Category: 2550-36-9

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 2550-36-9, name is (Bromomethyl)cyclohexane, A new synthetic method of this compound is introduced below., HPLC of Formula: C7H13Br

The compound prepared in Step 5 (35 mg, 0.08 mmol), (bromomethyl) cyclohexane (21 mg, 0.12 mmol), K2C03 (22 mg, 0.16 mmol), KI (2 mg) in DMF (2 mL) was stirred at 90C for 16 hours under N2. The mixture was concentrated, diluted with DCM, washed with brine, dried over Na2SC>4, filtered and the solvent was evaporated. The residue was purified by prep-HPLC to give pure product (15 mg, yield: 35%). 1H-NMR (400 MHz, CDCI3) delta 7.97-7 93 (m, 2H), 7.73 (s, 1H), 7.58 (s, 1H), 7.52-7.50 (m, 2H), 7.44-7.37 (m, 3H), 7.24-7.16 (m, 2H), 5.84 (s, 1H), 3.18-3.13 (m, 1H), 2.99-2.97 (m, 4H), 2.95 (s, 3H), 1.74-1.58 (m, 1H),1.54~1.51 (m, 2H), 1.43-1.41 (m, 2H), 1.04-0.91 (m, 4H), 0.89-0.79 (m, 2H), 0.76-0.56 (m, 1H). MS (M+H)+: 535.

The synthetic route of 2550-36-9 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; MERCK SHARP & DOHME CORP.; ISTITUTO DI RICERCHE DI BIOLOGIA MOLECOLARE P. ANGELETTI, SRL; MCCOMAS, Casey Cameron; LIVERTON, Nigel, J.; HABERMANN, Joerg; KOCH, Uwe; NARJES, Frank; LI, Peng; PENG, Xuanjia; SOLL, Richard; WU, Hao; WO2011/106929; (2011); A1;,
Bromide – Wikipedia,
bromide – Wiktionary

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 2550-36-9, name is (Bromomethyl)cyclohexane, A new synthetic method of this compound is introduced below., Recommanded Product: (Bromomethyl)cyclohexane

Example 4A 3-(Cyclohexylmethoxy)pyridine-2-amine At RT, 96 g of sodium hydroxide, 45% strength in water (1081 mmol, 1 equivalent), were initially charged in 1170 ml of methanol, 119 g of 2-amino-3-hydroxypyridine (1080 mmol, 1 equivalent) were added and the mixture was stirred at RT for another 10 min. The reaction mixture was concentrated under reduced pressure, the residue was taken up in 2900 ml of DMSO and 101 g of cyclohexylmethyl bromide (1135 mmol, 1.05 equivalents) were added. After 16 h at RT, the reaction mixture was slowly added to 6 l of water and the aqueous solution was extracted twice with in each case 21 of ethyl acetate. The combined organic phases were washed with in each case 1 l of saturated aqueous sodium bicarbonate solution and water, dried, filtered and concentrated. The residue was stirred with 500 ml of n-pentane, filtered and dried under reduced pressure. This gave 130 g (58% of theory) of the title compound. LC-MS (Method 3): Rt=1.41 min MS (ESpos): m/z=207.1 (M+H)+

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; Bayer Pharma Aktiengesellschaft; VAKALOPOULOS, Alexandros; BUCHGRABER, Philipp; LINDNER, Niels; FOLLMANN, Markus; WUNDER, Frank; STASCH, Johannes-Peter; MARQUARDT, Tobias; REDLICH, Gorden; DIETZ, Lisa; LI, Volkhart Min-Jian; (81 pag.)US2017/217954; (2017); A1;,
Bromide – Wikipedia,
bromide – Wiktionary

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 2550-36-9, name is (Bromomethyl)cyclohexane, A new synthetic method of this compound is introduced below., Recommanded Product: (Bromomethyl)cyclohexane

Example 4A 3-(Cyclohexylmethoxy)pyridine-2-amine At RT, 96 g of sodium hydroxide 45% strength in water (1081 mmol, 1 equivalent) were initially charged in 1170 ml of methanol, 119 g of 2-amino-3-hydroxypyridine (1080 mmol, 1 equivalent) were added and the mixture was stirred at RT for 10 min. The reaction mixture was concentrated under reduced pressure, the residue was taken up in 2900 ml of DMSO and 101 g of cyclohexylmethyl bromide (1135 mmol, 1.05 equivalents) were added. After 16 h at RT, the reaction mixture was added slowly to 6 l of water and the aqueous solution was extracted twice with in each case 21 of ethyl acetate. The combined organic phases were washed with in each case 1 l of saturated aqueous sodium bicarbonate solution and water, dried, filtered and concentrated. The residue was triturated with 500 ml of n-pentane, filtered and dried under reduced pressure. This gave 130 g (58% of theory) of the title compound. LC-MS (Method 3): Rt=1.41 min MS (ESpos): m/z=207.1 (M+H)+

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; BAYER PHARMA AKTIENGESELLSCHAFT; VAKALOPOULOS, Alexandros; FOLLMANN, Markus; HARTUNG, Ingo; BUCHGRABER, Philipp; JAUTELAT, Rolf; HAssFELD, Jorma; LINDNER, Niels; WUNDER, Frank; STASCH, Johannes-Peter; REDLICH, Gorden; LI, Volkhart Min-Jian; BECKER, Eva-Maria; KNORR, Andreas; US2014/128372; (2014); A1;,
Bromide – Wikipedia,
bromide – Wiktionary

2550-36-9, name is (Bromomethyl)cyclohexane, belongs to bromides-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. HPLC of Formula: C7H13Br

Step 1 : Ethyl 1-(cvclohexylmethyl)-5-methyl-1 H-pyrrole-2-carboxylate (1a)A solution of ethyl 5-methyl-1 –pyrrole-2-carboxylate (15.0 g, 98.0 mmol), (bromo- methyl)cyclohexane (17.6 g, 100 mmol) and K2C03 (41.4 g, 300 mmol) in dry DMF (150 mL) was stirred at 50C overnight, then cooled to rt and filtered. To the filtrate was added NaH (12.0 g, 60%, 300 mmol) slowly. Then the mixture was stirred overnight at 50C. The reaction mixture was quenched with water and extracted with EA twice. The combined organic phases were washed with water (3 x) and brine (2 x), dried over Na2S04l filtered, concentrated and purified by CC (EA/PE = 1/20) to give compound 1a (19.9 g, 82%) as a white solid.

The synthetic route of 2550-36-9 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; PHENEX PHARMACEUTICALS AG; STEENECK, Christoph; KINZEL, Olaf; GEGE, Christian; KLEYMANN, Gerald; HOFFMANN, Thomas; WO2012/139775; (2012); A1;,
Bromide – Wikipedia,
bromide – Wiktionary

Application of 2550-36-9, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 2550-36-9, name is (Bromomethyl)cyclohexane belongs to bromides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

The first step of Scheme 19: To a solution of 4-bromo-3-ethoxycarbonylmethoxy-5-(3-hydroxy-phenyl)-thiophene-2-carboxylic acid methyl ester in DMF was added bromomethyl-cyclohexane (21 muL) and K2CO3 (27.6 mg). The resultant suspension was stirred at room temperature, then heated to 80 C. until the disappearance of the starting material as monitored by TLC. The reaction mixture was cooled to room temperature and diluted with EtOAc, and filtered through a pad of Celite, rinsed with EtOAc. The solvent was removed, the crude product was purified on CombiFlash column eluting with hexane/EtOAc to give the desire product, 4-bromo-3-ethoxycarboxymethoxyl-5-3-cyclohexylmethoxy-phenyl)-thiophene-2-carboxylic acid methyl ester (44 mg, 85%) as a colorless oil. 1H NMR (400 MHz, CHLOROFORM-D) delta ppm 1.2 (m, 8H) 1.8 (m, 6H) 3.8 (d, J=6.3 Hz, 2H) 3.9 (s, 3H) 4.3 (q, J=7.1 Hz, 2H) 4.9 (s, 2H) 7.0 (m, 1H) 7.2 (m, 2H) 7.3 (m, 1H).

The synthetic route of (Bromomethyl)cyclohexane has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Lee, Jinbo; Wan, Zhao-Kui; Wilson, Douglas P.; Follows, Bruce C.; Kirincich, Steven J.; Smith, Michael J.; Wu, Jun-Jun; Foreman, Kenneth W.; Erbe, David V.; Zhang, Yan-Ling; Xu, Weixin; Tam, Steve Y.; US2005/203087; (2005); A1;,
Bromide – Wikipedia,
bromide – Wiktionary

Reference of 2550-36-9,Some common heterocyclic compound, 2550-36-9, name is (Bromomethyl)cyclohexane, molecular formula is C7H13Br, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: The 7-alkoxy-1-methyl-beta-carbolines (3a-o) were synthesized according to a previously reported procedure.13 The appropriate alkyl halide (by portion) or 1-tosyl-4,4,4-trifluorobutane (for compound 3e) and cesium carbonate were added to harmol (2) dissolved in anhydrous dimethylformamide (DMF). Then, the reaction mixture was stirred at room temperature or heated for several hours. At the end of the reaction, the mixture was cooled and diluted with dichloromethane, washed once with water and three times with brine. The organic layer was dried over MgSO4 and concentrated. The crude product was purified by liquid chromatography.

The synthetic route of 2550-36-9 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Reniers; Robert; Frederick; Masereel; Vincent; Wouters; Bioorganic and Medicinal Chemistry; vol. 19; 1; (2011); p. 134 – 144;,
Bromide – Wikipedia,
bromide – Wiktionary

These common heterocyclic compound, 2550-36-9, name is (Bromomethyl)cyclohexane, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. category: bromides-buliding-blocks

1H-indole-6-carboxylic acid methyl ester (300mg, 1.71mmol) was dissolved in dimethyl formamide (7ml). Bromomethyl cyclohexane (0.5ml, 3.42mmol) and sodium hydride (150mg, 3.42mmol) were added dropwise thereto at 0, and then the mixture was stirred for 8 hours at room temperature. 1N hydrochloric acid solution was added, and the mixture was extracted with ethyl acetate. The extract was washed with saturated aqueous sodium chloride solution, dried over anhydrous magnesium sulfate and filtered. Filtrate was distilled under reduced pressure and separated by column chromatography to obtain the title compound (150mg, 32%). [611] NMR:1H-NMR(400HMz, CDCl3); delta 7.29-7.39 (m, 2H), 7.19 (d, 1H), 7.13 (m, 1H), 7.00-7.09 (m, 2H), 6.66 (m, 1H), 4.83 (s, 2H), 2.06 (s, 3H)

The synthetic route of (Bromomethyl)cyclohexane has been constantly updated, and we look forward to future research findings.

Reference:
Patent; LG LIFE SCIENCES LTD.; LEE, Sung Bae; PAEK, Seung Yup; YOON, Sook Kyung; YOON, Seung Hyun; CHOI, Jeung Soon; WO2014/73904; (2014); A1;,
Bromide – Wikipedia,
bromide – Wiktionary

Related Products of 2550-36-9, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 2550-36-9, name is (Bromomethyl)cyclohexane, This compound has unique chemical properties. The synthetic route is as follows.

4-(4-chlorophenyl)-1 -(2-methoxyethyl)-6-methyl-2-oxo-3,4-dihydropyridine-5-carboxylic acid (example 74, 75 mg, 0.23 mmol) was dissolved in anhydrous DMF (1 mL) then cesium carbonate (1 14 mg, 0.35 mmol) and cyclohexylmethylbromide (49 muIota_, 0.35 mmol) were added. The reaction mixture was stirred at 50 C for 24 h. The solvent was removed under reduced pressure. The residue was dissolved in EtOAc and water. The aqueous phase was extracted with EtOAc. The organic layers were assembled, washed with brine and dried over MgS04. The solvent was removed under reduced pressure to give the desired [cyclohexylmethyl 4-(4- chlorophenyl)-1 -(2-methoxyethyl)-6-methyl-2-oxo-3,4-dihydropyridine-5-c a r b o x y l a t e a s a yellowish oil (95 mg, 99 %). 1 H N MR (300 MHz, CDCI3) delta 0.71 -1 .18 (m, 5H), 1 .46-1 .63 (m, 6H), 2.61 (s, 3H), 2.71 (dd, J = 15.7, 2.3 Hz, 1 H), 2.92 (dd, J = 15.7, 7.5 Hz, 1 H), 3.32 (s, 3H), 3.38 (ddd, J = 9.8, 8.5, 3.7 Hz, 1 H), 3.47 (dt, J = 9.8, 3.9 Hz, 1 H), 3.75 (ddd, J = 14.6, 8.5, 3.9 Hz, 1 H), 3.81 -3.91 (m, 2H), 4.13-4.21 (m, 2H), 7.1 1 (d, J = 8.5 Hz, 2H), 7.22 (d, J = 8.5 Hz, 2H). MS [M+H]+ 420. HRMS : calcd for C23H3i N04CI, [M+H]+ 420.1942, found 420.1937.

The chemical industry reduces the impact on the environment during synthesis (Bromomethyl)cyclohexane. I believe this compound will play a more active role in future production and life.

Reference:
Patent; UNIVERSITE DE LILLE 2 DROIT ET SANTE; INSTITUT PASTEUR DE LILLE; INSERM (INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE); CHARTON, Julie; DEPREZ, Benoit; LEROUX, Florence; STAELS, Bart; MUHR-TAILLEUX, Anne; HENNUYER, Nathalie; LESTAVEL, Sophie; PICON, Sylvain; AKNIN, Karen; BOULAHJAR, Rajaa; DUBANCHET, Barbara; (234 pag.)WO2016/16238; (2016); A1;,
Bromide – Wikipedia,
bromide – Wiktionary

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 2550-36-9, name is (Bromomethyl)cyclohexane, This compound has unique chemical properties. The synthetic route is as follows., Formula: C7H13Br

2,6-dihydroxy acetophenone solution (2,6-dihydroxyacetophenone, compound 7, 1.0 eq.), Anhydrous potassium carbonate (anhydrouspotassium carbonate, 2.0 eq.), Dissolved in acetone, alkyl bromide mixture (alkyl bromides, 1.0 eq.) Were mixed and it reacted for 18 hours at 70 ~ 80 . After evaporation of acetone, the remaining reaction product was diluted with dichloromethane and washed three times in water. The organic layer was then collected and concentrated under reduced pressure and then dehydrated with anhydrous Na2SO4 and the crude product obtained by separating the crude product was purified by column chromatography to obtain a compound 9a ~ 9d.

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 2550-36-9.

Reference:
Patent; Chungnam National University Industry-Academic Cooperation Foundation; Chungbuk National University Industry-Academic Cooperation Foundation; Jung, Sang Hun; Kim, Young Soo; (39 pag.)KR101535119; (2015); B1;,
Bromide – Wikipedia,
bromide – Wiktionary

Synthetic Route of 2550-36-9, The chemical industry reduces the impact on the environment during synthesis 2550-36-9, name is (Bromomethyl)cyclohexane, I believe this compound will play a more active role in future production and life.

Synthesis of 9-(cyclohexylmethyl)-2-methoxy-6-methyl-9H-carbazole (Compound 42) Under argon atmosphere, a solution of 7-methoxy-3-methylcarbazole (Krahl et al., Organic & Biomolecular Chemistry 4:3215 (2006)) (600 mg, 2.84 mmol), bromomethylcyclohexane (635 muL, 4.55 mmol), and Cs2CO3 (1.8 g) in DMF (15 mL) was subjected to microwave irradiation at 140 C. for 1 h. The reaction mixture was cooled, diluted with ethyl acetate (150 mL), filtered, and extracted with diethyl ether. The organic layer was washed consecutively with concentrated sodium bicarbonate (150 mL*3), brine, dried over magnesium sulfate, filtered, and concentrated in vacuo. The obtained residue was purified by column chromatography on silica gel using heptanes/ethyl acetate in different proportions to afford the title compound as a brownish solid. Yield: 743 mg (85%), mp 136-137 C.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, (Bromomethyl)cyclohexane, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Diaz, Philippe; Diaz, Fanny; Petrov, Ravil Rashitovich; US2012/39804; (2012); A1;,
Bromide – Wikipedia,
bromide – Wiktionary