Category: 2576-47-8

Vinyl bromides undergo the Heck reaction, which involves C-C coupling with alkene to give substituted alkenes. 2576-47-8, formula is C2H7Br2N, Name is 2-Bromoethylamine hydrobromide. Methyl bromide is a precursor in the manufacture of several chemicals and is employed as a soil sterilant, mainly for seed production. Quality Control of 2576-47-8.

Barravecchia, Liliana;Neira, Iago;Pazos, Elena;Peinador, Carlos;Garcia, Marcos D. research published 《 Amino acid-viologen hybrids: Synthesis, cucurbituril host-guest chemistry, and implementation on the production of peptides》, the research content is summarized as follows. We present herein the development of a series of viologen-amino acid hybrids, obtained in good yields either by successive alkylations of 4,4′-bipyridine, or by Zincke reactions followed by a second alkylation step. The potential of the obtained amino acids has been exemplified, either as typical guests of the cucurbituril family of hosts (particularly CB[7]/[8]) or as suitable building blocks for the solution/solid-phase synthesis of two model tripeptides with the viologen core inserted within their sequences.

Quality Control of 2576-47-8, 2-Bromoethylamine hydrobromide is a useful building block for proteomics research.
2-Bromoethylamine hydrobromide is used in the synthesis of analogs of 5,​10,​15,​20-​tetrakis(1-​methylpyridinium-​4-​yl)​porphyrin (TMPyP4) as inhibitors of human telomerase. It is also used to prepare SB-705498, a potent, selective and orally bioavailable TRPV1 antagonist. It is used to construct C2-symmetric imidazolidinylidene ligands with a dioxolane backbone.
2-Bromoethylamine Hydrobromide is used in the synthesis of analogs of 5,​10,​15,​20-​tetrakis(1-​methylpyridinium-​4-​yl)​porphyrin (TMPyP4) as inhibitors of human telomerase. It is also used to prepare SB-705498, a potent, selective and orally bioavailable TRPV1 antagonist.
2-Bromoethylamine hydrobromide is a nonsteroidal anti-inflammatory drug that is used to treat inflammation and pain. It is a prodrug that is hydrolyzed in vivo to its active form, 2-Bromoethylamine hydrobromide. The bound form of this drug has been shown to inhibit the development of cell nuclei in the nucleus of cells. This drug also inhibits the production of nitric oxide, which leads to cell death by necrosis. 2-Bromoethylamine hydrobromide has been shown to have an inhibitory effect on the activity of glycol ethers, which are used as solvents for resins in coatings and adhesives., 2576-47-8.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Organic compounds having carbon bonded to bromine are called organic bromides. 2576-47-8, formula is C2H7Br2N, Name is 2-Bromoethylamine hydrobromide. Depending on the type of carbon to which the bromine is bonded, organic bromide could be alkyl, alkenyl, alkynyl, or aryl. Reference of 2576-47-8.

Anizon, Fabrice;Giraud, Francis;Ivanova, Ekaterina S.;Kaluzhny, Dmitry N.;Shtil, Alexander A.;Cisnetti, Federico;Moreau, Pascale research published 《 Synthesis and biological activities of new pyrrolocarbazole-imidazobenzimidazole conjugates》, the research content is summarized as follows. New pyrrolocarbazole-imidazobenzimidazole conjugates I (R = H, CF₃) were prepared and evaluated for their inhibitory potencies toward Pim-1 kinase, DNA binding and antiproliferative activities against human tumor cell lines. The results demonstrated that conjugation of pyrrolocarbazole II Pim inhibitors with imidazobenzimidazole derivatives III could enhance the antiproliferative potency of conjugates I compared to the derived compds II and III.

Reference of 2576-47-8, 2-Bromoethylamine hydrobromide is a useful building block for proteomics research.
2-Bromoethylamine hydrobromide is used in the synthesis of analogs of 5,​10,​15,​20-​tetrakis(1-​methylpyridinium-​4-​yl)​porphyrin (TMPyP4) as inhibitors of human telomerase. It is also used to prepare SB-705498, a potent, selective and orally bioavailable TRPV1 antagonist. It is used to construct C2-symmetric imidazolidinylidene ligands with a dioxolane backbone.
2-Bromoethylamine Hydrobromide is used in the synthesis of analogs of 5,​10,​15,​20-​tetrakis(1-​methylpyridinium-​4-​yl)​porphyrin (TMPyP4) as inhibitors of human telomerase. It is also used to prepare SB-705498, a potent, selective and orally bioavailable TRPV1 antagonist.
2-Bromoethylamine hydrobromide is a nonsteroidal anti-inflammatory drug that is used to treat inflammation and pain. It is a prodrug that is hydrolyzed in vivo to its active form, 2-Bromoethylamine hydrobromide. The bound form of this drug has been shown to inhibit the development of cell nuclei in the nucleus of cells. This drug also inhibits the production of nitric oxide, which leads to cell death by necrosis. 2-Bromoethylamine hydrobromide has been shown to have an inhibitory effect on the activity of glycol ethers, which are used as solvents for resins in coatings and adhesives., 2576-47-8.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Vinyl bromides undergo the Heck reaction, which involves C-C coupling with alkene to give substituted alkenes. 2576-47-8, formula is C2H7Br2N, Name is 2-Bromoethylamine hydrobromide. Methyl bromide is a precursor in the manufacture of several chemicals and is employed as a soil sterilant, mainly for seed production. Application In Synthesis of 2576-47-8.

Aldahdooh, Mohammed K.;Ali, Shaikh A. research published 《 Synthesis and application of a poly(bis-zwitterion) containing chelating motifs of N-(2-aminoethyl)iminodiacetic acid》, the research content is summarized as follows. A bis-cationic (+ +) diallyl monomer [(H₂C=CHCH₂)₂NH⁺(CH₂)₂NH⁺(CH₂CO₂H)₂·2Cl^–] (I) was prepared by a one-pot, two-step reaction of 2-bromoethylamine hydrobromide, Et bromoacetate and diallylamine to generate [(H₂C=CHCH₂)₂N(CH₂)₂N(CH₂CO₂Et)₂] followed by ester hydrolysis. I underwent cyclopolymn. to afford a unique poly(bis-zwitterion) (PBZ) (± ±) II, containing repeating unit embedded with chelating motifs of N-(2-aminoethyl)iminodiacetic acid in bis-zwitterionic form NH⁺(CH₂)₂NH⁺(CH₂CO^–₂)₂. Electroneutral II was found to be water-insoluble, while salts like NaCl imparted water-solubility The polymer was soluble outside a pH window of 1.5-3.5 owing to the equilibration of pH-responsive II to charge-imbalanced polymer chain. The ‘apparent’ pKas of the two NH⁺ centers were determined to be 5.89 and 10.57. At 2.5 ppm concentration, antiscalant PBZ II imparted 100% inhibition of CaSO₄ scale formation for 30 min from its supersaturated solution, while at 20 ppm concentration aided by KI, it demonstrated an outstanding synergistic 99% inhibition of mild steel corrosion in 1 M HCl.

Application In Synthesis of 2576-47-8, 2-Bromoethylamine hydrobromide is a useful building block for proteomics research.
2-Bromoethylamine hydrobromide is used in the synthesis of analogs of 5,​10,​15,​20-​tetrakis(1-​methylpyridinium-​4-​yl)​porphyrin (TMPyP4) as inhibitors of human telomerase. It is also used to prepare SB-705498, a potent, selective and orally bioavailable TRPV1 antagonist. It is used to construct C2-symmetric imidazolidinylidene ligands with a dioxolane backbone.
2-Bromoethylamine Hydrobromide is used in the synthesis of analogs of 5,​10,​15,​20-​tetrakis(1-​methylpyridinium-​4-​yl)​porphyrin (TMPyP4) as inhibitors of human telomerase. It is also used to prepare SB-705498, a potent, selective and orally bioavailable TRPV1 antagonist.
2-Bromoethylamine hydrobromide is a nonsteroidal anti-inflammatory drug that is used to treat inflammation and pain. It is a prodrug that is hydrolyzed in vivo to its active form, 2-Bromoethylamine hydrobromide. The bound form of this drug has been shown to inhibit the development of cell nuclei in the nucleus of cells. This drug also inhibits the production of nitric oxide, which leads to cell death by necrosis. 2-Bromoethylamine hydrobromide has been shown to have an inhibitory effect on the activity of glycol ethers, which are used as solvents for resins in coatings and adhesives., 2576-47-8.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Organic bromides such as alkyl bromides are used as fumigants in agriculture to control insects. 2576-47-8, formula is C2H7Br2N, Name is 2-Bromoethylamine hydrobromide. Ethylene bromide is one of the commercially important organic bromides which are the component of leaded gasoline. Application In Synthesis of 2576-47-8.

Aldahdooh, Mohammed K.;Ali, Shaikh A. research published 《 Synthesis and application of alternate cyclopolymers of β-diallylaminoethyliminodiacetic acid with maleic acid and sulfur dioxide》, the research content is summarized as follows. Bis-cationic monomer β-diallylaminoethyliminodiacetic acid dihydrochloride (I) underwent alternate cyclocopolymns. with SO₂ and maleic acid to give poly(bis-zwitterion) (PBZ) (± ±) II, and III, resp. The PBZs contained the chelating motifs of [NH⁺(CH₂)₂NH⁺(CH₂CO^–₂)₂] embedded in the pyrrolidine ring of each repeating unit. Both the PBZs were water-insoluble, however they became water-soluble with assistance from salts like NaCl. PBZs II and III, having the point of zero charge at pH 2.4, became water soluble outside the pH-windows of 0.81-4.46 and 1.49-3.35, resp., whereby the electroneutral pH-responsive polymers become charge-imbalanced. The ‘apparent’ pK_as of the protonated amine centers in II were found to be 5.18 and 9.92. As an antiscalant, PBZ III (2.5 ppm) demonstrated inhibition of CaSO₄ scale formation with 99% efficacy for over 180 min, while at 1.5 ppm inhibition efficiency was found to be 98% for 50 min. PBZ II at concentrations of 20 and 10 ppm demonstrated CaCO₃ scale inhibition of 98% for over 240 min and 95% for over 90 min, resp. A synergistic mixture of III (20 ppm) and KI (400 ppm) arrested corrosion of mild steel in 1 M HCl with a remarkable efficacy of 98% for 24 h at 60°C.

Application In Synthesis of 2576-47-8, 2-Bromoethylamine hydrobromide is a useful building block for proteomics research.
2-Bromoethylamine hydrobromide is used in the synthesis of analogs of 5,​10,​15,​20-​tetrakis(1-​methylpyridinium-​4-​yl)​porphyrin (TMPyP4) as inhibitors of human telomerase. It is also used to prepare SB-705498, a potent, selective and orally bioavailable TRPV1 antagonist. It is used to construct C2-symmetric imidazolidinylidene ligands with a dioxolane backbone.
2-Bromoethylamine Hydrobromide is used in the synthesis of analogs of 5,​10,​15,​20-​tetrakis(1-​methylpyridinium-​4-​yl)​porphyrin (TMPyP4) as inhibitors of human telomerase. It is also used to prepare SB-705498, a potent, selective and orally bioavailable TRPV1 antagonist.
2-Bromoethylamine hydrobromide is a nonsteroidal anti-inflammatory drug that is used to treat inflammation and pain. It is a prodrug that is hydrolyzed in vivo to its active form, 2-Bromoethylamine hydrobromide. The bound form of this drug has been shown to inhibit the development of cell nuclei in the nucleus of cells. This drug also inhibits the production of nitric oxide, which leads to cell death by necrosis. 2-Bromoethylamine hydrobromide has been shown to have an inhibitory effect on the activity of glycol ethers, which are used as solvents for resins in coatings and adhesives., 2576-47-8.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Application of 2576-47-8, A common heterocyclic compound, 2576-47-8, name is 2-Bromoethylamine hydrobromide, molecular formula is C2H7Br2N, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

A solution of 2-bromoethylamine hydrobromide (1.1 g, 5.4 mmol) and aniline (3.0 g, 32 mmol) in toluene (8 ml) was stirred for 1 day at 120 C under an argon atmosphere and the precipitated product was collected by filtration. The salt was then treated with a 20% aqueous NaOH solution and extracted with dichloromethane. The organic phase was dried over anhydrous Na2SO4. After the Na2SO4 was filtered out and the solvent was distilled the crude product was further purified by column chromatography on silica gel (eluant: methanol) to afford N-phenylethylenediamine as a red-brown liquid. Yield: 87% (0.64 g); 1H NMR (400 MHz, CDCl3) delta 1.51 (br s, 3H), 2.93 (t, 2H), 3.17 (t, 2H), 6.63 (d, 2H), 6.70 (t, 1H), 7.17 (t, 2H). 2-(Chloromethyl)pyridine hydrochloride (1.8 g, 11 mmol) was treated with a 20% aqueous NaOH solution and extracted with dichloromethane and the organic phase was dried over anhydrous Na2SO4. After Na2SO4 was filtered out and the solvent was evaporated off, a solution of 2-(chloromethyl)pyridine in benzene (3 ml) was added to a solution of N-phenylethylenediamine (0.69 g, 5.1 mmol), which was prepared as described above, and triethylamine (5.1 g, 51 mmol) in benzene (4 ml) and stirred for 17 h at 80 C under an argon atmosphere. After being cooled to room temperature and the addition of diethyl ether, the inorganic by-products were removed by washing with a saturated NaHCO3 solution and with brine. The organic phase was dried over anhydrous Na2SO4. After the Na2SO4 was filtered out and the solvent was removed the crude product was purified by column chromatography on silica gel (eluant: ethyl acetate) to afford 2a as a red-brown viscous liquid. Yield: 69% (1.1 g);

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Article; Maruyama, Takayuki; Fujie, Yasuyuki; Oya, Noriyuki; Hosaka, Eisuke; Kanazawa, Aki; Tanaka, Daisuke; Hattori, Yoshiyuki; Motoyoshiya, Jiro; Tetrahedron; vol. 67; 36; (2011); p. 6927 – 6933;,
Bromide – Wikipedia,
bromide – Wiktionary

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 2576-47-8, name is 2-Bromoethylamine hydrobromide, This compound has unique chemical properties. The synthetic route is as follows., SDS of cas: 2576-47-8

Reference Example 66Benzyl 2-bromoethylcarbamate To a solution prepared by adding 1,4-dioxane (50 mL) to benzyl chloroformate (17.5729 g; manufactured by Wako Pure Chemical Industries, Ltd.), an aqueous solution of 2-bromoethanamine hydrobromide-1,4-dioxane [104 mL; solution prepared by dissolving 2-bromoethanamine hydrobromide (21.3617 g; manufactured by Tokyo Chemical Industry Co., Ltd.) in water (54 mL) and 1,4-dioxane (54 mL)]and a 2 mol/L aqueous solution of sodium hydroxide (104 mL; manufactured by Kanto Chemical Co., Inc.) were simultaneously added dropwise. The mixture was stirred for 2 hours at 0 C. Water was added to the reaction solution, and the mixture was extracted two times with ethyl acetate. The organic layer was washed with a saturated solution of sodium hydrogen carbonate, and was dried over magnesium sulfate. The organic layer was concentrated under reduced pressure. The resulting residue was purified by column chromatography (?COLUMN-A?; n-hexane:ethyl acetate=94:6?73:27), and thus the title compound (19.2014 g) was obtained.1H-NMR (300 MHz, CDCl3); delta(ppm) 3.47(2H, t, J=5.8), 3.60(2H, t, J=5.8), 5.11(2H, s), 7.27-7.40(5H, m)LCMS: 258 [M+H]; Retention time: 1.42 minutes; LCMS condition; C

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 2576-47-8.

Reference:
Patent; ASAHI KASEI PHARMA CORPORATION; US2010/160256; (2010); A1;,
Bromide – Wikipedia,
bromide – Wiktionary

Application of 2576-47-8, A common heterocyclic compound, 2576-47-8, name is 2-Bromoethylamine hydrobromide, molecular formula is C2H7Br2N, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General Synthesis Instructions for N-Z-2-bromoethylamine/N-Z-3-bromopropylamine: Add a solution of 1.5 equivalents of benzylchloroformiate in 50 ml Rotisol in drops to a solution of one equivalent of 2-bromoethylamine-hydrobromide or 3-bromopropylamine-hydrobromide and three equivalents of triethylamine in 150 ml Rotisol under refrigeration. Stir for 20 hours at room temperature, then concentrate the formulation to a small volume, take it up in 200 ml ethyl acetate, and extract twice against 200 ml 2 N hydrochloric acid each time. Remove the solvent and purify the residue via column chromatography on 100 g silica gel. Elute the apolar impurities with cyclohexane/diisopropyl ether (10:1), and elute the product with diisopropyl ether; N-Z-2-bromoethylamine (72): Quantities Used: 34.8 g (170 mmol) 2-bromoethylamine-hydrobromide, 72.0 ml (255 mmol) 50% solution of benzylchloroformiate in toluene, 70.6 ml (510 mmol) triethylamine

The synthetic route of 2576-47-8 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Massing, Ulrich; Fichert, Thomas; US2003/229037; (2003); A1;,
Bromide – Wikipedia,
bromide – Wiktionary

Application of 2576-47-8, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 2576-47-8, name is 2-Bromoethylamine hydrobromide belongs to bromides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

General procedure: A mixture of aniline (or PhNHEt) (0.05 mol)), 2-bromoethyl- (or 3-bromopropyl)amine hydrobromide and water (6 mL) was heated to 95 C (ina bath), Then, NaHCO3 was added in small portions with stirring. After ~15 min (at 95 C), the reaction mixture was refluxed with stirring using a heating mantle until reaction reached completion. The amount of hydrobromide and NaHCO3 and the timeof heating are given in Table 1. Still warm reaction mixture was diluted with 50% aqueous KOH (11 mL) and water (16 mL). The organic layer was separated, the aqueous layer was saturated with NaCl and extracted with chloroform (4×20 mL), each timeadding NaCl into the aqueous phase. The combined organic layers were dried with MgSO4 and fractionally distilled in vacuo.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2-Bromoethylamine hydrobromide, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Vasilyeva; Vorobyeva; Osipov; Russian Chemical Bulletin; vol. 65; 9; (2016); p. 2211 – 2215; Izv. Akad. Nauk, Ser. Khim.; 9; (2016); p. 2211 – 2215,5;,
Bromide – Wikipedia,
bromide – Wiktionary

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 2576-47-8, name is 2-Bromoethylamine hydrobromide, A new synthetic method of this compound is introduced below., COA of Formula: C2H7Br2N

A cooled (0 C.) mixture of 2-bromoethylamine hydrobromide (12.000 g ; 58.56 mmol ; 1.0 eq.) in dioxane (60 ml) was treated with aq. 1M NaOH (117.2 ml ; 117.20 mmol ; 2.0 eq.), and dropwise (over 10 min.) with benzyl chloroformate (8.4 ml ; 58.8 mmol ; 1.0 eq.). The resulting mixture was further stirred at 0 C., under nitrogen, for 10 min., and then at rt for 13 h. Et2O (300 ml) was added, and the colorless organic layer was further washed with water (75 ml), dried over anh. MgSO4, filtered, and finally concentrated to dryness under reduced pressure to afford (2-bromo-ethyl)-carbamic acid benzyl ester as a colorless oil which was further dried under HV (15.020 g ; 99%). LC-MS: tR=0.95 min. ; [M+H]+: no ionisation.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; Aissaoui, Hamed; Boss, Christoph; Koberstein, Ralf; Siegrist, Romain; Sifferlen, Thierry; US2011/105514; (2011); A1;,
Bromide – Wikipedia,
bromide – Wiktionary

Reference of 2576-47-8,Some common heterocyclic compound, 2576-47-8, name is 2-Bromoethylamine hydrobromide, molecular formula is C2H7Br2N, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

2-Bromoethylamine hydrobromide (500 mg, 2.44 mmol) and sodium azide (475.9 mg, 7.32 mmol) were dissolved in water (2 mL). The solution was heated to 75 C, stirred for 21 h, cooled to 0 C, Potassium (800 mg) and diethyl ether (2 mL). Purified by chloroform-methanol (20:1) column chromatography2-azidoethylamine (171 mg, 82%).

The synthetic route of 2576-47-8 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; China Institute Of Forestry Forest Products Chemical Industry Institute; Nanjing Zhongsen Biological Technology Co., Ltd.; Wang Chengzhang; Qi Zhiwen; (7 pag.)CN109180594; (2019); A;,
Bromide – Wikipedia,
bromide – Wiktionary