Category: 25462-61-7

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 25462-61-7, name is 2,5-Dibromobenzene-1,4-diamine, A new synthetic method of this compound is introduced below., name: 2,5-Dibromobenzene-1,4-diamine

Add a solution of peroxytrifluoroacetic acid in the reaction vessel, lower the temperature to -5 to 5 C, add 797.8 g (3mol) of 2,5-dibromo-p-aminoaniline, and keep the reaction at -5 to 5 C with stirring for 6 hours. After the reaction is complete, Add 2L of water, stir, and let stand. The organic layer was washed with 2L of saturated sodium bisulfite solution, 2L of saturated sodium bicarbonate solution, and water to pH 7-8. The solvent was distilled off under reduced pressure, and dichloromethane and methanol were used. The volume ratio of dichloromethane and methanol is 1: 2) The solution was recrystallized to obtain the product as a yellow solid 782.2 g of 2,5-dibromo-p-nitronitrobenzene (yield 80%).

The synthetic route of 25462-61-7 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Chongqing Pharmaceutical College; Liu Dianqing; He Dongxian; Wang Kun; Guo Shengchao; Wang Guangming; (7 pag.)CN110330432; (2019); A;,
Bromide – Wikipedia,
bromide – Wiktionary

Synthetic Route of 25462-61-7, The chemical industry reduces the impact on the environment during synthesis 25462-61-7, name is 2,5-Dibromobenzene-1,4-diamine, I believe this compound will play a more active role in future production and life.

Under a stream of nitrogen 2,5-dibromobenzene-1 ,4-diamine (53.18 g, 200.0 mmol), phenyl acetylene (40.86 g, 400.0 mmol), Cs2CO3 (260.66 g, 800.0 mmol), [Cu(phen)(PPh3)2]NO3 (33.21 g, 40.0 mmol), were combined and mixed to toluene (2 L) was stirred at 110 C for 24 hours. Put Sodium butoxide (115.32 g, 1200.0 mmol) was stirred for for 2 h at 110 C. After completion of the reaction, and extracted with methylene chloride, it was put into the filter MgSO4. The solvent of the filtered organic layer was purified by column chromatography to Sub 1-1 (39.47 g, yield: 64%) was obtained.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2,5-Dibromobenzene-1,4-diamine, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Doosan Corporation; Jo, Hung Sang; Son, Hyo Suk; (40 pag.)KR2016/78138; (2016); A;,
Bromide – Wikipedia,
bromide – Wiktionary

Synthetic Route of 25462-61-7, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 25462-61-7, name is 2,5-Dibromobenzene-1,4-diamine belongs to bromides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

In a Schienk flask, 2,5-dibromo-1,4-phenylenediamine (1 g, 3.76 mmol) and 2-(4,4,5,5-Tetramethyl-1,3,2-dioXaborolan-2-yl)-5-propylthiophene 10 (3.8 g, 15.04 mmol) were charged under the protection of nitrogen. After adding 75 ml toluene, 30 ml ethanol and 20 ml Cs2CO3 aqueous solution (2.0 mol/l), the mixture was degassed for 45 mm. Pd(PPh3)4 (435 mg, 0.376 mmol) was added. The mixture was thenheated to 80 C, stirred overnight, poured into brine and extracted by dichloromethane for several times. The organic phase was dried over Mg2SO4 and the solvent was evaporated in vacuo. The product was purified by chromatography on silica gel (CH2CI2) to give product 11 as yellow flaky crystal (860 mg, 63%). ?H NMR (400 MHz, CDCl3,. ppm): 1.00 (t, J 7.34 Hz, 6H), 1.73 (dd, .1= 15.00, 7.44 Hz, 4H), 2.80 (t, J = 7.36 Hz, 4H), 4.27-3.02 (br, 2H), 6.76 (m, 4H),7.02 (d, J = 1.96 Hz, 2H). 13C NMR (100 MHz, CDCl3, ppm): 145.9, 138.4, 136.2,125.8, 124.8, 121.9, 118.5, 32.4, 25.1, 14.0.

The synthetic route of 2,5-Dibromobenzene-1,4-diamine has been constantly updated, and we look forward to future research findings.

Reference:
Patent; MERCK PATENT GMBH; ZHANG, Fan; WANG, Xinyang; TANG, Ruizhi; FU, Yubin; ZHUANG, Xiaodong; FENG, Xinliang; WU, Dongqing; WO2015/43722; (2015); A1;,
Bromide – Wikipedia,
bromide – Wiktionary

Reference of 25462-61-7, These common heterocyclic compound, 25462-61-7, name is 2,5-Dibromobenzene-1,4-diamine, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

In a Schlenk flask, 2,5-dibromo-1,4-phenylenediamine (500 mg, 1.88 mmol) and 2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yI)-5-hexylthiophene 13 (2.21 g, 7.52 mmol)were charged under the protection of nitrogen. After adding 25 ml toluene, 10 mlethanol and 10 ml Cs2CO3 aqueous solution (2.0 mo/l), the mixture was degassedfor 30 mm. Pd(PPh3)4 (217.3 mg, 18.8 mmol) was added, then the mixture washeated to 80 C and stirred overnight. The reactant was poured into brine andextracted by dichloromethane for several times. The organic phase was dried overMg2504 and the solvent was evaporated in vacuo. The product was purified bychromatography on silica gel (petroleum ether/CH2CI2=1) to give product 14 asyellow flaky crystal (550 mg, 66%). 1H NMR (400 MHz, CDCI3, ppm): 0.90 (t, J = 7.02Hz, 6H), 1.46-1.23 (m, 12H), 1.76-1.64 (m, 4H), 2.82 (t, J = 7.65 Hz, 4H), 3.70 (br,4H), 6.79-6.73 (m, 4H), 7.02 (d, J 3.48 Hz, 2H). m/z[M+HJ calcd for C26H37N2S2441.2399; HR-ESI observed 441.2393. 13C NMR (100 MHz, CDCl3, ppm): 149.5,146.0, 133.3, 129.4, 128.9, 128.4, 122.2, 112.9, 32.0, 31.9, 30.7, 29.1, 22.8, 14.3.

The synthetic route of 25462-61-7 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; MERCK PATENT GMBH; ZHANG, Fan; WANG, Xinyang; TANG, Ruizhi; FU, Yubin; ZHUANG, Xiaodong; FENG, Xinliang; WU, Dongqing; WO2015/43722; (2015); A1;,
Bromide – Wikipedia,
bromide – Wiktionary