Category: 2550-36-9

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 2550-36-9, name is (Bromomethyl)cyclohexane belongs to bromides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. Computed Properties of C7H13Br

Scheme V, step A: 2-Picoline (5 g, 54 mmol) is dissolved in THF (100 mL) and cooled to -78 C. N-Butyllithium (40 mL of a 1.6M solution in THF, 64.3 mmol) was added to the solution over 10 minutes. The reaction mixture was then warmed to room temperature for 5 minutes and then cooled back down to -78 C. Then cyclohexylmethyl bromide (10 g, 57 mmol) was added, the reaction was warmed to room temperature and allowed to stir overnight. The reaction was then heated at reflux for 6 hours and then cooled to room temperature. The solvent was removed under vacuum and water and ethyl acetate were then added to the residue. The layers were separated and the aqueous was extracted with ethyl acetate. The organic extracts were combined, dried over anhydrous magnesium sulfate, filtered and concentrated to provide a dark oil. The oil was purified by flash chromatography to provide 2-pyridyl-1-cyclohexylethane (9 g, 89%).

The synthetic route of 2550-36-9 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Eli Lilly and Company; US6828332; (2004); B1;,
Bromide – Wikipedia,
bromide – Wiktionary

Some common heterocyclic compound, 2550-36-9, name is (Bromomethyl)cyclohexane, molecular formula is C7H13Br, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. COA of Formula: C7H13Br

General procedure: In Example 1, 17.98 g (108.95 mmol) of 1-bromohexane,(Bromomethyl) cyclohexane 19.29 g (108.95 mmol), In the same manner as in Example 1,19.74 g of Compound 5 was obtained as white crystals. The results are summarized in Table 1.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 2550-36-9, its application will become more common.

Reference:
Patent; ZEON CORPORATION; JAPAN FINECHEM INCORPORATED; SANUKI, KANAKO; OKUYAMA, KUMI; SATO, KOKI; TAMAKI, RYUSUKE; KURODA, TOSHIHIRO; SUZAKI, DAISUKE; (19 pag.)JP2016/190818; (2016); A;,
Bromide – Wikipedia,
bromide – Wiktionary

Reference of 2550-36-9, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 2550-36-9 name is (Bromomethyl)cyclohexane, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

Step 1: To a solution of 3-bromo-6-methylimidazo[1 ,5-a]pyrazin-8(7H)-one (1 g, 4.39 mmol, 1 eq) and Cs2003 (2.86 g, 8.78 mmol, 2 eq) in DMF (20 mL) was added (bromomethyl)cyclohexane (1 .55 g, 8.78 mmol, 1.22 mL, 2 eq). The mixture was stirred at6000 for 18 hour. The reaction mixture was filtered and the filtrate was concentrated. The crude mixture was purified by flash chromatography with petroleum ether:ethyl acetate = 5:1 3:1. 3-bromo-7-(cyclohexylmethyl)-6-methylimidazo[1 ,5-a]pyrazin-8(7H)-one (1 g, 3.02 mmol, 69% yield) was obtained.1H NMR (ODd3, 400 MHz): 7.86 (s, 1H), 6.80 (s, 1H), 3.79 (d, J= 7.2 Hz, 2H), 2.29 (s,3H), 1.75 -1.66 (m, 6H), 1.22 – 1.04 (m, 5H).LC-MS: tR = 0.791 mm (method 15), mlz= 325.9 [M + H].

At the same time, in my other blogs, there are other synthetic methods of this type of compound, (Bromomethyl)cyclohexane, and friends who are interested can also refer to it.

Reference:
Patent; H. LUNDBECK A/S; KEHLER, Jan; RASMUSSEN, Lars, Kyhn; LANGGARD, Morten; JESSING, Mikkel; VITAL, Paulo, Jorge, Vieira; JUHL, Karsten; (159 pag.)WO2016/174188; (2016); A1;,
Bromide – Wikipedia,
bromide – Wiktionary

Electric Literature of 2550-36-9, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 2550-36-9, name is (Bromomethyl)cyclohexane belongs to bromides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

General procedure: 2,6-Dihydroxyacetophenone 7 (1.0equiv.) was dissolved in acetone (10mL) and then anhydrous potassium carbonate (2.0equiv.) with corresponding alkyl bromides (1.0equiv.) were added and the reaction mixture was stirred at 80C for overnight. After evaporating the solvent under reduced pressure the reaction mixture was further diluted with dichloromethane (20mL) and washed with water (20mL×3). The organic layer was dried over anhydrous sodium sulfate and evaporated under reduced pressure. The crude product was purified by flash column chromatography to afford the title compounds 8. 6.1.1.1 1-(2-(Cyclohexylmethoxy)-6-hydroxyphenyl)ethanone (8a) Yield 50%; Yellow colored solid; 1H NMR (CDCl3) delta 13.20 (s, 1H), 7.29 (t, J = 8.4 Hz, 1H), 6.53 (d, J = 8.4 Hz, 1H), 6.40 (d, J = 8.4 Hz, 1H), 3.81 (d, J = 6.0, 2H), 2.72 (s, 3H), 1.69-1.87 (m, 5H), 1.19-1.29 (m, 6H).

The synthetic route of (Bromomethyl)cyclohexane has been constantly updated, and we look forward to future research findings.

Reference:
Article; Yang, Hyun-Sun; Venkateswararao, Eeda; Boggu, Pulla Reddy; Sharma, Vinay K.; Kim, Youngsoo; Jung, Sang-Hun; Bioorganic and Medicinal Chemistry; vol. 25; 16; (2017); p. 4330 – 4338;,
Bromide – Wikipedia,
bromide – Wiktionary

2550-36-9, name is (Bromomethyl)cyclohexane, belongs to bromides-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. category: bromides-buliding-blocks

General procedure: To a solution of 9d (94 mg, 0.49 mmol) and potassium tert-butoxide (55 mg, 0.49 mmol) in anhydrous THF (10 mL) under argon was added benzyl bromide (0.06 mL, 0.54 mmol). The mixture was stirred at room temperature and monitored by TLC until complete. The solution was concentrated and dichloromethane (20 mL) was added. The organic layer was washed with water, dried (MgSO4), and evaporated under reduced pressure to afford the crude product which was purified on a silica gel column (5% MeOH/dichloromethane). The desired product was isolated as a white solid (83 mg, 60%).

The synthetic route of 2550-36-9 has been constantly updated, and we look forward to future research findings.

Reference:
Article; White, Alex W.; Carpenter, Nicholas; Lottin, Jerome R. P.; McClelland, Richard A.; Nicholson, Robert I.; European Journal of Medicinal Chemistry; vol. 56; (2012); p. 246 – 253,8;,
Bromide – Wikipedia,
bromide – Wiktionary

Synthetic Route of 2550-36-9, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 2550-36-9, name is (Bromomethyl)cyclohexane, This compound has unique chemical properties. The synthetic route is as follows.

2,4-Dibenzyloxyphenol was dissolved in 2 mL of DMF, bromomethylcyclohexane (0.23 g, 1.2 mmol) and K2CO3 (0.46 g, 3.30 mmol) were added and stirred at 50 C. overnight. Ethyl acetate (30 mL) was added to the reaction solution to giveThe separated organic layer was washed three times with water (5 mL) and saturated brine (5 mL).The aqueous layers were combined and further extracted three times with ethyl acetate (5 mL), and all the obtained organic layers were dried over anhydrous sodium sulfate. The anhydrous sodium sulfate was filtered off, and the filtrate was concentrated to give a crude product. thisThe crude product is subjected to silica gel column chromatography (1-2.5% ethyl acetate / hexane)Then, 0.25 g of colorless oil 2,4-dibenzyloxy-1- (cyclohexylmethoxy) benzene was obtained (yield 90%).

The chemical industry reduces the impact on the environment during synthesis (Bromomethyl)cyclohexane. I believe this compound will play a more active role in future production and life.

Reference:
Patent; National University corporation Utsunomiya University; Nihei, Ken’ichi; (23 pag.)JP5893442; (2016); B2;,
Bromide – Wikipedia,
bromide – Wiktionary

Adding a certain compound to certain chemical reactions, such as: 2550-36-9, name is (Bromomethyl)cyclohexane, belongs to bromides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 2550-36-9, Recommanded Product: 2550-36-9

The compound prepared in Step 5 (35 mg, 0.08 mmol), (bromomethyl) cyclohexane (21 mg, 0.12 mmol), 2C03 (22 mg, 0.16 mmol), I (2 mg) in DMF (2 mL) was stirred at 90C for 16 hours under N2. The mixture was concentrated, diluted with DCM, washed with brine, dried over Na2S04, filtered and the solvent was evaporated. The residue was purified by prep-HPLC to give pure product (15 mg, yield: 35%).-NMR (400 MHz, CDC13) delta 7.97-7.93 (m, 2H), 7.73 (s, 1H), 7.58 (s, 1 H), 7.52-7.50 (m, 2H), 7.44-7.37 (m, 3H), 7.24-7.16 (m, 2H), 5.84 (s, 1H), 3.18-3.13 (m, 1 H), 2.99-2.97 (m, 4H), 2.95 (s, 3H), 1.74-1.58 (m, 1 H),1.54~1.51 (m, 2H), 1.43-1.41 (m, 2H), 1 .04-0.91 (m, 4H), 0.89-0.79 (m, 2H), 0.76-0.56 (m, 1H). MS (M+H)+: 535.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.

Reference:
Patent; MERCK SHARP & DOHME CORP.; MCCOMAS, Casey, Cameron; LIVERTON, Nigel, J.; SOLL, Richard; LI, Peng; PENG, Xuanjia; WU, Hao; NARJES, Frank; HABERMANN, Joerg; KOCH, Uwe; LIU, Shilan; ISTITUTO DI RICERCHE DI BIOLOGIA MOLECOLARE P. ANGELETTI, SRL; WO2011/106992; (2011); A1;,
Bromide – Wikipedia,
bromide – Wiktionary

Synthetic Route of 2550-36-9, These common heterocyclic compound, 2550-36-9, name is (Bromomethyl)cyclohexane, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Step 1 : To a solution of 3-bromo-6-methylimidazo[1,5-a]pyrazin-8(7H)-one (1 g, 4.39 mmol, 1 eq) and Cs2CO3 (2.86 g, 8.78 mmol, 2 eq) in DMF (20 mL) was added (bromomethyl)cyclohexane (1.55 g, 8.78 mmol, 1.22 mL, 2 eq). The mixture was stirred at 60C for 18 hour. The reaction mixture was filtered and the filtrate was concentrated. The crude mixture was purified by flash chromatography with petroleum ethenethyl acetate = 5:1 ~ 3: 1. 3-bromo-7-(cyclohexylmethyl)-6-methylimidazo[1,5-a]pyrazin-8(7H)-one (1 g, 3.02 mmol, 69% yield) was obtained. 1H NMR (CDCl3 , 400 MHz): delta 7.86 (s, 1 H), 6.80 (s, 1 H), 3.79 (6, J = 1.2 Hz, 2H), 2.29 (s, 3H), 1.75 -1.66 (m, 6H), 1.22 – 1.04 (m, 5H). LC-MS: tR = 0.791 min (method 15), m/z = 325.9 [M + H]+.

The synthetic route of 2550-36-9 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; H. LUNDBECK A/S; KEHLER, Jan; RASMUSSEN, Lars, Kyhn; LANGGARD, Morten; JESSING, Mikkel; VITAL, Paulo, Jorge, Vieira; JUHL, Karsten; (157 pag.)WO2018/78038; (2018); A1;,
Bromide – Wikipedia,
bromide – Wiktionary

Reference of 2550-36-9, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 2550-36-9, name is (Bromomethyl)cyclohexane belongs to bromides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

20 g of bromomethyl cyclohexane,After 12.5 g of 1-naphthol was dissolved in 300 g of NMP in a three-necked flask,12g of potassium carbonate was added,14g potassium iodide was heated at 120 C for 8 hours.In the reaction solution was added 300g of water,Extraction was performed three times with 100 g of hexane,The resulting organic layers were combined,Washed once with 100 g of 1 N aqueous sodium hydroxide solution,Water 100g washed once,Brine 100g washed once,Concentration gave 13 g of compound 1.

The synthetic route of (Bromomethyl)cyclohexane has been constantly updated, and we look forward to future research findings.

Reference:
Patent; FUJIFILM CORPORATION; SHIRAKAWA, MICHIHIRO; TANGO, NAOHIRO; SHIBUYA, AKINORI; YAMAGUCHI, SHUHEI; KATAOKA, SHOHEI; (175 pag.)TWI579263; (2017); B;,
Bromide – Wikipedia,
bromide – Wiktionary

Reference of 2550-36-9, The chemical industry reduces the impact on the environment during synthesis 2550-36-9, name is (Bromomethyl)cyclohexane, I believe this compound will play a more active role in future production and life.

General procedure: The solution of dihydroxyacetophenone (1, 1.0equiv), anhydrous potassium carbonate (2.0equiv) and corresponding alkyl bromides (2, 1.1equiv) in acetonitrile was stirred at 70-80C for 4-5h. After evaporation of acetonitrile, the reaction mixture was diluted with dichloromethane and washed with water three times. The organic layer was dried with anhydrous sodium sulfate and evaporated under reduced pressure. The crude product was purified by column chromatography to give 3.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, (Bromomethyl)cyclohexane, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Venkateswararao, Eeda; Sharma, Vinay K.; Yun, Jieun; Kim, Youngsoo; Jung, Sang-Hun; Bioorganic and Medicinal Chemistry; vol. 22; 13; (2014); p. 3386 – 3392;,
Bromide – Wikipedia,
bromide – Wiktionary