Category: 2623-87-2

Hassan, Mohamed; Krieg, Sara-Cathrin; Ndefo Nde, Cedric; Roos, Jessica; Maier, Thorsten J.; El Rady, Eman A.; Raslan, Mohamed A.; Sadek, Kamal U.; Manolikakes, Georg published an article in 2021. The article was titled 《Streamlined One-Pot Synthesis of Nitro Fatty Acids》, and you may find the article in European Journal of Organic Chemistry.Computed Properties of C4H7BrO2 The information in the text is summarized as follows:

A novel method for the synthesis of nitro fatty acids (NFAs), an intriguing class of endogenously occurring lipid mediators, is reported. This one-pot procedure enables the controlled and stereoselective construction of nitro fatty acids from a simple set of common building blocks in a highly facile manner. Thereby, this methodol. offers a streamlined, highly modular access to naturally occurring nitro fatty acids as well as non-natural NFA derivatives In addition to this study using 4-Bromobutanoic acid, there are many other studies that have used 4-Bromobutanoic acid(cas: 2623-87-2Computed Properties of C4H7BrO2) was used in this study.

4-Bromobutanoic acid(cas: 2623-87-2) belongs to carboxylic acids. The chief chemical characteristic of the carboxylic acids is their acidity. They are generally more acidic than other organic compounds containing hydroxyl groups but are generally weaker than the familiar mineral acids (e.g., hydrochloric acid, HCl, sulfuric acid, H2SO4, etc.).Computed Properties of C4H7BrO2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

《Wide thermal range, exclusive occurrence of technically significant chiral nematic phase: synthesis and mesomorphism of cholesterol-based non-symmetric dimers》 was published in Bulletin of Materials Science in 2020. These research results belong to Nayak, Rashmi Ashwathama; Bhat, Sachin A.; Rao, D. S. Shankar; Yelamaggad, C. V.. Quality Control of 4-Bromobutanoic acid The article mentions the following:

Fifteen new non-sym. chiral dimers belonging to three different series have been synthesized and evaluated for their mesomorphic properties. They were formed by interlinking cholesterol with salicylaldimine (SAN) cores (with reverse imine groups) via an ω-oxyalkanoyloxy spacer. Within a series, the length of the terminal n-alkoxy tails had been varied for a fixed even-parity spacer. Three even-parity spacers such as 4-oxybutanoyloxy, 6-oxyhexanoyloxy and 8-oxyoctanoyloxy have been used to join two cores, whereas the terminal tails such as n-butyloxy, n-hexyloxy, n-octyloxy, n-decyloxy and n-dodecyloxy chains have been attached to the SAN core. Microscopic and calorimetric exptl. results show that all the dimers behave identically exhibiting the chiral nematic (N*) phase solely, which was authenticated by powder X-ray diffraction studies carried out on some selected samples. In the vast majority of the cases,the phase was thermodynamically stable, and while cooling, it exists over a wide thermal range covering room temperature(RT)due to supercooling. Finding was notable given the fact that the N* phase possesses technol. significant optical properties. At RT, the N* phase displayed one of the iridescent colors characteristically caused by interference and diffraction of the reflected and scattered light. A comparative study reveals that the lengths of both the terminal chain and central spacer influence the clearing temperature of the dimers, and also the temperature range of the N* phase. The selective reflection measurements revealed that the pitch of the N* phase was either temperature sensitive or temperature insensitive. Temperature-dependent CD (CD) spectra were recorded for the planar texture of the N* phase formed by a dimer, as a representative case. The presence of an intense neg. CD band suggests the left-handed screw sense of the N* phase helix. In the experiment, the researchers used 4-Bromobutanoic acid(cas: 2623-87-2Quality Control of 4-Bromobutanoic acid)

4-Bromobutanoic acid(cas: 2623-87-2) belongs to carboxylic acids. The chief chemical characteristic of the carboxylic acids is their acidity. They are generally more acidic than other organic compounds containing hydroxyl groups but are generally weaker than the familiar mineral acids (e.g., hydrochloric acid, HCl, sulfuric acid, H2SO4, etc.).Quality Control of 4-Bromobutanoic acid

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

The author of 《A Novel Fluorescence Sensor Towards Hydrazine in Living Cells》 were Wang, Jinjin; Guo, Jing; Dou, Lili; Wang, Rui; Song, Yan; Yang, Qingbiao; Du, Jianshi; Li, Yaoxian. And the article was published in Chemical Research in Chinese Universities in 2019. Computed Properties of C4H7BrO2 The author mentioned the following in the article:

By a simple one-step reaction, a new fluorescein-based probe, 3′-hydroxy-3-oxo-3H-spiro[isobenzofu-ran-1,9′-xanthen]-6′-yl-4-bromobutanoate(FLB), was designed and synthesized. Relative to other cations, anions or amines, the probe exhibited high sensitivity and specificity towards hydrazine with approx. 40-fold fluorescence enhancement at 515 nm. The detection limit(DL) was calculated to be 2.87×10-8 mol/L, which was about 10 times lower than maximum allowable level of hydrazine(3.12×10-7 mol/L) in drinking water permitted by the US Environment and Protection Association(EPA). Simultaneously, through mass spectroscopy and proton NMR titration, the detection mechanism was further confirmed. Eventually, due to the low cytotoxicity and excellent water solubility, FLB could be employed to detect hydrazine in living cells. In the experiment, the researchers used 4-Bromobutanoic acid(cas: 2623-87-2Computed Properties of C4H7BrO2)

4-Bromobutanoic acid(cas: 2623-87-2) belongs to carboxylic acids. The chief chemical characteristic of the carboxylic acids is their acidity. They are generally more acidic than other organic compounds containing hydroxyl groups but are generally weaker than the familiar mineral acids (e.g., hydrochloric acid, HCl, sulfuric acid, H2SO4, etc.).Computed Properties of C4H7BrO2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

In 2022,Zhang, Dapeng; Atochina-Vasserman, Elena N.; Lu, Juncheng; Maurya, Devendra S.; Xiao, Qi; Liu, Matthew; Adamson, Jasper; Ona, Nathan; Reagan, Erin K.; Ni, Houping; Weissman, Drew; Percec, Virgil published an article in Journal of the American Chemical Society. The title of the article was 《The Unexpected Importance of the Primary Structure of the Hydrophobic Part of One-Component Ionizable Amphiphilic Janus Dendrimers in Targeted mRNA Delivery Activity》.Name: 4-Bromobutanoic acid The author mentioned the following in the article:

Viral and synthetic vectors for delivery of nucleic acids impacted genetic nanomedicine by aiding the rapid development of the extraordinarily efficient Covid-19 vaccines. Access to targeted delivery of nucleic acids is expected to expand the field of nanomedicine beyond most expectations. Both viral and synthetic vectors have advantages and disadvantages. The major advantage of the synthetic vectors is their unlimited synthetic capability. The four-component lipid nanoparticles (LNPs) are the leading nonviral vector for mRNA used by Pfizer and Moderna in Covid-19 vaccines. Their synthetic capacity inspired us to develop a one-component multifunctional sequence-defined ionizable amphiphilic Janus dendrimer (IAJD) delivery system for mRNA. The first experiments on IAJDs provided, through a rational-library design combined with orthogonal-modular accelerated synthesis and sequence control in their hydrophilic part, some of the most active synthetic vectors for the delivery of mRNA to lung. The second experiments employed a similar strategy, generating, by a less complex hydrophilic structure, a library of IAJDs targeting spleen, liver, and lung. Here, we report preliminary studies designing the hydrophobic region of IAJDs by using dissimilar alkyl lengths and demonstrate the unexpectedly important role of the primary structure of the hydrophobic part of IAJDs by increasing up to 90.2-fold the activity of targeted delivery of mRNA to spleen, lymph nodes, liver, and lung. The principles of the design strategy reported here and in previous publications indicate that IAJDs could have a profound impact on the future of genetic nanomedicine. After reading the article, we found that the author used 4-Bromobutanoic acid(cas: 2623-87-2Name: 4-Bromobutanoic acid)

4-Bromobutanoic acid(cas: 2623-87-2) belongs to carboxylic acids. The chief chemical characteristic of the carboxylic acids is their acidity. They are generally more acidic than other organic compounds containing hydroxyl groups but are generally weaker than the familiar mineral acids (e.g., hydrochloric acid, HCl, sulfuric acid, H2SO4, etc.).Name: 4-Bromobutanoic acid

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Application In Synthesis of 4-Bromobutanoic acidIn 2021 ,《Targeted Delivery of mRNA with One-Component Ionizable Amphiphilic Janus Dendrimers》 was published in Journal of the American Chemical Society. The article was written by Zhang, Dapeng; Atochina-Vasserman, Elena N.; Maurya, Devendra S.; Liu, Matthew; Xiao, Qi; Lu, Juncheng; Lauri, George; Ona, Nathan; Reagan, Erin K.; Ni, Houping; Weissman, Drew; Percec, Virgil. The article contains the following contents:

Targeted and efficient delivery of nucleic acids with viral and synthetic vectors is the key step of genetic nanomedicine. The four-component lipid nanoparticle synthetic delivery systems consisting of ionizable lipids, phospholipids, cholesterol, and a PEG-conjugated lipid, assembled by microfluidic or T-tube technol., have been extraordinarily successful for delivery of mRNA to provide Covid-19 vaccines. Recently, we reported a one-component multifunctional sequence-defined ionizable amphiphilic Janus dendrimer (IAJD) synthetic delivery system for mRNA relying on amphiphilic Janus dendrimers and glycodendrimers developed in our laboratory Amphiphilic Janus dendrimers consist of functional hydrophilic dendrons conjugated to hydrophobic dendrons. Co-assembly of IAJDs with mRNA into dendrimersome nanoparticles (DNPs) occurs by simple injection in acetate buffer, rather than by microfluidic devices, and provides a very efficient system for delivery of mRNA to lung. Here we report the replacement of most of the hydrophilic fragment of the dendron from IAJDs, maintaining only its ionizable amine, while changing its interconnecting group to the hydrophobic dendron from amide to ester. The resulting IAJDs demonstrated that protonated ionizable amines play dual roles of hydrophilic fragment and binding ligand for mRNA, changing delivery from lung to spleen and/or liver. Replacing the interconnecting ester with the amide switched the delivery back to lung. Delivery predominantly to liver is favored by pairs of odd and even alkyl groups in the hydrophobic dendron. This simple structural change transformed the targeted delivery of mRNA mediated with IAJDs, from lung to liver and spleen, and expands the utility of DNPs from therapeutics to vaccines. The results came from multiple reactions, including the reaction of 4-Bromobutanoic acid(cas: 2623-87-2Application In Synthesis of 4-Bromobutanoic acid)

4-Bromobutanoic acid(cas: 2623-87-2) belongs to carboxylic acids. The chief chemical characteristic of the carboxylic acids is their acidity. They are generally more acidic than other organic compounds containing hydroxyl groups but are generally weaker than the familiar mineral acids (e.g., hydrochloric acid, HCl, sulfuric acid, H2SO4, etc.).Application In Synthesis of 4-Bromobutanoic acid

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Recommanded Product: 2623-87-2In 2021 ,《Synthesis and Biological Activity of Novel Antifungal Leads: 3,5-Dichlorobenzyl Ester Derivatives》 was published in Journal of Agricultural and Food Chemistry. The article was written by Du, Shaoqing; Yuan, Qinglong; Hu, Xueping; Fu, Wen; Xu, Qi; Wei, Ziyi; Xu, Jiazheng; Shao, Xusheng; Qian, Xuhong. The article contains the following contents:

Succinate dehydrogenase (SDH) is one of the most important mol. targets for the development of new fungicides. Carboxamide fungicides are a class of SDH inhibitors widely used to inhibit highly destructive plant pathogens. Although cases of resistance have been found in fungal pathogens due to the unrestricted use in recent years, there is still demand for new compounds with improved fungicidal activity. Therefore, a series of ester compounds were designed to investigate potential novel antifungal mols. First, the antifungal activity of different benzyl alc. compounds (A1-A21) was tested, and a highly active fragment (3,5-dichlorobenzyl alc.) was found. Subsequently, various compounds were synthesized by esterification between different acids and 3,5-dichlorobenzyl alc., among which compound (I) exhibited remarkable antifungal activity against Botrytis cinerea and Rhizoctonia solani with EC50 values of 6.60 and 1.61 mg/L, resp., which were comparable to those of com. fungicide boscalid (EC50 = 1.24 and 1.01 mg/L). In vivo testing further demonstrated that compound I was effective in suppressing B. cinerea (200 mg/L, 50.9%). Moreover, SDH inhibition assays, fluorescence quenching anal., and determination of mitochondrial membrane potential revealed that compound I has similar effects to boscalid. Furthermore, the fungicidal activity of target compounds can be maintained by modifying the amide bond to an ester bond. These results will provide basis for the development of novel fungicides. In the experiment, the researchers used many compounds, for example, 4-Bromobutanoic acid(cas: 2623-87-2Recommanded Product: 2623-87-2)

4-Bromobutanoic acid(cas: 2623-87-2) belongs to carboxylic acids. The chief chemical characteristic of the carboxylic acids is their acidity. They are generally more acidic than other organic compounds containing hydroxyl groups but are generally weaker than the familiar mineral acids (e.g., hydrochloric acid, HCl, sulfuric acid, H2SO4, etc.).Recommanded Product: 2623-87-2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

In 2019,Journal of Colloid and Interface Science included an article by Zoratto, Nicole; Grillo, Isabelle; Matricardi, Pietro; Dreiss, Cecile A.. Safety of 4-Bromobutanoic acid. The article was titled 《Supramolecular gels of cholesterol-modified gellan gum with disc-like and worm-like micelles》. The information in the text is summarized as follows:

The association between a hydrophobically modified polysaccharide, gellan gum, with micelles based on a surfactant bearing the same hydrophobic tail as pendant groups was investigated by rheol. and small-angle neutron scattering (SANS). Gellan gum grafted with cholesterol groups (20% mol/mol tetrasaccharide unit), GeCh, was mixed with polyoxyethylene cholesteryl ether (ChEO10), which comprises a cholesterol group as the tail linked to a small polyoxyethylene headgroup, and self-assembles into micelles with an unusual disk-like morphol. The addition of 0.5% polymer to solutions of ChEO10 induced a remarkable transition from a Newtonian fluid to a predominantly solid-like viscoelastic behavior, leading to a ×105 increase in zero-shear viscosity (with 5% ChEO10). Increasing surfactant concentration led to an enhancement of the viscoelasticity, but the elastic modulus G’ reached a plateau around 15% surfactant, attributed to a saturation of the sticker groups. The effect of micellar morphol. on the network was studied by adding a small headgroup co-surfactant, triethylene glycol monododecyl ether, to ChEO10 micelles, which drives their elongation into wormlike micelles. Networks obtained with the long, flexible micelles displayed enhanced solid-like behavior, with no cross-over between G’ and G” over the measured range of frequencies, reflecting relaxation times of the order of minutes or hours. The morphol. of the gels studied by SANS revealed a scattering dominated by strongly interacting micelles (described by disks of 140 Å diameter and a hydrated ∼38 Å PEO corona) and the presence of micellar clusters induced by the presence of the polymer. The scattering data therefore confirm that the onset of gelation is due to surfactant micelles acting as junction points for the network. The results came from multiple reactions, including the reaction of 4-Bromobutanoic acid(cas: 2623-87-2Safety of 4-Bromobutanoic acid)

4-Bromobutanoic acid(cas: 2623-87-2) belongs to carboxylic acids. The chief chemical characteristic of the carboxylic acids is their acidity. They are generally more acidic than other organic compounds containing hydroxyl groups but are generally weaker than the familiar mineral acids (e.g., hydrochloric acid, HCl, sulfuric acid, H2SO4, etc.).Safety of 4-Bromobutanoic acid

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

In 2022,Cromwell, Simon; Sutio, Randy; Zhang, Changhe; Such, Georgina K.; Lupton, David W. published an article in Angewandte Chemie, International Edition. The title of the article was 《Lewis Base Catalyzed Synthesis of Sulfur Heterocycles via the C1-Pyridinium Enolate》.Formula: C4H7BrO2 The author mentioned the following in the article:

Herein, a reaction cascade in which a C1-pyridinium enolate undergos addition to dithioesters, trithiocarbonates and xanthates was reported. The reaction provided access to a range of dihydrothiophenes I [R = cyclohexyl, Ph, SBn, etc.; R1 = R2 = H; R1 = Me; R2 = CN, Ph] and dihydrothiopyrans II [R3 = H, Me, OMe, F] and III [R4 = H, Me, F]. Mechanistic investigations, including isolation of intermediates, electronic correlation, and kinetic isotope effect studies support the viability of an activated acid intermediate giving rise to the C1-pyridinium enolate which undergoes turnover limiting cyclization. Subsequent formation of a β-thiolactone regenerates the catalyst with loss of carbon oxysulfide providing the observed products. The experimental part of the paper was very detailed, including the reaction process of 4-Bromobutanoic acid(cas: 2623-87-2Formula: C4H7BrO2)

4-Bromobutanoic acid(cas: 2623-87-2) belongs to carboxylic acids. The chief chemical characteristic of the carboxylic acids is their acidity. They are generally more acidic than other organic compounds containing hydroxyl groups but are generally weaker than the familiar mineral acids (e.g., hydrochloric acid, HCl, sulfuric acid, H2SO4, etc.).Formula: C4H7BrO2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Murphy, Manoharan; Theyagarajan, K.; Thenmozhi, Kathavarayan; Senthilkumar, Sellappan published an article in 2021. The article was titled 《Direct electrochemistry of covalently immobilized hemoglobin on a naphthylimidazolium butyric acid ionic liquid/MWCNT matrix》, and you may find the article in Colloids and Surfaces, B: Biointerfaces.Application of 2623-87-2 The information in the text is summarized as follows:

Monitoring the concentration levels of hydrogen peroxide (H2O2) is significant in both clin. and industrial applications. Herein, we develop a facile biosensor for the detection of H2O2 based on direct electron transfer of Hb (Hb), which was covalently immobilized on a hydrophobic naphthylimidazolium butyric acid ionic liquid (NIBA-IL) over a multiwalled carbon nanotube (MWCNT) modified glassy carbon electrode (GCE) to obtain an Hb/NIBA-IL/MWCNT/GCE. Highly water-soluble Hb protein was firmly immobilized on NIBA-IL via stable amide bonding between the free -NH2 groups of Hb and -COOH groups of NIBA-IL via EDC/NHS coupling. Thus fabricated biosensor showed a well resolved redox peak with a cathodic peak potential (Epc) at -0.35 V and anodic peak potential (Epa) at -0.29 V with a formal potential (E°’) of -0.32 V, which corresponds to the deeply buried FeIII/FeII redox center of Hb, thereby direct electrochem. of Hb was established. Further, the modified electrode demonstrated very good electrocatalytic activity towards H2O2 reduction and showed a wide linear range of detection from 0.01 to 6.3 mM with a limit of detection and sensitivity of 3.2μM and 111μA mM-1 cm-2, resp. Moreover, the developed biosensor displayed high operational stability under dynamic conditions as well as during continuous potential cycles and showed reliable reproducibility. The superior performance of the fabricated biosensor is attributed to the effective covalent immobilization of Hb on the newly developed highly conducting and biocompatible NIBA-IL/MWCNT/GCE platform. In the experimental materials used by the author, we found 4-Bromobutanoic acid(cas: 2623-87-2Application of 2623-87-2)

4-Bromobutanoic acid(cas: 2623-87-2) belongs to carboxylic acids. The chief chemical characteristic of the carboxylic acids is their acidity. They are generally more acidic than other organic compounds containing hydroxyl groups but are generally weaker than the familiar mineral acids (e.g., hydrochloric acid, HCl, sulfuric acid, H2SO4, etc.).Application of 2623-87-2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

《Spontaneously Blinking Fluorophores Based on Nucleophilic Addition/Dissociation of Intracellular Glutathione for Live-Cell Super-resolution Imaging》 was written by Morozumi, Akihiko; Kamiya, Mako; Uno, Shin-nosuke; Umezawa, Keitaro; Kojima, Ryosuke; Yoshihara, Toshitada; Tobita, Seiji; Urano, Yasuteru. Recommanded Product: 2623-87-2 And the article was included in Journal of the American Chemical Society in 2020. The article conveys some information:

Single-mol. localization microscopy (SMLM) allows the reconstruction of super-resolution images but generally requires prior intense laser irradiation and in some cases additives to induce blinking of conventional fluorophores. The authors previously introduced a spontaneously blinking rhodamine fluorophore based on an intramol. spirocyclization reaction for live-cell SMLM under physiol. conditions. Here, the authors report a novel principle of spontaneous blinking in living cells, which utilizes reversible ground-state nucleophilic attack of intracellular glutathione (GSH) upon a xanthene fluorophore. Structural optimization afforded two pyronine fluorophores with different colors, both of which exhibit equilibrium (between the fluorescent dissociated form and the nonfluorescent GSH adduct form) and blinking kinetics that enable SMLM of microtubules or mitochondria in living cells. Furthermore, by using spontaneously blinking fluorophores working in the near-IR (NIR) and green ranges, the authors succeeded in dual-color live-cell SMLM without the need for optimization of the imaging medium. In the experiment, the researchers used many compounds, for example, 4-Bromobutanoic acid(cas: 2623-87-2Recommanded Product: 2623-87-2)

4-Bromobutanoic acid(cas: 2623-87-2) belongs to carboxylic acids. The chief chemical characteristic of the carboxylic acids is their acidity. They are generally more acidic than other organic compounds containing hydroxyl groups but are generally weaker than the familiar mineral acids (e.g., hydrochloric acid, HCl, sulfuric acid, H2SO4, etc.).Recommanded Product: 2623-87-2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary