Category: 21524-34-5

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 21524-34-5, name is 2-Bromo-1,3,5-triisopropylbenzene, This compound has unique chemical properties. The synthetic route is as follows., Quality Control of 2-Bromo-1,3,5-triisopropylbenzene

General procedure: Ligand comparison reactions were setup at the same time using the same batches of reagents. In a N2 filled glove-box, a microwave vialwas charged with a magnetic stir bar, Pd2(dba)3 (2.3 mg, 0.0025mmol), the respective ligand L1-L5 (0.010 mmol), K3PO4 (424 mg, 2.00 mmol), and 2-biphenyboronic acid (9; 158 mg, 0.800 mmol). Degassed (argon sparge) toluene (1.3 mL) followed by bromide 8 (0.169 mL, 0.667 mmol) were added, and the vial was sealed with acrimp-cap septum and removed from the glove-box. The reaction vialwas then inserted into a heating block pre-heated to 80 C. Aliquots were removed using argon-purged syringes and quenched into MeOH and analyzed by UPLC. After complete consumption of the starting aryl bromide (2 h), the reaction mixture was cooled to r.t. and partitioned between H2O and CH2Cl2. The organic layer was collected,dried (anhyd Na2SO4), and concentrated in vacuo. The yield of thecrude mixture was determined by 1HNMR spectroscopy using dimethyl fumarate as the analytical standard.

According to the analysis of related databases, 21524-34-5, the application of this compound in the production field has become more and more popular.

Reference:
Article; Zhang, Yongda; Lao, Kendricks S.; Sieber, Joshua D.; Xu, Yibo; Wu, Linglin; Wang, Xiao-Jun; Desrosiers, Jean-Nicolas; Lee, Heewon; Haddad, Nizar; Han, Zhengxu S.; Yee, Nathan K.; Song, Jinhua J.; Howell, Amy R.; Senanayake, Chris H.; Synthesis; vol. 50; 22; (2018); p. 4429 – 4434;,
Bromide – Wikipedia,
bromide – Wiktionary

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 21524-34-5, name is 2-Bromo-1,3,5-triisopropylbenzene, This compound has unique chemical properties. The synthetic route is as follows., Product Details of 21524-34-5

General procedure: Aryl bromide (1mmol), palladium catalyst (1mol%), t-KOBu (1mmol) and DMF (4ml) were added under air to a Schlenck tube containing a stirring bar, followed by (1.5mmol) of phenylacetylene. The reaction mixture was heated to 100C and stirred vigorously for the indicate time then cooled to room temperature. The reaction was quenched with water, and the mixture was extracted with ethyl acetate, dried with MgSO4, and filtered on short silica. Purity of compounds is checked by GC using an internal standard (undecane) and yields are based on aryl bromide

According to the analysis of related databases, 21524-34-5, the application of this compound in the production field has become more and more popular.

Reference:
Article; Dehimat, Zineb Imene; Ya?ar, Sedat; Tebbani, Dahmane; Oezdemir, ?smail; Inorganica Chimica Acta; vol. 469; (2018); p. 325 – 334;,
Bromide – Wikipedia,
bromide – Wiktionary

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 21524-34-5, name is 2-Bromo-1,3,5-triisopropylbenzene, A new synthetic method of this compound is introduced below., Recommanded Product: 2-Bromo-1,3,5-triisopropylbenzene

General procedure: The Suzuki reaction was performed in a 50 mL round-bottomed flask, aryl halide (0.5 mmol), arylboronic acid (0.65 mmol), K2CO3 (1 mmol), Complex 1 (0.2-1 mol%) and water (4 mL) were charged and stirred for the required time at room temperature for aryl bromides or at 100 C for aryl chlorides. After completion, the mixture was cooled down to room temperature, diluted with water (10 mL) and extracted with diethyl ether (3 × 15 mL). The organic layer was washed with brine (3 × 15 mL), dried over anhydrous Na2SO4. The crude products were chromatographed on silica gel (ethyl acetate/hexane).

The synthetic route of 21524-34-5 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Shahnaz, Nasifa; Puzari, Amlan; Paul, Bidisha; Das, Pankaj; Catalysis Communications; vol. 86; (2016); p. 55 – 58;,
Bromide – Wikipedia,
bromide – Wiktionary

Electric Literature of 21524-34-5,Some common heterocyclic compound, 21524-34-5, name is 2-Bromo-1,3,5-triisopropylbenzene, molecular formula is C15H23Br, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: An oven-dried, resealable Schlenk tube containing a stirbar was charged with aryl halide (1.0 mmol), ketone (1.1 mmol), potassium tert-butoxide (1.5 mmol), and 1 mol % catalyst, and backfilled with nitrogen. Toluene (1.5 mL) was sequentially injected, and the mixture was stirred in an oil bath at reflux temperature for the time specified. After the reaction was completed, the reaction mixture was filtered by chromatographed on silica gel and washed with EtOAc. The filtrate was dried over MgSO4 and filtered before the solvent was removed on a rotary evaporator. The pure product was obtained by preparative TLC and the yield was calculated based on ArX (the purified products were identified by comparison of melting points with the literature data or by 1H NMR and 13C NMR spectra. New compounds were determined by HRMS spectra).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 2-Bromo-1,3,5-triisopropylbenzene, its application will become more common.

Reference:
Article; Zhang, Jinli; Yang, Xueqian; Cui, Xiuling; Wu, Yangjie; Tetrahedron; vol. 67; 45; (2011); p. 8800 – 8807;,
Bromide – Wikipedia,
bromide – Wiktionary

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 21524-34-5, name is 2-Bromo-1,3,5-triisopropylbenzene, A new synthetic method of this compound is introduced below., Formula: C15H23Br

1L three bottles,To a solution of 32.5 g of 2,4,6-triisopropylbromobenzene,5.6 g of magnesium turnings and 300 mL of anhydrous THF,20 g of o-chlorobromobenzene was dropwise added,2,4,6-triisopropyl-2-bromobiphenyl Grignard reagent,Refluxed for 2 hours,Down to room temperature,2.4 g of tetrakis (triphenylphosphine) palladium was added,Stirred for 30 minutes,18.8 g of di-tert-butylphosphonium chloride was added dropwise at room temperature,The reaction was refluxed for 5 hours.And the mixture was added dropwise to the reaction solution under ice-water bath200 mL of saturated aqueous ammonium chloride was quenched,Liquid separation,The organic phase is dissolved,Add methanol crystallization,And filtered to obtain 41.7 g of white 2-di-tert-butylphosphine-2,4,6-triisopropylbiphenyl,Yield 94%.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; Panjin Gelin Kaimo Technology Co., Ltd.; Rao, Zhihua; Gong, Ningrui; (12 pag.)CN105859774; (2016); A;,
Bromide – Wikipedia,
bromide – Wiktionary

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 21524-34-5, name is 2-Bromo-1,3,5-triisopropylbenzene, A new synthetic method of this compound is introduced below., COA of Formula: C15H23Br

General procedure: Pd(dba)2/1-catalyzed amination of aryl halides: An oven-dried Schlenk tube equipped with a magnetic stirring bar was charged with Pd(dba)2 (5.8 mg, 0.010 mmol), ligand 1 (8.6 mg, 0.020 mmol) and tBuONa (134 mg, 1.4 mmol). The flask was capped with a rubber septum, evacuated, and then flushed with argon. This cycle was repeated three times. Amine (1.2 mmol), aryl halide (1.0 mmol) and DME (4 mL) were then successively added by syringe. The tube was stirred at room temperature for several minutes and then placed into a preheated oil bath (120 C) for the time period as indicated in tables. After completion of reaction as judged by GC analysis, the reaction tube was allowed to cool to room temperature and the reaction mixture was adsorbed onto silica gel, and then purified by column chromatography (hexane/ethyl acetate as eluent) to afford the desired product.

The synthetic route of 21524-34-5 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Hao, Xiaowei; Yuan, Jia; Yu, Guang-Ao; Qiu, Ming-Qiang; She, Neng-Fang; Sun, Yue; Zhao, Cui; Mao, Shu-Lan; Yin, Jun; Liu, Sheng-Hua; Journal of Organometallic Chemistry; vol. 706-707; (2012); p. 99 – 105;,
Bromide – Wikipedia,
bromide – Wiktionary

Related Products of 21524-34-5,Some common heterocyclic compound, 21524-34-5, name is 2-Bromo-1,3,5-triisopropylbenzene, molecular formula is C15H23Br, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Reactor thoroughly dried and purged with nitrogen was 300mL, 2-bromo-1,3,5-triisopropyl benzene 12.0g (42.4mmol), (2- methoxy-5-methylphenylboronic acid) 14.1g (85.0mmol), tripotassium phosphate (K3PO4) 27.0g (127mmol), Tris(dibenzylideneacetone)dipalladium(0) (chloroform adduct), 0.44g (0.42mmol), 2-dicyclohexylphosphino-2′,6′-dimethoxybiphenyl 0.35g (0.85mmol), was charged with toluene 100mL, and the mixture was stirred for 17 hours at 100C. The reaction solution was cooled to room temperature and filtered through celite. When the resultant residue by distilling off the filtrate purified by silica gel column chromatography, the desired product shown by the following formula (11) (hereinafter Compound (11) hereinafter) is 5.61 g (41% yield) obtained.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 2-Bromo-1,3,5-triisopropylbenzene, its application will become more common.

Reference:
Patent; MITSUI CHEMICALS INCORPORATED; KONDO, MASATAKA; UEHARA, NAOKI; MICHIGAMI, KENJI; ISHII, SEIICHI; TANAKA, KENICHI; (154 pag.)JP2015/193612; (2015); A;,
Bromide – Wikipedia,
bromide – Wiktionary

Adding a certain compound to certain chemical reactions, such as: 21524-34-5, name is 2-Bromo-1,3,5-triisopropylbenzene, belongs to bromides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 21524-34-5, Recommanded Product: 2-Bromo-1,3,5-triisopropylbenzene

Raw materials la (56 mg, 0 ¡¤ 2 mmol) and 2 j (204 mg, 0 ¡¤ 72 mmol) were sequentially added to the reaction flask, and cesium carbonate was added.(130 mg, 2.0 eq), double dilute ligand L2_l (2.6 mg, 5 mol%), tricyclohexylphosphine tetrafluoroborate (1.8 mg, 2.5 mol 1%), [Rh (cod) Cl] 2 (2.5 Mg, 2 ¡¤ 5 mol %), di-tert-butylphosphonium chloride (18 mg, 0 ¡¤ lmmol) and toluene 2 mL), stirred at 120 C for 24 hours under nitrogen atmosphere, cooled to room temperature, ethyl acetate (5 mL) Dilute, dilute 1M dilute hydrochloric acid (2 mL), and wash with saturated brine (5 mL). The organic phase is dried over anhydrous magnesium sulfate. /15), the product was 3h as a white solid 25mg, yield 18%

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 2-Bromo-1,3,5-triisopropylbenzene, and friends who are interested can also refer to it.

Reference:
Patent; UNIV NANKAI; Nankai University; YE MENGCHUN; Ye Mengchun; YANG JINFEI; Yang Jinfei; (18 pag.)CN107840784; (2018); A;,
Bromide – Wikipedia,
bromide – Wiktionary

Some common heterocyclic compound, 21524-34-5, name is 2-Bromo-1,3,5-triisopropylbenzene, molecular formula is C15H23Br, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. SDS of cas: 21524-34-5

A 20 mL oven-dried Schlenk tube was charged with magnesium (57.6 mg, 2.4 mmol) and anhydrous THF (1.5 mL), 5 drops of diisobutylaluminium hydride (DIBAL) was added and stirred for 5 min to activate magnesium. 2-bromo-1,3,5-triisopropylbenzene (566 mg, 2 mmol) was added potion-by-potion with vigorous stirring. The tube was capped with a rubber septum and was heated to 70 C. for 2 h. 1-bromo-2-iodo-3,4-dimethoxybenzene (700 mg, 2.1 mmol) in anhydrous THF (3 mL) was injected through syringe. An additional 1 mL of THF was used to rinse the reaction and was also transferred into the mixture. The combined reaction mixture was stirred at 70 C. overnight. At this time, the mixture was cooled to 0 C. using ice bath, and iodine (1.3 g, 5 mmol) in 6 mL anhydrous THF was added drop-wise over 10 min, then the reaction mixture was stirred for 30 min, and then warmed to stir at room temperature for 2 h. Then, the mixture was quenched with saturated Na2S2O3 (aq.) solution until the red color of bromine disappeared. The aqueous phase was extracted with Et2O (20 mL¡Á3) and the combined organic phases were dried over anhydrous MgSO4. After concentration, the crude product was purified by silica gel chromatography (EtOAc/petroleum ether=1/20) followed by crystallization in methanol to get a white solid (415 mg, 40%), labeled as 23MeOTIP-I. 1H NMR (600 MHz, Chloroform-d) delta 7.41-7.31 (m, 4H), 7.27-7.23 (m, 1H), 7.20 (s, 1H), 7.00 (d, J=8.3 Hz, 1H), 6.94 (d, J=8.3 Hz, 1H), 3.94 (s, 3H), 3.90 (s, 3H), 2.76-2.66 (m, 1H), 2.51 (p, J=6.9 Hz, 1H), 2.38 (p, J=6.9 Hz, 1H), 1.26 (d, J=6.9 Hz, 3H), 1.13 (d, J=6.9 Hz, 6H), 1.08 (d, J=6.9 Hz, 3H), 1.04 (d, J=6.8 Hz, 3H), 0.80 (d, J=7.3 Hz, 3H), 0.76 (d, J=7.2 Hz, 3H) ppm. 13C NMR (151 MHz, CDCl3) delta 150.79, 148.74, 144.81, 143.30, 142.70, 142.16, 137.90, 131.47, 130.65, 127.18, 126.35, 126.27, 119.60, 119.38, 111.62, 60.37, 55.93, 32.28, 31.97, 30.58 (d), 29.79 (d), 25.09, 24.98, 24.32 (t), 23.58, 23.45 ppm.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 21524-34-5, its application will become more common.

Reference:
Patent; Agency for Science, Technology and Research; Johannes, Charles W.; Robins, Edward G.; Jong, Howard; Lim, Yee Hwee; Chia, Saei Weng; Yang, Yong; Podichetty, Anil; (84 pag.)US2016/207034; (2016); A1;,
Bromide – Wikipedia,
bromide – Wiktionary

21524-34-5, name is 2-Bromo-1,3,5-triisopropylbenzene, belongs to bromides-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. 21524-34-5

General procedure: vial with a screw cap and a silicon-coated rubber septum wasconnected to a vacuum/nitrogen manifold through a needle,and it was evacuated and refilled with nitrogen three times. Dimethylphenylsilyllithium (0.4 M in THF, 2.5 mL, 2.0 equiv)was added to the vial under nitrogen atmosphere. 1-Bromo-3,5-dimethylbenzene (93.5 mg, 0.51 mmol) was added to the vial,then stirred at 30 C. After 1 h, the reaction mixture was analyzedby GC to check completeness of the reaction. When thereaction was complete, H2O was added and the mixture wasextracted three times with Et2O. The organic layer was washedwith water and the combined organic layer was then dried overMgSO4 followed by filtration and evaporation. The crudeproduct was purified by silica-gel column chromatography with hexane eluent, then further purified by gel permeation chromatographyto give 3da in 63% isolated yield (76.5 mg, 0.318mmol).

Statistics shows that 21524-34-5 is playing an increasingly important role. we look forward to future research findings about 2-Bromo-1,3,5-triisopropylbenzene.

Reference:
Article; Yamamoto, Eiji; Ukigai, Satoshi; Ito, Hajime; Synlett; vol. 28; 18; (2017); p. 2460 – 2464;,
Bromide – Wikipedia,
bromide – Wiktionary