Category: 2576-47-8

Electric Literature of 2576-47-8, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 2576-47-8 as follows.

General procedure: The different arylsulfonyl chloride 2a-s (4 mmol) and 3-bromopropylamine hydrobromide (3) (4.6mmol) or 2-bromoethylamine hydrobromide (4) (4.6 mmol) were suspended in anhydrous DCM (14 mL)under nitrogen atmosphere. The reaction mixture was cooled to 0C in an ice-bath and then treateddropwise with triethylamine (1.34 mL, 9.6 mmol) over a period of 10 min. The reaction mixture wasstirred for 10 min under ice-cooling, then diluted with DCM (50 mL) and washed with 2M hydrochloricacid solution (2 x 60 mL) and brine (2 x 60 mL). The organic solvent was evaporated at reduced pressureafter drying over MgSO4.

According to the analysis of related databases, 2576-47-8, the application of this compound in the production field has become more and more popular.

Reference:
Article; Bassetto, Marcella; Leyssen, Pieter; Neyts, Johan; Yerukhimovich, Mark M.; Frick, David N.; Courtney-Smith, Matthew; Brancale, Andrea; European Journal of Medicinal Chemistry; vol. 125; (2017); p. 1115 – 1131;,
Bromide – Wikipedia,
bromide – Wiktionary

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 2576-47-8, name is 2-Bromoethylamine hydrobromide belongs to bromides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. Quality Control of 2-Bromoethylamine hydrobromide

A solution of bromoethylamine hydrobromide (4.2 g, 20 mmol) in 10 mL water was treated successively with benzenesulfonyl chloride (2.61 mL, 20 mmol) and a solution of sodium carbonate (6.5 g, 30 mmol) in 20 mL water. The reaction mixture was stirred at ambient temperature for 16h. Diethyl ether and water were added, the two layers were separated and the organic layer was dried (MgSO4) and concentrated to dryness. Purification on a Redisep cartridge using a gradient 0-100 % of DCM/cyclohexane as eluent provided the title compound. Yield: 3.5 g (66%). LC-MS (Method 4): Rt 2.81 min, m/z no molecular ion observed

The synthetic route of 2576-47-8 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; ARGENTA DISCOVERY LTD; WO2008/96128; (2008); A1;,
Bromide – Wikipedia,
bromide – Wiktionary