Category: 24358-62-1

Related Products of 24358-62-1, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 24358-62-1, name is 1-(4-Bromophenyl)ethylamine, This compound has unique chemical properties. The synthetic route is as follows.

A solution of 4-bromo-alpha-methylbenzylamine (1.5 g, 7.7 mmol), 3-pyridinecarboxaldehyde (0.8 g, 7.5 mmol), and sodium triacetoxyborohydride (2.25 g, 10.5 mmol) in 60 ml of 1,2-dichloroethane was stirred at room temperature for 18 h. The solution was diluted with dichloromethane and washed twice with a saturated sodium bicarbonate solution, once with water, and once with brine. The organic layer was separated, dried over sodium sulfate, filtered, and concentrated in vacuo to afford the title compound. 1H NMR: 8.70 (m,2H), 7.85 (m,1H), 7.67 (d,2H,J=8 Hz), 7.45 (d,2H,J=8 Hz), 7.43 (m,1H), 3.95 (q,1H,J=8 Hz), 3.83 (q,ABX,2H), 1.57 (d,3H,J=8 Hz). MS calcd. 291.2; MS (M+1) 292.1.

The chemical industry reduces the impact on the environment during synthesis 1-(4-Bromophenyl)ethylamine. I believe this compound will play a more active role in future production and life.

Reference:
Patent; Coleman, Darrell Stephen; Jagdmann, Gunnar Erik; Johnson, Kirk Willis; Johnson, Michael Parvin; Large, Thomas Hallett; Monn, James Allen; Schoepp, Darryle Darwin; Barda, David Anthony; Britton, Thomas Charles; Dressman, Bruce Anthony; Henry, Steven Scott; Hornback, William Joseph; Tizzano, Joseph Patrick; Fichtner, Michael William; US2004/6114; (2004); A1;,
Bromide – Wikipedia,
bromide – Wiktionary

In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 24358-62-1 as follows. name: 1-(4-Bromophenyl)ethylamine

A solution of 4-bromo-alfa-methylbenzylamine (1 mmol) and 3,5-bis-(trifluoromethyl)phenyl isothiocyanate (1 mmol) in CHCI2 (5 mL) was stirred at r.t. for 24 h. The precipitate was collected and washed with n-heptane, giving compound C as white crystals (158 mg).

According to the analysis of related databases, 24358-62-1, the application of this compound in the production field has become more and more popular.

Reference:
Patent; LICA PHARMACEUTICALS; WO2008/43840; (2008); A2;,
Bromide – Wikipedia,
bromide – Wiktionary

Related Products of 24358-62-1,Some common heterocyclic compound, 24358-62-1, name is 1-(4-Bromophenyl)ethylamine, molecular formula is C8H10BrN, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

EXAMPLE 193A 1-bromo-4-(1-isocyanatoethyl)benzene The title compound was prepared using the procedure described in Example 61A using 1-(4-bromophenyl)ethylamine instead of 5-aminoisoquinoline.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 1-(4-Bromophenyl)ethylamine, its application will become more common.

Reference:
Patent; Abbott Laboratories; US6933311; (2005); B2;,
Bromide – Wikipedia,
bromide – Wiktionary

In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 24358-62-1 as follows. Safety of 1-(4-Bromophenyl)ethylamine

To a mixture of the compound represented by the structural formula (Q-1) (5.0 g, 25 mmol) and NaOH (2.0 g, 50 mmol) in water (18 mL) and isopropanol (18 mL), the compound represented by the structural formula (Q-1A) (3.31 g, 27.5 mmol) was added dropwise at 20C, and the resulting mixture was stirred at the same temperature for 0.5 hour. Then, the mixture was cooled to 10C, water (50 mL) was added to the mixture, and the resulting mixture was filtered to give white solid. The resulting solid was dissolved in EA (150 mL), and the solution was washed with brine (50 mL), dried over anhydrous sodium sulfate, filtered, and concentrated to give N-[(4-bromophenyl)ethyl]-2,2-dimethylpropanamide as white solid (6.27 g, yield 88%). 1H-NMR Spectrum (300MHz, CDCl3):delta (ppm): 7.43-7.47 (m, 2H), 7.14-7.19 (m, 2H), 5.75 (brs, 1H), 5.02-5.07 (m, 1H), 1.40-1.46 (m, 3H), 1.21 (s, 9H)

According to the analysis of related databases, 24358-62-1, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Juntendo Educational Foundation; HIRAMATSU Keiichi; MORIMOTO Yuh; BABA Tadashi; HAYAKAWA Isao; (76 pag.)EP2987787; (2016); A1;,
Bromide – Wikipedia,
bromide – Wiktionary

Reference of 24358-62-1, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 24358-62-1, name is 1-(4-Bromophenyl)ethylamine belongs to bromides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

General procedure: The corresponding ketone (20 mmol, 1.0 eq) and CH3OH (20 mL) were added to a 250 mL Schlenk tube containing [RhCp*Cl2]2 (61.8 mg, 100 mumol, 0.005 equiv) and HCOONH4 (6.36 g, 100 mmol, 5.0eq). The brown mixture was frozen, and the whole system was evacuated. The system was closed and then stirred at 70 C for 7 h. After the dark green resulting solution was cooled to room temperature, 1M aqueous HCl solution (38.4 mL) was added, and the mixture was washed twice with CH2Cl2 (5 mL) to remove the neutral compounds. After addition of a cold 12 M aqueous NaOH solution (3.6 mL) to the aqueous layer, the mixture was extracted six times with CH2Cl2 (12 mL). The combined organic layers were dried over anhydrous Na2SO4. Filtration and evaporation under reduced pressure gave crude amine,which was used without purification. All the crude corresponding amine was dissolved in dichloromethane (50 mL), and TCCA (trichloroisocyanuric acid) (3.2 g, 14 mmol) was added in a250 ml round-bottom flask at 0 C. Then, the mixture was stirred at ambient temperature during 1 h. Triethylamine (6.0 g, 6 mol) dissolved in dichloromethane (50 mL) was added, and the resulting mixture was washed with water (200 mL) and hydrochloric acid (1 M, 200 mL)successively. The organic layer was dried over anhydrous sodium sulfate. After concentration under reduced pressure, purification by column chromatography on silica gel (n-hexane/EtOAc:40/1) afforded pure product.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1-(4-Bromophenyl)ethylamine, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Chu, Benfa; Fang, Lili; Guo, Shan; Qi, Bing; Shi, Pengfei; Wang, Qi; Zhu, Jin; Tetrahedron Letters; (2020);,
Bromide – Wikipedia,
bromide – Wiktionary

Electric Literature of 24358-62-1, A common heterocyclic compound, 24358-62-1, name is 1-(4-Bromophenyl)ethylamine, molecular formula is C8H10BrN, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

First, N-(1-(4-(2,5-bicyclo[2.2.1]heptenyl) phenyl)ethyl)maleimide was synthesized in three stages. 1-(4-Bromophenyl)ethylamine (25.1 g, 0.125 mol) was dissolved in diethyl ether (100 mL), and slowly added dropwise at 0 C. to a diethyl ether solution (200 mL) of maleic anhydride (10.4 g, 0.106 mol). The reaction solution was stirred for two hours at room temperature, and the solid that precipitated was filtered out and washed several times by diethyl ether. The solid filtered out and sodium acetate (1.20 g) were dissolved in acetic anhydride (120 mL), and stirred for four hours at 140 C. The solvent was distilled off under reduced pressure, water was added, and the solution was extracted by methylene chloride. The organic layer was dried using anhydrous magnesium sulfate, and the solvent was distilled off under reduced pressure. The residue was purified by silica gel column chromatography using chloroform-hexane mixed solvent (mixture ratio 4:1) as the developing solvent, and N-(1-(4-bromophenyl)ethyl)maleimide (23.5 g, 84.0 mmol, 79%) was obtained as a white solid. The spectra data of N-(1-(4-bromophenyl)ethyl)maleimide were as follows. 1H NMR (400 MHz, CDCl3): delta 7.46-7.43 (m, 2H), 7.31-7.28 (m, 2H), 6.64 (s, 2H), 5.30 (q, J=7.6 Hz, 1H), 1.79 (d, J=7.6 Hz, 3H); 13C NMR (100 MHz, CDCl3): delta 170.3, 139.1, 140.0, 131.5, 129.0, 121.6, 48.9, 17.4; HRMS (APCI, positive): [M+] calcd. for C12H10BrNO2, 278.9895; found 278.9904.

The synthetic route of 24358-62-1 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Japan Science and Technology Agency; Yabu, Hiroshi; Saito, Yuta; Saito, Shohei; Yamaguchi, Shigehiro; Nobusue, Shunpei; (47 pag.)US10442886; (2019); B2;,
Bromide – Wikipedia,
bromide – Wiktionary

Related Products of 24358-62-1, These common heterocyclic compound, 24358-62-1, name is 1-(4-Bromophenyl)ethylamine, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: (R)-1-(4-bromophenyl)ethanamine (2b) (2.00g, 10.0mmol) was dissolved in MeOH (50mL). To this solution was added 1-butanal (1.78mL, 20.0mmol) and NaBH(OAc)3 (4.24g, 20.0mmol). After stirring for 18h at room temperature, 5% NaOH was added. The mixture was extracted with CHCl3, dried over MgSO4, filtered, and concentrated under reduced pressure. The crude material was purified by silica gel column chromatography eluted with 5-10% MeOH in CHCl3 to afford the titled compound (2.17g, 85%) as a colorless oil. 1H NMR (400MHz, CDCl3) delta: 7.44 (d, J=8.8Hz, 2H), 7.19 (d, J=8.8Hz, 2H), 3.72 (q, J=6.8Hz, 1H), 2.50-2.44 (m, 1H), 2.41-2.34 (m, 1H), 1.47-1.38 (m, 2H), 1.35-1.24 (m, 5H), 0.87 (t, J=7.3Hz, 3H). 13C NMR (100MHz, CDCl3) delta: 143.5, 131.6(2C), 128.5(2C), 120.8, 57.9, 47.2, 31.7, 23.7, 20.3, 13.9. LC-MS (ESI) m/z=256 [M+H]+.

The synthetic route of 24358-62-1 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Imaizumi, Takamichi; Kobayashi, Atsuko; Otsubo, Shigeki; Komai, Masato; Magara, Megumiko; Otsubo, Nobumasa; Bioorganic and Medicinal Chemistry; vol. 27; 21; (2019);,
Bromide – Wikipedia,
bromide – Wiktionary

24358-62-1, name is 1-(4-Bromophenyl)ethylamine, belongs to bromides-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Product Details of 24358-62-1

Propionic anhydride (1.86g) was added to the solution of 1 -(4-bromophenyl)ethylamine (2.38g) and triethylamine (1.45g) in tetrahydrofuran (50ml), and the mixture was stirred at room temperature for 6 hours. The reaction mixture concentrated under reduced pressure, and the residue was purified by silica gel column chromatography to obtain N-[l-(4-bromophenyl)ethyl]propanamide (2.81g).1H-NMR (CDC13) delta: 1.15 (3H, t), 1.46 (3H, d), 2.21 (2H, q), 5.04-5.13 ( 1 H, m), 5.63 (1H, br s), 7.19-7.24 (2H, m), 7.44-7.47 (2H, m).

The synthetic route of 24358-62-1 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; BAYER CROPSCIENCE AG; MURATA, Tetsuya; HATAZAWA, Mamoru; BRUeCHNER, Peter; SHIMOJO, Eiichi; ICHIHARA, Teruyuki; ATAKA, Masashi; SHIBUYA, Katsuhiko; GOeRGENS, Ulrich; WO2011/51455; (2011); A1;,
Bromide – Wikipedia,
bromide – Wiktionary

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 24358-62-1, name is 1-(4-Bromophenyl)ethylamine, This compound has unique chemical properties. The synthetic route is as follows., name: 1-(4-Bromophenyl)ethylamine

EXAMPLE 141 N-[1-(4-bromophenyl)ethyl]-3-(biphenyl-2-carbonylamino)-benzoic acid amide Prepared analogously to Example 34 from 3-(biphenyl-2-carbonylamino)-benzoic acid, 1-(4-bromophenyl)ethylamine, TBTU and N-ethyldiisopropylamine in dimethylformamide. C28H23BrN2O2 (499.41) Mass spectrum:(M-H)-=497/499 (bromine isotopes)

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 24358-62-1.

Reference:
Patent; Priepke, Henning; Hauel, Norbert; Thomas, Leo; Mark, Michael; Dahmann, Georg; US2002/32238; (2002); A1;,
Bromide – Wikipedia,
bromide – Wiktionary

Adding a certain compound to certain chemical reactions, such as: 24358-62-1, name is 1-(4-Bromophenyl)ethylamine, belongs to bromides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 24358-62-1, category: bromides-buliding-blocks

l-(4-Bromophenyl)ethanamine (3.58 ml, 25 mmol) and Et3N (4.39 ml, 31.25 mmol) was dissolved in CH2Cl2 and cooled to 00C. To this was added (Boc)2O (6.0 g, 27.5 mmol) and the resulting solution was stirred 5 minutes at 00C for 5 and then 3 h at room temperature. The reaction was washed with HCl (50 ml, IM) followed by NaHCO3 (sat) (2*50 ml). The organic phase was dried over MgSO4, filtered and evaporated. The residue was purified by precipitation from MeOH/H2O (10:1) to give 6.35 g (85%) of the title compound as a white powder.1H NMR (CDCl3) delta 7.45 (d, 2H), 7.18 (d, 2H), 4.83-4.70 (br, 2H), 1.46-1.32 (br, 12H).

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.

Reference:
Patent; RESPIRATORIUS AB; JOHANSSON, Martin; THORNQVIST-OLTNER, Viveca; TOFTERED, Joergen; WENSBO, David; DALENCE, Maria; WO2010/97410; (2010); A1;,
Bromide – Wikipedia,
bromide – Wiktionary