A chemoselective Reformatsky-Negishi approach to α-haloaryl esters was written by Wong, Brian;Linghu, Xin;Crawford, James J.;Drobnick, Joy;Lee, Wendy;Zhang, Haiming. And the article was included in Tetrahedron in 2014.Recommanded Product: 2178-24-7 This article mentions the following:
A practical synthesis of α-haloaryl esters was achieved via a chemoselective Negishi coupling of poly-halogenated aromatics and Reformatskii reagents in the presence of catalytic Pd(dba)2 and Xantphos. This chem. tolerates a variety of aryl halides and was successfully applied to the synthesis of Ibuprofen. The α-haloaryl ester products, exemplified by Et 2-(4-bromo-2-chlorophenyl)acetate , can be further functionalized via palladium or copper catalysis to afford an array of α-aryl esters. In the experiment, the researchers used many compounds, for example, Ethyl (2-bromophenyl)acetate (cas: 2178-24-7Recommanded Product: 2178-24-7).
Ethyl (2-bromophenyl)acetate (cas: 2178-24-7) belongs to organobromine compounds. A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals. Organobromine compounds have fallen under increased scrutiny for their environmental impact. The reactivity of organobromine compounds resembles but is intermediate between the reactivity of organochlorine and organoiodine compounds. For many applications, organobromides represent a compromise of reactivity and cost.Recommanded Product: 2178-24-7
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary