Category: 261723-28-8

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 261723-28-8, name is (3-Bromo-2-fluorophenyl)methanamine belongs to bromides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. Safety of (3-Bromo-2-fluorophenyl)methanamine

Step 1: A-(3-Bromo-2-fluorobenz l)-2-mercaptoacetamide (3-Bromo-2-fluorophenyl)methanamine (1.50 g, 7.35 mmol) was added to mercaptoacetic acid (0.613 mL, 8.82 mmol) under nitrogen. The mixture was heated to reflux using a Dean-Stark apparatus for about 18 h. The volatiles were evaporated in vacuo and the residue was purified on silica gel using a gradient of 10-50% EtOAc/heptane to afford the title product (1.53 g, 75%). lH NMR (500 MHz, DMSO-d6) delta 8.56 (t, J —– 5.8 Hz, M I L 7.60 (ddd, J —— 8.2, 6.7, 1.7 Hz, IH), 7.34 (dddd, J —— 7.7, 6.9, 1.7, 0.8 Hz, 1H), 7.14 (td, J= 7.8, 0.9 Hz, IH), 4.42 – 4.29 (m, 2H), 3.16 (s, 21 h. 2.80 (s, 1H).

The synthetic route of 261723-28-8 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; ABBVIE INC.; ARGIRIADI, Maria; BREINLINGER, Eric; DIETRICH, Justin, D.; FRIEDMAN, Michael; IHLE, David; MORYTKO, Michael; MULLEN, Kelly; OSUMA, Augustine; LO SCHIAVO, Gloria, Y.; WILSON, Noel, S.; (303 pag.)WO2016/168633; (2016); A1;,
Bromide – Wikipedia,
bromide – Wiktionary

Adding a certain compound to certain chemical reactions, such as: 261723-28-8, name is (3-Bromo-2-fluorophenyl)methanamine, belongs to bromides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 261723-28-8, category: bromides-buliding-blocks

Example 58 1,1-Dimethylethyl[(3-bromo-2-fluorophenyl)methyl]carbamate To a suspension of [(3-bromo-2-fluorophenyl)methyl]amine (5.0 g, 20.3 mmol) and Na2CO3 (5.5 g, 51.9 mmol) in CH2Cl2 (100 mL), was added dropwise a solution of Boc2O (4.5 g, 20.6 mmol) in CH2Cl2 (10 ml). Then the reaction mixture was stirred overnight at room temperature. After filtration, the solid was washed with CH2Cl2 (50 mL*2), and then the filtrate was washed with water (70 mL*2), brine (70 mL*2) and dried over Na2SO4. After removing the solvent, 5.6 g of 1,1-dimethylethyl[(3-bromo-2-fluorophenyl)methyl]carbamate was obtained (yield: 94%).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, (3-Bromo-2-fluorophenyl)methanamine, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Glaxo Group Limited; US2009/203657; (2009); A1;,
Bromide – Wikipedia,
bromide – Wiktionary

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 261723-28-8, name is (3-Bromo-2-fluorophenyl)methanamine belongs to bromides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. Product Details of 261723-28-8

TEA (2.11 g, 20.88 mmol) and B0C2O (1.67 g, 7.66 mmol) were added to a solution of Compound BDl l-4 (1.42 g, 6.96 mmol) in DCM (30.00 mL). The mixture was stirred at 15C for 12 hours. LCMS showed the production of BD11-5. The reaction was concentrated to give a residue. The residue was purified by column chromatography (S1O2, petroleum ether: ethyl acetate mixture with a ratio of 30: 1 to 10: 1) to afford Compound BD11-5 (2.00 g, crude) as a white solid.

The synthetic route of 261723-28-8 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; THE BROAD INSTITUTE, INC.; VACCA, Joseph, P.; (103 pag.)WO2018/75871; (2018); A1;,
Bromide – Wikipedia,
bromide – Wiktionary

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 261723-28-8, name is (3-Bromo-2-fluorophenyl)methanamine, A new synthetic method of this compound is introduced below., COA of Formula: C7H7BrFN

Example 61 1,1-Dimethylethyl [(3-bromo-2-fluorophenyl)methyl]carbamate To a suspension of [(3-bromo-2-fluorophenyl)methyl]amine (5.0 g, 20.3 mmol) and Na2CO3 (5.5 g, 51.9 mmol) in CH2Cl2 (100 mL), the solution of Boc2O (4.5 g, 20.6 mmol) in CH2Cl2 (10 ml) was added dropwise. Then the reaction mixture was stirred overnight at room temperature. After filtration, the solid was washed with CH2Cl2 (50 mL*2), and then the filtrate was washed with water (70 mL*2), brine (70 mL*2) and dried over Na2SO4. After removing the solvent, 5.6 g of 1,1-dimethylethyl [(3-bromo-2-fluorophenyl)methyl]carbamate was obtained (yield: 94%).

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; Glaxo Group Limited; US2009/197871; (2009); A1;,
Bromide – Wikipedia,
bromide – Wiktionary