Category: 2635-13-4

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 2635-13-4, name is 5-Bromobenzo[d][1,3]dioxole, A new synthetic method of this compound is introduced below., SDS of cas: 2635-13-4

Benzo[1,3]dioxole-5-carbaldehyde (1.80 g, 11.96 mmol), 5-bromobenzo[1,3]dioxole (2.65 g, 13.16 mmol), and n-butyl lithium (5.26 ml, 13.16 mmol) were treated in the same manner as described above for the synthesis of (2,3-dihydrobenzo[1,4]dioxin-6-yl)-(3,5-dimethoxyphenyl)methanol. The crude material was purified via flash column chromatography (5% EtOAc in hexane gradient to 40% EtOAc in hexane in about 40 min.) to give bis-benzo[1,3]dioxol-5-yl-methanol as a light brown oil (2.69 g, 83%): 1H-NMR (CDCl3) 6.86-6.74 (m, 6H, Ar), 5.93 (s, 4H, 2CH2), 5.68 (d, J=3 Hz, 1H, CHOH), 2.16 (d, J=3 Hz, 1H, OH). The product was carried over to the next step.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Bromide – Wikipedia,
bromide – Wiktionary

Synthetic Route of 2635-13-4, A common heterocyclic compound, 2635-13-4, name is 5-Bromobenzo[d][1,3]dioxole, molecular formula is C7H5BrO2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

EXAMPLE 3 Alternative Syntheses of (s)-alpha-methyl-1,3 benzodioxole-5-ethanol 3.47 grams of 4-bromo-1,2(methylenedioxy)benzene were dissolved in 100 ml of tetrahydrofuran at -78 C., 13.9 ml of 1,3M sec-butyllithium in cyclohexane was then added to consume the aryl halide in less than 30 minutes. 1.00 grams of (S)-(-)-propylene oxide in 2 ml THF was added by syringe and the solution stirred for 45 minutes. The solution was then warmed to 23 C. for 16 hours. The reaction mixture wag poured into 3M ammonium chloride solution and the product isolated by extraction with ethyl acetate. The combined extracts were dried over magnesium sulfate filtered through florisil and concentrated by rotary evaporation. The residual oil was purified by silica gel chromatography and eluted with a 50:50 mixture of hexane and diethyl ether to yield 1.40 g (45%) of the subtitled intermediate. Pchem: [alpha]365+117.2 (c 1.0, CHCl3) TLC Rf=0.26 (50:50 hexane:ether); IR (CHCl3) 3598, 3012, 2973, 2887, 1490, 1249, 1041 cm-1; 13C NMR (CDCl3) d 147.75, 146.19, 132.26, 122.27, 109.68, 108.30; mass spectrum, m/z (FD, M+) 180; Anal. Calcd. for C10H12O3: C, 66.65; H, 6.71. Found: C, 66.42; H, 6.66.

The synthetic route of 2635-13-4 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Eli Lilly and Company; US6329364; (2001); B1;,
Bromide – Wikipedia,
bromide – Wiktionary

Application of 2635-13-4, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 2635-13-4 name is 5-Bromobenzo[d][1,3]dioxole, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

A heavy-walled tube was charged with 5.01 grams (3 ml, 24.896 mmol) ofcommercially available 5-bromo-1,3-benzodioxole followed by dry DMF (5ml) followed by copper iodide (0.474 grams, 2.490 mmol, 0.10 equivalents), PdCl2(PPh3)2 (0.349 grams, 0.4979 mmol, 0.02 equivalents), and triethylamine (35 ml) and then subjected tooxygen removal using a freeze-pump-thaw method. Finally TMS-acetylene (3.68 grams, 5.3 ml,37.34 mmol) was then added and the tube was quickly sealed and heated in an oil bath at 90 Cfor 24 hours. At this time the reaction was cooled and worked up by concentration in vacuo andsubmitted to flash chromatography using straight hexanes to afford compound weighing 3.4 g.Yield is 62 %.

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 5-Bromobenzo[d][1,3]dioxole, and friends who are interested can also refer to it.

Reference:
Article; Abrams, Jason N.; Zhao, Qi; Ghiviriga, Ion; Minaruzzaman; Tetrahedron; vol. 68; 2; (2012); p. 423 – 428;,
Bromide – Wikipedia,
bromide – Wiktionary

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 2635-13-4, name is 5-Bromobenzo[d][1,3]dioxole, A new synthetic method of this compound is introduced below., SDS of cas: 2635-13-4

Step 1g. 5-Bromo-6-iodobenzo[d][1,3]dioxole (Compound 0107-1) A solution of compound 0106 (10.0 g, 50.0 mmol), anhydrous acetonitrile (150 mL), TFA (11.4 g, 100.0 mmol) and NIS (33.7 g, 150.0 mmol) was stirred at room temperature for 24 h. The solvent was removed under reduce pressure and the crude purified by column chromatography on silica gel (petroleum) to yield the title compound 0107-1 as a white solid (18.5 g, 91%): 1H NMR (DMSO-d6) delta 5.99 (s, 2H), 7.10 (s, 1H), 7.26 (s, 1H).

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; Cai, Xiong; Qian, Changgeng; Zhai, Haixiao; US2008/234314; (2008); A1;,
Bromide – Wikipedia,
bromide – Wiktionary

The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature. Quality Control of 5-Bromobenzo[d][1,3]dioxole, 2635-13-4, Name is 5-Bromobenzo[d][1,3]dioxole, SMILES is BrC1=CC=C(OCO2)C2=C1, in an article , author is Wu, Han, once mentioned of 2635-13-4.

miR-489 suppresses multiple myeloma cells growth through inhibition of LDHA-mediated aerobic glycolysis

Background Dysregulation of miR-489 in human tumors has been widely reported. Lactate dehydrogenase isoform A (LDHA)-mediated aerobic glycolysis participates in proliferation of multiple myeloma (MM) cells. Objective To investigate whether miR-489 induced MM growth inhibition via targeting to LDHA-mediated aerobic glycolysis. Methods Expression of miR-489 in representative MM cell lines was determined via qRT-PCR (quantitative real-time polymerase chain reaction). MTT (3-(4, 5-di methyl thiazol-2-yl)-2, 5-di phenyl tetrazolium bromide) and colony formation assays were utilized to detect cell viability and proliferation. Effect of miR-489 on aerobic glycolysis was detected via glucose uptake, lactate and ATP production. Binding ability between miR-489 and LDHA was conducted via luciferase activity assay. Results MiR-489 was down-regulated in representative MM cell lines. Gain-of functional assays indicated that over-expression of miR-489 decreased cell viability and inhibited cell proliferation of MM cells. Moreover, miR-489 inhibited aerobic glycolysis via decrease of glucose uptake, lactate and ATP production. LDHA was identified as target of miR-489, suggesting a negative correlation between miR-489 and LDHA in MM cells. Mechanically, the inhibition ability of miR-489 on proliferation of MM cells was through inhibition of LDHA-mediated aerobic glycolysis. Conclusions miR-489 inhibited MM tumor growth via LDHA-mediated glycolytic metabolism, suggesting potential therapeutic target ability of miR-489/LDHA for MM.

But sometimes, even after several years of basic chemistry education, it is not easy to form a clear picture on how they govern reactivity! 2635-13-4, you can contact me at any time and look forward to more communication. Quality Control of 5-Bromobenzo[d][1,3]dioxole.

The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature. Quality Control of 5-Bromobenzo[d][1,3]dioxole, 2635-13-4, Name is 5-Bromobenzo[d][1,3]dioxole, SMILES is BrC1=CC=C(OCO2)C2=C1, in an article , author is Li, Feiming, once mentioned of 2635-13-4.

Bromobenzene aliphatic nucleophilic substitution guided controllable and reproducible synthesis of high quality cesium lead bromide perovskite nanocrystals

Because of the intrinsic low formation energies of CsPbBr3 perovskite nanocrystal (PNC) lattices, it is still a big challenge to controllably fabricate high quality CsPbBr3 PNCs with reproducibility. We develop a new chemical design for the controllable and reproducible synthesis of high quality CsPbBr3 PNCs based on bromobenzene and alkane amine aliphatic nucleophilic substitution (BANS). In this design, bromobenzene reacts with alkane amines under heating to release HBr and the HBr is trapped by the deacid reagent Cs2CO3 and alkane amines under heating to produce CsBr and alkane ammonium bromide (AAmBr). The intermediate product, AAmBr, reacted with lead stearate to generate PbBr2 that finally formed CsPbBr3 PNCs. The nucleation and growth kinetics of CsPbBr3 PNCs were easily controlled via regulating the reactivity of bromobenzene and alkane amine. Typically, when 1,3,5-tris(bromomethyl)benzene and oleylamine were used, CsPbBr3 PNCs with a quantum yield of 88% and a narrow full-width at half-maximum of 22 nm could be produced by loading all reactants into a single reaction vessel under continuous heating under ambient atmospheric conditions. The whole synthesis was completed within 10 min with high simplicity and reproducibility and could be amplified to gram scale synthesis without hindering the photoluminescence properties of CsPbBr3 PNCs. Moreover, the CsPbBr3 PNCs obtained have been successfully applied for wavelength shift based fluorescent colorimetric detection of hydrochloric acid with high selectivity and accuracy.

But sometimes, even after several years of basic chemistry education, it is not easy to form a clear picture on how they govern reactivity! 2635-13-4, you can contact me at any time and look forward to more communication. Quality Control of 5-Bromobenzo[d][1,3]dioxole.

One of the major reasons for studying chemical kinetics is to use measurements of the macroscopic properties of a system, such as the rate of change in the concentration of reactants or products with time. 2635-13-4, Name is 5-Bromobenzo[d][1,3]dioxole, formurla is C7H5BrO2. In a document, author is Zhu, Yuanyuan, introducing its new discovery. Application In Synthesis of 5-Bromobenzo[d][1,3]dioxole.

Bromine Vacancy Redistribution and Metallic-Ion-Migration-Induced Air-Stable Resistive Switching Behavior in All-Inorganic Perovskite CsPbBr3 Film-Based Memory Device

All-inorganic halide perovskites have attracted a great deal of attention for applications in resistive switching (RS) memory devices due to their superior stability compared to organic-inorganic hybrid halide perovskites. RS memory devices utilizing air-stable all-inorganic halide perovskite cesium lead bromide (CsPbBr3) film as the switching layer, which are successfully prepared by spin coating at low temperature, are demonstrated. Memory devices based on CsPbBr3 film exhibit typical reproducible bipolar RS behavior and superior switching characteristics, including the high ON/OFF ratio (approximate to 10(4)), long data retention (>5 x 10(4) s), and environmental stability. In addition, multilevel storage capability can be achieved through controlling the different compliance currents. The formation and rupture of bromine (Br) vacancy conducting filaments (CFs) is proposed to explain the switching behavior in the Pt-anode-based memory devices, which is verified by XPS depth-profiling analysis. Moreover, the coexistence of Br vacancies and Ag metallic CFs is suggested to be responsible for the switching behavior in Ag-anode based device. These results demonstrate that the all-inorganic halide perovskite CsPbBr3 film will be the promising switching material for nonvolatile memory devices.

If you are hungry for even more, make sure to check my other article about 2635-13-4, Application In Synthesis of 5-Bromobenzo[d][1,3]dioxole.

Synthetic Route of 2635-13-4, Chemo-enzymatic cascade processes are invaluable due to their ability to rapidly construct high-value products from available feedstock chemicals in a one-pot relay manner. 2635-13-4, Name is 5-Bromobenzo[d][1,3]dioxole, SMILES is BrC1=CC=C(OCO2)C2=C1, belongs to bromides-buliding-blocks compound. In a article, author is Hong, Huachang, introduce new discover of the category.

Radial basis function artificial neural network (RBF ANN) as well as the hybrid method of RBF ANN and grey relational analysis able to well predict trihalomethanes levels in tap water

Many models have been developed in previous studies for predicting the formation of disinfection by-products (DBPs) in drinking water. However, most of them were linear or log-linear regression models, and generated based on simulated disinfection of source water or treated water in a laboratory other than real tap water, which shows low application potential in practice. In this study, a radial basis function artificial neural network (RBF ANN) as well as the hybrid method of RBF ANN and grey relational analysis (GRA) was proposed to predict trihalomethanes (THMs) levels in real distribution systems. A total of 64 sets of data including THM5 levels (trichloromethane (TCM), bromodichloromethane (BDCM) and total-THMs (T-THMs)) and 8 water quality parameters (temperature, pH, UV absorbance at 254 (UVA(254)), dissolved organic carbon, bromide, residual free chlorine, nitrite and ammonia) were used to train and verify the proposed model. As compared to linear and log-linear regression models (r(p) = 0.254-0.659; N-25 = 46-78%), RBF ANN5 for THM5 (TCM, BDCM and T-THMs) prediction consistently show higher regression coefficients (r(p) = 0.760-0.925) and prediction accuracy (N-25 = 92-98%), which indicates the high capability of RBF ANN to learn the complex non-linear relationships involved THM5 formation. Further analysis shows that RBF ANN5 using fewer water quality parameters based on GRA still make excellent performance in THM5 prediction (r(p) = 0.760-0.946; N-25 = 92-98%). This result demonstrates that GRA can be an effective technique to facilitate the generation of sound RBF ANN models with fewer factors.

Synthetic Route of 2635-13-4, The reactant in an enzyme-catalyzed reaction is called a substrate. Enzyme inhibitors cause a decrease in the reaction rate of an enzyme-catalyzed reaction.I hope my blog about 2635-13-4 is helpful to your research.

The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature. Safety of 5-Bromobenzo[d][1,3]dioxole, 2635-13-4, Name is 5-Bromobenzo[d][1,3]dioxole, SMILES is BrC1=CC=C(OCO2)C2=C1, in an article , author is Li, Meng-Yue, once mentioned of 2635-13-4.

Combined experimental and theoretical investigations of Ba3GaS4I: interesting structural transformation originated from halogen substitution

Inorganic chalcohalides have emerged as promising functional materials for a range of applications. However, most of them are chlorides and bromides, while iodides are still rare. Herein, a new quaternary iodine-based chalcohalide Ba3GaS4I has been acquired by the reaction of BaS, Ga, S and BaI2 at 1173 K. Single-crystal XRD analysis reveals that Ba3GaS4I has a centrosymmetric structure (orthorhombic, space group Cmcm, a = 6.991(3) angstrom, b = 15.910(7) angstrom, c = 9.698(4) angstrom, V = 1078.6(7) angstrom(3), and Z = 4) and consists of isolated [GaS4] tetrahedra with charge-balanced Ba2+ cations and I- anions. Ba3GaS4I can be regarded as the product of chemical substitution of Ba3GaS4X (X = Cl, Br), which adopts a different space group, Pnma. The influences of the halogen elements on the bandgap and birefringence have been discussed through first principles calculations and structural comparison.

But sometimes, even after several years of basic chemistry education, it is not easy to form a clear picture on how they govern reactivity! 2635-13-4, you can contact me at any time and look forward to more communication. Safety of 5-Bromobenzo[d][1,3]dioxole.

Synthetic Route of 2635-13-4, Children learn through play, and they learn more than adults might expect. Science experiments are a great way to spark their curiosity, 2635-13-4, Name is 5-Bromobenzo[d][1,3]dioxole, SMILES is BrC1=CC=C(OCO2)C2=C1, belongs to bromides-buliding-blocks compound. In a article, author is Sim, Ji-Han, introduce new discover of the category.

Melanogenesis Effect of 7-acetoxy-4-methylcoumarin in B16F10 Melanoma Cells

The increased interest in anti-whitening dyes has enhanced the research interest to identify efficient melanogenic activators. Melanogenesis is the process of melanin production by melanocytes in the hair follicles and skin, which is mediated by several enzymes, such as microphthalmia-associated transcription factor (MITF), tyrosinase (TYR), tyrosinase-related protein (TRP)-1, and TRP-2. This study investigated the melanogenesis-stimulating effect of 4-Methylumbelliferone (4MUMB) and its synthetic derivatives, 7-acetoxy-4-methylcoumarin (7A4MC) and 4-methylheriniarin (4MH) in B16F10 melanoma cells. The cytotoxicity of these compounds was investigated by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide (MTT) assay, followed by the assessment of the melanin content and the intracellular TYR activity. Finally, the expression levels of the key enzymes involved in melanogenesis were investigated. 7A4MC increased melanin production in B16F10 cells relative to that by 4MUMB and 4MH treated cells in a dose-dependent manner without significant cytotoxicity. Concomitantly, 7A4MC significantly increased TYR activity and enhanced the expression of MITF, which significantly induced the expression of TRP-1, TRP-2, and TYR. Furthermore, 7A4MC stimulated melanogenesis via increased phosphorylation of c-Jun N-terminal kinases (JNK) and reduced phosphorylation of protein kinase B (AKT). These results confirmed the melanogenesis-inducing effects of 7A4MC and indicated its potential use as an anti-hair bleaching agent in cosmetics industries.

Synthetic Route of 2635-13-4, Each elementary reaction can be described in terms of its molecularity, the number of molecules that collide in that step. The slowest step in a reaction mechanism is the rate-determining step.you can also check out more blogs about 2635-13-4.