Category: 2606-51-1

Adding a certain compound to certain chemical reactions, such as: 2606-51-1, name is 5-(Bromomethyl)benzo[d][1,3]dioxole, belongs to bromides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 2606-51-1, Recommanded Product: 2606-51-1

Compound 1 (500 mg, 2.5 mmol) was dissolved in THF (tetrahydrofuran, 25 ml), followed by Na 2 SO 4 (7.09 g, 50 mmol) and piperral.(piperonal, 375 mg, 2.5 mmol) was added, and AcOH (0.2 ml) was added dropwise, followed by stirring at room temperature for 20 minutes. NaB (OAc) 3H(1.059 g, 5 mmol) was added, followed by stirring at room temperature for 16 hours, followed by addition of MeOH (5 ml) and stirring for 24 hours.I was. The reaction mixture was dissolved in DCM, 1N NaOH was added and extracted twice. The obtained organic layer was washed with brineAfter filtration, it was dried over anhydrous MgSO 4 and filtered. The filtrate was concentrated under reduced pressure, and then silica column chromatography.Prufied with (Mc: MeOH = 15: 1) to purify to afford a white solid compound 2-j (290 mg, 35%).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 5-(Bromomethyl)benzo[d][1,3]dioxole, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Industry Academy Cooperation Foundation of Hanbat National University; Park Jeong-ho; Lee Seung-hwan; Kim Beom-cheol; Kim Jae-gwan; (24 pag.)KR101548927; (2015); B1;,
Bromide – Wikipedia,
bromide – Wiktionary

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 2606-51-1, name is 5-(Bromomethyl)benzo[d][1,3]dioxole, This compound has unique chemical properties. The synthetic route is as follows., Quality Control of 5-(Bromomethyl)benzo[d][1,3]dioxole

General procedure: Isatin (1 mmol), corresponding benzyl bromide (1 mmol) andK2CO3 (3 mmol) were heated in acetonitrile for 1e2 h. Aftercompletion of the reaction, acetonitrile was removed on rotavoparand the product was extracted using ethyl acetate. The organic layer was dried over anhydrous Na2SO4 and concentrated. Theproduct obtained was used for next step without furtherpurification

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 2606-51-1.

Reference:
Article; Kamal, Ahmed; Mahesh, Rasala; Nayak, V. Lakshma; Babu, Korrapati Suresh; Kumar, G. Bharath; Shaik, Anver Basha; Kapure, Jeevak Sopanrao; Alarifi, Abdullah; European Journal of Medicinal Chemistry; vol. 108; (2016); p. 476 – 485;,
Bromide – Wikipedia,
bromide – Wiktionary

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 2606-51-1, name is 5-(Bromomethyl)benzo[d][1,3]dioxole, A new synthetic method of this compound is introduced below., Quality Control of 5-(Bromomethyl)benzo[d][1,3]dioxole

General procedure: Isatin (1 mmol), corresponding benzyl bromide (1 mmol) andK2CO3 (3 mmol) were heated in acetonitrile for 1e2 h. Aftercompletion of the reaction, acetonitrile was removed on rotavoparand the product was extracted using ethyl acetate. The organic layer was dried over anhydrous Na2SO4 and concentrated. Theproduct obtained was used for next step without furtherpurification

The synthetic route of 2606-51-1 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Kamal, Ahmed; Mahesh, Rasala; Nayak, V. Lakshma; Babu, Korrapati Suresh; Kumar, G. Bharath; Shaik, Anver Basha; Kapure, Jeevak Sopanrao; Alarifi, Abdullah; European Journal of Medicinal Chemistry; vol. 108; (2016); p. 476 – 485;,
Bromide – Wikipedia,
bromide – Wiktionary

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 2606-51-1, name is 5-(Bromomethyl)benzo[d][1,3]dioxole belongs to bromides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. 2606-51-1

General procedure: The mixture of N-hydroxyhept-6-ynamide (141 mg, 1 mmol), benzyl bromide (256 mg, 1.5 mmol), sodium azide (98 mg, 1.5 mmol), copper(II) sulfate pentahydrate (38 mg, 0.13 mmol), sodium ascorbate (60 mg, 0.3 mmol) in wate and tert-butanol (v/v = 1:1, 10ml) was heated to 66 oC, the heterogeneous mixture was stirred vigrously for 24 h. After addition of water (50 ml), the mixture was filtered. The filter cake was dissloved in MeOH (20 ml), the insolubles was filtered, the filtrate was concentrated in vacuo and crystallized in ethyl acetate to give 2 (156 mg, 57%) as a white solid.

The synthetic route of 2606-51-1 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Sun, Qiao; Yao, Yiwu; Liu, Chunping; Li, Hua; Yao, Hequan; Xue, Xiaowen; Liu, Jinsong; Tu, Zhengchao; Jiang, Sheng; Bioorganic and Medicinal Chemistry Letters; vol. 23; 11; (2013); p. 3295 – 3299;,
Bromide – Wikipedia,
bromide – Wiktionary

2606-51-1, Adding a certain compound to certain chemical reactions, such as: 2606-51-1, name is 5-(Bromomethyl)benzo[d][1,3]dioxole, belongs to bromides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 2606-51-1.

To a suspension of 6-methyl-3-(tetrahydro-2H-pyran-4-yl )imidazo[1 ,5-a]pyrazin-8(7H)-one(100 mg, 429 pmol) in dry DMF (2 mL) was added 052003 (279 mg, 858 pmol) and 5-(bromomethyl)benzo[d][1 ,3]dioxole (138 mg, 643 pmol). The mixture was bubbled with N2 for 2 mm and heated at 6000 for 16 hours. The mixture was concentrated. DCM (30 mL) was added to the residue. It was filtered and the filter cake was washed with DCM (20 mL). The filtrate was concentrated and purified by flash chromatography on silica gel (1O%-100%ethyl acetate in petroleum ether) to give 7-(benzo[d][1 ,3]dioxol-5-ylmethyl)-6-methyl-3- (tetrahydro-2H-pyran-4-yl)imidazo[1 ,5-a]pyrazin-8(7H)-one (81.74 mg, 52% yield).1H NMR (ODd3 400 MHz): 7.92 (s, 1 H), 6.76 – 6.69 (m, 4H), 5.95 – 5.93 (m, 2H), 5.13 (s,2H), 4.14 – 4.11 (m, 2H), 3.61 – 3.55 (m, 2H), 3.10 – 3.05 (m, 1 H), 2.21 (s, 3H), 2.20 – 2.10(m, 2H), 1.90 – 1.86 (m, 2H).LC-MS: tR = 2.245 mm (method 3), mlz = 368.2 [M + H].

According to the analysis of related databases, 2606-51-1, the application of this compound in the production field has become more and more popular.

Reference:
Patent; H. LUNDBECK A/S; KEHLER, Jan; RASMUSSEN, Lars, Kyhn; LANGGARD, Morten; JESSING, Mikkel; VITAL, Paulo, Jorge, Vieira; JUHL, Karsten; (159 pag.)WO2016/174188; (2016); A1;,
Bromide – Wikipedia,
bromide – Wiktionary

In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 2606-51-1 as follows. 2606-51-1

General procedure: Benzyl bromide (1 g) in dry toluene (15 mL). To this tripheylphosphine (1.5 g) was added and the reaction mixture was refluxed for 1-3 h at 120 C to get the wittig salt as precipitate. It was filtered and washed with dry benzene (yield 62-87%).

According to the analysis of related databases, 2606-51-1, the application of this compound in the production field has become more and more popular.

Reference:
Article; Parihar, Swati; Kumar, Amit; Chaturvedi, Amit K.; Sachan, Naresh Kumar; Luqman, Suaib; Changkija, Bendangla; Manohar, Murli; Prakash, Om; Chanda; Khan, Feroz; Chanotiya; Shanker, Karuna; Dwivedi, Anila; Konwar, Rituraj; Negi, Arvind S.; Journal of Steroid Biochemistry and Molecular Biology; vol. 137; (2013); p. 332 – 344;,
Bromide – Wikipedia,
bromide – Wiktionary

2606-51-1, Adding a certain compound to certain chemical reactions, such as: 2606-51-1, name is 5-(Bromomethyl)benzo[d][1,3]dioxole, belongs to bromides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 2606-51-1.

General procedure: The synthesis of 4-hydroxyquinoline (2) was performed in accordance to an already reported procedure [9]. The appropriate alkyl halide (1.2 mmol) was added to a mixture of 4-hydroxyquinoline (1 mmol) and potassium carbonate (K2CO3,3.12 mmol) in DMF (6 mL). The reaction mixturewas stirred at 25 C for 18 h. Afterwards, the reaction mixture was diluted in water(10 mL) with concomitant precipitation of the product. The solid was separated using a centrifuge (18,000 RPM, 4 C, 10 min),washed with water (3 15 mL), and dried under reduced pressure to afford the products in good purity, which was measured by HPLC experiments. In some cases where the purity of the products was not satisfactory, the solids were washed with ethyl ether or purified by flash chromatography using ethyl acetate and hexane in a ratioof 3:7; 1:1, and, finally, 7:3, respectively.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 5-(Bromomethyl)benzo[d][1,3]dioxole, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Abbadi, Bruno Lopes; Basso, Luiz Augusto; Bizarro, Cristiano Valim; Borsoi, Ana Flavia; Macchi, Fernanda Souza; Machado, Diana; Machado, Pablo; Paz, Josiane Delgado; Pissinate, Kenia; Rambo, Raoni S.; Ramos, Alessandro Silva; Sperotto, Nathalia; Viveiros, Miguel; European Journal of Medicinal Chemistry; vol. 192; (2020);,
Bromide – Wikipedia,
bromide – Wiktionary