Category: 2623-87-2

《Synthesis of Novel Vindoline-Chrysin Hybrids》 was written by Mayer, Szabolcs; Nagy, Nora; Keglevich, Peter; Szigetvari, Aron; Dekany, Miklos; Szantay, Csaba Junior; Hazai, Laszlo. COA of Formula: C4H7BrO2This research focused onvindoline chrysin doxorubicin cisplatin ciglitazone diphenylamine 10 chloroacetamidovindoline anticancer; anticancer effect; chrysin; hybrid molecule; reaction mechanism; vindoline. The article conveys some information:

Vinca alkaloids are well-known microtubule targeting agents, which are used against some types of cancer. Vindoline is one of the monomeric Vinca alkaloids which does not have anti-tumor effect, although its derivatives have serious impact on the field of these indole alkaloids. Chrysin is a secondary plant metabolite, which has broad-spectrum biol. activity, among others anticancer activity. Chrysin had shown synergic effect with several antiproliferative compounds (e. g., doxorubicin, cisplatin and ciglitazone), therefore, we attempted the synthesis of a novel vindoline-chrysin hybrid mol. However, in the first case a diphenylamine structure was isolated. The mechanism of the unexpected reaction was studied, and then the originally targeted hybrid was synthesized by a reverse route coupling. A further hybrid was produced using a different site of the mol. The antitumor activities were determined against 60 human tumor cell lines (NCI60), where the aimed hybrid showed low micromolar GI50 values on most of the cell lines. In addition to this study using 4-Bromobutanoic acid, there are many other studies that have used 4-Bromobutanoic acid(cas: 2623-87-2COA of Formula: C4H7BrO2) was used in this study.

4-Bromobutanoic acid(cas: 2623-87-2) belongs to carboxylic acids. The chief chemical characteristic of the carboxylic acids is their acidity. They are generally more acidic than other organic compounds containing hydroxyl groups but are generally weaker than the familiar mineral acids (e.g., hydrochloric acid, HCl, sulfuric acid, H2SO4, etc.).COA of Formula: C4H7BrO2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Application of 2623-87-2In 2019 ,《Imprinting supramolecular chirality on silica from natural triterpenoid-regulated helical ribbons》 was published in Materials Chemistry Frontiers. The article was written by Gao, Yuxia; Hao, Jie; Liu, Jinguo; Liang, Yun; Du, Fengpei; Hu, Jun; Ju, Yong. The article contains the following contents:

Supramol. chirality has attracted significant attention because of its critical roles in the life and material sciences. In this study, a natural triterpenoid-tailored amphiphilic mol. C4-MOP was designed and synthesized, in which the pyridinium head group was modified on the skeleton of triterpenoid through an alkyl linker. The introduction of pyridinium not only offers a hydrophilic cation to promote the assembly process but also renders itself as the nucleation point to adsorb silica precursors. The results showed that by adjusting the solvent compositions and the concentration of C4-MOP, well-ordered helical nanoribbons with both right- and left-handedness were fabricated by the assembly of C4-MOP, where the hydrophilic pyridinium cations were helically displayed on the surface of ribbons. Subsequently, by taking advantage of electrostatic interactions between pyridinium and the silica precursor, the supramol. chirality of C4-MOP was successfully imprinted onto the silica nanostructures using the gel-sol mineralization process. Our work provides a simple yet useful strategy to prepare chiral silica, which could promote the applications of chiral natural products in material science. The experimental part of the paper was very detailed, including the reaction process of 4-Bromobutanoic acid(cas: 2623-87-2Application of 2623-87-2)

4-Bromobutanoic acid(cas: 2623-87-2) belongs to carboxylic acids. The chief chemical characteristic of the carboxylic acids is their acidity. They are generally more acidic than other organic compounds containing hydroxyl groups but are generally weaker than the familiar mineral acids (e.g., hydrochloric acid, HCl, sulfuric acid, H2SO4, etc.).Application of 2623-87-2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Tian, Yanxin; He, Yulin; Liu, Pan; Zhang, Hui; Zheng, Qiuying; Liu, Jialiang; Xiao, Linghan; Wang, Xibin; Ao, Yuhui; Li, Ming published their research in Journal of Materials Science in 2021. The article was titled 《Mild and in situ photo-crosslinking of anthracene-functionalized poly(aryl ether ketone) for enhancing temporal stability of organic NLO materials》.Quality Control of 4-Bromobutanoic acid The article contains the following contents:

Developing a mild and efficient method to simultaneously enhance poling efficiency and temporal stability is meaningful and challenging for organic second-order nonlinear optical materials. In this paper, a new poly(aryl ether ketone) and chromophores functionalized with anthracene groups have been designed and prepared Poling and crosslinking process could be separated by the mild and photo-initiated cycloaddition of anthracene group. As the UV-Vis spectrum, DSC and TGA curves, the networks had formed by 30-min irradiation of the lower-power UV light which led little decomposition of dipolar chromophores. The maximum electro-optic coefficient (r33) of these polymers is 28.5 pm V-1 (at 1.3μm), and the order parameter reaches 0.22. Moreover, the depolarization temperature of α peak, related to the dipole relaxation, has been increased to 129°C after crosslinking, which is 17°C higher than uncrosslinked ones. All these results indicated that the photo-crosslinking of anthracene exhibited promising potential for improving alignment stability and NLO activity at the same time. After reading the article, we found that the author used 4-Bromobutanoic acid(cas: 2623-87-2Quality Control of 4-Bromobutanoic acid)

4-Bromobutanoic acid(cas: 2623-87-2) belongs to carboxylic acids. The chief chemical characteristic of the carboxylic acids is their acidity. They are generally more acidic than other organic compounds containing hydroxyl groups but are generally weaker than the familiar mineral acids (e.g., hydrochloric acid, HCl, sulfuric acid, H2SO4, etc.).Quality Control of 4-Bromobutanoic acid

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

In 2022,Zhu, Hong; Liu, Zhichao; Xu, Chenbo; Chen, Caiqi; Wen, Jinxuan; Yang, Keqin; Chen, Suqin; Pan, Yuexiao published an article in Journal of Alloys and Compounds. The title of the article was 《Large red shift from blue to green in the photoluminescence of pure CsPbBr3 nanoplatelets triggered by the cooperative effect of ligands combination》.Recommanded Product: 4-Bromobutanoic acid The author mentioned the following in the article:

A viable design strategy toward cubic CsPbBr3 (CPB) nanoplatelet (NPs) with blue emission at 450-467 nm and a large red shift to the green region at 500-512 nm occurs was developed through a cooperative effect of the ligands 4-bromobutyric acid (BBA) and oleylamine (OLA). The influence of the mol. ratio of BBA/OLA, reaction time and temperature on the transformation from blue to green was studied systematically. The red shift in the PL of CPB NPs is ascribed to the growth of the crystals with decreased quantum confinement. The luminescence quantum yields (PLQYs) of the blue and green luminescence of the obtained CPB NPs reach 94.4 and 84.4%, resp. This proposed strategy not only exptl. fabricates size-adjustable CPB NPs but also helps to reveal in depth the mechanisms of the large variation of quantum confinement in pure cubic CPB NPs. The results came from multiple reactions, including the reaction of 4-Bromobutanoic acid(cas: 2623-87-2Recommanded Product: 4-Bromobutanoic acid)

4-Bromobutanoic acid(cas: 2623-87-2) belongs to carboxylic acids. The chief chemical characteristic of the carboxylic acids is their acidity. They are generally more acidic than other organic compounds containing hydroxyl groups but are generally weaker than the familiar mineral acids (e.g., hydrochloric acid, HCl, sulfuric acid, H2SO4, etc.).Recommanded Product: 4-Bromobutanoic acid

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

《A bicyclic pentapeptide-based highly potent and selective pan-SIRT1/2/3 inhibitor harboring Nε-thioacetyl-lysine》 was published in Bioorganic & Medicinal Chemistry in 2020. These research results belong to Li, Renwu; Yan, Lingling; Sun, Xun; Zheng, Weiping. Electric Literature of C4H7BrO2 The article mentions the following:

Past few years have seen an active pursuit of the inhibitors for the deacylation catalyzed by the seven human sirtuins (i.e. SIRT1-7) as valuable chem. biol./pharmacol. probes of this enzymic deacylation and lead compounds for developing novel therapeutics for human diseases. In the current study, we prepared eight monocyclic and one bicyclic analogs of a linear pentapeptide-based potent (sub-μM IC50’s) pan-SIRT1/2/3 inhibitor Zheng laboratory discovered recently that harbors the catalytic mechanism-based SIRT1/2/3 inhibitory warhead Nε-thioacetyl-lysine at its central position. We found that the bicyclic analog exhibited largely comparable SIRT1/2/3 inhibitory potencies to those of the parent linear pentapeptide, however, the former is proteolytically much more stable than the latter. Moreover, the bicyclic analog displayed very weak inhibition against SIRT5/6/7, was cell permeable, and exhibited an anti-proliferative effect on the human SK-MEL-2 melanoma cells. This bicyclic analog could be a lead for the future development of more potent and still selective pan-SIRT1/2/3 inhibitors whose use in studies on human sirtuin biol., pharmacol., and medicinal chem. could complement with the use of the potent inhibitors selective for a single human sirtuin. In the experimental materials used by the author, we found 4-Bromobutanoic acid(cas: 2623-87-2Electric Literature of C4H7BrO2)

4-Bromobutanoic acid(cas: 2623-87-2) belongs to carboxylic acids. The chief chemical characteristic of the carboxylic acids is their acidity. They are generally more acidic than other organic compounds containing hydroxyl groups but are generally weaker than the familiar mineral acids (e.g., hydrochloric acid, HCl, sulfuric acid, H2SO4, etc.).Electric Literature of C4H7BrO2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

《Synthesis and in vitro Antitumor Effect of New Vindoline Derivatives Coupled with Triphenylphosphine》 was written by Keglevich, Andras; Szigetvari, Aron; Dekany, Miklos; Szantay, Csaba; Keglevich, Peter; Hazai, Laszlo. COA of Formula: C4H7BrO2This research focused onvindoline preparation antitumor activity. The article conveys some information:

An important approach to the development of new antitumor agents is the synthesis of conjugates containing two or more structural units. Taking this into consideration, vindoline derivatives I (n = 1, 3, 4) were coupled with triphenylphosphine, to afford the expected phosphonium salts II. The new hybrid entities were characterized by NMR spectroscopy, and their anticancer activity was also evaluated. In the part of experimental materials, we found many familiar compounds, such as 4-Bromobutanoic acid(cas: 2623-87-2COA of Formula: C4H7BrO2)

4-Bromobutanoic acid(cas: 2623-87-2) belongs to carboxylic acids. The chief chemical characteristic of the carboxylic acids is their acidity. They are generally more acidic than other organic compounds containing hydroxyl groups but are generally weaker than the familiar mineral acids (e.g., hydrochloric acid, HCl, sulfuric acid, H2SO4, etc.).COA of Formula: C4H7BrO2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

《Deoxofluorination of Aliphatic Carboxylic Acids: A Route to Trifluoromethyl-Substituted Derivatives》 was written by Bugera, Maksym; Trofymchuk, Serhii; Tarasenko, Karen; Zaporozhets, Olga; Pustovit, Yurii; Mykhailiuk, Pavel K.. Application of 2623-87-2This research focused ontrifluoromethyl substituted derivative preparation; aliphatic carboxylic acid deoxofluorination sulfur tetrafluoride water additive. The article conveys some information:

A practical method for the synthesis of functionalized aliphatic trifluoromethyl-substituted derivatives from aliphatic acids was developed. The transformation proceeds with sulfur tetrafluoride in the presence of water as a key additive. Compared to previous methods, the reaction gives products with full retention of stereo- and absolute configuration of chiral centers. After reading the article, we found that the author used 4-Bromobutanoic acid(cas: 2623-87-2Application of 2623-87-2)

4-Bromobutanoic acid(cas: 2623-87-2) belongs to carboxylic acids. The chief chemical characteristic of the carboxylic acids is their acidity. They are generally more acidic than other organic compounds containing hydroxyl groups but are generally weaker than the familiar mineral acids (e.g., hydrochloric acid, HCl, sulfuric acid, H2SO4, etc.).Application of 2623-87-2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

《Stepwise dual targeting and dual responsive polymer micelles for mitochondrion therapy》 was published in Journal of Controlled Release in 2020. These research results belong to Zhang, Xiaobin; Wang, Yi; Wei, Guoqing; Zhao, Jingya; Yang, Guang; Zhou, Shaobing. Product Details of 2623-87-2 The article mentions the following:

Methods to selectively destroy mitochondria of tumor cells and induce cell apoptosis with nanomedicine constitute challenges in cancer therapy. In the present study, we develop cell membrane/mitochondria dual targeting and pH/redox dual responsive nanoparticles for mitochondrion therapy. The nanoparticles are fabricated by the self-assembly of triphenylphosphonium (TPP) grafted poly(ethylene glycol)(PEG)-poly(d,L-lactide)(PLA) copolymers (TPP-PEG-ss-PLA) using disulfide bonds as the intermediate linkers. To shield the surface pos. charge of the nanoparticles from TPP composition, chondroitin sulfate (CS) is employed to coat the nanoparticles, and this prolongs blood circulation while endowing an active targeting ability to the cell membrane. In acidic lyso-somes/endosomes, the neg. charged CS layer falls away to expose the TPP component. Subsequently, in the cyto-plasm, the nanoparticles can anchor to the mitochondrial outer membrane by TPP-mediated targeting, thereby inducing a decrease in the membrane potential and opening of the permeability transition pore. Thus, the overproduction of ROS in the mitochondria promotes cell apoptosis. The released DOX directly diffuse into the mitochondria, thereby resulting in mito-chondrial DNA damage. Therefore, the nanoparticles exhibit significant potential in terms of a new avenue for mitochondrion therapy in cancer treatment. The results came from multiple reactions, including the reaction of 4-Bromobutanoic acid(cas: 2623-87-2Product Details of 2623-87-2)

4-Bromobutanoic acid(cas: 2623-87-2) belongs to carboxylic acids. The chief chemical characteristic of the carboxylic acids is their acidity. They are generally more acidic than other organic compounds containing hydroxyl groups but are generally weaker than the familiar mineral acids (e.g., hydrochloric acid, HCl, sulfuric acid, H2SO4, etc.).Product Details of 2623-87-2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Recommanded Product: 4-Bromobutanoic acidIn 2019 ,《Synthesis of solandelactone F, constanolactone A and an advanced intermediate towards solandelactone E from a common synthetic intermediate》 was published in Organic & Biomolecular Chemistry. The article was written by Yalla, Raju; Raghavan, Sadagopan. The article contains the following contents:

The stereoselective synthesis of solandelactone F, constanolactone A and an advanced intermediate towards solandelactone E, from a common synthetic intermediate, is disclosed. The propargylic sulfide stereo-center is created stereoselectively via carbon-carbon bond formation in the reaction of α-chloro sulfides with alkynyl zinc reagents via 1,2-asym. induction by a β-siloxy group. The characteristic 1,4-diol motif of the natural products is introduced by a [2,3] sigmatropic rearrangement of an allylic sulfoxide or by the Mislow-Evans-Braverman rearrangement of a propargylic sulfoxide followed by stereoselective reduction of the ensuing α,β-unsaturated ketone. Unlike earlier reports, the C11/C9 carbinol center is created with excellent stereocontrol and derivatives of natural products differing at C14/C12 can be readily obtained. In the experiment, the researchers used 4-Bromobutanoic acid(cas: 2623-87-2Recommanded Product: 4-Bromobutanoic acid)

4-Bromobutanoic acid(cas: 2623-87-2) belongs to carboxylic acids. The chief chemical characteristic of the carboxylic acids is their acidity. They are generally more acidic than other organic compounds containing hydroxyl groups but are generally weaker than the familiar mineral acids (e.g., hydrochloric acid, HCl, sulfuric acid, H2SO4, etc.).Recommanded Product: 4-Bromobutanoic acid

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Jia, Xuhong; Huang, Rui; Yang, Xiaoguang; Tao, Wan; Zhu, Xinhua published an article in 2021. The article was titled 《Synthesis and Characterization of a Novel Class of Zwitterionic Fluorocarbon Surfactants Based on Perfluorobutyl》, and you may find the article in Tenside, Surfactants, Detergents.Formula: C4H7BrO2 The information in the text is summarized as follows:

Perfluorooctane sulfonate (PFOS) and its derivatives had been banned due to their potential environmental hazards, although they possessed excellent surface activity. An effective method to solve this problem was to shorten the fluorocarbon chain of these surfactants from C8H17 to C4F9. As previous studies had shown, zwitterionic surfactants possess higher surface activity but have lower toxicity compared to other types of surfactants. In view of this, a class of novel zwitterionic fluorocarbon surfactants (n-CFNA-Br) with perfluorobutyl moiety was synthesized in this work. Their structures were characterized by FTIR, 1H NMR, 13C NMR, 19F NMR and MS. The results showed that all synthesized n-CFNA-Br had almost the same min. surface tension, but their critical micelle concentration (CMC) decreased with increasing length of hydrophobic carbon chain. In pure water, the surface tension at the CMC (γCMC) of the four n-CFNA-Br were about 20 mN/m, and the CMC values were 7.73 mmol/L for 1-CFNA-Br, 4.70 mmol/L for 2-CFNA-Br, 4.13 mmol/L for 3-CFNA-Br, and 3.36 mmol/L for 4-CFNA-Br, indicating high efficiency and effectiveness. In 0.1 mol/L NaCl, the CMC values reduced to less than half of the CMC values measured in the pure aqueous surfactant solution, while the surface tensions γCMC remained almost unchanged, indicating good salinity tolerance of the synthesized surfactants. The acidic surfactant solutions exhibited similar CMC values to the saline solutions, but the surface tension γCMC increased slightly to 25 mN/m. However, further investigation showed that the n-CFNA-Br surfactants exhibited poor surface activity in alk. solution (0.1 mol/L NaOH). In the pH range of 6.6 to 10.4, white precipitates appeared in the surfactant solutions after some time, indicating that the n-CFNA-Br are not suitable for use in alk. systems with pH greater than 6.6. In the experiment, the researchers used many compounds, for example, 4-Bromobutanoic acid(cas: 2623-87-2Formula: C4H7BrO2)

4-Bromobutanoic acid(cas: 2623-87-2) belongs to carboxylic acids. The chief chemical characteristic of the carboxylic acids is their acidity. They are generally more acidic than other organic compounds containing hydroxyl groups but are generally weaker than the familiar mineral acids (e.g., hydrochloric acid, HCl, sulfuric acid, H2SO4, etc.).Formula: C4H7BrO2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary