Category: 2178-24-7

Oxygen Donor-Mediated Equilibration of Diastereomeric Alkene-Palladium(II) Intermediates in Enantioselective Desymmetrizing Heck Cyclizations was written by Machotta, Axel B.;Straub, Bernd F.;Oestreich, Martin. And the article was included in Journal of the American Chemical Society in 2007.Application of 2178-24-7 This article mentions the following:

This investigation examines the origin of enantioselection in the desymmetrization of an acyclic prochiral Heck cyclization precursor. High asym. induction (97-98% ee) is attributed to a temporary interaction of a Lewis basic oxygen donor with weakly Lewis acidic palladium(II). A series of control experiments combined with quantum-chem. model calculations provided sound evidence for a mechanism involving oxygen donor-mediated, rapid equilibration of diastereomeric alkene-palladium(II) complexes prior to the selectivity-determining ring-closing event, a Curtin-Hammett scenario. Our study also highlights the importance of the cationic pathway (triflate counter anions vs. halido ligand) and alkene stereochem. (E vs. Z) in asym. Heck reactions. In the experiment, the researchers used many compounds, for example, Ethyl (2-bromophenyl)acetate (cas: 2178-24-7Application of 2178-24-7).

Ethyl (2-bromophenyl)acetate (cas: 2178-24-7) belongs to organobromine compounds. A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals. Organobromine compounds have fallen under increased scrutiny for their environmental impact. In the pharmaceutical industry organo bromine derivatives are used as sedatives, vasodilators, antiseptic agents, and anticancer agents.Application of 2178-24-7

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Regio- and Chemoselective C-H Chlorination/Bromination of Electron-Deficient Arenes by Weak Coordination and Study of Relative Directing-Group Abilities was written by Sun, Xiuyun;Shan, Gang;Sun, Yonghui;Rao, Yu. And the article was included in Angewandte Chemie, International Edition in 2013.Name: Ethyl (2-bromophenyl)acetate This article mentions the following:

A palladium(II)-catalyzed ortho-chlorination/bromination reaction was developed using electron-deficient arenes as substrates. A preliminary evaluation was conducted on the relative abilities of the directing groups. In the experiment, the researchers used many compounds, for example, Ethyl (2-bromophenyl)acetate (cas: 2178-24-7Name: Ethyl (2-bromophenyl)acetate).

Ethyl (2-bromophenyl)acetate (cas: 2178-24-7) belongs to organobromine compounds. Bromine is more electronegative than carbon (2.9 vs 2.5). Consequently, the carbon in a carbon闂佺偨鍎茶ぐ绲﹐mine bond is electrophilic, i.e. alkyl bromides are alkylating agents. The reactivity of organobromine compounds resembles but is intermediate between the reactivity of organochlorine and organoiodine compounds. For many applications, organobromides represent a compromise of reactivity and cost.Name: Ethyl (2-bromophenyl)acetate

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

An iron(II)-based metalloradical system for intramolecular amination of C(sp²)-H and C(sp³)-H bonds: synthetic applications and mechanistic studies was written by Das, Sandip Kumar;Das, Subrata;Ghosh, Supratim;Roy, Satyajit;Pareek, Monika;Roy, Brindaban;Sunoj, Raghavan B.;Chattopadhyay, Buddhadeb. And the article was included in Chemical Science in 2022.Recommanded Product: Ethyl (2-bromophenyl)acetate This article mentions the following:

A catalytic system for intramol. C(sp²)-H and C(sp³)-H amination of substituted tetrazolopyridines was successfully developed. The amination reactions were developed using an iron-porphyrin based catalytic system. It was demonstrated that the same iron-porphyrin based catalytic system efficiently activates both the C(sp²)-H and C(sp³)-H bonds of the tetrazole as well as azide-featuring substrates with a high level of regioselectivity. The method exhibited an excellent functional group tolerance. The method afforded three different classes of high-value N-heterocyclic scaffolds. A number of important late-stage C-H aminations were performed to access important classes of mols. Detailed studies (exptl. and computational) showed that both the C(sp²)-H and C(sp³)-H amination reactions involve a metalloradical activation mechanism, which is different from the previously reported electro-cyclization mechanism. Collectively, this study reports the discovery of a new class of metalloradical activation modes using a base metal catalyst that should find wide application in the context of medicinal chem., drug discovery and industrial applications. In the experiment, the researchers used many compounds, for example, Ethyl (2-bromophenyl)acetate (cas: 2178-24-7Recommanded Product: Ethyl (2-bromophenyl)acetate).

Ethyl (2-bromophenyl)acetate (cas: 2178-24-7) belongs to organobromine compounds. Organo bromine compounds are versatile compounds and are widely used in diverse fields. Organo bromine derivatives are used in the dye sector, as an indicator in analytical chemistry (Bromothymol blue is a popular indicator). The principal reactions for organobromides include dehydrobromination, Grignard reactions, reductive coupling, and nucleophilic substitution.Recommanded Product: Ethyl (2-bromophenyl)acetate

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Benzocyclo闁哄鐡璽atetraenes. IV. 1,2,3,4,5,6-Tribenzo-闁?sup>1,3,5,7-cyclo闁哄鐡璽atetraene was written by Shuttleworth, R. G.;Rapson, W. S.;Stewart, E. T.. And the article was included in Journal of the Chemical Society in 1944.COA of Formula: C10H11BrO2 This article mentions the following:

Tetraphenylene (I) (3 g.) in 200 cc. AcOH at 80-90闁? treated with 7 g. CrO₃ in 7 cc. H₂O and 50 cc. AcOH during 2 h., gives 0.6 g. unchanged I and 0.6 g. of 1,2,3,4,5,6-tribenzo-1,3,5,7-cyclo闁哄鐡璽atetraene-7,8-dicarboxylic anhydride (II), deep yellow, m. 228-9闁? 0.1 g. 闁?diphenylbenzene-2′,2”-dicarboxylic acid (III), m. 262.5-3.5闁? was isolated also; III seps. with 2 mols. of AcOH, lost at 150闁? The Na salt from II is stable to KMnO₄ and II in AcOH gives III with CrO₃ only at 100闁? II is not decarboxylated by refluxing in quinoline with Cu dronze but pyrolysis of 0.5 g. of II with Ba(OH)₂ at about 300闁?gives 0.15 g. of 1,2,3,4,5,6-tribenzo-1,3,5,7-cyclooctatetraene (IV), m. 138.5-9闁? which is stable to KMnO₄ in Me₂CO. IV and Br in CCl₄ give the 7,8-dibromide, light yellow, m. 155-6闁? Hydrogenation of IV with reduced PtO₂ gives 1,2,3,4,5,6-tribenzo-1,3,5-cyclo闁哄鐡璽atriene, m. 111-13闁? 2-O₂NC₆H₄C₆H₄CO₂H-2 (68% yield) does not yield an alkali-soluble product on reduction with FeSO₄ and NH₄OH or Ba(OH)₂. 2-O₂NC₆H₄C₆H₄Me2 (37% yield) with Sn and HCl gives 83% of the 2-NH₂ derivative, which yields 63% of the 2-I derivative; oxidation with KMnO₄ results in extensive degradation of the nucleus and CrO₃ gives only 23% of 2-IC₆H₄C₆H₄CO₂H-2 (V). 闁?C₆H₄I₂ (37% yield) (50 g.) and 20 g. 闁?IC₆H₄CO₂Et with 15 g. Cu bronze at 280-5闁? followed by hydrolysis, give 8.5 g. of V; the Et ester (VI) b₃ 168-9闁? VI (5 g.) and 20 g. 闁?IC₆H₄CO₂Et with 10 g. Cu bronze at 320闁?give 0.5 g. III. VI and 闁?C₆H₄CH₂CO₂Et with Cu bronze at 290-5闁?yield 3,4-benzocoumarin. Et (闁?bromophenyl)acetate, b₄ 114闁? m. 35-6闁? (2-BrC₆H₄)₂, transformed into the Grignard reagent by refluxing with Mg for 36 h., HC(OEt)₃ added and the mixture refluxed for 5 h., gives 2-bromo-2′-aldehydobiphenyl (contaminated with (2-BrC₆H₄)₂, b₇ 152-7闁? (VII); 2,4-dinitrophenylhydrazone, orange-yellow, m. 217闁? semicarbazone, m. 198闁? VII, 闁?BrC₆H₄CH₂CO₂Na and AcOH, heated 12 h. at 150-60闁? give 濞?闁?bis(闁?bromophenyl)cinnamic acid, m. 186闁? its conversion into IV was not attempted. In the experiment, the researchers used many compounds, for example, Ethyl (2-bromophenyl)acetate (cas: 2178-24-7COA of Formula: C10H11BrO2).

Ethyl (2-bromophenyl)acetate (cas: 2178-24-7) belongs to organobromine compounds. Bromo compounds are employed in a variety of metal-catalyzed coupling reactions. They are also ideal candidates for the synthesis of Grignard reagents that have wide-applicability in organic synthesis. alpha-Bromoesters are employed in the Reformatsky reaction for the synthesis of beta-hydroxyesters. Many of the alkyl bromine derivatives are excellent alkylating agents since bromides are good leaving groups. Tribromides, like tetrabutylammonium tribromide, are used as a solid source of bromine. N-bromosuccimide (NBS) is used for the selective bromination of allylic bonds.COA of Formula: C10H11BrO2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Borylation of Unactivated C(sp³)-H Bonds with Bromide as a Traceless Directing Group was written by Zhang, Ge;Li, Meng-Yao;Ye, Wen-Bo;He, Zhi-Tao;Feng, Chen-Guo;Lin, Guo-Qiang. And the article was included in Organic Letters in 2021.Electric Literature of C10H11BrO2 This article mentions the following:

A Pd-catalyzed alkyl C-H borylation of aryl bromides with bromide as a traceless directing group is described, providing a convenient approach to access alkyl boronates bearing a 閻?all-C quaternary stereocenter. The protocol features a broad substrate scope, excellent site selectivity, and good functional group tolerance. In the experiment, the researchers used many compounds, for example, Ethyl (2-bromophenyl)acetate (cas: 2178-24-7Electric Literature of C10H11BrO2).

Ethyl (2-bromophenyl)acetate (cas: 2178-24-7) belongs to organobromine compounds. Bromo compounds are employed in a variety of metal-catalyzed coupling reactions. They are also ideal candidates for the synthesis of Grignard reagents that have wide-applicability in organic synthesis. Bromine-containing agents predominate because not only are they more efficient than similar chlorine-containing species, but also the high atomic weight of bromine ensures that it is present in a high mass fraction within most organobromine compounds.Electric Literature of C10H11BrO2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Synthesis of benzocarbacephem and benzocarbapemen derivatives by copper-promoted intramolecular aromatic substitution was written by Joyeau, Roger;Yadav, Lal D. S.;Wakselman, Michel. And the article was included in Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999) in 1987.Product Details of 2178-24-7 This article mentions the following:

Copper-mediated cyclization of 4-[2-(o-bromophenyl)ethyl]azetidinones and 4-[o-bromophenyl)methyl]azetidinones gave benzocarbacephem and benzocarbapenem derivatives resp. Halogenation of the diastereoisomeric 2-hydroxybenzocarbacephem-4′-carboxylate (I, R = OH) afforded I (R=Cl) as racemic diastereoisomers or I (R = F) as a single racemic diastereoisomer. The free carboxylic acids of I (R = Cl, F) were inactivators of 閻?lactamases. In the experiment, the researchers used many compounds, for example, Ethyl (2-bromophenyl)acetate (cas: 2178-24-7Product Details of 2178-24-7).

Ethyl (2-bromophenyl)acetate (cas: 2178-24-7) belongs to organobromine compounds. Organo bromine compounds are versatile compounds and are widely used in diverse fields. Organo bromine derivatives are used in the dye sector, as an indicator in analytical chemistry (Bromothymol blue is a popular indicator). One prominent application of synthetic organobromine compounds is the use of polybrominated diphenyl ethers as fire-retardants, and in fact fire-retardant manufacture is currently the major industrial use of the element bromine.Product Details of 2178-24-7

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Synthesis of 浼?Aryl Esters and Nitriles: Deaminative Coupling of 浼?Amino-Esters and 浼?Aminoacetonitriles with Arylboronic Acids was written by Wu, Guojiao;Deng, Yifan;Wu, Chaoqiang;Zhang, Yan;Wang, Jianbo. And the article was included in Angewandte Chemie, International Edition in 2014.Related Products of 2178-24-7 This article mentions the following:

Transition-metal-free synthesis of 浼?aryl esters and nitriles using arylboronic acids with 浼?amino esters and 浼?(amino)acetonitrile derivatives, resp., as starting materials has been developed. The reaction represents a rare case of converting C(sp³)-N bonds (carbon-nitrogen bonds) into C(sp³)-C(sp²) bonds (carbon-carbon bonds). The reaction conditions are mild, demonstrate good functional-group tolerance, and can be scaled up. The synthesis of the target compounds was achieved using glycine ester hydrochloride, leucine ester hydrochloride, aspartate ester hydrochloride, alanine ester hydrochloride as starting materials in a reaction with (aryl)boronic acids. The title compounds thus formed included benzeneacetic acid esters, 1-naphthaleneacetic acid ester, benzenepropanoic acid esters, 浼?phenyl-1H-indole-3-propanoic acid ester, benzenebutanoic acid ester and similar substances. A reaction of (aryl)boronic acids with 浼?(amino)acetonitrile gave 浼?(alkyl)benzeneacetonitrile derivatives Nitriles included 浼?(hexyl)benzeneacetonitrile, 浼?phenyl-3-thiophenepropanenitrile and similar compounds In the experiment, the researchers used many compounds, for example, Ethyl (2-bromophenyl)acetate (cas: 2178-24-7Related Products of 2178-24-7).

Ethyl (2-bromophenyl)acetate (cas: 2178-24-7) belongs to organobromine compounds. A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals. Organobromine compounds have fallen under increased scrutiny for their environmental impact. When the molecular ion is detected, the bromine and chlorine isotope patterns are very distinct, but caution is to be exercised for certain mixed chlorinated/brominated compounds, which can look similar to homohalogen patterns.Related Products of 2178-24-7

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Domino Direct Arylation and Cross-Aldol for Rapid Construction of Extended Polycyclic 锜?Scaffolds was written by Nitti, Andrea;Bianchi, Gabriele;Po, Riccardo;Swager, Timothy M.;Pasini, Dario. And the article was included in Journal of the American Chemical Society in 2017.Synthetic Route of C10H11BrO2 This article mentions the following:

Five-membered aromatic heterocycles are a ubiquitous skeleton of 锜?conjugated organic compounds, and their incorporation requires synthetic protocols that are not easily industrially sustainable or scalable. Improved methodologies for their insertion into 锜?scaffolds are therefore necessary. We report an efficient and scalable protocol involving a one-pot cross-Aldol direct arylation reaction protocol for the rapid construction of thiophene- and furan-based 锜?extended organic materials. In the experiment, the researchers used many compounds, for example, Ethyl (2-bromophenyl)acetate (cas: 2178-24-7Synthetic Route of C10H11BrO2).

Ethyl (2-bromophenyl)acetate (cas: 2178-24-7) belongs to organobromine compounds. Many of the organo bromine compounds are relatively nonpolar. Bromine is more electronegative than carbon (2.8 vs 2.5) and hence the carbon in a carbon鑱砨romine bond is electrophilic in nature. In the pharmaceutical industry organo bromine derivatives are used as sedatives, vasodilators, antiseptic agents, and anticancer agents.Synthetic Route of C10H11BrO2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Customized Buchwald-type phosphines bearing an “inverted” pyrimidinium betaine as an aryl group surrogate – synthesis and coordination chemistry with gold(I) was written by Noel-Duchesneau, Ludovik;Lugan, Noel;Lavigne, Guy;Labande, Agnes;Cesar, Vincent. And the article was included in European Journal of Inorganic Chemistry in 2015.Quality Control of Ethyl (2-bromophenyl)acetate This article mentions the following:

A new ligand scaffold I (1, R = ⁱPr) inspired by Buchwald-type phosphines is disclosed. Its design consists of the formal replacement of the distal aryl group of the original archetype by a pyrimidinium betaine connected to the o-phosphinophenyl moiety through the C-5 position of its malonate subunit. A productive synthetic pathway towards this phosphine is described along with its ability to coordinate to a gold(I) center. A weak bonding interaction between the metal center and the malonate group is observed in the solid state. In the experiment, the researchers used many compounds, for example, Ethyl (2-bromophenyl)acetate (cas: 2178-24-7Quality Control of Ethyl (2-bromophenyl)acetate).

Ethyl (2-bromophenyl)acetate (cas: 2178-24-7) belongs to organobromine compounds. A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals. Organobromine compounds have fallen under increased scrutiny for their environmental impact. The reactivity of organobromine compounds resembles but is intermediate between the reactivity of organochlorine and organoiodine compounds. For many applications, organobromides represent a compromise of reactivity and cost.Quality Control of Ethyl (2-bromophenyl)acetate

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

New effective inhibitors of the Abelson kinase was written by Kraus, George A.;Gupta, Vinayak;Mokhtarian, Marjan;Mehanovic, Samir;Nilsen-Hamilton, Marit. And the article was included in Bioorganic & Medicinal Chemistry in 2010.Related Products of 2178-24-7 This article mentions the following:

The effects of substituents on the aryl ring were studied by the preparation and testing of several PD173955 analogs. Inserting a single carbon atom into the C-N bond in the aniline subunit (PDC) reduced the kinase inhibition by a factor of 200. Despite its decreased affinity for Abl compared with PD173955, PDC exhibits a Ki very similar to that reported for Imatinib. Increased water solubility is also gained by replacing the thiomethyl group with an amino or glycyl moiety. For both PD173955 and PDC, the analogs with amino groups in place of the methylthio group are 10 times more inhibitory than the parent mols. Two mols. were identified with Kis about three orders of magnitude lower than reported for Imatinib. In the experiment, the researchers used many compounds, for example, Ethyl (2-bromophenyl)acetate (cas: 2178-24-7Related Products of 2178-24-7).

Ethyl (2-bromophenyl)acetate (cas: 2178-24-7) belongs to organobromine compounds. Bromine is more electronegative than carbon (2.9 vs 2.5). Consequently, the carbon in a carbon閳ユ彽romine bond is electrophilic, i.e. alkyl bromides are alkylating agents. The reactivity of organobromine compounds resembles but is intermediate between the reactivity of organochlorine and organoiodine compounds. For many applications, organobromides represent a compromise of reactivity and cost.Related Products of 2178-24-7

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary