Category: 2567-29-5

Kwon, Ye-Mi; Kim, Sou Hyun; Jung, Young-Suk; Kwak, Jae-Hwan published an article in 2021, the title of the article was Synthesis and Biological Evaluation of (S)-2-(Substituted arylmethyl)-1-oxo-1,2,3,4-tetrahydropyrazino[1,2-a]indole-3-carboxamide Analogs and Their Synergistic Effect against PTEN-Deficient MDA-MB-468 Cells.Reference of 4-(Bromomethyl)-1,1′-biphenyl And the article contains the following content:

A series of twenty-six compounds of furfuryl or benzyl tetrahydropyrazino[1,2-a]indole analogs were synthesized and evaluated for cytotoxic activity against the estrogen receptor (ER)-pos. breast cancer cell line (MCF-7) and the epidermal growth factor receptor (EGFR) over-expressed triple-neg. breast cancer cell line (MDA-MB-468). Among them, compounds 2b, 2f and 2i showed more potent activity and selectivity against MDA-MB-468 cells than gefitinib, as an EGFR- tyrosine kinase inhibitor. In addition, it was confirmed by means of isobologram anal. of combinational treatment with gefitinib that they have a synergistic effect, especially compounds 2b and 2f, which inhibit Akt T308 phosphorylation. Moreover, it was confirmed that 2-benzyl-1-oxo-1,2,3,4-tetrahydropyrazino[1,2-a]indole-3-carboxamide analogs (2b, 2f, and Ref 2) tend to selectively inhibit PI3Kβ, which is involved in the phosphorylation of Akt. The experimental process involved the reaction of 4-(Bromomethyl)-1,1′-biphenyl(cas: 2567-29-5).Reference of 4-(Bromomethyl)-1,1′-biphenyl

The Article related to arylmethyl tetrahydropyrazinoindole carboxamide analog synergistic effect pten cancer cell, egfr-tki resistance, pten-deficient cancer cells, anti-tnbc, pyrazinoindolone scaffold, synergistic effects and other aspects.Reference of 4-(Bromomethyl)-1,1′-biphenyl

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Sisto, Francesca; Carradori, Simone; Guglielmi, Paolo; Spano, Mattia; Secci, Daniela; Granese, Arianna; Sobolev, Anatoly P.; Grande, Rossella; Campestre, Cristina; Marcantonio, Maria Carmela Di; Mincione, Gabriella published an article in 2021, the title of the article was Synthesis and evaluation of thymol-based synthetic derivatives as dual-action inhibitors against different strains of H. pylori and AGS cell line.Related Products of 2567-29-5 And the article contains the following content:

Herein, the synthesis of a new series of thymol-based ethers I [R = Me, H2C:CH, CN, EtO2C, Ph, 2-BrC6H4, etc.] and their microbiol. screening against eight strains of H. pylori and the cytotoxic activity against human gastric adenocarcinoma (AGS) cells are reported. Structural anal. comprehended elemental anal. and 1H/13C/19F NMR spectra. The anal. of structure-activity relationships within this mol. library of these structurally-related compounds showed that some chem. modifications of the OH group of thymol led to broad-spectrum growth inhibition on all isolates. Preferred substitutions were benzyl groups compared to alkyl chains and the specific presence of functional groups at para position of the benzyl moiety such as 4-CN and 4-Ph endowed the most anti-H. pylori activity toward all the strains with min. inhibitory concentration (MIC) values up to 4μg/mL. Poly-substitution on the benzyl ring was not essential. Moreover, several compounds characterized by the lowest min. inhibitory concentration/min. bactericidal concentration (MIC/MBC) values against H. pylori were also tested in order to verify a cytotoxic effect against AGS cells with respect to 5-fluorouracil and carvacrol. The experimental process involved the reaction of 4-(Bromomethyl)-1,1′-biphenyl(cas: 2567-29-5).Related Products of 2567-29-5

The Article related to thymol ether preparation helicobacter pylori antibacterial gastric adenocarcinoma, ags cells, helicobacter pylori, drug resistance, dual-action agents, antimicrobial activity, semi-synthesis, thymol and other aspects.Related Products of 2567-29-5

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

On November 5, 2021, Tak, Raj K.; Noda, Hidetoshi; Shibasaki, Masakatsu published an article.Category: bromides-buliding-blocks The title of the article was Ligand-enabled, copper-catalyzed electrophilic amination for the asymmetric synthesis of β-amino acids. And the article contained the following:

Catalytic asym. nitrene transfer has emerged as a reliable method for the synthesis of nitrogen-containing chiral compounds Herein, we report the copper-catalyzed intramol. asym. electrophilic amination of aromatic rings. The reactive intermediate is a copper-alkyl nitrene generated from isoxazolidin-5-ones. Copper catalysis promotes three classes of asym. transformations, namely, asym. desymmetrization, parallel kinetic resolution, and kinetic resolution, expanding the repertoire of alkyl nitrene transfer and providing various cyclic and linear β-amino acids in their enantioenriched forms. The experimental process involved the reaction of 4-(Bromomethyl)-1,1′-biphenyl(cas: 2567-29-5).Category: bromides-buliding-blocks

The Article related to amino acid beta cyclic linear enantioselective synthesis solvent effect, electrophilic amination copper catalyst isoxazolidinone nitrene, asym desymmetrization kinetic resolution nitrene transfer and other aspects.Category: bromides-buliding-blocks

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

On November 17, 2021, Bonnefoy, Clemence; Chefdeville, Emmanuel; Panosian, Armen; Hanquet, Gilles; Leroux, Frederic R.; Toulgoat, Fabien; Billard, Thierry published an article.Synthetic Route of 2567-29-5 The title of the article was Study of a Stable “Trifluoromethoxide Anion Solution” Arising from 2,4-Dinitro-Trifluoromethoxybenzene. And the article contained the following:

Despite recent advances, trifluoromethoxylation remains a challenging reaction. Here we describe an efficient trifluoromethoxylative substitution, using an inexpensive and easy-to-handle reagent. By mixing DMAP with a slight excess of 2,4-dinitro-trifluoromethoxybenzene (DNTFB), a stable solution of trifluoromethoxide anion is obtained and can be used to perform a SN2 reaction without any silver additives. A precise study of the properties and behavior of this unusual stable solution of CF3O- species is also performed. The experimental process involved the reaction of 4-(Bromomethyl)-1,1′-biphenyl(cas: 2567-29-5).Synthetic Route of 2567-29-5

The Article related to fluoromethoxylative substitution nitrotrifluoromethoxybenzene, 2,4-dinitro-trifluoromethoxybenzene, fluorine, nucleophilic substitution, trifluoromethoxide anion, trifluoromethoxylation and other aspects.Synthetic Route of 2567-29-5

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

On April 1, 2020, Wang, Guowei; Zhu, Dingcheng; Zhou, Zhuxian; Piao, Ying; Tang, Jianbin; Shen, Youqing published an article.COA of Formula: C13H11Br The title of the article was Glutathione-Specific and Intracellularly Labile Polymeric Nanocarrier for Efficient and Safe Cancer Gene Delivery. And the article contained the following:

Cationic polymers condense nucleic acids into nanosized complexes (polyplexes) that are widely explored for nonviral gene delivery, but their strong electrostatic binding with DNA causes inefficient intracellular gene release and translation and thereby unsatisfactory gene transfection efficiencies. Facilitated intracellular dissociation of polyplexes by making the polymer undergo pos.-to-neg./neutral charge reversal can effectively solve these problems, but they must be sufficiently stable during the delivery. Herein, we report the first glutathione (GSH)-specific intracellular labile polyplexes for cancer-targeted gene delivery. The polymers are made from p-(2,4-dinitrophenyloxybenzyl)-ammonium cationic moieties, whose p-2,4-dinitrophenyl ether is cleaved specifically by GSH, rather than other biol. thiols, triggering the conversion of the ammonium cation into the carboxylate anion and thus the fast intracellular DNA release of the polyplexes. Furthermore, the polyplexes coated with PEG-functionalized lipids are stable in biol. fluids to gain long blood circulation for tumor accumulation. Thus, the efficient tumor accumulation and cell transfection of the polyplexes loaded with the tumor suicide gene tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) give rise to potent antitumor activity similar to that of the first-line chemotherapy drug paclitaxel but with much less adverse effects. The experimental process involved the reaction of 4-(Bromomethyl)-1,1′-biphenyl(cas: 2567-29-5).COA of Formula: C13H11Br

The Article related to tumor antitumor trail gene therapy vector glutathione, cancer gene delivery, charge-reversal polymer, gene release, glutathione-responsive polymer, nonviral vectors, polymeric vector and other aspects.COA of Formula: C13H11Br

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

On August 31, 2020, Miura, Kazuki; Onodera, Chihiro; Takagi, Motonari; Koyama, Ryosuke; Hirano, Takako; Nishio, Toshiyuki; Hakamata, Wataru published an article.Recommanded Product: 2567-29-5 The title of the article was Screening, synthesis, and evaluation of novel isoflavone derivatives as inhibitors of human Golgi β-galactosidase. And the article contained the following:

The genes GLB1 and GALC encode GLB1 isoform 1 and galactocerebrosidase, resp., which exhibit β-galactosidase activity in human lysosomes. GLB1 isoform 1 has been reported to play roles in rare lysosomal storage diseases. In this study, we first constructed a cell-based high-throughput screening (HTS) system for Golgi β-galactosidase inhibitors, and then screened inhibitors from two compound libraries using the HTS system, in vitro assay, and cytotoxicity assay. An isoflavone derivative was identified among the final Golgi β-galactosidase inhibitor compound hits. Mol. docking simulations were performed to redesign the isoflavone derivative into a more potent inhibitor, and six designed derivatives were then synthesized. One of the derivatives, ARM07, exhibited potent inhibitory activity against β-galactosidase, with an IC50 value of 14.8 μM and competitive inhibition with Ki value of 13.3 μM. Furthermore, the in vitro and cellular inhibitory activities of ARM07 exceeded those of deoxygalactonojirimycin. ARM07 may contribute to the development of affinity-based chem. probes to identify the protein responsible for the newly discovered Golgi β-galactosidase activity. The therapeutic relevance of ARM07 against lysosomal storage diseases and its effect on senescent cells should be evaluated further. The experimental process involved the reaction of 4-(Bromomethyl)-1,1′-biphenyl(cas: 2567-29-5).Recommanded Product: 2567-29-5

The Article related to krabbe disease glb1 galactocerebrosidase mol docking simulation, inhibitor screening, isoflavone, lysosomal storage disease, senescence-associated β-galactosidase, β-galactosidase and other aspects.Recommanded Product: 2567-29-5

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

On November 11, 2021, Yan, Si-Shun; Liu, Shi-Han; Chen, Lin; Bo, Zhi-Yu; Jing, Ke; Gao, Tian-Yu; Yu, Bo; Lan, Yu; Luo, Shu-Ping; Yu, Da-Gang published an article.Category: bromides-buliding-blocks The title of the article was Visible-light photoredox-catalyzed selective carboxylation of C(sp3)-F bonds with CO2. And the article contained the following:

A novel selective carboxylation of C(sp3)-F bonds with CO2 via visible-light photoredox catalysis. A variety of mono-, di-, and trifluoroalkylarenes as well as α,α-difluorocarboxylic esters and amides undergo such reactions to give important aryl acetic acids and α-fluorocarboxylic acids, including several drugs and analogs, under mild conditions. Notably, mechanistic studies and DFT calculations demonstrate the dual role of CO2 as an electron carrier and electrophile during this transformation. The fluorinated substrates would undergo single-electron reduction by electron-rich CO2 radical anions, which were generated in situ from CO2 via sequential hydride-transfer reduction and hydrogen-atom-transfer processes. The experimental process involved the reaction of 4-(Bromomethyl)-1,1′-biphenyl(cas: 2567-29-5).Category: bromides-buliding-blocks

The Article related to fluoroalkylarene 4czipn photocatalyst carboxylation, aryl acetic acid preparation, fluorocarboxylic ester 3dpafipn photocatalyst carboxylation, fluoro carboxylic acid preparation and other aspects.Category: bromides-buliding-blocks

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Zhou, Han-Qi; Gu, Xing-Wei; Zhou, Xiao-Hua; Li, Li; Ye, Fei; Yin, Guan-Wu; Xu, Zheng; Xu, Li-Wen published an article in 2021, the title of the article was Enantioselective palladium-catalyzed C(sp2)-C(sp2) σ bond activation of cyclopropenones by merging desymmetrization and (3+2) spiroannulation with cyclic 1,3-diketones.Application of 2567-29-5 And the article contains the following content:

Herein, an unprecedented palladium-catalyzed (3+2) spiro-annulation merging C(sp2)-C(sp2) σ bond activation and click desymmetrization to form synthetically versatile and value-added oxaspiro products I [R1 = Me, Et; R2 = n-Pr, but-2-yn-1-yl, naphthalen-2-ylmethyl, thiophen-2-ylmethyl, etc.; R3 = n-Pr, Ph, 4-fluorophenyl, 3-methylphenyl, etc.; R4 = i-Pr, n-Pr, Ph, 4-fluorophenyl, etc.] have been presented. The operationally straightforward and enantioselective palladium-catalyzed atom-economic annulation process exploits a TADDOL-derived bulky P-ligand bearing a large cavity to control enantioselective spiro-annulation that converts cyclopropenones II and cyclic 1,3-diketones III, 2′,3′-dihydrospiro[cyclopentane-1,1′-inden]-3-ene-2,5-dione and 5-((tert-butyldimethylsilyl)oxy)naphthalene-1,4-dione into chiral oxaspiro cyclopentenone-lactone scaffolds I with good diastereo- and enantio-selectivity. The click-like reaction is a successful methodol. with a facile construction of two vicinal carbon quaternary stereocenters and can be used to deliver addnl. stereocenters during late-state functionalization for the synthesis of highly functionalized or more complex mols. The experimental process involved the reaction of 4-(Bromomethyl)-1,1′-biphenyl(cas: 2567-29-5).Application of 2567-29-5

The Article related to oxaspiro cyclopentenone lactone preparation regioselective diastereoselective enantioselective, cyclopropenone cyclic diketone bond activation desymmetrization spiroannulation palladium catalyst and other aspects.Application of 2567-29-5

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

On April 22, 2022, Wang, Hui; Yang, Ren-Yin; Xu, Bo published an article.Application In Synthesis of 4-(Bromomethyl)-1,1′-biphenyl The title of the article was Synthesis of Cyclopropenes and Fluorinated Cyclopropanes via Michael Initiated Ring Closure of Alkyl Triflones. And the article contained the following:

A facile synthesis of cyclopropenes and fluorinated cyclopropanes from readily available alkyl triflones was developed. The reaction, regardless of electronic effect, gave products in good to excellent yields and moderate diastereoselectivity. The mechanism may involve tandem Michael addition of triflones/intramol. nucleophilic cyclization (elimination of -SO2CF3)/elimination of fluoride. The experimental process involved the reaction of 4-(Bromomethyl)-1,1′-biphenyl(cas: 2567-29-5).Application In Synthesis of 4-(Bromomethyl)-1,1′-biphenyl

The Article related to cyclopropene fluorinated cyclopropane preparation diastereoselective, alkyl triflone chalcone michael initiated ring closure, michael initiated ring closure, alkyl triflones, cyclopropenes, fluorinated cyclopropanes and other aspects.Application In Synthesis of 4-(Bromomethyl)-1,1′-biphenyl

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

On May 31, 2022, Zhang, Naichen; Ye, Yuanzhi; Bai, Lu; Liu, Jingjing; Wang, Han; Luan, Xinjun published an article.Safety of 4-(Bromomethyl)-1,1′-biphenyl The title of the article was Transition metal-free dearomatization of halonaphthols with C(sp3)-electrophiles. And the article contained the following:

The first intermol. electrophilic dearomatization of halonaphthols I (R1 = H, 7-MeO, 6-Me3Si, 3-Cl, etc.) with benzyl/allyl bromides R2Br (R2 = PhCH2, PhCHMe, 4-MeO2CC6H4CH2, H2C:CHCH2, PhCH:CH, etc.) is described. Halonaphthols are used as carbon nucleophiles in dearomatization to form three-dimensional cyclic enones II with excellent chemoselectivity, in which etherification of phenolic hydroxyl group could be restrained by using cesium carbonate as the base. A wide range of cyclic enones was directly prepared from various substituted benzyl/allyl bromides and halonaphthols. Mechanistic investigations suggest a direct SN2 reaction pathway. The experimental process involved the reaction of 4-(Bromomethyl)-1,1′-biphenyl(cas: 2567-29-5).Safety of 4-(Bromomethyl)-1,1′-biphenyl

The Article related to allylic bromide fluoronaphthol chemoselective electrophilic allylation dearomatization, allyl benzyl fluoro naphthalenone preparation, fluoronaphthol chemoselective electrophilic benzylation benzyl bromide dearomatization and other aspects.Safety of 4-(Bromomethyl)-1,1′-biphenyl

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary