Category: 2623-87-2

Safety of 4-Bromobutanoic acidIn 2020 ,《Supramolecular Design of Unsymmetric Reverse Bolaamphiphiles for Cell-Sensitive Hydrogel Degradation and Drug Release》 was published in Angewandte Chemie, International Edition. The article was written by Chakroun, Rami W.; Sneider, Alexandra; Anderson, Caleb F.; Wang, Feihu; Wu, Pei-Hsun; Wirtz, Denis; Cui, Honggang. The article contains the following contents:

Self-assembly of peptide-based building units into supramol. nanostructures creates an important class of biomaterials with robust mech. properties and improved resistance to premature degradation Yet, upon aggregation, substrate-enzyme interactions are often compromised because of the limited access of macromol. proteins to the peptide substrate, leading to either a reduction or loss of responsiveness to biomol. cues. Reported here is the supramol. design of unsym. reverse bolaamphiphiles (RBA) capable of exposing a matrix metalloproteinase (MMP) substrate on the surface of their filamentous assemblies. Upon addition of MMP-2, these filaments rapidly break into fragments prior to reassembling into spherical micelles. Using 3D cell culture, it is shown that drug release is commensurate with cell d., revealing more effective cell killing when more cancer cells are present. This design platform could serve as a cell-responsive therapeutic depot for local chemotherapy. In the experiment, the researchers used many compounds, for example, 4-Bromobutanoic acid(cas: 2623-87-2Safety of 4-Bromobutanoic acid)

4-Bromobutanoic acid(cas: 2623-87-2) belongs to carboxylic acids. The chief chemical characteristic of the carboxylic acids is their acidity. They are generally more acidic than other organic compounds containing hydroxyl groups but are generally weaker than the familiar mineral acids (e.g., hydrochloric acid, HCl, sulfuric acid, H2SO4, etc.).Safety of 4-Bromobutanoic acid

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Reference of 4-Bromobutanoic acidIn 2021 ,《Remote C-H Pyridylation of Hydroxamates through Direct Photoexcitation of O-Aryl Oxime Pyridinium Intermediates》 appeared in Angewandte Chemie, International Edition. The author of the article were Kweon, Byeongseok; Kim, Changha; Kim, Seonyul; Hong, Sungwoo. The article conveys some information:

An efficient strategy for the remote C-H pyridylation of hydroxamates with excellent ortho-selectivity by designing a new class of photon-absorbing O-aryl oxime pyridinium salts generated in-situ from the corresponding pyridines and hydroxamates. When irradiated by visible light, the photoexcitation of oxime pyridinium intermediates generated iminyl radicals via the photolytic N-O bond cleavage, which does not require an external photocatalyst. The efficiency of light absorption and N-O bond cleavage of the oxime pyridinium salts was modulated through the electronic effect of substitution on the O-aryl ring. The resultant iminyl radicals enabled the installation of pyridyl rings at the γ-CN position, which yields synthetically valuable C2-substituted pyridyl derivatives This novel synthetic approach provided significant advantages in terms of both efficiency and simplicity and exhibits broad functional group tolerance in complex settings under mild and metal-free conditions. The results came from multiple reactions, including the reaction of 4-Bromobutanoic acid(cas: 2623-87-2Reference of 4-Bromobutanoic acid)

4-Bromobutanoic acid(cas: 2623-87-2) belongs to carboxylic acids. The chief chemical characteristic of the carboxylic acids is their acidity. They are generally more acidic than other organic compounds containing hydroxyl groups but are generally weaker than the familiar mineral acids (e.g., hydrochloric acid, HCl, sulfuric acid, H2SO4, etc.).Reference of 4-Bromobutanoic acid

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

《Multikilogram Synthesis of a Potent Dual Bcl-2/Bcl-xL Antagonist. 2. Manufacture of the 1,3-Diamine Moiety and Improvement of the Final Coupling Reaction》 was published in Organic Process Research & Development in 2020. These research results belong to Hardouin, Christophe; Baillard, Sandrine; Bariere, Francois; Craquelin, Anthony; Grandjean, Mathieu; Janvier, Solenn; Le Roux, Stephane; Penloup, Christine; Russo, Olivier. Computed Properties of C4H7BrO2 The article mentions the following:

This paper describes the synthesis of kilogram quantities of the sulfonamide moiety I involved in a coupling reaction with acid moiety II to provide batches of drug candidate III for preclin. studies and first-in-human clin. trials. A first approach relying on a chiral separation furnished the desired enantiomer of 1,3-diamine IV, precursor of sulfonamide I. An enantiomeric synthesis of IV using the Ellman’s chiral auxiliary coupled with an aza-Reformatsky reaction to control the stereochem. is also discussed. Coupling conditions of the final step involving EDCI to provide III under a cGMP process are detailed. An alternative approach using N-(1-methanesulfonyl)benzotriazole is also presented. In the experimental materials used by the author, we found 4-Bromobutanoic acid(cas: 2623-87-2Computed Properties of C4H7BrO2)

4-Bromobutanoic acid(cas: 2623-87-2) belongs to carboxylic acids. The chief chemical characteristic of the carboxylic acids is their acidity. They are generally more acidic than other organic compounds containing hydroxyl groups but are generally weaker than the familiar mineral acids (e.g., hydrochloric acid, HCl, sulfuric acid, H2SO4, etc.).Computed Properties of C4H7BrO2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Kretschmer, Nadine; Hufner, Antje; Durchschein, Christin; Popodi, Katrin; Rinner, Beate; Lohberger, Birgit; Bauer, Rudolf published an article in 2021. The article was titled 《Synthesis and pharmacological in vitro investigations of novel shikonin derivatives with a special focus on cyclopropane bearing derivatives》, and you may find the article in International Journal of Molecular Sciences.Application of 2623-87-2 The information in the text is summarized as follows:

In previous studies, author’s showed that the constituents of the roots of Onosma paniculata as well as a synthetic derivative of the most active constituent showed promising results in metastatic melanoma cell lines. In the current study, author’s address the question whether author’s can generate further derivatives with optimized activity by synthesis. Therefore, author’s prepared 31, mainly novel shikonin derivatives and screened them in different melanoma cell lines (WM9, WM164, and MUG-Mel2 cells) using the XTT viability assay. Author’s identified (R)-1-(1,4-dihydro-5,8-dihydroxy-1,4-dioxonaphthalen-2-yl)-4-methylpent-3-enyl 2-cyclopropyl-2-oxoacetate as a novel derivative with even higher activity. Furthermore, pharmacol. investigations including the ApoToxGloM Triplex assay, LDH assay, and cell cycle measurements revealed that this compound induced apoptosis and reduced cells in the G1 phase accompanied by an increase of cells in the G2/M phase. Moreover, it showed hardly any effects on the cell membrane integrity. However, it also exhibited cytotoxicity against non-tumorigenic cells. Nevertheless, in summary, author’s could show that shikonin derivatives might be promising drug leads in the treatment of melanoma. In the experimental materials used by the author, we found 4-Bromobutanoic acid(cas: 2623-87-2Application of 2623-87-2)

4-Bromobutanoic acid(cas: 2623-87-2) belongs to carboxylic acids. The chief chemical characteristic of the carboxylic acids is their acidity. They are generally more acidic than other organic compounds containing hydroxyl groups but are generally weaker than the familiar mineral acids (e.g., hydrochloric acid, HCl, sulfuric acid, H2SO4, etc.).Application of 2623-87-2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

The author of 《Development of BODIPY dyes with versatile functional groups at 3,5-positions from diacyl peroxides via Cu(II)-catalyzed radical alkylation》 were Tang, Bing; Lv, Fan; Chen, Kangkang; Jiao, Lijuan; Liu, Qingyun; Wang, Hua; Hao, Erhong. And the article was published in Chemical Communications (Cambridge, United Kingdom) in 2019. Recommanded Product: 4-Bromobutanoic acid The author mentioned the following in the article:

An efficient Cu(II)-catalyzed, C-H alkylation of BODIPY with a variety of alkyl diacyl peroxides has been developed for the first time, providing a late-stage and straightforward method for controllable synthesis of monoalkylated and dialkylated BODIPYs via a radical process that otherwise is difficult to obtain by literature methods. This chemo- and site-selective transformation will allow for the introduction of a variety of functionalities on the BODIPY core for highly versatile tethering to receptors and to other mols. of interest. After reading the article, we found that the author used 4-Bromobutanoic acid(cas: 2623-87-2Recommanded Product: 4-Bromobutanoic acid)

4-Bromobutanoic acid(cas: 2623-87-2) belongs to carboxylic acids. The chief chemical characteristic of the carboxylic acids is their acidity. They are generally more acidic than other organic compounds containing hydroxyl groups but are generally weaker than the familiar mineral acids (e.g., hydrochloric acid, HCl, sulfuric acid, H2SO4, etc.).Recommanded Product: 4-Bromobutanoic acid

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

《Iridium(I)-catalyzed hydration/esterification of 2-alkynylphenols and carboxylic acids》 was written by Zeng, Linwei; Chen, Renjie; Zhang, Chen; Xie, Hujun; Cui, Sunliang. Synthetic Route of C4H7BrO2 And the article was included in Chemical Communications (Cambridge, United Kingdom) in 2020. The article conveys some information:

An iridium(I)-catalyzed hydration/esterification of 2-alkynylphenols and carboxylic acids was described. Various 2-alkynylphenols and carboxylic acids could be used in this process to furnish aromatic ortho-acyloxyketones I [R1 = H, 4-Me, 2-C≡CPh-4-Cl; R2 = n-Bu, Ph, 2-thienyl, etc.; R3 = Me, 2-naphthyl, Bn, etc.] via a regio- and stereo-selective addition reaction followed by intramol. rearrangement. Unexpectedly, changing the purification method of the products from silica gel column chromatog. to direct concentration or recrystallization resulted in exclusively obtaining (E)-enol esters II [R4 = Ph, 4-MeC6H4, 2-ClC6H4, 4-FC6H4; R5 = Ph, 2-MeC6H4, 2,4-di-O2NC6H3, etc.]. This protocol featured mild reaction conditions and broad substrate scope. To demonstrate the synthetic utility of this reaction, four obtained ortho-acyloxyketones were treated with NaH and subsequently refluxed in acetic acid gave flavones III [R1 = 2-furyl, 2-thienyl, 2-naphthyl, tetrahydropyran-4-yl]. The experimental process involved the reaction of 4-Bromobutanoic acid(cas: 2623-87-2Synthetic Route of C4H7BrO2)

4-Bromobutanoic acid(cas: 2623-87-2) belongs to carboxylic acids. The chief chemical characteristic of the carboxylic acids is their acidity. They are generally more acidic than other organic compounds containing hydroxyl groups but are generally weaker than the familiar mineral acids (e.g., hydrochloric acid, HCl, sulfuric acid, H2SO4, etc.).Synthetic Route of C4H7BrO2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

The author of 《A light-responsive liposomal agent for MRI contrast enhancement and monitoring of cargo delivery》 were Reessing, F.; Stuart, M. C. A.; Samplonius, D. F.; Dierckx, R. A. J. O.; Feringa, B. L.; Helfrich, W.; Szymanski, W.. And the article was published in Chemical Communications (Cambridge, United Kingdom) in 2019. Safety of 4-Bromobutanoic acid The author mentioned the following in the article:

Medical magnetic resonance imaging (MRI) produces high-resolution anatomical images of the human body, but has limited capacity to provide useful mol. information. The light-responsive, liposomal MRI contrast agent described herein could be used to provide an intrinsic theranostic aspect to MRI and enable tracking the distribution and cargo release of drug delivery systems upon light-triggered activation. After reading the article, we found that the author used 4-Bromobutanoic acid(cas: 2623-87-2Safety of 4-Bromobutanoic acid)

4-Bromobutanoic acid(cas: 2623-87-2) belongs to carboxylic acids. The chief chemical characteristic of the carboxylic acids is their acidity. They are generally more acidic than other organic compounds containing hydroxyl groups but are generally weaker than the familiar mineral acids (e.g., hydrochloric acid, HCl, sulfuric acid, H2SO4, etc.).Safety of 4-Bromobutanoic acid

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

《Conductivity properties of selected aliphatic monocarboxylic acid anions in water at 298.15 K》 was published in International Journal of Electrochemical Science in 2020. These research results belong to Kinart, Zdzislaw; Tomas, Renato. Synthetic Route of C4H7BrO2 The article mentions the following:

The article presents the elec. conductivity values of sodium salts of four selected monocarboxylic acid derivatives in aqueous solution: those with a chlorine substituent in the peripheral position, i.e. ClCH(CH2)nCOOH; those with a bromine substituent in the peripheral position, i.e. BrCH(CH2)nCOOH; as well as unsaturated sodium salts with a double bond in the peripheral position, i.e. CH2 = CH(CH2)nCOOH; and unsaturated sodium salts with a double bond in the second position, i.e. CH3-CH = CH(CH2)nCOOH. All conductivity measurements were performed at 298.15 K in the concentration range of 0.0005 < c / mol · dm-3 < 0.018. The obtained values allowed the limiting molar conductivities (Λ0m) of the studied electrolytes to be determined using the Fuoss-Justice equation. Based on these (Λ0m) values, the molar limiting conductivity values (λ0A-) for individual anions of the tested electrolytes were calculated and analyzed as a function of carbon chain length. The work also examines the effect of substituent type (Cl or Br) and double bond location on the limiting molar conductivity values of the tested monocarboxylic acid anions and compares them with literature values.4-Bromobutanoic acid(cas: 2623-87-2Synthetic Route of C4H7BrO2) was used in this study.

4-Bromobutanoic acid(cas: 2623-87-2) belongs to carboxylic acids. The chief chemical characteristic of the carboxylic acids is their acidity. They are generally more acidic than other organic compounds containing hydroxyl groups but are generally weaker than the familiar mineral acids (e.g., hydrochloric acid, HCl, sulfuric acid, H2SO4, etc.).Synthetic Route of C4H7BrO2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

The author of 《A Simple 3D-Printed Enzyme Reactor Paper Spray Mass Spectrometry Platform for Detecting BuChE Activity in Human Serum》 were Yang, Yanmei; Liu, Huimin; Chen, Zhenzhen; Wu, Tianhong; Jiang, Zhongyao; Tong, Lili; Tang, Bo. And the article was published in Analytical Chemistry (Washington, DC, United States) in 2019. Application In Synthesis of 4-Bromobutanoic acid The author mentioned the following in the article:

To achieve personalized healthcare, a quick, accurate, and high-throughput method to detect disease biomarkers is essential. In the traditional practice, mass spectrometry is one of the most powerful tools and is widely studied. However, the test of human serum usually requires complicated sample pretreatment, tedious operations, and precise condition control, especially for the detection of enzymes as biomarkers. As butyrylcholinesterase (BuChE) has an indicative significance in detecting degenerative disease, liver injury, and organophosphate poisoning, the quick quantification of BuChE is of vital importance to the clinic. In this paper, we report the design and fabrication of a portable 3D-printed enzyme reactor paper spray cartridge (3D ER-PS) with integrated functions: temperature control, enzyme reaction, analyte transfer, and paper spray ionization. Coupled with mass spectrometry, quant. testing of BuChE activity in human serum was realized conveniently and accurately. While it only requires very simple sample preparation, the results from current 3D ER-PS approach are well consistent with those obtained using Ellman’s method. This 3D ER-PS platform not only provides a novel solution for the liquid biopsy of BuChE in clinics but also contributes to the development of quick and targeted medical approaches for analyzing other types of serum biomarker mols. in the field of disease diagnosis. In the experimental materials used by the author, we found 4-Bromobutanoic acid(cas: 2623-87-2Application In Synthesis of 4-Bromobutanoic acid)

4-Bromobutanoic acid(cas: 2623-87-2) belongs to carboxylic acids. The chief chemical characteristic of the carboxylic acids is their acidity. They are generally more acidic than other organic compounds containing hydroxyl groups but are generally weaker than the familiar mineral acids (e.g., hydrochloric acid, HCl, sulfuric acid, H2SO4, etc.).Application In Synthesis of 4-Bromobutanoic acid

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

The author of 《Synthesis of vinca alkaloid-triphenylphosphine derivatives having potential antitumor effect》 were Keglevich, Andras; Szigetvari, Aron; Dekany, Miklos; Szantay, Csaba Jr.; Keglevich, Peter; Hazai, Laszlo. And the article was published in Phosphorus, Sulfur and Silicon and the Related Elements in 2019. Safety of 4-Bromobutanoic acid The author mentioned the following in the article:

The successful therapy of cancer is still unresolved. For that reason enormous efforts are being made to increase the effectiveness of anticancer drugs and reduce their side effects at least. An important approach to the development of selective mols. is the synthesis of drug conjugates, also called as “”hybrids””. Taking this into consideration two Vinca alkaloid derivatives conjugated with triphenylphosphine have been synthesized. The incorporation of the mentioned two pharmacophores in the same mol. could amplify the evolving cumulative antineoplastic impact and/or counterbalance the side effects. Thus a development of hybrid anticancer mols. has been started by synthesis of Vinca alkaloid-triphenylphosphine conjugates, which could have higher efficacies and safety profiles than the present drugs available in market. The experimental part of the paper was very detailed, including the reaction process of 4-Bromobutanoic acid(cas: 2623-87-2Safety of 4-Bromobutanoic acid)

4-Bromobutanoic acid(cas: 2623-87-2) belongs to carboxylic acids. The chief chemical characteristic of the carboxylic acids is their acidity. They are generally more acidic than other organic compounds containing hydroxyl groups but are generally weaker than the familiar mineral acids (e.g., hydrochloric acid, HCl, sulfuric acid, H2SO4, etc.).Safety of 4-Bromobutanoic acid

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary