Category: 2550-36-9

Related Products of 2550-36-9, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 2550-36-9, name is (Bromomethyl)cyclohexane belongs to bromides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

20 g of bromomethyl cyclohexane,After 12.5 g of 1-naphthol was dissolved in 300 g of NMP in a three-necked flask,12g of potassium carbonate was added,14g potassium iodide was heated at 120 C for 8 hours.In the reaction solution was added 300g of water,Extraction was performed three times with 100 g of hexane,The resulting organic layers were combined,Washed once with 100 g of 1 N aqueous sodium hydroxide solution,Water 100g washed once,Brine 100g washed once,Concentration gave 13 g of compound 1.

The synthetic route of (Bromomethyl)cyclohexane has been constantly updated, and we look forward to future research findings.

Reference:
Patent; FUJIFILM CORPORATION; SHIRAKAWA, MICHIHIRO; TANGO, NAOHIRO; SHIBUYA, AKINORI; YAMAGUCHI, SHUHEI; KATAOKA, SHOHEI; (175 pag.)TWI579263; (2017); B;,
Bromide – Wikipedia,
bromide – Wiktionary

Synthetic Route of 2550-36-9, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 2550-36-9, name is (Bromomethyl)cyclohexane, This compound has unique chemical properties. The synthetic route is as follows.

4-(4-chlorophenyl)-1 -(2-methoxyethyl)-6-methyl-2-oxo-3,4-dihydropyridine-5-carboxylic acid (example 74, 75 mg, 0.23 mmol) was dissolved in anhydrous DMF (1 mL) then cesium carbonate (1 14 mg, 0.35 mmol) and cyclohexylmethylbromide (49 muIota_, 0.35 mmol) were added. The reaction mixture was stirred at 50 C for 24 h. The solvent was removed under reduced pressure. The residue was dissolved in EtOAc and water. The aqueous phase was extracted with EtOAc. The organic layers were assembled, washed with brine and dried over MgS04. The solvent was removed under reduced pressure to give the desired [cyclohexylmethyl 4-(4- chlorophenyl)-1 -(2-methoxyethyl)-6-methyl-2-oxo-3,4-dihydropyridine-5-c a r b o x y l a t e a s a yellowish oil (95 mg, 99 %). 1 H N MR (300 MHz, CDCI3) delta 0.71 -1 .18 (m, 5H), 1 .46-1 .63 (m, 6H), 2.61 (s, 3H), 2.71 (dd, J = 15.7, 2.3 Hz, 1 H), 2.92 (dd, J = 15.7, 7.5 Hz, 1 H), 3.32 (s, 3H), 3.38 (ddd, J = 9.8, 8.5, 3.7 Hz, 1 H), 3.47 (dt, J = 9.8, 3.9 Hz, 1 H), 3.75 (ddd, J = 14.6, 8.5, 3.9 Hz, 1 H), 3.81 -3.91 (m, 2H), 4.13-4.21 (m, 2H), 7.1 1 (d, J = 8.5 Hz, 2H), 7.22 (d, J = 8.5 Hz, 2H). MS [M+H]+ 420. HRMS : calcd for C23H3i N04CI, [M+H]+ 420.1942, found 420.1937.

The chemical industry reduces the impact on the environment during synthesis (Bromomethyl)cyclohexane. I believe this compound will play a more active role in future production and life.

Reference:
Patent; UNIVERSITE DE LILLE 2 DROIT ET SANTE; INSTITUT PASTEUR DE LILLE; INSERM (INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE); CHARTON, Julie; DEPREZ, Benoit; LEROUX, Florence; STAELS, Bart; MUHR-TAILLEUX, Anne; HENNUYER, Nathalie; LESTAVEL, Sophie; PICON, Sylvain; AKNIN, Karen; BOULAHJAR, Rajaa; DUBANCHET, Barbara; (234 pag.)WO2016/16238; (2016); A1;,
Bromide – Wikipedia,
bromide – Wiktionary

Electric Literature of 2550-36-9, The chemical industry reduces the impact on the environment during synthesis 2550-36-9, name is (Bromomethyl)cyclohexane, I believe this compound will play a more active role in future production and life.

General procedure: The solution of dihydroxyacetophenone (1, 1.0equiv), anhydrous potassium carbonate (2.0equiv) and corresponding alkyl bromides (2, 1.1equiv) in acetonitrile was stirred at 70-80C for 4-5h. After evaporation of acetonitrile, the reaction mixture was diluted with dichloromethane and washed with water three times. The organic layer was dried with anhydrous sodium sulfate and evaporated under reduced pressure. The crude product was purified by column chromatography to give 3.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, (Bromomethyl)cyclohexane, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Venkateswararao, Eeda; Sharma, Vinay K.; Yun, Jieun; Kim, Youngsoo; Jung, Sang-Hun; Bioorganic and Medicinal Chemistry; vol. 22; 13; (2014); p. 3386 – 3392;,
Bromide – Wikipedia,
bromide – Wiktionary

Adding a certain compound to certain chemical reactions, such as: 2550-36-9, name is (Bromomethyl)cyclohexane, belongs to bromides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 2550-36-9, category: bromides-buliding-blocks

At RT, 96 g of sodium hydroxide, 45% strength in water (1081 mmol, 1 equivalent), were initially charged in 1170 ml of methanol, 119 g of 2-amino-3-hydroxypyridine (1080 mmol, 1 equivalent) were added and the mixture was stirred at RT for another 10 min. The reaction mixture was concentrated under reduced pressure, the residue was taken up in 2900 ml of DMSO and 101 g of cyclohexylmethyl bromide (1135 mmol, 1.05 equivalents) were added. After 16 h at RT, the reaction mixture was slowly added to 6 l of water and the aqueous solution was extracted twice with in each case 2 l of ethyl acetate. The combined organic phases were washed with in each case 1 l of saturated aqueous sodium bicarbonate solution and water, dried, filtered and concentrated. The residue was stirred with 500 ml of n-pentane, filtered and dried under reduced pressure. This gave 130 g (58% of theory) of the title compound. LC-MS (Method 3): Rt=1.41 min MS (ESpos): m/z=207.1 (M+H)+

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.

Reference:
Patent; BAYER PHARMA AKTIENGESELLSCHAFT; VAKALOPOULOS, Alexandros; BROCKSCHNIEDER, Damian; WUNDER, Frank; STASCH, Johannes-Peter; MARQUARDT, Tobias; DIETZ, Lisa; LI, Volkhart Min-Jian; (50 pag.)US2017/304278; (2017); A1;,
Bromide – Wikipedia,
bromide – Wiktionary

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 2550-36-9, name is (Bromomethyl)cyclohexane, This compound has unique chemical properties. The synthetic route is as follows., Formula: C7H13Br

[0307] A four-necked reactor equipped with a thermometer was charged with 3.00 g (18.2 mmol) of 2-hydrazinobenzothiazole and 30 ml of DMF under a nitrogen stream to prepare a homogeneous solution. After the addition of 7.55 g (54.6 mmol) of potassium carbonate and 3.86 g (21.8 mmol) of (bromomethyl)cyclohexane to the solution, the mixture was stirred at 80C for 9 hours. After completion of the reaction, the reaction mixture was cooled to 20C, added to 300 ml of water, and extracted with 500 ml of ethyl acetate. After drying the ethyl acetate layer over anhydrous sodium sulfate, sodium sulfate was filtered off. Ethyl acetate was evaporated from the filtrate under reduced pressure using a rotary evaporator to obtain a yellow solid. The yellow solid was purified by silica gel column chromatography (n-hexane:ethyl acetate=85:15 (volume ratio)) to obtain 2.36 g of an intermediate S as a white solid (yield: 49.7%). [0308] The structure of the target product was identified by 1H-NMR. [0309] 1H-NMR (400 MHz, CDCl3, TMS, delta ppm): 7.58 (d, 1H, J=8.0 Hz), 7.51 (d, 1H, J=8.1 Hz), 7.26 (dd, 1H, J=7.0 Hz, 8.1 Hz), 7.04 (dd, 1H, J=7.0 Hz, 8.0 Hz), 4.24 (s, 2H), 3.59 (d, 2H, J=7.4 Hz), 1.84-1.92 (m, 1H), 1.67-1.77 (m, 5H), 1.16-1.29 (m, 3H), 1.02-1.13 (m, 2H).

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 2550-36-9.

Reference:
Patent; Zeon Corporation; SAKAMOTO Kei; OKUYAMA Kumi; EP2703385; (2014); A1;,
Bromide – Wikipedia,
bromide – Wiktionary

In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 2550-36-9 as follows. Safety of (Bromomethyl)cyclohexane

179a) (3-Bromophenyl)(cyclohexylmethyl)sulfane To a solution of 3-bromobenzenethiol (4.158 g, 21 .99 mmol) in DMF (30 ml_) was added K2C03 (9.12 g, 66.0 mmol). The reaction mixture was stirred for 30 mins at room temperature. Then (bromomethyl)cyclohexane (4.28 g, 24.19 mmol) was added. The reaction mixture was stirred at 25C for 16 h. Then it was poured into water (50ml_) and extracted with ethyl acetate(3x). The combined organic phase was concentrated to obtain the title compound (3-bromophenyl)(cyclohexylmethyl)sulfane (6g, 18.93 mmol, 86 % yield) which was used in the next step without further purification.

According to the analysis of related databases, 2550-36-9, the application of this compound in the production field has become more and more popular.

Reference:
Patent; GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED; ASTEX THERAPEUTICS LIMITED; CALLAHAN, James Francis; KERNS, Jeffrey K.; LI, Peng; LI, Tindy; MCCLELAND, Brent W.; NIE, Hong; PERO, Joseph E.; DAVIES, Thomas Glanmor; GRAZIA CARR, Maria; GRIFFITHS-JONES, Charlotte Mary; HEIGHTMAN, Thomas Daniel; NORTON, David; VERDONK, Marinus Leendert; WOOLFORD, Alison Jo-Anne; WILLEMS, Hendrika Maria Gerarda; (664 pag.)WO2017/60854; (2017); A1;,
Bromide – Wikipedia,
bromide – Wiktionary

Electric Literature of 2550-36-9, These common heterocyclic compound, 2550-36-9, name is (Bromomethyl)cyclohexane, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

A suspension of compound 33 (496 mg, 2.88 mmol), solid potassium hydroxide (182 mg, 3.24 mmol) and tetrabutyl ammonium bisulfate (11 mg, 0.29 mmol) in toluene (4 mL) was heated to 50 C and the reaction was conducted for 2 h with vigorous stirring. To the above reaction mixture bromomethyl cyclohexane (639 mg, 3.61 mmol) was added dropwise and the reaction mixture was heated to 80 C. After 2 h, the reaction was cooled to rt, diluted with ethyl acetate, washed with water, brine and dried over anhydrous Na2SO4. The organic layer was concentrated to yield the product 34 as a yellow oil which is a mixture of rotamers (720 mg, 2.68 mmol, 93%); 1H NMR (CDCl3) delta 0.84-1.07 (m, 2H), 1.08-1.32 (m, 4H), 1.44 and 1.50 (s, 9H), 1.57-1.77 (m, 5H), 1.80 and 1.86 (s, 3H), 2.03 and 2.06 (s, 3H), 3.31 (d, J = 8.00 Hz, 2H).

Statistics shows that (Bromomethyl)cyclohexane is playing an increasingly important role. we look forward to future research findings about 2550-36-9.

Reference:
Article; Purohit, Meena K.; Chakka, Sai Kumar; Scovell, Iain; Neschadim, Anton; Bello, Angelica M.; Salum, Norue; Katsman, Yulia; Bareau, Madeleine C.; Branch, Donald R.; Kotra, Lakshmi P.; Bioorganic and Medicinal Chemistry; vol. 22; 9; (2014); p. 2739 – 2752;,
Bromide – Wikipedia,
bromide – Wiktionary

Synthetic Route of 2550-36-9, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 2550-36-9, name is (Bromomethyl)cyclohexane, This compound has unique chemical properties. The synthetic route is as follows.

Example 4A 3-(Cyclohexylmethoxy)pyridine-2-amine At RT, 96 g of sodium hydroxide, 45% strength in water (1081 mmol, 1 equivalent), were initially charged in 1170 ml of methanol, 119 g of 2-amino-3-hydroxypyridine (1080 mmol, 1 equivalent) were added and the mixture was stirred at RT for another 10 min. The reaction mixture was concentrated under reduced pressure, the residue was taken up in 2900 ml of DMSO and 101 g of cyclohexylmethyl bromide (1135 mmol, 1.05 equivalents) were added. After 16 h at RT, the reaction mixture was slowly added to 6 l of water and the aqueous solution was extracted twice with in each case 2 l of ethyl acetate. The combined organic phases were washed with in each case 1 l of saturated aqueous sodium bicarbonate solution and water, dried, filtered and concentrated. The residue was stirred with 500 ml of n-pentane, filtered and dried under reduced pressure. This gave 130 g (58% of theory) of the title compound. LC-MS (Method 3): Rt=1.41 min MS (ESpos): m/z=207.1 (M+H)+

The chemical industry reduces the impact on the environment during synthesis (Bromomethyl)cyclohexane. I believe this compound will play a more active role in future production and life.

Reference:
Patent; Bayer Pharma Aktiengesellschaft; VAKALOPOULOS, Alexandros; VALOT, Gaelle; LINDNER, Niels; FOLLMANN, Markus; WUNDER, Frank; STASCH, Johannes-Peter; MARQUARDT, Tobias; REDLICH, Gorden; DIETZ, Lisa; Ll, Volkhart Min-Jian; (94 pag.)US2017/57954; (2017); A1;,
Bromide – Wikipedia,
bromide – Wiktionary

Synthetic Route of 2550-36-9, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 2550-36-9, name is (Bromomethyl)cyclohexane belongs to bromides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

To a solution of 3-(tetrahydro-2H-pyran-4-yl)imidazo[1 ,5-a]pyrazin-8(7H)-one (300 mg, 1 .37 mmol) in anhydrous DMF (5 mL) was added K2003 (379 mg, 2.74mmol) and (bromomethyl)cyclohexane (364 mg, 2.06 mmol). The reaction mixture was stirred at 60C for 16 hours. The mixture was filtered and the filtrate was purified by preparative LC-MS to yield 7-(cyclohexylmethyl)-3-(tetrahydro-2H-pyran-4-yl )imidazo[1 ,5-a]pyrazin-8(7H)-one 240 mg (55%).1H NMR (DMSO-d6, 400 Mhz): 7.62 (s, 1H), 7.47 (d, J= 6.0 Hz, 1H), 6.84 (d, J= 6.2 Hz,1H), 3.91-3.88 (m, 2H), 3.60 (d, J= 7.2 Hz, 2H), 3.48-3.42 (m, 2H), 3.30-3.29 (m, 1H), 1.78-1.52 (m, 1OH), 1.10-1.06 (m, 3H), 0.93-0.91 (m, 2H).LC-MS: (mlz) 316.2 (MH) tR (minutes, method 3) = 2.44 minutes.

The synthetic route of (Bromomethyl)cyclohexane has been constantly updated, and we look forward to future research findings.

Reference:
Patent; H. LUNDBECK A/S; KEHLER, Jan; RASMUSSEN, Lars, Kyhn; LANGGARD, Morten; JESSING, Mikkel; VITAL, Paulo, Jorge, Vieira; JUHL, Karsten; (159 pag.)WO2016/174188; (2016); A1;,
Bromide – Wikipedia,
bromide – Wiktionary

Electric Literature of 2550-36-9, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 2550-36-9 name is (Bromomethyl)cyclohexane, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

[Synthesis of Compound 1]In a three-necked flask, 20 g of bromomethylcyclohexane and 12.5 g of 1-naphthol were dissolved in 300 g of NMP. Thereafter, 12 g of potassium carbonate and 14 g of potassium iodide were added to the solution, and heated at 120 C. for 8 hours. Water amounting to 300 g was added to the thus obtained reaction liquid, and was extracted with 100 g of hexane three times. The obtained organic phases were collected, and washed with 100 g of 1N aqueous sodium hydroxide solution once, with 100 g of water once and with 100 g of brine once. The thus washed organic phase was concentrated, thereby obtaining 13 g of compound 1.An NMR chart of the compound 1 is given in FIG. 1.

At the same time, in my other blogs, there are other synthetic methods of this type of compound, (Bromomethyl)cyclohexane, and friends who are interested can also refer to it.

Reference:
Patent; FUJIFILM CORPORATION; US2012/237874; (2012); A1;,
Bromide – Wikipedia,
bromide – Wiktionary