Category: 2635-13-4

In 2022,Deng, Xuemei; Luo, Tian; Li, Zhao; Wen, Huaixiu; Zhang, Honghua; Yang, Xiaoyan; Lei, Fang; Liu, Dan; Shi, Tao; Zhao, Quanyi; Wang, Zhen published an article in European Journal of Medicinal Chemistry. The title of the article was 《Design, synthesis and anti-hepatocellular carcinoma activity of 3-arylisoquinoline alkaloids》.Related Products of 2635-13-4 The author mentioned the following in the article:

This article describes the syntheses and biol. activity of five 3-arylisoquinoline natural products corydamine (1), N-formyl Corydamine (2), hypecumine (3), Decumbenine B (XW) and 2-(1,3-dioxolo [4,5-h]isoquinolin-7-yl)-4,5-dimethoxy-N-methyl-Benzeneethanamine (A), and twelve analogs. Among them, 1, 2, and A were synthesized for the first time. In vitro screening for anti-proliferative activity showed that derivative 1a could significantly inhibit the proliferation of HCC cells (IC50 = 9.82 μM on Huh7 cells and 6.83 μM on LM9 cells), and arrest cell cycle at G2/M phase. The mechanistic studies further suggested compound 1a was a dual inhibitor of Topo I and Topo II, and Topo II inhibitory activity was superior to etoposide. In addition, 1a could significantly inhibit the invasion and migration of cancer cells by inhibiting the expression of MMP-9, and induce apoptosis through inhibiting the activation of the PI3K/Akt/mTOR signaling pathway. Moreover, in vivo studies demonstrated 1a could obviously reduce the growth of xenograft tumor and possessed good pharmacokinetic parameters, which indicated the potential value of 1a in treating liver cancer.5-Bromobenzo[d][1,3]dioxole(cas: 2635-13-4Related Products of 2635-13-4) was used in this study.

Furthermore, the coupling of 5-Bromobenzo[d][1,3]dioxole(cas: 2635-13-4) with β-methallyl alcohol was catalyzed by Pd(OAc)2 in combination with P(t-Bu)3.Related Products of 2635-13-4

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

《Synthesis of Alkenylboronates from N-Tosylhydrazones through Palladium-Catalyzed Carbene Migratory Insertion》 was written by Ping, Yifan; Wang, Rui; Wang, Qianyue; Chang, Taiwei; Huo, Jingfeng; Lei, Ming; Wang, Jianbo. Formula: C7H5BrO2This research focused ontosylhydrazone palladium catalyzed borylation carbene migratory insertion; mol structure calculation palladium catalyzed borylation tosylhydrazone NBO. The article conveys some information:

The palladium-catalyzed oxidative borylation reaction of N-tosylhydrazones has been developed. The reaction features mild conditions, broad substrate scope, and good functional group tolerance. It thus represents a highly efficient and practical method for the synthesis of di-, tri-, and tetrasubstituted alkenylboronates from readily available N-tosylhydrazones. One-pot Suzuki coupling and other transformations highlight the synthetic utility of the approach. DFT calculations have revealed that palladium-carbene formation and subsequent boryl migratory insertion are the key steps in the catalytic cycle. The high stereoselectivity observed in the formation of trisubstituted alkenylboronates has been explained by distortion-interaction anal. and NBO anal. In the part of experimental materials, we found many familiar compounds, such as 5-Bromobenzo[d][1,3]dioxole(cas: 2635-13-4Formula: C7H5BrO2)

Furthermore, the coupling of 5-Bromobenzo[d][1,3]dioxole(cas: 2635-13-4) with β-methallyl alcohol was catalyzed by Pd(OAc)2 in combination with P(t-Bu)3.Formula: C7H5BrO2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

《Nickel-Catalyzed Electrochemical Reductive Relay Cross-Coupling of Alkyl Halides to Aryl Halides》 was written by Jiao, Ke-Jin; Liu, Dong; Ma, Hong-Xing; Qiu, Hui; Fang, Ping; Mei, Tian-Sheng. Category: bromides-buliding-blocks And the article was included in Angewandte Chemie, International Edition in 2020. The article conveys some information:

A highly regioselective Ni-catalyzed electrochem. reductive relay cross-coupling between an aryl halide and an alkyl halide was developed in an undivided cell. Various functional groups are tolerated under these mild reaction conditions, which provides an alternative approach for the synthesis of 1,1-diarylalkanes. In the experimental materials used by the author, we found 5-Bromobenzo[d][1,3]dioxole(cas: 2635-13-4Category: bromides-buliding-blocks)

Furthermore, the coupling of 5-Bromobenzo[d][1,3]dioxole(cas: 2635-13-4) with β-methallyl alcohol was catalyzed by Pd(OAc)2 in combination with P(t-Bu)3.Category: bromides-buliding-blocks

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

《Structure Ligation Relationship of Amino Acids for the Selective Indole C-H Arylation Reaction: L-Aspartic acid as Sustainable Alternative of Phosphine Ligands》 was written by Lokhande†, Shyam Kumar; Vaidya†, Gargi Nikhil; Satpute, Dinesh Parshuram; Venkatesh, Ashwini; Kumar, Sanjeev; Kumar, Dinesh. Name: 5-Bromobenzo[d][1,3]dioxole And the article was included in Advanced Synthesis & Catalysis in 2020. The article conveys some information:

The Structure Ligation Relationship (SLR) of free amino acids (AAs) under Pd-catalysis were examined for the chemo- and regioselective indole C-H arylation reactions. While the majority of AAs were minor or ineffective, the L-aspartic acid (L-Asp) stands out promising to deliver high-value C3-arylated indoles with excellent chemo- (C vs N) and regioselectivity (C3 vs C2) with high functional group tolerance. Thus, the protocol offers a cost-effective and sustainable alternative of phosphine-based ligands for the indole C3-H arylation reactions. Preliminary mechanistic investigations suggested the simultaneous involvement of -NH2, α-CO2H, and β-CO2H functionalities of L-Asp and found critical for its ligation efficiency. The developed catalytic system was compatible with the tandem decarboxylation/arylation procedure for the chemoselective synthesis of 3-aryl indoles. The experimental part of the paper was very detailed, including the reaction process of 5-Bromobenzo[d][1,3]dioxole(cas: 2635-13-4Name: 5-Bromobenzo[d][1,3]dioxole)

Furthermore, the coupling of 5-Bromobenzo[d][1,3]dioxole(cas: 2635-13-4) with β-methallyl alcohol was catalyzed by Pd(OAc)2 in combination with P(t-Bu)3.Name: 5-Bromobenzo[d][1,3]dioxole

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

In 2022,Yan, Xiang-Yu; Leng, Jia-Fu; Chen, Ting-Ting; Zhao, Yong-Jun; Kong, Ling-Yi; Yin, Yong published an article in European Journal of Medicinal Chemistry. The title of the article was 《Design, synthesis, and biological evaluation of novel diphenylamine derivatives as tubulin polymerization inhibitors targeting the colchicine binding site》.HPLC of Formula: 2635-13-4 The author mentioned the following in the article:

A novel series of diphenylamine derivatives were designed and synthesized I and their biol. activities were evaluated. The anti-proliferative activities of the derivatives were tested against five human cancer cell lines (MCF-7, MDA-MB-231, A549, HeLa and HT29). Among them, I exhibited the promising anti-proliferative activity against HT29 cell lines with the IC50 value of 23 nM. Further biol. studies depicted that I inhibited cancer cell migration, colony formation and angiogenesis. Besides, dynamics studies and mol. docking studies revealed that I inhibited tubulin polymerization which may be a result of the compound binding to the colchicine site of tubulin. Furthermore,I arrested HT29 cell cycle at G2/M phase, and induced HT29 cell apoptosis by upregulating cyclin B1, Bcl-2, Bax, Cleaved-caspase9, Cleaved-caspase3, PARP, Cleaved-PARP proteins, and downregulating p-cdc25c (S216), p-cdc2 (T15) proteins. Mitochondrial membrane potential (MMP) and reactive oxygen species (ROS) were also determined to confirm the cell apoptosis process. Finally, I greatly inhibited the tumor growth in HT29 xenograft mice by 75.5% at 10 mg/kg. Meanwhile, I owned the good pharmacokinetic properties. All the results promised that I is of potential to act as an antitumor candidate and worthy of further investigation. In the part of experimental materials, we found many familiar compounds, such as 5-Bromobenzo[d][1,3]dioxole(cas: 2635-13-4HPLC of Formula: 2635-13-4)

Furthermore, the coupling of 5-Bromobenzo[d][1,3]dioxole(cas: 2635-13-4) with β-methallyl alcohol was catalyzed by Pd(OAc)2 in combination with P(t-Bu)3.HPLC of Formula: 2635-13-4

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

In 2022,Zhang, Qingyu; Chan, Yung-Yin; Zhang, Muyin; Yeung, Ying-Yeung; Ke, Zhihai published an article in Angewandte Chemie, International Edition. The title of the article was 《Hypervalent Chalcogenonium…π Bonding Catalysis》.Application of 2635-13-4 The author mentioned the following in the article:

A proof-of-concept study of hypervalent chalcogenonium…π bonding catalysis was performed. A new catalytic strategy using 1,2-oxaselenolium salts as chalcogen bond donors and alkenes as chalcogen bond acceptors is described. The feasibility of this concept is demonstrated by the use of trisubstituted selenonium salts in the metal-free catalytic hydrofunctionalization and polymerization of alkenes via unconventional seleniranium ion-like intermediates. The results indicate that counter anions have a significant effect on the catalysis based on hypervalent chalcogenonium…π bonding interactions. In addition to this study using 5-Bromobenzo[d][1,3]dioxole, there are many other studies that have used 5-Bromobenzo[d][1,3]dioxole(cas: 2635-13-4Application of 2635-13-4) was used in this study.

Furthermore, the coupling of 5-Bromobenzo[d][1,3]dioxole(cas: 2635-13-4) with β-methallyl alcohol was catalyzed by Pd(OAc)2 in combination with P(t-Bu)3.Application of 2635-13-4

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

《Copper-Catalyzed Asymmetric Radical 1,2-Carboalkynylation of Alkenes with Alkyl Halides and Terminal Alkynes》 was published in Journal of the American Chemical Society in 2020. These research results belong to Dong, Xiao-Yang; Cheng, Jiang-Tao; Zhang, Yu-Feng; Li, Zhong-Liang; Zhan, Tian-Ya; Chen, Ji-Jun; Wang, Fu-Li; Yang, Ning-Yuan; Ye, Liu; Gu, Qiang-Shuai; Liu, Xin-Yuan. SDS of cas: 2635-13-4 The article mentions the following:

A copper-catalyzed intermol. three-component asym. radical 1,2-carboalkynylation of alkenes has been developed, providing straightforward access to diverse chiral alkynes from readily available alkyl halides and terminal alkynes. The utilization of a cinchona alkaloid-derived multidentate N,N,P-ligand is crucial for the efficient radical generation from mildly oxidative precursors by copper and the effective inhibition of the undesired Glaser coupling side reaction. The substrate scope is broad, covering (hetero)aryl-, alkynyl-, and aminocarbonyl-substituted alkenes, (hetero)aryl and alkyl as well as silyl alkynes, and tertiary to primary alkyl radical precursors with excellent functional group compatibility. Facile transformations of the obtained chiral alkynes have also been demonstrated, highlighting the excellent complementarity of this protocol to direct 1,2-dicarbofunctionalization reactions with C(sp2/sp3)-based reagents. In the experiment, the researchers used many compounds, for example, 5-Bromobenzo[d][1,3]dioxole(cas: 2635-13-4SDS of cas: 2635-13-4)

Furthermore, the coupling of 5-Bromobenzo[d][1,3]dioxole(cas: 2635-13-4) with β-methallyl alcohol was catalyzed by Pd(OAc)2 in combination with P(t-Bu)3.SDS of cas: 2635-13-4

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Tian, Duanshuai; Xu, Ronghua; Zhu, Jinbin; Huang, Jianxun; Dong, Wei; Claverie, Jerome; Tang, Wenjun published their research in Angewandte Chemie, International Edition in 2021. The article was titled 《Asymmetric Hydroesterification of Diarylmethyl Carbinols》.Reference of 5-Bromobenzo[d][1,3]dioxole The article contains the following contents:

An efficient asym. hydroesterfication of diarylmethyl carbinols is developed for the first time with a Pd-WingPhos catalyst, resulting in a series of chiral 4-aryl-3,4-dihydrocoumarins in excellent enantioselectivities and good yields. The method features mild reaction conditions, a broad substrate scope, use of easily accessible starting materials, and low palladium loadings. A plausible stereochem. model is also proposed with the Pd-WingPhos catalyst. This method has enabled a 4-step asym. synthesis of (R)-tolterodine from readily available starting materials. In the experiment, the researchers used 5-Bromobenzo[d][1,3]dioxole(cas: 2635-13-4Reference of 5-Bromobenzo[d][1,3]dioxole)

Furthermore, the coupling of 5-Bromobenzo[d][1,3]dioxole(cas: 2635-13-4) with β-methallyl alcohol was catalyzed by Pd(OAc)2 in combination with P(t-Bu)3.Reference of 5-Bromobenzo[d][1,3]dioxole

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

In 2022,Echemendia, Radell; De Jesus, Matheus P.; Furniel, Lucas G.; Day, David Philip; Burtoloso, Antonio C. B. published an article in European Journal of Organic Chemistry. The title of the article was 《Molecular Iodine Mediated Oxidation of Arylated α-Carbonyl Sulfoxonium Ylides to 1,2-Dicarbonyl-Containing Compounds》.Category: bromides-buliding-blocks The author mentioned the following in the article:

In this work, a new oxidative, mol. iodine-mediated transformation on sterically encumbered arylated sulfoxonium ylides, which give access to 1,2-dicarbonyl containing compounds was reported. Twenty-six examples were realized (47-92% yields), with structural diversity modified at two key sites on the sulfoxonium ylide reactants. Furthermore, the protocol benefits from the use of inexpensive mol. iodine to mediate the oxidation and, from a sustainability viewpoint, short reaction times (30 min), ambient temperature, and Et acetate as a greener reaction solvent. Exptl. studies also gave insight to the mechanism of the reaction, involving DMSO as an oxygen source. The results came from multiple reactions, including the reaction of 5-Bromobenzo[d][1,3]dioxole(cas: 2635-13-4Category: bromides-buliding-blocks)

Furthermore, the coupling of 5-Bromobenzo[d][1,3]dioxole(cas: 2635-13-4) with β-methallyl alcohol was catalyzed by Pd(OAc)2 in combination with P(t-Bu)3.Category: bromides-buliding-blocks

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Tien, Chieh-Hung; Trofimova, Alina; Holownia, Aleksandra; Kwak, Branden S.; Larson, Reed T.; Yudin, Andrei K. published their research in Angewandte Chemie, International Edition in 2021. The article was titled 《Carboxyboronate as a Versatile In Situ CO Surrogate in Palladium-Catalyzed Carbonylative Transformations》.Formula: C7H5BrO2 The article contains the following contents:

The application of carboxy-MIDA-boronate (MIDA=N-methyliminodiacetic acid) as an in situ CO surrogate for various palladium-catalyzed transformations is described. Carboxy-MIDA-boronate was previously shown to be a bench-stable boron-containing building block for the synthesis of borylated heterocycles. The present study demonstrates that, in addition to its utility as a precursor to heterocycle synthesis, carboxy-MIDA-boronate is an excellent in situ CO surrogate that is tolerant of reactive functionalities such as amines, alcs., and carbon-based nucleophiles. Its wide functional-group compatibility is highlighted in the palladium-catalyzed aminocarbonylation, alkoxycarbonylation, carbonylative Sonogashira coupling, and carbonylative Suzuki-Miyaura coupling of aryl halides. A variety of amides, esters, (hetero)aromatic ynones, and bis(hetero)aryl ketones were synthesized in good-to-excellent yields in a one-pot fashion. The experimental part of the paper was very detailed, including the reaction process of 5-Bromobenzo[d][1,3]dioxole(cas: 2635-13-4Formula: C7H5BrO2)

Furthermore, the coupling of 5-Bromobenzo[d][1,3]dioxole(cas: 2635-13-4) with β-methallyl alcohol was catalyzed by Pd(OAc)2 in combination with P(t-Bu)3.Formula: C7H5BrO2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary