244205-40-1 Archives - Bromides-buliding-blocks

Zhu, Dong team published research in Chemical Science in 2022 | 244205-40-1

244205-40-1, 2-Bromophenylboronic Acid is used as an inhibitor of the hormone sensitive lipase.
2-Bromophenylboronic acid, also known as 2-Bromophenylboronic acid, is a useful research compound. Its molecular formula is C6H6BBrO2 and its molecular weight is 200.83 g/mol. The purity is usually 95%.
2-Bromophenylboronic acid is a glucose monitoring agent that has a ruthenium complex with an acidic environment. The nitro group and the amines are in close proximity to the boron center, and this proximity leads to a high nucleophilic character of the molecule. This reactivity allows 2-bromophenylboronic acid to be used as a fluorescence probe for acidic environments. 2-Bromophenylboronic acid also inhibits secretase enzymes, which are involved in Alzheimer’s disease and other neurodegenerative disorders. It is an inhibitor of γ-secretase, which is responsible for cleaving the amyloid precursor protein (APP), and it has shown efficacy against biphenyl, an anticancer drug that binds to benzodiazepine receptors. 2-Bromophenylboronic acid is also an enantiopure compound because all four substituents are different from each other., Safety of (2-Bromophenyl)boronic acid

Vinyl bromides undergo the Heck reaction, which involves C-C coupling with alkene to give substituted alkenes. 244205-40-1, formula is C6H6BBrO2, Name is (2-Bromophenyl)boronic acid. Methyl bromide is a precursor in the manufacture of several chemicals and is employed as a soil sterilant, mainly for seed production. Safety of (2-Bromophenyl)boronic acid.

Zhu, Dong;Cao, Tongxiang;Chen, Kai;Zhu, Shifa research published 《 Rh₂(II)-catalyzed enantioselective intramolecular Buchner reaction and aromatic substitution of donor-donor carbenes》, the research content is summarized as follows. The chiral dirhodium(II) tetracarboxylate-catalyzed enantioselective intramol. Buchner reaction of donor/donor-carbenes was reported and a series of valuable chiral polycyclic products were synthesized. Both aryloxy enynones and diazo compounds were efficient carbene precursors for this reaction. Excellent yields (up to 99%) and outstanding enantioselectivities (up to >99% ee) were achieved under standard conditions. For furyl substituted chiral cyclohepta[b]benzofurans bearing a substituent at the C4 position on cycloheptatrienes, control reactions showed that the chiral Buchner products could slowly racemize either under dark or natural light conditions. A diradical-involved mechanism rather than a zwitterionic intermediate was proposed to explain the racemization. Furthermore, furyl substituted chiral fluorene derivatives were obtained via asym. aromatic substitution when biaryl enynones were employed as carbene precursors.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Zhu, Xiaoyan team published research in Organic Letters in 2022 | 244205-40-1

One prominent application of synthetic organobromine compounds is the use of polybrominated diphenyl ethers as fire-retardants, and in fact fire-retardant manufacture is currently the major industrial use of the element bromine. 244205-40-1, formula is C6H6BBrO2, Name is (2-Bromophenyl)boronic acid, Product Details of C6H6BBrO2

Zhu, Xiaoyan;Liu, Feng;Ba, Xinwu;Wu, Yonggang research published 《 Synthesis of Ladder-Type 9,9′-Bifluorenylidene-Based Conjugated Oligomers via a Pd-Catalyzed Tandem Suzuki Coupling/Heck Cyclization Approach》, the research content is summarized as follows. For new ladder-type oligomers and polymers with versatile and robust synthetic strategies, in this study, four fully conjugated ladder-type overcrowded 9,9′-bifluorenylidene-based compounds and oligomers (BFY1, BFY2, BFY3, and BFY4) were synthesized via a Pd-catalyzed tandem Suzuki coupling/Heck cyclization reaction. By monomer screening and route optimization, the target products were obtained in high yields and characterized by ¹H and ¹³C NMR spectroscopy and high resolution mass spectroscopy.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Zhong, Jing team published research in Organic Letters in 2022 | 244205-40-1

Product Details of C6H6BBrO2, 2-Bromophenylboronic Acid is used as an inhibitor of the hormone sensitive lipase.
2-Bromophenylboronic acid, also known as 2-Bromophenylboronic acid, is a useful research compound. Its molecular formula is C6H6BBrO2 and its molecular weight is 200.83 g/mol. The purity is usually 95%.
2-Bromophenylboronic acid is a glucose monitoring agent that has a ruthenium complex with an acidic environment. The nitro group and the amines are in close proximity to the boron center, and this proximity leads to a high nucleophilic character of the molecule. This reactivity allows 2-bromophenylboronic acid to be used as a fluorescence probe for acidic environments. 2-Bromophenylboronic acid also inhibits secretase enzymes, which are involved in Alzheimer’s disease and other neurodegenerative disorders. It is an inhibitor of γ-secretase, which is responsible for cleaving the amyloid precursor protein (APP), and it has shown efficacy against biphenyl, an anticancer drug that binds to benzodiazepine receptors. 2-Bromophenylboronic acid is also an enantiopure compound because all four substituents are different from each other., 244205-40-1.

Organic bromides such as alkyl bromides are used as fumigants in agriculture to control insects. 244205-40-1, formula is C6H6BBrO2, Name is (2-Bromophenyl)boronic acid. Ethylene bromide is one of the commercially important organic bromides which are the component of leaded gasoline. Product Details of C6H6BBrO2.

Zhong, Jing;Zhou, Wuxin;Yan, Xufei;Xia, Ying;Xiang, Haifeng;Zhou, Xiangge research published 《 Selective Activation of Unstrained C(O)-C Bond in Ketone Suzuki-Miyaura Coupling Reaction Enabled by Hydride-Transfer Strategy》, the research content is summarized as follows. A Rh(I)-catalyzed ketone Suzuki-Miyaura coupling reaction of benzylacetone with arylboronic acids RB(OH)₂ (R = Ph, 4-methoxyphenyl, naphthalen-2-yl, etc.) is developed. Selective C(O)-C bond activation, which employs aminopyridine as temporary directing group (TDG) and Et vinyl ketone as hydride acceptor, occurs on the alkyl chain containing β-position hydrogen. A series of acetophenone products CH₃C(O)R was obtained in yields up to 75%.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Zhou, Liwei team published research in Organic Letters in 2021 | 244205-40-1

Zhou, Liwei;Sun, Mingjie;Zhou, Fengru;Deng, Guobo;Yang, Yuan;Liang, Yun research published 《 Atmosphere-Controlled Palladium-Catalyzed Divergent Decarboxylative Cyclization of 2-Iodobiphenyls and α-Oxocarboxylic Acids》, the research content is summarized as follows. A novel palladium-catalyzed divergent decarboxylative cyclization of 2-iodobiphenyls and α-oxocarboxylic acids utilizing the atm. as a controlled switch was reported. Under the protection of a nitrogen atm., tribenzotropones are synthesized by a [4 + 3] decarboxylative cyclization. Employing a palladium/O₂ system enables a [4 + 2] decarboxylative cyclization to assemble triphenylenes. Notably, preliminary mechanistic studies indicate that the formation of triphenylenes involved a double decarboxylation.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Zhang, Yuanzhe team published research in Angewandte Chemie, International Edition in 2020 | 244205-40-1

Zhang, Yuanzhe;Li, Bo;Liu, Shih-Yuan research published 《 Pd-Senphos Catalyzed trans-Selective Cyanoboration of 1,3-Enynes》, the research content is summarized as follows. The first trans-selective cyanoboration reaction of an alkyne, specifically a 1,3-enyne, is described. The reported palladium-catalyzed cyanoboration of 1,3-enynes is site-, regio-, and diastereoselective, and is uniquely enabled by the 1,4-azaborine-based Senphos ligand structure. Tetra-substituted alkenyl nitriles, e.g. I, are obtained providing useful boron-dienenitrile building blocks that can be further functionalized. The utility of our method has been demonstrated with the synthesis of Satigrel, an anti-platelet aggregating agent.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Zhao, Jie team published research in Advanced Synthesis & Catalysis in 2021 | 244205-40-1

Category: bromides-buliding-blocks, 2-Bromophenylboronic Acid is used as an inhibitor of the hormone sensitive lipase.
2-Bromophenylboronic acid, also known as 2-Bromophenylboronic acid, is a useful research compound. Its molecular formula is C6H6BBrO2 and its molecular weight is 200.83 g/mol. The purity is usually 95%.
2-Bromophenylboronic acid is a glucose monitoring agent that has a ruthenium complex with an acidic environment. The nitro group and the amines are in close proximity to the boron center, and this proximity leads to a high nucleophilic character of the molecule. This reactivity allows 2-bromophenylboronic acid to be used as a fluorescence probe for acidic environments. 2-Bromophenylboronic acid also inhibits secretase enzymes, which are involved in Alzheimer’s disease and other neurodegenerative disorders. It is an inhibitor of γ-secretase, which is responsible for cleaving the amyloid precursor protein (APP), and it has shown efficacy against biphenyl, an anticancer drug that binds to benzodiazepine receptors. 2-Bromophenylboronic acid is also an enantiopure compound because all four substituents are different from each other., 244205-40-1.

Dehydrobromination, Grignard reactions, reductive coupling, Wittig reaction, and several nucleophilic substitution reactions are some of the principal reactions which involve organic bromides. 244205-40-1, formula is C6H6BBrO2, Name is (2-Bromophenyl)boronic acid. Organic compounds having carbon bonded to bromine are called organic bromides. Category: bromides-buliding-blocks.

Zhao, Jie;Huang, Bing-Qing;Zhu, Bin-Can;Ma, Xiao-Pan;Mo, Dong-Liang research published 《 Visible Light Promoted Chan-Lam Reaction and Cycloaddition to Prepare Chromeno[4,3-c]isoxazolidines in One-Pot Reaction》, the research content is summarized as follows. A variety of chromeno[4,3-c]isoxazolidines were prepared in good yields through visible light promoted Chan-Lam reaction and [3+2] cycloaddition cascade reaction in one pot. Mechanistic studies showed that visible light promoted both Chan-Lam reaction and cycloaddition The obtained products were converted to various useful chromenone derivatives Moreover, the reaction was easily performed at gram scales with the purification of products without column chromatog. and used to efficiently synthesize estrone-derived chromeno[4,3-c]isoxazolidine.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Zhang, Ming-Lu team published research in Journal of Organic Chemistry in 2022 | 244205-40-1

A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals. 244205-40-1, formula is C6H6BBrO2, Name is (2-Bromophenyl)boronic acid. Organobromine compounds have fallen under increased scrutiny for their environmental impact., Category: bromides-buliding-blocks.

Zhang, Ming-Lu;Zhang, Xing-Long;Guo, Rui-Li;Wang, Meng-Yue;Zhao, Bao-Yin;Yang, Jin-Hui;Jia, Qiong;Wang, Yong-Qiang research published 《 Switchable, Reagent-Controlled C(sp³)-H Selective Iodination and Acetoxylation of 8-Methylquinolines》, the research content is summarized as follows. An efficient Pd-catalyzed C(sp³)-H selective iodination of 8-methylquinolines I (R = H, Ph, 4-chlorophenyl; R¹ = H, Cl, Ph, etc.; R² = H, F, Cl, Br; R³ = H, Cl, Br, I) is reported herein for the first time. Because of the versatility of organic iodides, the method offers a facile access to various C8-substituted quinolines II. By slightly switching the reaction conditions, an efficient C(sp³)-H acetoxylation of 8-methylquinolines I has also been enabled. Both approaches feature mild reaction conditions, good tolerance of functional groups, and a broad substrate scope.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Zhang, Qiaohong team published research in Journal of Chemical Technology and Biotechnology in 2020 | 244205-40-1

Safety of (2-Bromophenyl)boronic acid, 2-Bromophenylboronic Acid is used as an inhibitor of the hormone sensitive lipase.
2-Bromophenylboronic acid, also known as 2-Bromophenylboronic acid, is a useful research compound. Its molecular formula is C6H6BBrO2 and its molecular weight is 200.83 g/mol. The purity is usually 95%.
2-Bromophenylboronic acid is a glucose monitoring agent that has a ruthenium complex with an acidic environment. The nitro group and the amines are in close proximity to the boron center, and this proximity leads to a high nucleophilic character of the molecule. This reactivity allows 2-bromophenylboronic acid to be used as a fluorescence probe for acidic environments. 2-Bromophenylboronic acid also inhibits secretase enzymes, which are involved in Alzheimer’s disease and other neurodegenerative disorders. It is an inhibitor of γ-secretase, which is responsible for cleaving the amyloid precursor protein (APP), and it has shown efficacy against biphenyl, an anticancer drug that binds to benzodiazepine receptors. 2-Bromophenylboronic acid is also an enantiopure compound because all four substituents are different from each other., 244205-40-1.

Zhang, Qiaohong;Wang, Huibin;Hu, Wenkang;Xu, Xiaqing;Xu, Zhaojun;Chen, Chen;Wang, Dawei research published 《 The Cascade C-H functionalization with sequential hydroxylation and oxidation through heterogeneous BINAP-copper on hydrotalcite》, the research content is summarized as follows. A cascade C-H hydroxylation and further oxidation process, 2-sulfanylphenols 6-OH-R¹C₆H₃S(R² C₆H₄) (R¹ = H, 2-Br, 3-Br, 4-CF₃, etc.; R² = H, 2-OMe, 3-OMe, 4-F, etc.) and arylthioquinones I (R³ = H, 2,6-Cl₂, 3-Br, 4-tBu, etc.) use the heterogeneous catalyst [Cu(binap)I]₂@HT. The catalytic system was tolerant to various substituents including alkyl, alkoxy, ester, halogen or trifluoromethyl on the Ph ring of the thiophenols R¹C₆H₄SH/3-R⁴OC₆H₄SH (R⁴ = H, Me) or arylboronic acids R⁵B(OH)₂ (R⁵ = Ph, 4-ethoxyphenyl, 2,6-dichlorophenyl, etc.). In addition to electron-donating groups, the products with strong electron-withdrawing groups, such as Me formylate and trifluoromethyl also were achieved with good yields at 90°C for 12h (68% and 66%, resp.). Repeated experiment results showed that the catalyst could be reused at least five times without obvious decrease in catalytic activity.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Zeng, Yan team published research in Journal of Heterocyclic Chemistry in 2022 | 244205-40-1

Reference of 244205-40-1, 2-Bromophenylboronic Acid is used as an inhibitor of the hormone sensitive lipase.
2-Bromophenylboronic acid, also known as 2-Bromophenylboronic acid, is a useful research compound. Its molecular formula is C6H6BBrO2 and its molecular weight is 200.83 g/mol. The purity is usually 95%.
2-Bromophenylboronic acid is a glucose monitoring agent that has a ruthenium complex with an acidic environment. The nitro group and the amines are in close proximity to the boron center, and this proximity leads to a high nucleophilic character of the molecule. This reactivity allows 2-bromophenylboronic acid to be used as a fluorescence probe for acidic environments. 2-Bromophenylboronic acid also inhibits secretase enzymes, which are involved in Alzheimer’s disease and other neurodegenerative disorders. It is an inhibitor of γ-secretase, which is responsible for cleaving the amyloid precursor protein (APP), and it has shown efficacy against biphenyl, an anticancer drug that binds to benzodiazepine receptors. 2-Bromophenylboronic acid is also an enantiopure compound because all four substituents are different from each other., 244205-40-1.

Zeng, Yan;Nie, Lifei;Liu, Liu;Niu, Chao;Li, Yi;Bozorov, Khurshed;Zhao, Jiangyu;Shen, Jingshan;Aisa, Haji Akber research published 《 Design, synthesis, in vitro evaluation of a new pyrrolo[1,2-a]thiazolo[5,4-d]pyrimidinone derivatives as cholinesterase inhibitors against Alzheimer’s disease》, the research content is summarized as follows. Synthesis of pyrrolo[1,2-a]thiazolo[5,4-d]pyrimidinone derivatives I (R = Ph, 2-methylphenyl, 4-(trifluoromethyl)phenyl, etc.) were designed as cholinesterase inhibitor agents. The in vitro enzyme assays proved that most of the compounds effectively inhibited cholinesterases in the micromolar range with little cytotoxicity. Compound I (R = 4-(trifluoromethyl)phenyl) exhibited the best inhibitory activity against acetylcholinesterase with an IC₅₀ of 2.69±0.17μ M. Kinetic anal. and mol. modeling testified that the competitive inhibition manner of I (R = 4-(trifluoromethyl)phenyl) was more likely to bind to the active center of acetylcholinesterase. Thus, compound I (R = 4-(trifluoromethyl)phenyl) can be considered as promising lead compounds or candidates for the development of novel drugs against Alzheimer’ disease.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Zhang, Chenlu team published research in Reactive & Functional Polymers in 2021 | 244205-40-1

Zhang, Chenlu;Zhu, Hai;Gang, Kaiyue;Tao, Minli;Ma, Ning;Zhang, Wenqin research published 《 Immobilization of copper(II) into polyacrylonitrile fiber toward efficient and recyclable catalyst in Chan-Lam coupling reactions》, the research content is summarized as follows. A series of polyacrylonitrile fiber (PANF)-supported copper(II) catalysts were prepared through the immobilization of Cu(II) into prolinamide-modified PANF (PAN_PA-2F) and subsequently used for the synthesis of diverse N-arylimidazoles from arylboronic acids and imidazole. The prepared Cu(II)@PAN_PA-2Fs were well characterized by mech. strength, FT-IR, XRD, XPS and SEM. Among them, CuCl₂@PAN_PA-2F exhibited excellent catalytic performance and its activity was significantly affected by the Cu loading. This catalytic system also displayed good activity in the synthesis of N-arylsulfonamides from arylboronic acids and tosyl azide. The catalyst was highly efficient in gram-scale reactions and could be reused five times. The advantages of low cost, easy preparation, good durability, and facile recovery made the fiber catalyst attractive.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary