Category: 2270-59-9

In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 2270-59-9 as follows. COA of Formula: C6H11Br

Example 5: Synthesis of N-[(l a, 5 a, 6 aV3-(4-methvl-pent-3-enyl)-3-aza-bicyclor3.1.01hex-6-vlmethyl)-9H-xanthene-9-carboxylic acid amide (Compound No. 8); To a solution of the compound No. 2 (1 mmol) in acetonitrile (5.0 ml), was added 5-bromo-2-methyl-pent-2-ene (1.2 mmol), potassium carbonate (8 mmol) and potassium iodide (2 mmol). The reaction mixture was refiuxed for overnight. The reaction mixture was concentrated under reduced pressure and the residue thus obtained was taken in water ;and extracted with ethyl acetate. The organic layer was dried over anhydrous sodiumsulphate and the solvent was evaporated under reduced pressure. The residue thus obtained was purified by column chromatography using ethylacetate in hexane as eluent to furnish the title compound (80%).IR(KBr): 1639.9 cm-1lR NMR (CDC13):8 7.28-7.40 (m, 4H), 7.10-7.15 (m, 4H), 5.50 (brs, 1H), 5.00 (m, 1H), 4.87 (s, 1H), 3.03-3.07 (m, 2H), 2.64-2.66 (m, 4H), 2.33 (m, 2H), 1.68 (s, 3H), 1.62 (s, 3H), 1.33-1.37 (m, 2H), 0.86-0.88 (m, 1H).Mass (m/z): 403 (M++l).

According to the analysis of related databases, 2270-59-9, the application of this compound in the production field has become more and more popular.

Reference:
Patent; RANBAXY LABORATORIES LIMITED; WO2006/5980; (2006); A1;,
Bromide – Wikipedia,
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Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 2270-59-9, name is 5-Bromo-2-methylpent-2-ene, A new synthetic method of this compound is introduced below., Safety of 5-Bromo-2-methylpent-2-ene

Example 7 Synthesis of 2-hydroxy-N-methyl-N-[3-(4-methylpent-3-en-1-yl)-3-azabicyclo[3.2.1]oct-8-yl]-2,2-diphenylacetamide (Compound No. 15) Potassium carbonate (49 mg), potassium iodide (29.4 mg) and 5-bromo-2-methyl-2-pentene (35.3 muL) was added to a solution of Compound No. 12 (62 mg) in acetonitrile (3 mL). The mixture was stirred at 80 C. for 5 hours and subsequently at room temperature overnight. The mixture was concentrated under reduced pressure and the residue thus obtained was partitioned between dichloromethane and water. The separated organic layer was washed with water and brine, dried over anhydrous sodium sulphate and concentrated under reduced pressure. The residue thus obtained was purified by preparative column chromatography to yield the title compound. Yield: 27 mg 1H NMR (CDCl3): delta 7.43-7.33 (10H, m), 5.07-5.04 (1H, m), 3.65-3.47 (1H, m), 3.15-2.05 (13H, m), 21.78-1.73 (6H, m), 1.33-1.1 (4H, m). Mass (m/z): 433 (M++1).

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; Kumar, Naresh; Kaur, Kirandeep; Gupta, Suman; Chugh, Anita; Salman, Mohammad; Shirumalla, Raj Kumar; Malhotra, Shivani; US2009/131410; (2009); A1;,
Bromide – Wikipedia,
bromide – Wiktionary

Reference of 2270-59-9,Some common heterocyclic compound, 2270-59-9, name is 5-Bromo-2-methylpent-2-ene, molecular formula is C6H11Br, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

A mixture of 5-bromo-2-methylpent-2-ene (0.66 mL, 5.0 mmol) in CH3CN (15 mL) was added 2-hydroxyisoindoline-l,3-dione (3.33 g, 6.0 mmol) and DBU (4.5 mL, 30 mmol) was heated at 1000C for 4 h. Work-up analogous to the procedure described in Example 58 afforded2-(4-methylpent-3-enyloxy)isoindoline-l,3-dione (1.14g, 90%) as a viscous oil.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 5-Bromo-2-methylpent-2-ene, its application will become more common.

Reference:
Patent; TAKEDA PHARMACEUTICAL COMPANY LIMITED; WO2009/97578; (2009); A1;,
Bromide – Wikipedia,
bromide – Wiktionary

Some common heterocyclic compound, 2270-59-9, name is 5-Bromo-2-methylpent-2-ene, molecular formula is C6H11Br, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Computed Properties of C6H11Br

General procedure: A 50-mL Schlenk flask equipped with a magnetic stirring bar and a rubber septum was charged with 1H-indole substrate 1 (1.00 mmol), norbornene (188 mg, 2.00 mmol), the base [K2CO3 (276 mg, 2.00mmol), KHCO3 (300 mg, 3.00 mmol), or K2HPO4 (522 mg, 3.00mmol) as indicated], and PdCl2(MeCN)2 (25.9 mg, 0.100 mmol). A 0.5 M solution of H2O in DMA (5 mL) was added. The alkyl bromide 2 (2.00 mmol) was then added from a syringe, and the resulting mixture was degassed by three freeze-pump-thaw cycles with liquid nitrogen under high vacuum. The flask was then placed in an oil bath preheated to 70 C or 90 C, as indicated, and the mixture was stirred vigorously under balloon pressure of argon. Upon completion of the reaction (TLC), the mixture was cooled to r.t., diluted with Et2O (30 mL), and filtered. The filtrate was concentrated in arotary evaporator (60 C water bath, 8-10 mbar) to remove the Et2O and most of the DMA. The residue was purified directly by flash column chromatography [silica gel (dry loading)] to give the alkylation product 3.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 2270-59-9, its application will become more common.

Reference:
Article; Jiao, Lei; Bach, Thorsten; Synthesis; vol. 46; 1; (2014); p. 35 – 41;,
Bromide – Wikipedia,
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Synthetic Route of 2270-59-9, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 2270-59-9, name is 5-Bromo-2-methylpent-2-ene, This compound has unique chemical properties. The synthetic route is as follows.

1.55 kg of magnesium and 10 kg of THF are charged into a stainless steel reactor provided with liquid nitrogen cooling . This is heated under reflux (60-700C) and, still at that temperature, 0.5 I of the solution containing 10 kg of 5-bromo-2-methyl- pentene (II) at 100% is poured. This is kept under reflux for at least 10 minutes until the reaction starts. The reaction mixture is then cooled to 50-600C and, keeping it at that temperature with a brine bath, the remaining solution of 5-bromo- 2-methyl-pentene (II) in THF is poured. The reaction mixture is kept at 50-600C for at least 1.5 hours and 40 kg of THF are added. The reaction mixture is then cooled with liquid nitrogen to -65/-700C and at that temperature 7.2 kg of diethyloxalate are added. The reaction mixture is kept at -65/-700C for at least 1 hour, under EPO stirring. The mixture thus obtained is then poured into another enamelled reactor containing 10kg of 32% hydrochloric acid dissolved in 30 kg of demineralised water and previously cooled to 0-100C.The reaction mixture is then brought to 20-300C and left until the phases separate. The aqueous phase is removed, while the organic phase is washed at 20-300C with 0.25 kg of sodium bicarbonate dissolved in 5 kg of demineralised water. The reaction mixture is stirred at the same temperature and left until the phases separate. The lower aqueous phase is removed, while the solvent is removed from the organic phase by vacuum distillation until an oily residue is obtained. Then 15 kg of THF are added and the mixture obtained is stirred until a solution is obtained which is sent to the next stage. Yield not determined.

The chemical industry reduces the impact on the environment during synthesis 5-Bromo-2-methylpent-2-ene. I believe this compound will play a more active role in future production and life.

Reference:
Patent; ERREGIERRE S.p.A.; STRAGEN PHARMA SA; WO2007/9953; (2007); A1;,
Bromide – Wikipedia,
bromide – Wiktionary

These common heterocyclic compound, 2270-59-9, name is 5-Bromo-2-methylpent-2-ene, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Product Details of 2270-59-9

To a mixture of 7-chloro-3-(2-(6-cyclopropyl-lH-indol-3-yl)-2-oxoethoxy)- 2-naphthamide (419mg, 1 mmol) in anhydrous DMF (10 mL) were added 5-bromo-2-methylpent-2-ene (0.6 g, 4 mmol) and K2CO3 (400 mg, 2.9 mmol).The reaction mixture was stirred at 20C overnight then concentrated under high vacuum. The residue was purified by column chromatography to afford the desired product (450 mg, 92.2% yield) as white solid. LC-MS: m/z 501(M+H)+.

The synthetic route of 5-Bromo-2-methylpent-2-ene has been constantly updated, and we look forward to future research findings.

Reference:
Patent; SPERO THERAPEUTICS, INC.; ZAHLER, Robert; (262 pag.)WO2016/112088; (2016); A1;,
Bromide – Wikipedia,
bromide – Wiktionary

2270-59-9, name is 5-Bromo-2-methylpent-2-ene, belongs to bromides-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Quality Control of 5-Bromo-2-methylpent-2-ene

To a solution of 1- ( 6-Amino-9H-purin-8-yl) -3, 6, 6- trimethyl-1, 5, 6, 7-tetrahydro-indazol-4-one (0.0327 g, 0.105 mmol) in DMF (1 mL) are added Cs2CO3 (0.041 g, 0.126 mmol) , and5-bromo-2-methyl-2-pentene (0.02 mL, 0.126 mmol). The reaction mixture is stirred at RT for 1 day. The resulting precipitate is removed by vaccum filtration, and the filtrate is evaporated under reduced pressure. Purification of the crude material using a Biotage column (10 – 70% EtOAc/hexanes for 10 CV) affords 0.0113 g of 1- [ 6-Amino-9- (4-methyl-pent-3- enyl) -9H-purin-8-yl] -3, 6, 6-trimethyl-l, 5, 6, 7-tetrahydro- indazol-4-one (28%) . LC/MS Calculated for C21H27N7O: m/z = 393. Found: m/z = 394 [M+H]+.

The synthetic route of 2270-59-9 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; SERENEX, INC.; WO2008/24981; (2008); A1;,
Bromide – Wikipedia,
bromide – Wiktionary

Electric Literature of 2270-59-9, These common heterocyclic compound, 2270-59-9, name is 5-Bromo-2-methylpent-2-ene, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: Freshly activated and dried magnesium turnings (1.38 equiv relative to aldehyde) were weighed into a flame-dried round bottom flask equipped with a stir bar. The flask was purged with nitrogen, cooled to 0 C, and diethyl ether dispensed (to approximate concentration 0.6 mmol/mL). Seventy microliters 1,2-dibromoethane were added to activate the magnesium and stirred for 15 minutes. At 0 C, 5-bromo-2-methyl-2-pentene (1.25 equiv relative to aldehyde) was added dropwise to the stirring magnesium turnings and stirred for 2 hours (consumption of magnesium observed). After formation of the Grignard reagent, the necessary aldehyde (freshly distilled to ensure purity), in diethyl ether, was added to the reaction mixture dropwise at 0 C and stirred for 18 hours. The reaction was quenched with concentrated NH4Cl solution dropwise and diluted with DI water and diethyl ether. The organic layer was separated and aqueous layer extracted three times with diethyl ether in a separatory funnel. The combined organics were washed with brine, dried with anhydrous MgSO4, filtered, and concentrated to afford a crude oil, which was taken on to the next step without further purification

The synthetic route of 2270-59-9 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Gesmundo, Nathan J.; Nicewicz, David A.; Beilstein Journal of Organic Chemistry; vol. 10; (2014); p. 1272 – 1281;,
Bromide – Wikipedia,
bromide – Wiktionary

Adding a certain compound to certain chemical reactions, such as: 2270-59-9, name is 5-Bromo-2-methylpent-2-ene, belongs to bromides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 2270-59-9, Safety of 5-Bromo-2-methylpent-2-ene

Potassium carbonate (49 mg), potassium iodide (29.4 mg) and 5-bromo-2-methyl- 2-pentene (35.3 muL) was added to a solution of Compound No. 12 (62 mg) in acetonitrile (3 mL). The mixture was stirred at 800C for 5 hours and subsequently at room temperature overnight. The mixture was concentrated under reduced pressure and the residue thus obtained was partitioned between dichloromethane and water. The separated organic layer was washed with water and brine, dried over anhydrous sodium sulphate and concentrated under reduced pressure. The residue thus obtained was purified by preparative column chromatography to yield the title compound. Yield: 27mg1H NMR (CDCl3):delta 7.43-7.33 (1OH, m), 5.07-5.04 (IH, m), 3.65-3.47 (IH, m), 3.15-2.05 (13H, m), 21.78-1.73 (6H, m), 1.33-1.1 (4H, m).Mass (m/z): 433 (M++.).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 5-Bromo-2-methylpent-2-ene, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; RANBAXY LABORATORIES LIMITED; WO2007/39884; (2007); A1;,
Bromide – Wikipedia,
bromide – Wiktionary

2270-59-9, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 2270-59-9 as follows.

General procedure: In a well-ventilated fume hood, a 15 mL round-bottomed flaskequipped with a Teflon-coated magnetic stirrer bar was chargedwith NiBr2¡¤3H2O (40.9 mg, 0.150 mmol, 0.05 equiv), bathophenanthroline(4; 49.9 mg, 0.150 mmol, 0.05 equiv), DMF (2.0 mL), andalkyl bromide 2 (3.3 mmol, 1.1 equiv). The vessel was stopperedwith a rubber septum and heated to 40 C in a fume hood until agreen homogeneous solution formed (~20 min). The vessel wasthen removed from the heat and 2-halopyridine 1 (3.00 mmol, 1.00equiv) and manganese(0) (-325 mesh; 330 mg, 6.00 mmol, 2.00equiv) were added. The vessel was resealed with the septum, purgedwith argon, and heated again to 40 C while the progress of the reactionwas monitored by GC analysis of aliquots of the crude reactionmixture. In general, the mixtures turned dark brown or blackwhen the reaction was complete. Upon completion of the reaction,the mixture was cooled to r.t., diluted with Et2O (10 mL), and filteredthrough a short pad of Celite 545 (approx. 1 ¡Á 1 ¡Á 1 inch) wettedwith Et2O (~10 mL) to remove metal salts. The Celite pad waswashed with additional Et2O (2 ¡Á 10 mL), and the filtrate was transferredto a separatory funnel and washed with 1 M aq NH4Cl (10mL). The layers were separated and the aqueous layer was washedwith additional Et2O (3 ¡Á 10 mL). The organic extracts were combined,washed with brine (10 mL), dried (MgSO4), filtered, and concentratedunder reduced pressure. The crude products were purifiedby flash column chromatography on silica gel.

According to the analysis of related databases, 5-Bromo-2-methylpent-2-ene, the application of this compound in the production field has become more and more popular.

Reference:
Article; Everson, Daniel A.; Buonomo, Joseph A.; Weix, Daniel J.; Synlett; vol. 25; 2; (2014); p. 233 – 238;,
Bromide – Wikipedia,
bromide – Wiktionary