Category: 25121-87-3

Application of 25121-87-3, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 25121-87-3 as follows.

Take a 500 ml three-neck round bottom bottle and place the stirrer with the upper addition funnel.After drying, it is filled with nitrogen;First, 92 mL of lithium diisopropylamide (0.184 mol, 2.3 eq) was added at a concentration of 2M, followed by dissolving 23.841 g of compound P01 (0.08 mol, 1 eq) in 150 mL of anhydrous tetrahydrofuran in an addition funnel.And the resulting solution was added dropwise to a three-necked round bottom bottle at -78 C.After the reaction gradually returns to temperature, the reaction is continued for 18 hours;The reaction was stopped with 120 mL of saturated aqueous sodium bicarbonate solution.It was then extracted with 200 mL of ethyl acetate and repeated 3 times.The obtained extract is sequentially added with magnesium sulfate to dry, filtered and spin-dried;The crude product was purified by recrystallization from ethanol to give 22.172 g of 3,6-dibromothieno[3,2-b]thiophene (yield: 93%).

According to the analysis of related databases, 25121-87-3, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Ningbo Lumilan New Materials Co., Ltd.; Ningbo Jizhichuang New Materials Institute Co., Ltd.; Wei Dingwei; Xie Kunshan; Ding Huanda; Chen Zhikuan; (39 pag.)CN109836436; (2019); A;,
Bromide – Wikipedia,
bromide – Wiktionary

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 25121-87-3, name is 2,5-Dibromothieno[3,2-b]thiophene, A new synthetic method of this compound is introduced below., COA of Formula: C6H2Br2S2

Tetrakis(triphenylphosphine)palladium(0) (0.05 g) was added to a solution 2,5-dibromothieno [3,2-b]thiophene (0.10 g, 0.34 mmol) in dry THF (30 ml), with stirring, under nitrogen. After 20 min, 2-{5-[6-(tert- Butyldimethylsilanyloxy)-hexyl]-thieno[3,2-b]thiophen-2-yl}-4,4,5,5- tetramethyl-[1,3,2]dioxaborolane (0.49 g, 1.02 mmol ) and a solution of potassium carbonate (0.28 g, 2.04 mmol) in water (10 ml) was added. The resultant mixture was heated at reflux for 1.5 h. After cooling, water (100 ml) was added and the precipitate filtered off, washed with water and diethyl ether, to give a yellow solid, which was recrystallised with toluene to give 5 as yellow crystals (0.23 g, 82 %). LC Phases: K – 88C – Sx – 229C – SX1 – 290C – I. ?H NMR (300 MHz, CDC13): 8 (ppm) 7.30 (s, 2H, Ar-H), 7.28 (s, 2H, Ar-H), 6.91 (s, 2H, Ar-H), 3.61 (t, J = 6.4 Hz, 4H, OCH2), 2.88 (t, J = 7.5 Hz, 4H, ArCH2), 1.35-1.80 (m, 16 H, CH2), 0.90 (s, 18 H, CH3), 0.05 (s, 12 H, CH3); ??C NMR (75 MHz, CDC13): 8 (ppm) 148.9 (quat.), 139.4 (quat.), 138.4 (quat.), 137.8 (quat.), 137.7 (quat.), 137.3 (quat.), 116.4 (CH), 116.1 (CH), 115.4 (CH), 63.2 (OCH2), 32.8 (CH2), 31.6 (CH2), 31.2 (CH2), 28.9 (CH2), 26.0 (CH3) 25.6 (CH2), 18.4 (quat.), -5.2 (CH3)

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; MERCK PATENT GMBH; WO2005/121150; (2005); A1;,
Bromide – Wikipedia,
bromide – Wiktionary