Category: 2623-87-2

Wang, Kai; Ye, Ya-Xi; Jiang, Cheng-Yan; Guo, Meng-Ya; Zhang, Xiang-Yang; Jiang, Ai-Qin; Yang, Yu-Shun; Jiao, Qing-Cai; Zhu, Hai-Liang published an article in 2021. The article was titled 《Design and synthesis of a novel “”turn-on”” fluorescent probe based on benzofuran-3(2H)-one for detection of hydrazine in water samples and biological systems》, and you may find the article in Dyes and Pigments.Reference of 4-Bromobutanoic acid The information in the text is summarized as follows:

Hydrazine is a very important industrial chem. with high toxicity to the human body. In this work, a fluorescent probe HZ (I), based on the substitution-cyclization-elimination cascade which initiated by hydrazine, was designed and synthesized. HZ had various characteristics such as high selectivity, high sensitivity, fast detection speed, wide application range, and so on. After treating with hydrazine, the fluorescence signal of HZ at 520 nm in aqueous solution was significantly enhanced. Furthermore, HZ had the linear range of 1-10 equiv for monitoring hydrazine, and the solution showed a colorless to yellow color change. In practical application, the detection limit of HZ for the detection of hydrazine was only 0.75μM, which could be utilized for trace detection of hydrazine in different water samples. These indicated that HZ had a broad application prospect in the fields of environmental protection and water treatment. This work not only provided a useful instrument for the detection of the ecol. environment but also supplied important information for the system optimization of other ecol. environment detectors. In addition, HZ could monitor endogenous and exogenous hydrazine in MCF-7 cells successfully, which demonstrated its potential for practical application in complex biol. systems. In addition to this study using 4-Bromobutanoic acid, there are many other studies that have used 4-Bromobutanoic acid(cas: 2623-87-2Reference of 4-Bromobutanoic acid) was used in this study.

4-Bromobutanoic acid(cas: 2623-87-2) belongs to carboxylic acids. The chief chemical characteristic of the carboxylic acids is their acidity. They are generally more acidic than other organic compounds containing hydroxyl groups but are generally weaker than the familiar mineral acids (e.g., hydrochloric acid, HCl, sulfuric acid, H2SO4, etc.).Reference of 4-Bromobutanoic acid

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

《Synthesis and cytotoxic activity of new vindoline derivatives coupled to natural and synthetic pharmacophores》 was written by Keglevich, Andras; Danyi, Leonetta; Rieder, Alexandra; Horvath, Dorottya; Szigetvari, Aron; Dekany, Miklos; Szantay, Csaba Jr.; Latif, Ahmed Dhahir; Hunyadi, Attila; Zupko, Istvan; Keglevich, Peter; Hazai, Laszlo. Product Details of 2623-87-2This research focused onvindoline derivative anticancer antiproliferative agent cytotoxicity breast cervical cancer; IC50 values; Vinca alkaloids; anticancer drugs; organic synthesis; pharmacophores; vindoline. The article conveys some information:

New Vinca alkaloid derivatives were synthesized to improve the biol. activity of the natural alkaloid vindoline. To this end, experiments were performed to link vindoline with various structural units, such as amino acids, a 1,2,3-triazole derivative, morpholine, piperazine and N-methylpiperazine. The structure of the new compounds was characterized by NMR spectroscopy and mass spectrometry (MS). Several compounds exhibited in vitro antiproliferative activity against human gynecol. cancer cell lines with IC50 values in the low micromolar concentration range. In addition to this study using 4-Bromobutanoic acid, there are many other studies that have used 4-Bromobutanoic acid(cas: 2623-87-2Product Details of 2623-87-2) was used in this study.

4-Bromobutanoic acid(cas: 2623-87-2) belongs to carboxylic acids. The chief chemical characteristic of the carboxylic acids is their acidity. They are generally more acidic than other organic compounds containing hydroxyl groups but are generally weaker than the familiar mineral acids (e.g., hydrochloric acid, HCl, sulfuric acid, H2SO4, etc.).Product Details of 2623-87-2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

In 2022,Yu, Wan-Lei; Ren, Zi-Gang; Ma, Wei; Zheng, Haixue; Wu, Wangsuo; Xu, Peng-Fei published an article in Green Chemistry. The title of the article was 《Intramolecular dehydrogenative amination of alkenes via dual organic photoredox and cobalt catalysis without a hydrogen acceptor》.Application In Synthesis of 4-Bromobutanoic acid The author mentioned the following in the article:

A conceptually novel oxidant-free dehydrogenative amination of alkenes I (Ar = Ph, 4-Me-ph, naphthalen-1-yl, etc.; R1 = H, Me, Ph, Et, etc.; R2 = H, Me, Et; R1R2 = cyclohexyl, 1-[(tert-butoxy)(oxo)methane]piperidin-4-yl, cyclopentyl, etc.; X = CH2, O, N, S) through a synergistic photoredox and cobalt catalysis with H2 evolution has been achieved. With this approach, a wide range of five-membered N-heterocycles II and III (R3 = Ph, 2,4,6-trimethylphenyl, 2-phenylethyl, etc.) was synthesized with excellent atom-economy. The green system will address the challenges that are sensitive to traditionally oxidative conditions. Furthermore, the scope and mechanistic details of the method are discussed. The experimental part of the paper was very detailed, including the reaction process of 4-Bromobutanoic acid(cas: 2623-87-2Application In Synthesis of 4-Bromobutanoic acid)

4-Bromobutanoic acid(cas: 2623-87-2) belongs to carboxylic acids. The chief chemical characteristic of the carboxylic acids is their acidity. They are generally more acidic than other organic compounds containing hydroxyl groups but are generally weaker than the familiar mineral acids (e.g., hydrochloric acid, HCl, sulfuric acid, H2SO4, etc.).Application In Synthesis of 4-Bromobutanoic acid

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

《Synthesis of Alkyl Triphenylphosphonium Ostruthin Derivatives as Potential Cytotoxic Candidates》 was published in ChemistrySelect in 2020. These research results belong to Dang, Phu H.; Dao, Thien H. X.; Le, Vien T.; Nguyen, Chien M.; Ly, Tin T.; Nguyen, Hai X.; Le, Tho H.; Do, Truong N. V.; Nguyen, Mai T. T.; Sun, Sijia; Awale, Suresh; Nguyen, Nhan T.. Application In Synthesis of 4-Bromobutanoic acid The article mentions the following:

Ostruthin, isolated from Paramignya trimera, was used as a scaffold to design its alkyl triphenylphosphonium derivatives With the optimal reaction conditions in hand, five alkyl triphenylphosphonium ostruthin derivatives I [n = 3, 4, 5, etc.] were synthesized. Ostruthin and its derivatives I were tested for cytotoxicity against human PANC-1 pancreatic, HeLa cervical, and HepG2 liver cancer cell lines. Ostruthin and its hexyl and heptyl triphenylphosphonium derivatives I [n = 6, 7] showed strong preferential cytotoxicity against PANC-1 cells with the PC50 values of 10.3 and 14.4μM, resp. In addition, compounds I [n = 6, 7] also exhibited potent cytotoxicity towards HeLa cells with the IC50 values of 24.8 and 18.5μM, resp. The hexyl triphenylphosphonium group in I [n = 6] was found to slightly enhance cytotoxicity against HepG2 cells. Further, the morphol. changes and the live-cell imaging result suggested the anticancer potential against HeLa cells of the synthesized ostruthin derivative I [n = 7]. In addition to this study using 4-Bromobutanoic acid, there are many other studies that have used 4-Bromobutanoic acid(cas: 2623-87-2Application In Synthesis of 4-Bromobutanoic acid) was used in this study.

4-Bromobutanoic acid(cas: 2623-87-2) belongs to carboxylic acids. The chief chemical characteristic of the carboxylic acids is their acidity. They are generally more acidic than other organic compounds containing hydroxyl groups but are generally weaker than the familiar mineral acids (e.g., hydrochloric acid, HCl, sulfuric acid, H2SO4, etc.).Application In Synthesis of 4-Bromobutanoic acid

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

In 2019,Nanotechnology included an article by Wu, Hongshuai; You, Chaoqun; Jiao, Jia; Chen, Fanghui; Sun, Baiwang; Zhu, Xiaoli. SDS of cas: 2623-87-2. The article was titled 《A novel near-infrared triggered dual-targeted nanoplatform for mitochondrial combined photothermal-chemotherapy of cancer in vitro》. The information in the text is summarized as follows:

A combination of photothermal-chemotherapy has received widespread attention in drug delivery systems for cancer treatment. However, the combination therapy operated in subcellular organelles, such as mitochondria, has been rarely reported. Herein, we designed a novel near-IR (NIR) triggered dual-targeted nanoplatform (FA/TPP-DINPs) based on mitochondrial combined photothermal-chemotherapy by co-loading FDA-approved NIR dye indocyanine green (ICG) and anticancer drug doxorubicin (DOX). The resulting nanoparticles showed a monodispersed sphere and excellent colloidal stability. Specially, the simultaneous introduction of targeted ligands folic acid (FA) and triphenylphosphine (TPP) to nanoparticles significantly promoted the cellular internalization and mitochondrial co-localization of nanoparticles. Moreover, the encapsulated dye could convert NIR light into heat with high efficiency, which makes the FA/TPP-DINPs an effective platform for mitochondrial combination therapy with chemotherapy drug DOX. Meanwhile, the thermal expansion in response to the change of temperature after sustained 808 nm laser irradiation could cause the disintegration of nanoparticles, which triggered the rapid release of DOX from nanoparticles. As expected, the prepared FA/TPP-DINPs exhibited evidently enhanced cytotoxicity and preeminent combination therapy efficiency on MCF-7 cells. Thus, the NIR triggered dual-targeted nanoplatform provides a new drug delivery strategy for mitochondrial combined photothermal-chemotherapy of cancer. The experimental process involved the reaction of 4-Bromobutanoic acid(cas: 2623-87-2SDS of cas: 2623-87-2)

4-Bromobutanoic acid(cas: 2623-87-2) belongs to carboxylic acids. The chief chemical characteristic of the carboxylic acids is their acidity. They are generally more acidic than other organic compounds containing hydroxyl groups but are generally weaker than the familiar mineral acids (e.g., hydrochloric acid, HCl, sulfuric acid, H2SO4, etc.).SDS of cas: 2623-87-2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Safety of 4-Bromobutanoic acidIn 2019 ,《Commercial Polymer Microsphere Grafted TBD-Based Ionic Liquids as Efficient and Low-Cost Catalyst for the Cycloaddition of CO2 with Epoxides》 appeared in Catalysis Letters. The author of the article were Dai, Weili; Mao, Jie; Liu, Ying; Mao, Pei; Luo, Xubiao; Zou, Jianping. The article conveys some information:

Development of efficient, cheap and recyclable catalysts for the synthesis of cyclic carbonates from CO2 and epoxides is still a very attractive topic. Herein, the polymer grafted TBD-(1,5,7-triazabicyclo[4.4.0]dec-5-ene)-based ionic liquids (ILs) were fabricated from com. available polystyrene (PS) and ingredients of the ILs, and used as heterogeneous catalysts for the conversion of CO2 into cyclic carbonates in the absence of solvent and co-catalyst. To improve the catalytic performance, various substitutes (such as -COOH, -OH and -NH2) were functionalized on the TBD cation. Among the as-obtained catalysts, carboxyl-containing catalyst (PS-[CETBD]Br) showed superior activity than others, which may be attributed to the stronger polarization capability of -COOH on the C-O bond of epoxide through the formed hydrogen bonding. Addnl., the combined synergistic effect of the nucleophilic attack by the halide anions also account for the facile ring-opening of epoxide. It is noted that CO2 can be activated by the formation of carbamate between CO2 and alk. nitrogen of the TBD cations, thus facilitating the formation of cyclic carbonates. Moreover, the catalyst shows good chem. stability and catalytic reusability, which is very important for the practical conversion of CO2 in chem. industry. The experimental part of the paper was very detailed, including the reaction process of 4-Bromobutanoic acid(cas: 2623-87-2Safety of 4-Bromobutanoic acid)

4-Bromobutanoic acid(cas: 2623-87-2) belongs to carboxylic acids. The chief chemical characteristic of the carboxylic acids is their acidity. They are generally more acidic than other organic compounds containing hydroxyl groups but are generally weaker than the familiar mineral acids (e.g., hydrochloric acid, HCl, sulfuric acid, H2SO4, etc.).Safety of 4-Bromobutanoic acid

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

The author of 《Dependence of the Properties of 2D Nanocomposites Generated by Covalent Crosslinking of Nanosheets on the Interlayer Separation: A Combined Experimental and Theoretical Study》 were Singh, Reetendra; Gupta, Uttam; Kumar, V. Sampath; Ayyub, Mohd Monis; Waghmare, Umesh V.; Rao, C. N. R.. And the article was published in ChemPhysChem in 2019. Category: bromides-buliding-blocks The author mentioned the following in the article:

Covalently cross-linked heterostructures of 2D materials are a new class of materials which possess electrochem. and photochem. hydrogen evolution properties. It was of considerable interest to investigate the role of interlayer spacing in the nanocomposites involving MoS2 and graphene sheets and its control over electronic structures and catalytic properties. We have investigated this problem with emphasis on the hydrogen evolution properties of these structures by a combined exptl. and theor. study. We have linked MoS2 based nanocomposites with other 2D materials with varying interlayer spacing by changing the linker and studied their hydrogen evolution properties. The hydrogen evolution activity for these composites decreases with increasing linker length, which we can link to a decrease in magnitude of charge transfer across the layers with increasing interlayer spacing. Factors such as the nature of the sheets, interlayer distance as well as the nature of the linker provide pathways to tune the properties of covalently cross-linked 2D material rendering this new class of materials highly interesting. In the experiment, the researchers used 4-Bromobutanoic acid(cas: 2623-87-2Category: bromides-buliding-blocks)

4-Bromobutanoic acid(cas: 2623-87-2) belongs to carboxylic acids. The chief chemical characteristic of the carboxylic acids is their acidity. They are generally more acidic than other organic compounds containing hydroxyl groups but are generally weaker than the familiar mineral acids (e.g., hydrochloric acid, HCl, sulfuric acid, H2SO4, etc.).Category: bromides-buliding-blocks

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Hanieh, Patrizia N.; Forte, Jacopo; Meo, Chiara Di; Ammendolia, Maria Grazia; Del Favero, Elena; Cantu, Laura; Rinaldi, Federica; Marianecci, Carlotta; Carafa, Maria published an article in 2021. The article was titled 《Hyaluronic acid derivative effect on niosomal coating and interaction with cellular mimetic membranes》, and you may find the article in Molecules.Electric Literature of C4H7BrO2 The information in the text is summarized as follows:

Hyaluronic acid (HA) is one of the most used biopolymers in the development of drug delivery systems, due to its biocompatibility, biodegradability, non-immunogenicity and intrinsic-targeting properties. HA specifically binds to CD44; this property combined to the EPR effect could provide an option for reinforced active tumor targeting by nanocarriers, improving drug uptake by the cancer cells via the HA-CD44 receptor-mediated endocytosis pathway. Moreover, HA can be easily chem. modified to tailor its physico-chem. properties in view of specific applications. The derivatization with cholesterol confers to HA an amphiphilic character, and then the ability of anchoring to niosomes. HA-Chol was then used to coat Span or Tween niosomes providing them with an intrinsic targeting shell. The nanocarrier physico-chem. properties were analyzed in terms of hydrodynamic diameter, ζ-potential, and bilayer structural features to evaluate the difference between naked and HA-coated niosomes. Niosomes stability was evaluated over time and in bovine serum. Moreover, interaction properties of HA-coated nanovesicles with model membranes, namely liposomes, were studied, to obtain insights on their interaction behavior with biol. membranes in future experiments The obtained coated systems showed good chem. phys. features and represent a good opportunity to carry out active targeting strategies. In addition to this study using 4-Bromobutanoic acid, there are many other studies that have used 4-Bromobutanoic acid(cas: 2623-87-2Electric Literature of C4H7BrO2) was used in this study.

4-Bromobutanoic acid(cas: 2623-87-2) belongs to carboxylic acids. The chief chemical characteristic of the carboxylic acids is their acidity. They are generally more acidic than other organic compounds containing hydroxyl groups but are generally weaker than the familiar mineral acids (e.g., hydrochloric acid, HCl, sulfuric acid, H2SO4, etc.).Electric Literature of C4H7BrO2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

In 2022,Inomata, Tomohiko; Matsunaga, Ayaka; Jin, Guangzhu; Kitagawa, Takuma; Muramatsu, Mizuho; Ozawa, Tomohiro; Masuda, Hideki published an article in RSC Advances. The title of the article was 《Improvements in photoelectric performance of dye-sensitised solar cells using ionic liquid-modified TiO2 electrodes》.Reference of 4-Bromobutanoic acid The author mentioned the following in the article:

One of the major problems in dye-sensitized solar cells (DSSCs) is the aggregation of dyes on TiO2 electrodes, which leads to undesirable electron transfer. Various anti-aggregation agents, such as deoxycholic acid, have been proposed and applied to prevent dye aggregation on the electrodes. In this study, we designed and synthesized a phosphonium-type ionic liquid that can be modified on the TiO2 electrode surface and used as a new anti-aggregation agent. Although the modification of the ionic liquid onto the electrode reduced the amount of dye adsorbed on the electrode, it showed a significant anti-aggregation effect, thereby improving the photovoltaic performance of DSSCs with N3 and J13 dyes. This finding suggests that ionic liquids are effective as anti-aggregation agents for DSSCs. The experimental part of the paper was very detailed, including the reaction process of 4-Bromobutanoic acid(cas: 2623-87-2Reference of 4-Bromobutanoic acid)

4-Bromobutanoic acid(cas: 2623-87-2) belongs to carboxylic acids. The chief chemical characteristic of the carboxylic acids is their acidity. They are generally more acidic than other organic compounds containing hydroxyl groups but are generally weaker than the familiar mineral acids (e.g., hydrochloric acid, HCl, sulfuric acid, H2SO4, etc.).Reference of 4-Bromobutanoic acid

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Kachkovskyi, Georgii; Cieslak, Marcin; Graczyk, Piotr; Zawadzki, Przemyslaw; Kalinowska-Tluscik, Justyna; Werlos, Mateusz published an article in 2022. The article was titled 《Photocatalytic Approach to α,α-Difluoroalkyl Alcohols》, and you may find the article in Synthesis.Quality Control of 4-Bromobutanoic acid The information in the text is summarized as follows:

A convenient approach to previously poorly accessible α,α-difluoroalkyl alcs. R1R2OHCCF2R3 [R1 = Ph, 3-MeC6H4, 4-MeOC6H4, etc.; R2 = H, Me; R3 = i-Pr, t-Bu, cyclohexyl, etc.] by visible light-mediated photocatalysis was developed. Broad scope of the transformation together with exptl. simplicity and scalability using flow techniques opened good prospects for further studies of properties (including biol.) of these novel products. The results came from multiple reactions, including the reaction of 4-Bromobutanoic acid(cas: 2623-87-2Quality Control of 4-Bromobutanoic acid)

4-Bromobutanoic acid(cas: 2623-87-2) belongs to carboxylic acids. The chief chemical characteristic of the carboxylic acids is their acidity. They are generally more acidic than other organic compounds containing hydroxyl groups but are generally weaker than the familiar mineral acids (e.g., hydrochloric acid, HCl, sulfuric acid, H2SO4, etc.).Quality Control of 4-Bromobutanoic acid

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary