244205-40-1 Archives - Page 5 of 13 - Bromides-buliding-blocks

Xu, Feiyang team published research in Journal of the American Chemical Society in 2020 | 244205-40-1

SDS of cas: 244205-40-1, 2-Bromophenylboronic Acid is used as an inhibitor of the hormone sensitive lipase.
2-Bromophenylboronic acid, also known as 2-Bromophenylboronic acid, is a useful research compound. Its molecular formula is C6H6BBrO2 and its molecular weight is 200.83 g/mol. The purity is usually 95%.
2-Bromophenylboronic acid is a glucose monitoring agent that has a ruthenium complex with an acidic environment. The nitro group and the amines are in close proximity to the boron center, and this proximity leads to a high nucleophilic character of the molecule. This reactivity allows 2-bromophenylboronic acid to be used as a fluorescence probe for acidic environments. 2-Bromophenylboronic acid also inhibits secretase enzymes, which are involved in Alzheimer’s disease and other neurodegenerative disorders. It is an inhibitor of γ-secretase, which is responsible for cleaving the amyloid precursor protein (APP), and it has shown efficacy against biphenyl, an anticancer drug that binds to benzodiazepine receptors. 2-Bromophenylboronic acid is also an enantiopure compound because all four substituents are different from each other., 244205-40-1.

A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals. 244205-40-1, formula is C6H6BBrO2, Name is (2-Bromophenyl)boronic acid. Organobromine compounds have fallen under increased scrutiny for their environmental impact., SDS of cas: 244205-40-1.

Xu, Feiyang;Duke, Olivia M.;Rojas, Daniel;Eichelberger, Hanka M.;Kim, Raphael S.;Clark, Timothy B.;Watson, Donald A. research published 《 Arylphosphonate-Directed Ortho C-H Borylation: Rapid Entry into Highly-Substituted Phosphoarenes》, the research content is summarized as follows. Phosphonate-directed ortho C-H borylation of aromatic phosphonates is reported. Using simple starting materials and com. accessible catalysts, this method provides steady access to o-phosphonate arylboronic esters, e.g. I, bearing pendant functionality and flexible substitution patterns. These products serve as flexible precursors for a variety of highly substituted phosphoarenes, and in situ downstream functionalization of the products is described.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Wu, Yingtao team published research in Angewandte Chemie, International Edition in 2022 | 244205-40-1

Computed Properties of 244205-40-1, 2-Bromophenylboronic Acid is used as an inhibitor of the hormone sensitive lipase.
2-Bromophenylboronic acid, also known as 2-Bromophenylboronic acid, is a useful research compound. Its molecular formula is C6H6BBrO2 and its molecular weight is 200.83 g/mol. The purity is usually 95%.
2-Bromophenylboronic acid is a glucose monitoring agent that has a ruthenium complex with an acidic environment. The nitro group and the amines are in close proximity to the boron center, and this proximity leads to a high nucleophilic character of the molecule. This reactivity allows 2-bromophenylboronic acid to be used as a fluorescence probe for acidic environments. 2-Bromophenylboronic acid also inhibits secretase enzymes, which are involved in Alzheimer’s disease and other neurodegenerative disorders. It is an inhibitor of γ-secretase, which is responsible for cleaving the amyloid precursor protein (APP), and it has shown efficacy against biphenyl, an anticancer drug that binds to benzodiazepine receptors. 2-Bromophenylboronic acid is also an enantiopure compound because all four substituents are different from each other., 244205-40-1.

Organic bromides such as alkyl bromides are used as fumigants in agriculture to control insects. 244205-40-1, formula is C6H6BBrO2, Name is (2-Bromophenyl)boronic acid. Ethylene bromide is one of the commercially important organic bromides which are the component of leaded gasoline. Computed Properties of 244205-40-1.

Wu, Yingtao;Li, Mingrui;Sun, Jiaqiong;Zheng, Guangfan;Zhang, Qian research published 《 Synthesis of Axially Chiral Aldehydes by N-Heterocyclic-Carbene-Catalyzed Desymmetrization Followed by Kinetic Resolution》, the research content is summarized as follows. Herein an NHC-catalyzed atroposelective esterification of biaryl dialdehydes as a general and practical strategy for the construction of axially chiral aldehydes I [Ar = Ph, 1-naphthyl, 9-phenanthryl, etc.; R¹ = Et, CH₂CF₃, cyclopropyl, etc.] was described. Mechanistic studies indicated that coupling proceeds through a novel combination of NHC-catalyzed desymmetrization of the dialdehydes and kinetic resolution This protocol featured excellent enantioselectivity, mild conditions, good functional-group tolerance and applicability to late-stage functionalization and provided a modular platform for the synthesis of axially chiral aldehydes and their derivatives

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Xi, Yang team published research in Journal of the American Chemical Society in 2022 | 244205-40-1

HPLC of Formula: 244205-40-1, 2-Bromophenylboronic Acid is used as an inhibitor of the hormone sensitive lipase.
2-Bromophenylboronic acid, also known as 2-Bromophenylboronic acid, is a useful research compound. Its molecular formula is C6H6BBrO2 and its molecular weight is 200.83 g/mol. The purity is usually 95%.
2-Bromophenylboronic acid is a glucose monitoring agent that has a ruthenium complex with an acidic environment. The nitro group and the amines are in close proximity to the boron center, and this proximity leads to a high nucleophilic character of the molecule. This reactivity allows 2-bromophenylboronic acid to be used as a fluorescence probe for acidic environments. 2-Bromophenylboronic acid also inhibits secretase enzymes, which are involved in Alzheimer’s disease and other neurodegenerative disorders. It is an inhibitor of γ-secretase, which is responsible for cleaving the amyloid precursor protein (APP), and it has shown efficacy against biphenyl, an anticancer drug that binds to benzodiazepine receptors. 2-Bromophenylboronic acid is also an enantiopure compound because all four substituents are different from each other., 244205-40-1.

Xi, Yang;Huang, Wenyi;Wang, Chenchen;Ding, Haojie;Xia, Tingting;Wu, Licheng;Fang, Ke;Qu, Jingping;Chen, Yifeng research published 《 Catalytic Asymmetric Diarylation of Internal Acyclic Styrenes and Enamides》, the research content is summarized as follows. Enantioselective transformations of olefins are among the most important strategies for the asym. synthesis of organic compounds Chemo-, diastereo-, and stereoselective control of reactions with internal acyclic alkenes for the construction of functionalized acyclic alkanes still remain a persistent challenge. Here, authors report a palladium-catalyzed asym. regiodivergent Heck-type diarylation of internal acyclic alkenes. The 1,2-diarylation of two accessible acyclic alkenes, cinnamyl carbamates and enamides with diazonium salts and aromatic boronic acids, furnishes products containing vicinal stereogenic centers via the stereospecific formation of carbonyl coordination-assisted transient palladacycles. Moreover, the asym. migratory diarylation of enamides enables the formation of incontiguous stereocenters by an interrupted diastereoselective 1,3-chain-walking process. This protocol streamlines access to highly functionalized multisubstituted enantioenriched carbamates and amine derivatives which are embedded in the key biol. active motifs.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Wood, James M. team published research in Bioorganic & Medicinal Chemistry in 2020 | 244205-40-1

Reference of 244205-40-1, 2-Bromophenylboronic Acid is used as an inhibitor of the hormone sensitive lipase.
2-Bromophenylboronic acid, also known as 2-Bromophenylboronic acid, is a useful research compound. Its molecular formula is C6H6BBrO2 and its molecular weight is 200.83 g/mol. The purity is usually 95%.
2-Bromophenylboronic acid is a glucose monitoring agent that has a ruthenium complex with an acidic environment. The nitro group and the amines are in close proximity to the boron center, and this proximity leads to a high nucleophilic character of the molecule. This reactivity allows 2-bromophenylboronic acid to be used as a fluorescence probe for acidic environments. 2-Bromophenylboronic acid also inhibits secretase enzymes, which are involved in Alzheimer’s disease and other neurodegenerative disorders. It is an inhibitor of γ-secretase, which is responsible for cleaving the amyloid precursor protein (APP), and it has shown efficacy against biphenyl, an anticancer drug that binds to benzodiazepine receptors. 2-Bromophenylboronic acid is also an enantiopure compound because all four substituents are different from each other., 244205-40-1.

Vinyl bromides undergo the Heck reaction, which involves C-C coupling with alkene to give substituted alkenes. 244205-40-1, formula is C6H6BBrO2, Name is (2-Bromophenyl)boronic acid. Methyl bromide is a precursor in the manufacture of several chemicals and is employed as a soil sterilant, mainly for seed production. Reference of 244205-40-1.

Wood, James M.;Satam, Nishikant S.;Almeida, Renata G.;Cristani, Vinicius S.;de Lima, Denis P.;Dantas-Pereira, Luiza;Salomao, Kelly;Menna-Barreto, Rubem F. S.;Namboothiri, Irishi N. N.;Bower, John F.;da Silva, Eufranio N. Junior research published 《 Strategies towards potent trypanocidal drugs: Application of Rh-catalyzed [2 + 2 + 2] cycloadditions, sulfonyl phthalide annulation and nitroalkene reactions for the synthesis of substituted quinones and their evaluation against Trypanosoma cruzi》, the research content is summarized as follows. Rhodium-catalyzed [2 + 2 + 2] cycloadditions, sulfonyl phthalide annulations and nitroalkene reactions were employed for the synthesis of 56 quinone-based compounds such as I [R¹ = H, I, OMe, NMePh, etc.; R² = H, Me, Ph, etc.], II [R = 2-Me, 2-OMe, 4-OEt, etc.] and III [X = O, NBu, NPh, etc.; Ar = Ph, 4-tolyl, 2-furyl, etc.]. These were evaluated against Trypanosoma cruzi, the parasite that causes Chagas disease. The reactions described here were part of a program that aims to utilize modern, versatile and efficient synthetic methods for the one or two step preparation of trypanocidal compounds Among the tested compounds 9 compounds were identified with potent activity against the parasite; 3 of these were 30-fold more potent than benznidazole, a drug used for the treatment of Chagas disease. This article provides a comprehensive outline of reactions involving over 120 compounds aimed at the discovery of new quinone-based frameworks with activity against T. cruzi.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Wu, Dunqi team published research in ACS Catalysis in 2022 | 244205-40-1

Application of C6H6BBrO2, 2-Bromophenylboronic Acid is used as an inhibitor of the hormone sensitive lipase.
2-Bromophenylboronic acid, also known as 2-Bromophenylboronic acid, is a useful research compound. Its molecular formula is C6H6BBrO2 and its molecular weight is 200.83 g/mol. The purity is usually 95%.
2-Bromophenylboronic acid is a glucose monitoring agent that has a ruthenium complex with an acidic environment. The nitro group and the amines are in close proximity to the boron center, and this proximity leads to a high nucleophilic character of the molecule. This reactivity allows 2-bromophenylboronic acid to be used as a fluorescence probe for acidic environments. 2-Bromophenylboronic acid also inhibits secretase enzymes, which are involved in Alzheimer’s disease and other neurodegenerative disorders. It is an inhibitor of γ-secretase, which is responsible for cleaving the amyloid precursor protein (APP), and it has shown efficacy against biphenyl, an anticancer drug that binds to benzodiazepine receptors. 2-Bromophenylboronic acid is also an enantiopure compound because all four substituents are different from each other., 244205-40-1.

Wu, Dunqi;Fan, Wenzheng;Wu, Lianqian;Chen, Pinhong;Liu, Guosheng research published 《 Copper-Catalyzed Enantioselective Radical Chlorination of Alkenes》, the research content is summarized as follows. In this report, authors reviewed a copper-catalyzed asym. atom transfer radical addition (ATRA) reaction, which remains a great challenge since the discovery of racemic ATRA in the 1940s. This enantioselective radical chlorination of acrylamides was developed, where three reagents, including Togni-I and TMSCl, PhICF₃Cl, and CX₃SO₂Cl, were employed as the radical sources and chlorine source, affording a series of chlorinated carbon-centered quaternary compounds in good yields with excellent enantioselectivity. Notably, the well-designed bulky chiral ligand plays a key role in the successful enantioselective radical chlorination process.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Wu, Jiaoyu team published research in Chemical Communications (Cambridge, United Kingdom) in 2021 | 244205-40-1

Recommanded Product: (2-Bromophenyl)boronic acid, 2-Bromophenylboronic Acid is used as an inhibitor of the hormone sensitive lipase.
2-Bromophenylboronic acid, also known as 2-Bromophenylboronic acid, is a useful research compound. Its molecular formula is C6H6BBrO2 and its molecular weight is 200.83 g/mol. The purity is usually 95%.
2-Bromophenylboronic acid is a glucose monitoring agent that has a ruthenium complex with an acidic environment. The nitro group and the amines are in close proximity to the boron center, and this proximity leads to a high nucleophilic character of the molecule. This reactivity allows 2-bromophenylboronic acid to be used as a fluorescence probe for acidic environments. 2-Bromophenylboronic acid also inhibits secretase enzymes, which are involved in Alzheimer’s disease and other neurodegenerative disorders. It is an inhibitor of γ-secretase, which is responsible for cleaving the amyloid precursor protein (APP), and it has shown efficacy against biphenyl, an anticancer drug that binds to benzodiazepine receptors. 2-Bromophenylboronic acid is also an enantiopure compound because all four substituents are different from each other., 244205-40-1.

Dehydrobromination, Grignard reactions, reductive coupling, Wittig reaction, and several nucleophilic substitution reactions are some of the principal reactions which involve organic bromides. 244205-40-1, formula is C6H6BBrO2, Name is (2-Bromophenyl)boronic acid. Organic compounds having carbon bonded to bromine are called organic bromides. Recommanded Product: (2-Bromophenyl)boronic acid.

Wu, Jiaoyu;Bai, Lu;Han, Lingbo;Liu, Jingjing;Luan, Xinjun research published 《 A chemo- and regioselective Pd(0)-catalyzed three-component spiroannulation》, the research content is summarized as follows. A chemo- and regioselective Pd(0)-catalyzed spiroannulation has been successfully developed. The key feature of this method is the use of readily available 1,2-dihaloarenes (Cl, Br, I), alkynes and 2-naphthols for the rapid assembly of spirocarbocyclic mols I (R = H, 5-OMe, 6-F, etc.; R¹ = H, 6-OMe, 7- OMe, 3-Cl, etc.; R² = C₆H₅, Me, cyclopropyl, 2-thienyl, etc.; R³ = 4-MeC₆H₄, TMS, 4-FC₆H₄, 2-thienyl, etc.). Mechanistic studies revealed that this domino reaction proceeded through a cascade of oxidative addition to Pd(0), alkyne migratory insertion, and 2-naphthol-facilitated dearomatizing [4+1] spiroannulation.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Wei, Jingwen team published research in Organic Chemistry Frontiers in 2022 | 244205-40-1

Wei, Jingwen;Liu, Mengjia;Ye, Xiaohan;Zhang, Shuyao;Sun, Elaine;Shan, Chuan;Wojtas, Lukasz;Shi, Xiaodong research published 《 Facile synthesis of diverse hetero polyaromatic hydrocarbons (PAHs) via the styryl Diels-Alder reaction of conjugated diynes》, the research content is summarized as follows. The styryl dehydro-Diels-Alder reaction with a conjugated diyne was reported. While typical alkyne-styrene condensation requires elevated temperatures (>160°), the application of a conjugated diyne allowed for effective transformation under milder conditions (80°). The thermally stable triazole-gold (TA-Au) catalyst further improved the reaction yields (up to 95%), producing the desired alkynyl-naphthalene in a single step with mol. oxygen as the oxidant. Sequential alkyne activation resulted in various polyaromatic hydrocarbons (PAHs) in excellent yields, highlighting the efficiency of this new strategy for the preparation of PAHs with good functional group tolerance and structural diversity.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Wei, Leping team published research in Journal of Organic Chemistry in 2021 | 244205-40-1

COA of Formula: C6H6BBrO2, 2-Bromophenylboronic Acid is used as an inhibitor of the hormone sensitive lipase.
2-Bromophenylboronic acid, also known as 2-Bromophenylboronic acid, is a useful research compound. Its molecular formula is C6H6BBrO2 and its molecular weight is 200.83 g/mol. The purity is usually 95%.
2-Bromophenylboronic acid is a glucose monitoring agent that has a ruthenium complex with an acidic environment. The nitro group and the amines are in close proximity to the boron center, and this proximity leads to a high nucleophilic character of the molecule. This reactivity allows 2-bromophenylboronic acid to be used as a fluorescence probe for acidic environments. 2-Bromophenylboronic acid also inhibits secretase enzymes, which are involved in Alzheimer’s disease and other neurodegenerative disorders. It is an inhibitor of γ-secretase, which is responsible for cleaving the amyloid precursor protein (APP), and it has shown efficacy against biphenyl, an anticancer drug that binds to benzodiazepine receptors. 2-Bromophenylboronic acid is also an enantiopure compound because all four substituents are different from each other., 244205-40-1.

Wei, Leping;Deng, Xin;Yu, Xiaohui;Li, Xiaohui;Wang, Wei;Zhang, Chunfang;Xiao, Jinchong research published 《 Double π-Extended Helicene Derivatives Containing Pentagonal Rings: Synthesis, Crystal Analyses, and Photophysics》, the research content is summarized as follows. Two novel double π-extended [n]helicene (n = 5, 6) derivatives (7b and 9) including pentagonal rings have been synthesized and characterized. Both of them have three isomers containing two enantiomers (P₆), (M₆), and a diastereoisomer in a meso form (P,M). X-ray single crystal analyses suggest that mols. 7b and 9 exhibit offset packing models of (P₆,P₅)- and (M₆,M₅)-isomers. Optical resolution of the resultant compound 7b was finished, and their chiroptical properties, as well as the DFT calculations, were also examined

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Wang, Qiuyuan team published research in Organic Letters in 2022 | 244205-40-1

Quality Control of 244205-40-1, 2-Bromophenylboronic Acid is used as an inhibitor of the hormone sensitive lipase.
2-Bromophenylboronic acid, also known as 2-Bromophenylboronic acid, is a useful research compound. Its molecular formula is C6H6BBrO2 and its molecular weight is 200.83 g/mol. The purity is usually 95%.
2-Bromophenylboronic acid is a glucose monitoring agent that has a ruthenium complex with an acidic environment. The nitro group and the amines are in close proximity to the boron center, and this proximity leads to a high nucleophilic character of the molecule. This reactivity allows 2-bromophenylboronic acid to be used as a fluorescence probe for acidic environments. 2-Bromophenylboronic acid also inhibits secretase enzymes, which are involved in Alzheimer’s disease and other neurodegenerative disorders. It is an inhibitor of γ-secretase, which is responsible for cleaving the amyloid precursor protein (APP), and it has shown efficacy against biphenyl, an anticancer drug that binds to benzodiazepine receptors. 2-Bromophenylboronic acid is also an enantiopure compound because all four substituents are different from each other., 244205-40-1.

Wang, Qiuyuan;Lai, Mengnan;Luo, Huajun;Ren, Keke;Wang, Jingrui;Huang, Nianyu;Deng, Zhangshuang;Zou, Kun;Yao, Hui research published 《 Stereoselective O-Glycosylation of Glycals with Arylboronic Acids Using Air as the Oxygen Source》, the research content is summarized as follows. An open-air palladium-catalyzed O-glycosylation was developed using glycals and arylboronic acids with base additives at ambient conditions. The novel approach enabled facile access to various O-glycosides in high yields, with exclusive 1,4-cis-stereoselectivity tolerating reactive hydroxyl/amino groups. Mechanistic studies indicated that chemo-/stereoselectivity arose from the coordination between palladium and phenols generated in situ by oxidizing arylboronic acids, followed by an intramol. attack. Isotope-labeling experiments revealed that the oxygen of O-glycosidic bonds came from O₂.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Wang, Min team published research in Advanced Synthesis & Catalysis in 2021 | 244205-40-1

Electric Literature of 244205-40-1, 2-Bromophenylboronic Acid is used as an inhibitor of the hormone sensitive lipase.
2-Bromophenylboronic acid, also known as 2-Bromophenylboronic acid, is a useful research compound. Its molecular formula is C6H6BBrO2 and its molecular weight is 200.83 g/mol. The purity is usually 95%.
2-Bromophenylboronic acid is a glucose monitoring agent that has a ruthenium complex with an acidic environment. The nitro group and the amines are in close proximity to the boron center, and this proximity leads to a high nucleophilic character of the molecule. This reactivity allows 2-bromophenylboronic acid to be used as a fluorescence probe for acidic environments. 2-Bromophenylboronic acid also inhibits secretase enzymes, which are involved in Alzheimer’s disease and other neurodegenerative disorders. It is an inhibitor of γ-secretase, which is responsible for cleaving the amyloid precursor protein (APP), and it has shown efficacy against biphenyl, an anticancer drug that binds to benzodiazepine receptors. 2-Bromophenylboronic acid is also an enantiopure compound because all four substituents are different from each other., 244205-40-1.

Wang, Min;Liu, Yue;Wang, Liying;Lu, Haifeng;Feng, Lei;Gao, Hongyin research published 《 Cascade Chan-Lam C-O Coupling/[3,3]-Rearrangement of Arylhydroxylamines with Arylboronic Acids Toward NOBIN Analogues》, the research content is summarized as follows. A copper-mediated Chan-Lam type O-arylation of arylhydroxylamines RN(OH)R¹ (R = naphthalen-2-yl, Ph, 6-methoxy-5-(naphthalen-1-yl)pyridin-3-yl, etc.;R¹ = Bz, BOC, Cbz, etc.) with arylboronic acids R²B(OH)₂ (R² = Ph, phenanthren-9-yl, naphthalen-2-yl, etc.) to generate transient N,O-diarylhydroxylamines e.g., N-(1-(2-hydroxyphenyl)naphthalen-2-yl)benzamide that could rapidly undergo cascade [3,3]-sigmatropic rearrangement and rearomatization to afford NOBIN e.g., (R)-N-(2′-hydroxy-[1,1′-binaphthalen]-2-yl)benzamide and e.g., (S)-2′-benzamido-[1,1′-binaphthalen]-2-yl isobutyrate analogs under mild conditions was developed. The newly synthesized racemic biaryl products e.g., N-(2′-hydroxy-[1,1′-binaphthalen]-2-yl)benzamide can be further resolved by a chiral DMAP-catalyzed O-acylation/kinetic resolution protocol.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary