative was explored and a zwitterionic small mol. was successfully synthesized from the tertiary amine residue on the pyridine ring through a one-pot method. The coating conditions of the synthesized zwitterionic mols. on the gold surface were optimized through contact angle measurements, and the strong interactions between the gold surface and the disulfide moiety of the zwitterion small mol. were confirmed by surface plasmon resonance (SPR) anal. and XPS. The antibiofouling properties of the coated gold surface were analyzed by fluorescence microscopic observations after contacting with FITC-labeled bovine serum albumin (BSA) and SPR sensor as contacting with BSA solution In addition, the effect of zwitterion-coating on the salt stability of and protein adsorption on nanoscopic gold surfaces were examined through a NaCl stability test and BSA adsorption test, resp. From the obtained results, it was confirmed that the simply synthesized zwitterionic small mol. was effective in inhibiting nonspecific protein adsorption on macroscopic and nanoscopic gold surfaces; further, it enhanced the salt stability of gold nanoparticle surfaces.

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Reference:
Bromide – Wikipedia,
bromide – Wiktionary

So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Hinklin, Ronald J.; Baer, Brian R.; Boyd, Steven A.; Chicarelli, Mark D.; Condroski, Kevin R.; DeWolf, Walter E. Jr.; Fischer, John; Frank, Michele; Hingorani, Gary P.; Lee, Patrice A.; Neitzel, Nickolas A.; Pratt, Scott A.; Singh, Ajay; Sullivan, Francis X.; Turner, Timothy; Voegtli, Walter C.; Wallace, Eli M.; Williams, Lance; Aicher, Thomas D. researched the compound: 4,4-Dipyridyl Disulfide( cas:2645-22-9 ).Application of 2645-22-9.They published the article 《Discovery and preclinical development of AR453588 as an anti-diabetic glucokinase activator》 about this compound( cas:2645-22-9 ) in Bioorganic & Medicinal Chemistry. Keywords: hiadiazole heteroaryloxypyridine AR453588 synthesis antidiabetic SAR glucokinase activator diabetes; Diabetes; Glucokinase; Glucokinase activator; OGTT; S(0.5); Structure-aided design; Structure-based design; Type II diabetes; V(max); ob/ob mouse. We’ll tell you more about this compound (cas:2645-22-9).

Glucose flux through glucokinase (GK) controls insulin release from the pancreas in response to high levels of glucose. Flux through GK is also responsible for reducing hepatic glucose output. Since many individuals with type 2 diabetes appear to have an inadequacy or defect in one or both of these processes, identifying compounds that can activate GK could provide a therapeutic benefit. Herein we report the further structure activity studies of a novel series of glucokinase activators (GKA). These studies led to the identification of pyridine 72 as a potent GKA that lowered post-prandial glucose in normal C57BL/6J mice, and after 14d dosing in ob/ob mice. 3-(heteroaryloxy)pyridine.

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Bromide – Wikipedia,
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The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: 4,4-Dipyridyl Disulfide( cas:2645-22-9 ) is researched.Reference of 4,4-Dipyridyl Disulfide.Kanno, Takefumi; Nakabayashi, Koji; Imoto, Kenta; Ohkoshi, Shin-ichi published the article 《Manganese-Octacyanidoniobate-Based Ferrimagnet Possessing Bridging Ligands with Disulfide Bonds》 about this compound( cas:2645-22-9 ) in European Journal of Inorganic Chemistry. Keywords: manganese octacyanidoniobate ferrimagnet preparation crystal mol structure; cyanide bridging disulfide bond manganese octacyanidoniobate preparation. Let’s learn more about this compound (cas:2645-22-9).

Authors synthesized a cyanido-bridged Mn-Nb metal assembly possessing large-sized bridging ligands with disulfide bonds, [Mn(dpds)2]2[Nb(CN)8]·6H2O (MnNb, dpds: 4,4′-dipyridyl disulfide). MnNb has a three-dimensional coordination framework in which the Mn and Nb sites are bridged by cyanides, while the Mn sites are combined by dpds ligands. The two crystallog. independent dpds ligands are bent around the disulfide bond with large C(pyridine)-S-S-C(pyridine) dihedral angles of 105.4(5)° and 102.2(5)°, resp. For mol.-based magnets, dpds is a relatively large bridging ligand, but it is compatible with the limited space of the cyanido-bridged Mn-Nb coordination framework due to the bent structure. Addnl., antiferromagnetic coupling in MnNb of -13 cm-1 between MnII (S = 5/2, g = 2) and NbIV (S = 1/2, g = 2) induces ferrimagnetism with a critical temperature of 46 K.

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Reference:
Bromide – Wikipedia,
bromide – Wiktionary

Sun, Xiao-Peng; Liu, Tao; Yao, Zi-Shuo; Tao, Jun published the article 《Spin crossover and photomagnetic behaviors in one-dimensional looped coordination polymers》. Keywords: dipyridyl disulfide iron complex preparation spin crossover photomagnetic behavior; coordination polymer dipyridyl disulfide iron complex preparation light induced.They researched the compound: 4,4-Dipyridyl Disulfide( cas:2645-22-9 ).Recommanded Product: 4,4-Dipyridyl Disulfide. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:2645-22-9) here.

Three one-dimensional looped coordination polymers with the formula of [Fe(dpds)2{C(CN)3}2]·dpds (1, dpds = 4,4′-dipyridyl disulfide), [Fe(dpds)2(NCBH3)2] (2) and [Fe(dpds)2(NCSe)2]·3.5H2O (3) have been synthesized and characterized by single-crystal x-ray crystallog., Moessbauer spectroscopy and magnetic measurements. The spin-crossover (SCO) behaviors of these compounds depend significantly on axial ligands: compound 1 exhibited thermal-induced complete one-step SCO behavior with a T1/2 of 170 K, and 2 showed incomplete SCO behavior with T1/2 being 130 K, whereas 3 was paramagnetic. Meanwhile, both compounds 1 and 2 displayed light-induced excited spin-state trapping (LIESST) effects, featuring TLIESST values of 45 K and 61 K for 1 and 2, resp., which were independent of exciting laser wavelengths. These results suggest that anions such as C(CN)3- and NCBH3- with much stronger ligand fields are needed in order to realize spin-state switching, if a ligand such as dpds is adopted to synthesize SCO compounds

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Bromide – Wikipedia,
bromide – Wiktionary

Epoxy compounds usually have stronger nucleophilic ability, because the alkyl group on the oxygen atom makes the bond angle smaller, which makes the lone pair of electrons react more dissimilarly with the electron-deficient system. Compound: 4,4-Dipyridyl Disulfide, is researched, Molecular C10H8N2S2, CAS is 2645-22-9, about A 2D Cu(II)-based coordination polymer: treatment effect on Parkinson′s disease by increasing dopamine and VMA content.SDS of cas: 2645-22-9.

By using a mixed-ligand approach, a new Cu(II)-based coordination polymer with the chem. formula of [Cu(4-dpds)(bdc)(H2O)2] · 4-dpds () (4-dpds = 4,4′-dipyridyldusulfide and H2bdc = benzenedicarboxylic acid) has been synthesized and structurally determined by single-crystal X-ray diffractometer, powder X-ray diffraction, elemental anal., IR spectra and thermogravimetric anal. Furthermore, the treatment effect of the synthetic compound was evaluated on the Parkinson′s disease animal model and the enzyme linked immunosorbent assay (ELISA) was performed to detect the content of dopamine content in the substantia nigra. Then, the high efficiency liquid phase chromatogram (HPLC) was conducted for the measurement of the vanillyl mandelic acid (VMA) in urine.

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Bromide – Wikipedia,
bromide – Wiktionary

Synthetic Route of C10H8N2S2. The mechanism of aromatic electrophilic substitution of aromatic heterocycles is consistent with that of benzene. Compound: 4,4-Dipyridyl Disulfide, is researched, Molecular C10H8N2S2, CAS is 2645-22-9, about Crystal structures and magnetic properties of two Co(II) coordination polymers created via in situ ligand synthesis. Author is Zhao, Ying; Dang, Li-Long; Zhai, Zhi-Min; Ma, Lu-Fang; Wang, Li-Ya.

The authors present two new coordination polymers, [Co3(iBuOIPA)3(bps)(H2O)]n (1) and [Co2(iPrIPA)2(bps)]n (2) (bps = 4,4′-bipyridyl sulfide, iBuOIPA = 5-i-butoxyisophthalate, iPrIPA = 5-i-propoxyisophthalate), by the hydrothermal reactions of Co(OAc)2·4H2O and 4,4′-bipyridyl disulfide (bpds) with iBuOIPA or iPrIPA, resp. Both crystal structures were determined by single-crystal x-ray diffraction analyses and further characterized by elemental analyses, IR spectra and TG analyses. For 1 and 2, the starting bpds ligands were wholly transformed into bps. Polymer 1 displays a 3-dimensional network constructed from binuclear Co nodes while polymer 2 features a 2-dimensional infinite layer consisting of Co dimers. The existence of electron-donating groups in isophthalate derivatives plays a significant role during the self-assembly of polymers. Also, both 1 and 2 exhibit remarkable magnetic properties, which were studied and discussed in detail, showing a good prospect in magnetic and energy storage devices.

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Reference:
Bromide – Wikipedia,
bromide – Wiktionary

Computed Properties of C10H8N2S2. The protonation of heteroatoms in aromatic heterocycles can be divided into two categories: lone pairs of electrons are in the aromatic ring conjugated system; and lone pairs of electrons do not participate. Compound: 4,4-Dipyridyl Disulfide, is researched, Molecular C10H8N2S2, CAS is 2645-22-9, about Synthesis of mono/dinuclear rhenium(I) tricarbonyl substituted with 4-mercaptopyridine related ligands: spectral and theoretical evidence of thiolate/thione interconversion. Author is Gomez, Alejandra; Jara, Geraldine; Flores, Erick; Maldonado, Tamara; Godoy, Fernando; Munoz-Osses, Michelle; Vega, Andres; Mera, Raul; Silva, Carlos; Pavez, Jorge.

The synthesis, characterization, and spectroscopic and theor. studies of new κ1-S monometallic Re-spy (1)/Re-thiopy (2) and κ1-N-bimetallic Re2-dps (3)/Re2-dpds (4) complexes substituted with 4-mercaptopyridine derivatives are reported. The obtainment of either monosulfide bridge-complex (3) or disulfide bridge-complex (4) depends on the reaction media. The structure of complex 3 was confirmed by monocrystal x-ray diffraction. Addnl. it was possible to determine the presence of an intramol. interconversion between 1 and 2 mediated by solvent mols. through the intermediate species 1-H+ using UV-Vis and NMR spectroscopy. Electronic spectra calculated by TD-DFT feature distinct MLCT transitions for 2 and show that the π-stacking interaction present in 1 is broken in the methanol/water mixture, leading to a structural distribution similar to 2. Cyclic voltammograms of all complexes display the characteristic reduction process for the rhenium center and the bipyridine ligand. Addnl., an irreversible process associated with the bridging ligand for 3 and 4 is observed

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Reference:
Bromide – Wikipedia,
bromide – Wiktionary

Wang, Dan-Yang; Si, Yubing; Li, Junjie; Fu, Yongzhu published an article about the compound: 4,4-Dipyridyl Disulfide( cas:2645-22-9,SMILESS:C1(SSC2=CC=NC=C2)=CC=NC=C1 ).SDS of cas: 2645-22-9. Aromatic heterocyclic compounds can be classified according to the number of heteroatoms or the size of the ring. The authors also want to convey more information about this compound (cas:2645-22-9) through the article.

S-S bonds in organodisulfides can break and obtain Li+ and e- in the discharge of lithium batteries. Organodisulfides provide precise lithiation sites, and therefore are valuable models for the study of redox reactions in lithium batteries. To understand their electrochem. behavior, we investigate three disulfides with different N-containing heterocycles including 2,2′-dipyridyl disulfide (2,2′-DpyDS), 4,4′-dipyridyl disulfide (4,4′-DpyDS), and 2,2′-dipyridyl disulfide-N,N’-dioxide (DpyDSDO). The three disulfides all show higher discharge voltage plateaus due to the electron-withdrawing groups: DPDS (2.20 V) < 2,2'-DpyDS (2.45 V) = 4,4'-DpyDS (2.45 V) < DpyDSDO (2.80 V). In particular, 2,2'-DpyDS exhibits an outstanding 69% capacity retention over 500 cycles. Our theor. simulations show that lithium pyridine-2-thiolate, the discharge product of 2,2'-DpyDS, forms compact clusters via N···Li···S bridges coordinated by lithium ions, which can help reduce its dissolution in liquid electrolyte, and therefore increase the cycle life. Liquid chromatog.-mass spectrometry is demonstrated to be a powerful tool for the investigation of discharge/recharge products of soluble organodisulfides in rechargeable lithium batteries. In some applications, this compound(2645-22-9)SDS of cas: 2645-22-9 is unique.If you want to know more details about this compound, you can contact with the author or consult more relevant literature.

Reference:
Bromide – Wikipedia,
bromide – Wiktionary

Reference of 4,4-Dipyridyl Disulfide. Aromatic heterocyclic compounds can also be classified according to the number of heteroatoms contained in the heterocycle: single heteroatom, two heteroatoms, three heteroatoms and four heteroatoms. Compound: 4,4-Dipyridyl Disulfide, is researched, Molecular C10H8N2S2, CAS is 2645-22-9, about Porous Metal-Organic Frameworks Containing Reversible Disulfide Linkages as Cathode Materials for Lithium-Ion Batteries. Author is Shimizu, Takeshi; Wang, Heng; Matsumura, Daiju; Mitsuhara, Kei; Ohta, Toshiaki; Yoshikawa, Hirofumi.

Three porous disulfide-ligand-containing metal-organic frameworks (DS-MOFs) and two nonporous coordination polymers with disulfide ligands (DS-CPs) with various structural dimensionalities were used as cathode active materials in lithium batteries. Charge/discharge performance examinations revealed that only porous DS-MOF-based batteries exhibited significant capacities close to the theor. values, which was ascribed to the insertion of electrolyte ions into the DS-MOFs. The insolubility of porous 3 D DS-MOFs in the electrolyte resulted in cycling performances superior to that of their 1 D and 2 D porous counterparts. Battery reactions were probed by instrumental analyses. The dual redox reactions of metal ions and disulfide ligands in the MOFs resulted in higher capacities, and the presence of reversible electrochem. dynamic S-S bonds stabilized the cycling performance. Thus, the strategy of S-S moiety trapping in MOFs and the obtained correlation between the structural features and battery performance could contribute to the design of high-performance MOF-based batteries and the practical realization of Li-S batteries.

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Reference:
Bromide – Wikipedia,
bromide – Wiktionary

Reference of 4,4-Dipyridyl Disulfide. Aromatic compounds can be divided into two categories: single heterocycles and fused heterocycles. Compound: 4,4-Dipyridyl Disulfide, is researched, Molecular C10H8N2S2, CAS is 2645-22-9, about Chloromethyl acryl reagents for simple and site-selective cysteine and disulfide modification. Author is Xu, Lujuan; Kuan, Seah Ling; Weil, Tanja.

The generation of protein biotherapeutics with improved features compared to the synthetic drugs has received emerging interest. The conjugation of various synthetic functionalities to proteins provides access to new classes of protein conjugates, where the advantages from both the synthetic world and Nature can be combined in a synergistic fashion. Here, we reported that 2-chloromethyl acryl scaffold can serve as a simple yet versatile platform for synthesizing acrylamide or acrylate derivatives by coupling with different end-group functionalities (amino group or hydroxyl group) via a one-pot reaction. The chem. properties of the amide or ester linkage influence their inherent reactivity as bioconjugation reagents, which in turn allows synthetic customization of their features to achieve selective protein modification at cysteine or disulfide sites on demand. 2-Chloromethyl acrylamide reagents with amide linkage favors selective modification at cysteine site with high efficiency and the resultant bioconjugates exhibit superior stability compared to commonly employed maleimide-thiol conjugates. In contrast, 2-chloromethyl acrylate reagents bearing ester linkage can undergo two successive Michael reaction, allowing the selective modification of disulfides with high labeling efficiency and conjugate stability. These reagents could outperform widely applied maleimide reagents in terms of stability of the resultant bioconjugates without compromising on the ease of reagent preparation, reactivity and reaction speed.

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Reference:
Bromide – Wikipedia,
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