24468-88-0 Archives - Bromides-buliding-blocks

September 17, 2021 News Some tips on 24468-88-0

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, N-Benzyl-2-bromo-N-(2-bromoethyl)ethanamine, other downstream synthetic routes, hurry up and to see.

Synthetic Route of 24468-88-0, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 24468-88-0, name is N-Benzyl-2-bromo-N-(2-bromoethyl)ethanamine belongs to bromides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

To a solution of compound 1-2 (2.56 g, 14.34 mmol) and compound 32-1 (6.905 g, 21.51 mmol) in DMF (15mL) under N2 was added NaH (1.434g, 35.85 mmol, 60% dispersed in Mineral oil). The mixture was stirred at 50 C for18 hours, cooled to rt, and quenched with water (20 mL). The mixture was extracted with EtOAc (150 mL x 3). Thecombined organic phases were washed with water, dried over anhydrous Na2SO4 and concentrated in vacuo. Theresidue was purified by silica gel column chromatography (hexane/EtOAc (v/v) = 8/1) to give the title compound 32-2(0.752 g, 14.9%). The compound was characterized by the following spectroscopic data:MS-ESI: m/z 352.1 [M+H]+; and1H NMR (400 MHz, CDCl3): delta 7.63-7.56 (m, 1H), 7.41-7.22 (m, 6H), 3.82 (d, 6H), 3.56 (s, 2H), 3.03 (s, 2H), 2.98-2.89(m, 2H), 2.24-2.00 (m, 4H), 1.37 (d, J = 11.8 Hz, 2H).

Reference:
Patent; Sunshine Lake Pharma Co., Ltd.; ZHANG, Jiancun; ZHANG, Yingjun; XIE, Hongming; REN, Qingyun; LUO, Huichao; YU, Tianzhu; TAN, Yumei; EP2730572; (2015); B1;,
Bromide – Wikipedia,
bromide – Wiktionary

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The synthetic route of 24468-88-0 has been constantly updated, and we look forward to future research findings.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 24468-88-0, name is N-Benzyl-2-bromo-N-(2-bromoethyl)ethanamine, A new synthetic method of this compound is introduced below., Safety of N-Benzyl-2-bromo-N-(2-bromoethyl)ethanamine

To a 0 C solution of 6,7-dihydro-5H-cyclopenta[b]pyridin-5-one (1.70 g, 12.77 mmol) in DMF (20 mL) under nitrogen atmosphere was added NaH (60% dispersion in mineral oil, 982 mg, 24.55 mmol) in three portions, and the mixture was heated to 60 C, stirred for 1 h at thistemperature. Then N-benzyl-2-bromo-N-(2-bromoethyl)ethan-1-amine (4.54 g, 14.14 mmol) was added and stirred at 60 C for another 1 h. After cooling to RT, the reaction mixture was quenchedwith water (80 mL), extracted with EA (3 > 80 mL). The combined organic layers were washed with water (3 x 80 mL), dried over anhydrous Na2504, filtered and concentrated under reduced pressure. The residue was purified by silica chromatography (eluting with EA) to give1?-benzylspiro[cyclopenta[b]pyridine-6,4?-piperidin]-5(7H)-one (1.14 g). MS: m/z 293 (M+H).

The synthetic route of 24468-88-0 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; JACOBIO PHARMACEUTICALS CO., LTD.; JACOBIO-ALPHA PHARMACEUTICALS CO., LTD.; MA, Cunbo; GAO, Panliang; HU, Shaojing; XU, Zilong; HAN, Huifeng; WU, Xinping; KANG, Di; LONG, Wei; (202 pag.)WO2018/172984; (2018); A1;,
Bromide – Wikipedia,
bromide – Wiktionary

Extracurricular laboratory: Synthetic route of 24468-88-0

According to the analysis of related databases, 24468-88-0, the application of this compound in the production field has become more and more popular.

In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 24468-88-0 as follows. HPLC of Formula: C11H15Br2N

To a solution of compound 1-2 (2.56 g, 14.34 mmol) and compound 32-1 (6.905 g, 21.51 mmol) in DMF (15 mL) under N2 was added NaH (1.434g, 35.85 mmol, 60% dispersed in Mineral oil). The mixture was stirred at 50 C for 18 hours, cooled to rt, and quenched with water (20 mL). The mixture was extracted with EtOAc (150 mL x 3). The combined organic phases were washed with water, dried over anhydrous Na2SO4 and concentrated in vacuo. The residue was purified by silica gel column chromatography (hexane/EtOAc (v/v) = 8/1) to give the title compound 32-2 (0.752 g, 14.9%). The compound was characterized by the following spectroscopic data: MS-ESI: m/z 352.1 [M+H]+; and1H NMR (400 MHz, CDCl3): delta 7.63-7.56 (m, 1H), 7.41-7.22 (m, 6H), 3.82 (d, 6H), 3.56 (s, 2H), 3.03 (s, 2H), 2.98-2.89 (m, 2H), 2.24-2.00 (m, 4H), 1.37 (d, J = 11.8 Hz, 2H).

According to the analysis of related databases, 24468-88-0, the application of this compound in the production field has become more and more popular.

Some tips on 24468-88-0

Electric Literature of 24468-88-0, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 24468-88-0, name is N-Benzyl-2-bromo-N-(2-bromoethyl)ethanamine belongs to bromides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.