20469-65-2 Archives - Page 12 of 13 - Bromides-buliding-blocks

Cheng, Fei team published research on Organic Letters in 2022 | 20469-65-2

Electric Literature of 20469-65-2, 1-Bromo-3,5-dimethoxybenzene, also known as 1-Bromo-3,5-dimethoxybenzene, is a useful research compound. Its molecular formula is C8H9BrO2 and its molecular weight is 217.06 g/mol. The purity is usually 95%.
1-Bromo-3,5-dimethoxybenzene is used as an intermediate in the synthetic preparation of pharmaceutical inhibitors via cross-coupling reactions.
1-Bromo-3,5-dimethoxybenzene can be synthesized by using 1,3-dimethoxybenzene via iridium-catalyzed arene borylation.
1-Bromo-3,5-dimethoxybenzene (1BDMB) is a synthetic molecule that can be used as an electron acceptor in organic photovoltaic cells. 1BDMB is a salt of the sodium salt of resorcylic acid and 1,3-dibromo-5,5-dimethoxybenzene. It has been shown to have a radical mechanism for the generation of free radicals. The radical mechanism is initiated by light absorption by the ruthenium complex at the center of the molecule which induces photoinduced electron transfer from the ruthenium to 1BDMB. This process results in electron transfer from the donor to an acceptor molecule, such as oxygen or nitrogen. The pharmacokinetic properties of this compound are not well known; however, it has been demonstrated that it can be synthesized through a cross-coupling reaction with other aromatic compounds such as stemofuran., 20469-65-2.

Organic compounds having carbon bonded to bromine are called organic bromides. 20469-65-2, formula is C8H9BrO2, Name is 1-Bromo-3,5-dimethoxybenzene. Depending on the type of carbon to which the bromine is bonded, organic bromide could be alkyl, alkenyl, alkynyl, or aryl. Electric Literature of 20469-65-2.

Cheng, Fei;Chen, Tao;Huang, Yin-Qiu;Li, Jia-Wei;Zhou, Chen;Xiao, Xiao;Chen, Fen-Er research published 《 Copper-Catalyzed Ullmann-Type Coupling and Decarboxylation Cascade of Arylhalides with Malonates to Access α-Aryl Esters》, the research content is summarized as follows. Authors have developed a high-efficiency and practical Cu-catalyzed cross-coupling to directly construct versatile α-aryl-esters by utilizing readily available aryl bromides (or chlorides) and malonates. These gram-scale approaches occur with turnovers of up to 1560 and are smoothly conducted by the usage of a low catalyst loading, a new available ligand, and a green solvent. A variety of functional groups are tolerated, and the application occurs with α-aryl-esters to access nonsteroidal anti-inflammatory drugs (NSAIDs) on the gram scale.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Chishiro, Akane team published research on Dalton Transactions in 2022 | 20469-65-2

20469-65-2, 1-Bromo-3,5-dimethoxybenzene, also known as 1-Bromo-3,5-dimethoxybenzene, is a useful research compound. Its molecular formula is C8H9BrO2 and its molecular weight is 217.06 g/mol. The purity is usually 95%.
1-Bromo-3,5-dimethoxybenzene is used as an intermediate in the synthetic preparation of pharmaceutical inhibitors via cross-coupling reactions.
1-Bromo-3,5-dimethoxybenzene can be synthesized by using 1,3-dimethoxybenzene via iridium-catalyzed arene borylation.
1-Bromo-3,5-dimethoxybenzene (1BDMB) is a synthetic molecule that can be used as an electron acceptor in organic photovoltaic cells. 1BDMB is a salt of the sodium salt of resorcylic acid and 1,3-dibromo-5,5-dimethoxybenzene. It has been shown to have a radical mechanism for the generation of free radicals. The radical mechanism is initiated by light absorption by the ruthenium complex at the center of the molecule which induces photoinduced electron transfer from the ruthenium to 1BDMB. This process results in electron transfer from the donor to an acceptor molecule, such as oxygen or nitrogen. The pharmacokinetic properties of this compound are not well known; however, it has been demonstrated that it can be synthesized through a cross-coupling reaction with other aromatic compounds such as stemofuran., Application of C8H9BrO2

Vinyl bromides undergo the Heck reaction, which involves C-C coupling with alkene to give substituted alkenes. 20469-65-2, formula is C8H9BrO2, Name is 1-Bromo-3,5-dimethoxybenzene. Methyl bromide is a precursor in the manufacture of several chemicals and is employed as a soil sterilant, mainly for seed production. Application of C8H9BrO2.

Chishiro, Akane;Konishi, Masafumi;Inaba, Ryoto;Yumura, Takashi;Imoto, Hiroaki;Naka, Kensuke research published 《 Tertiary arsine ligands for the Stille coupling reaction》, the research content is summarized as follows. The Stille coupling reaction is one of the most important coupling reactions. It is well known that the triphenylarsine ligand can accelerate the reaction rate of Stille coupling. However, other arsine ligands have never been investigated for the Stille coupling reaction so far. In this work, authors prepared 13 kinds of C₃-sym. tertiary arsine ligands and discovered that tri(p-anisyl)arsine is the best ligand for the reaction of tributylvinyltin and p-iodoanisole. The reaction mechanism was studied by dispersion-corrected d. functional theory calculations to demonstrate the energetic feasibility of the Stille coupling reactions mediated by tri(p-anisyl)arsine.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Chen, Wangzhe team published research on Organic Letters in 2022 | 20469-65-2

Organic bromides such as alkyl bromides are used as fumigants in agriculture to control insects. 20469-65-2, formula is C8H9BrO2, Name is 1-Bromo-3,5-dimethoxybenzene. Ethylene bromide is one of the commercially important organic bromides which are the component of leaded gasoline. Category: bromides-buliding-blocks.

Chen, Wangzhe;Ni, Shengyang;Wang, Yi;Pan, Yi research published 《 Electrochemical-Promoted Nickel-Catalyzed Reductive Allylation of Aryl Halides》, the research content is summarized as follows. Compared with conventional reductive coupling, reductive coupling under electrochem. conditions without external reductants is greener, milder, and more efficient and is of increasing interest to organic chemists. In this work, authors report the sacrificial anode, nickel-catalyzed electrochem. allylation reaction of aryl and alkyl halides. The reaction can be applied to a range of allylation reagents such as trifluoroalkenes, oxalates, and acetates.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Chen, Wenmiao team published research on ACS Applied Materials & Interfaces in 2021 | 20469-65-2

Application In Synthesis of 20469-65-2, 1-Bromo-3,5-dimethoxybenzene, also known as 1-Bromo-3,5-dimethoxybenzene, is a useful research compound. Its molecular formula is C8H9BrO2 and its molecular weight is 217.06 g/mol. The purity is usually 95%.
1-Bromo-3,5-dimethoxybenzene is used as an intermediate in the synthetic preparation of pharmaceutical inhibitors via cross-coupling reactions.
1-Bromo-3,5-dimethoxybenzene can be synthesized by using 1,3-dimethoxybenzene via iridium-catalyzed arene borylation.
1-Bromo-3,5-dimethoxybenzene (1BDMB) is a synthetic molecule that can be used as an electron acceptor in organic photovoltaic cells. 1BDMB is a salt of the sodium salt of resorcylic acid and 1,3-dibromo-5,5-dimethoxybenzene. It has been shown to have a radical mechanism for the generation of free radicals. The radical mechanism is initiated by light absorption by the ruthenium complex at the center of the molecule which induces photoinduced electron transfer from the ruthenium to 1BDMB. This process results in electron transfer from the donor to an acceptor molecule, such as oxygen or nitrogen. The pharmacokinetic properties of this compound are not well known; however, it has been demonstrated that it can be synthesized through a cross-coupling reaction with other aromatic compounds such as stemofuran., 20469-65-2.

Dehydrobromination, Grignard reactions, reductive coupling, Wittig reaction, and several nucleophilic substitution reactions are some of the principal reactions which involve organic bromides. 20469-65-2, formula is C8H9BrO2, Name is 1-Bromo-3,5-dimethoxybenzene. Organic compounds having carbon bonded to bromine are called organic bromides. Application In Synthesis of 20469-65-2.

Chen, Wenmiao;Cai, Peiyu;Elumalai, Palani;Zhang, Peng;Feng, Liang;Al-rawashdeh, Ma’moun;Madrahimov, Sherzod t.;Zhou, Hong-cai research published 《 Site-Isolated Azobenzene-Containing Metal-Organic Framework for Cyclopalladated Catalyzed Suzuki-Miyuara Coupling in Flow》, the research content is summarized as follows. Sites isolation of active metals centers, systematically studied in homogeneous systems, was an alternative to develop low metal consuming, highly active next generation catalysts in heterogeneous condition. Because of the high porosity and facile synthetic procedures, MOF-based catalysts are excellent candidates for heterogenization of well-defined homogeneous catalysts. Herein, we report the direct Pd coordination on the azobenzene linker within a MOF catalyst through a postsynthetic modification method for a Suzuki-Miyaura coupling reaction. The immobilized cyclopalladated complexes in MOFs were analyzed by a series of characterization techniques including XPS, PXRD, and deuterium NMR (²H NMR) spectroscopy. The heterogeneous nature of the catalyst and its stability were demonstrated though “hot filtration” and recycling experiments Furthermore, we demonstrate that the MOF packed column promoted the reaction between Ph boronic acid and bromobenzene under microflow conditions with a 85% yield continuously for 12 h. This work sheds light on the potential of site-isolated MOF catalysts in efficient, recyclable and continuous flow systems for industrial application.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Chen, Yixuan team published research on Angewandte Chemie, International Edition in 2022 | 20469-65-2

Chen, Yixuan;Gu, Yuefei;Meng, Huan;Shao, Qianzhen;Xu, Zhenchuang;Bao, Wenjing;Gu, Yucheng;Xue, Xiao-Song;Zhao, Yanchuan research published 《 Metal-Free C-H Functionalization via Diaryliodonium Salts with a Chemically Robust Dummy Ligand》, the research content is summarized as follows. A two-step strategy for the transition-metal-free C-H functionalization of arenes using unsym. iodonium salts as versatile synthetic linchpins was presented. The key to the success of this strategy was the identification of the 3,5-dimethyl-4-isoxazolyl (DMIX) group as a superior dummy ligand, which enabled not only site-selective C-H functionalization to afford unsym. iodonium salts I [R = Ph, 2-thienyl, 3,4-di-ClC₆H₄, etc.; X = OAc, OTs], but also highly selective aryl transfer during the subsequent metal-free coupling reaction. Both electron-rich and moderately electron-deficient arenes could be converted into the iodonium salts through C-H functionalization, allowing for diverse structural elaboration by metal-free C-N, C-C, C-S, and C-O coupling.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Cheng, Bao team published research on European Journal of Medicinal Chemistry in 2022 | 20469-65-2

A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals. 20469-65-2, formula is C8H9BrO2, Name is 1-Bromo-3,5-dimethoxybenzene. Organobromine compounds have fallen under increased scrutiny for their environmental impact., Reference of 20469-65-2.

Cheng, Bao;Zhu, Guirong;Meng, Linghua;Wu, Guolin;Chen, Qin;Ma, Shengming research published 《 Identification and optimization of biphenyl derivatives as novel tubulin inhibitors targeting colchicine-binding site overcoming multidrug resistance》, the research content is summarized as follows. Microtubule targeting agents (MTAs) are among the most successful chemotherapeutic drugs, but their efficacy is often limited by the development of multidrug resistance (MDR). Therefore, the development of novel MTAs with the ability to overcome MDR is urgently needed. In this contribution, through modification of the unsym. biaryl compounds, we discovered a novel compound dxy-1-175 with potent anti-proliferative activity against cancer cells. Mechanistic study revealed that dxy-1-175 inhibited tubulin polymerization by interacting with the colchicine-binding site of tubulin, which caused cell cycle arrest at G2/M phase. Based on the predicted binding model of dxy-1-175 with tubulin, a series of new 4-benzoylbiphenyl analogs were designed and synthesized. Among them, the hydrochloride compound 12e with improved solubility and good stability in human liver microsome, exhibited the most potent anti-proliferative activity with IC50 value in the low nanomolar range, and markedly inhibited the growth of breast cancer 4T1 xenograft in vivo. Notably, 12e effectively overcame P-gp-mediated MDR and our preliminary data suggested that 12e may not be a substrate of P-glycoprotein (P-gp). Taken together, our study reveals a novel MTA 12e targeting the colchicine-binding site with potent anticancer activity and the ability to circumvent MDR.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Cauley, Anthony N. team published research on Reaction Chemistry & Engineering in 2021 | 20469-65-2

COA of Formula: C8H9BrO2, 1-Bromo-3,5-dimethoxybenzene, also known as 1-Bromo-3,5-dimethoxybenzene, is a useful research compound. Its molecular formula is C8H9BrO2 and its molecular weight is 217.06 g/mol. The purity is usually 95%.
1-Bromo-3,5-dimethoxybenzene is used as an intermediate in the synthetic preparation of pharmaceutical inhibitors via cross-coupling reactions.
1-Bromo-3,5-dimethoxybenzene can be synthesized by using 1,3-dimethoxybenzene via iridium-catalyzed arene borylation.
1-Bromo-3,5-dimethoxybenzene (1BDMB) is a synthetic molecule that can be used as an electron acceptor in organic photovoltaic cells. 1BDMB is a salt of the sodium salt of resorcylic acid and 1,3-dibromo-5,5-dimethoxybenzene. It has been shown to have a radical mechanism for the generation of free radicals. The radical mechanism is initiated by light absorption by the ruthenium complex at the center of the molecule which induces photoinduced electron transfer from the ruthenium to 1BDMB. This process results in electron transfer from the donor to an acceptor molecule, such as oxygen or nitrogen. The pharmacokinetic properties of this compound are not well known; however, it has been demonstrated that it can be synthesized through a cross-coupling reaction with other aromatic compounds such as stemofuran., 20469-65-2.

Cauley, Anthony N.;Sezen-Edmonds, Melda;Simmons, Eric M.;Cavallaro, Cullen L. research published 《 Increasing saturation: development of broadly applicable photocatalytic C_sp2-C_sp3 cross-couplings of alkyl trifluoroborates and (hetero)aryl bromides for array synthesis》, the research content is summarized as follows. Visible light photocatalysis has emerged as an enabling technol. capable of providing access to architecturally complex mols. This article described a systematic investigation of the nickel-mediated photocatalytic cross-coupling of alkyl trifluoroborates and (hetero)aryl bromides aided by high-throughput experimentation (HTE). The results obtained from HTE were utilized to select catalysts, bases and solvents for the production of chem. libraries. Six fourteen-member libraries were generated through couplings with secondary alkyl, primary α-alkoxymethyl, benzyl and secondary α-amino trifluoroborates, demonstrating that the optimized conditions were general, robust and exhibited broad functional group tolerance. The conditions were also successfully adapted for use in a flow reactor, showing the impact micro-scale screening can have in the development of scale-up procedures. These studies enabled the generation of a data-rich reaction guide that provided favorable conditions, as well as alternative conditions that can be used to address issues with substrate solubility or catalyst availability.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Chakraborty, Mithun team published research on ChemistrySelect in 2021 | 20469-65-2

Chakraborty, Mithun;Mahesh, Gaddam;Nakel, Omkar R.;Chavda, Gautamee;Anusha, Susarla;Sudhakar, Gangarajula research published 《 A Facile Approach to Access Multi-Substituted Indenes via Nazarov Cyclization of Aryl, Vinyl and Alkyl/Aryl Carbinols》, the research content is summarized as follows. A divergent approach to highly substituted functionalized indenes I [R¹ = H, Me, Ph, etc.; R² = H, Me; R³ = Me, Et, Ph; R⁴ = 6-OMe, 5,7-(OMe)₂, 5,6,7-(OMe)₃, etc.; R⁵ = CH₂-CO₂Et, 4-MeOC₆H₄, 2-FC₆H₄, etc.] was developed. The two-step reaction involved nucleophilic addition reaction of aryl vinyl ketone, an ideal intermediate with aryl or alkyl nucleophilic reagent, followed by electrocyclic reaction (Nazarov cyclization) in the presence of Lewis acid catalyst afforded indene derivatives I in good to excellent yield.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Chen, Bi-Hong team published research on Angewandte Chemie, International Edition in 2022 | 20469-65-2

SDS of cas: 20469-65-2, 1-Bromo-3,5-dimethoxybenzene, also known as 1-Bromo-3,5-dimethoxybenzene, is a useful research compound. Its molecular formula is C8H9BrO2 and its molecular weight is 217.06 g/mol. The purity is usually 95%.
1-Bromo-3,5-dimethoxybenzene is used as an intermediate in the synthetic preparation of pharmaceutical inhibitors via cross-coupling reactions.
1-Bromo-3,5-dimethoxybenzene can be synthesized by using 1,3-dimethoxybenzene via iridium-catalyzed arene borylation.
1-Bromo-3,5-dimethoxybenzene (1BDMB) is a synthetic molecule that can be used as an electron acceptor in organic photovoltaic cells. 1BDMB is a salt of the sodium salt of resorcylic acid and 1,3-dibromo-5,5-dimethoxybenzene. It has been shown to have a radical mechanism for the generation of free radicals. The radical mechanism is initiated by light absorption by the ruthenium complex at the center of the molecule which induces photoinduced electron transfer from the ruthenium to 1BDMB. This process results in electron transfer from the donor to an acceptor molecule, such as oxygen or nitrogen. The pharmacokinetic properties of this compound are not well known; however, it has been demonstrated that it can be synthesized through a cross-coupling reaction with other aromatic compounds such as stemofuran., 20469-65-2.

Chen, Bi-Hong;Du, Yi-Dan;Shu, Wei research published 《 Organophotocatalytic Regioselective C-H Alkylation of Electron-Rich Arenes Using Activated and Unactivated Alkenes》, the research content is summarized as follows. Direct alkylation of the C-H bond arenes in a selective manner is a long-standing challenge. Herein, a metal-free photocatalytic regioselective C-H alkylation method for electron-rich arenes with both activated and unactivated alkenes was developed. The reaction tolerates a wide range of aromatic rings with diverse substitution patterns, as well as terminal and internal alkenes, providing a general and straightforward metal-free method for C-C bond formation from inert C-H bonds. Moreover, alkynes are also compatible to give the C-H vinylation of electron-rich arenes.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Chen, Jun team published research on Chemical Science in 2021 | 20469-65-2

Chen, Jun;Shi, Zhan;Li, Chunyu;Lu, Ping research published 《 Catalytic enantioselective synthesis of benzocyclobutenols and cyclobutanols via a sequential reduction/C-H functionalization》, the research content is summarized as follows. A sequential enantioselective reduction/C-H functionalization to install contiguous stereogenic carbon centers of benzocyclobutenols and cyclobutanols is reported. This strategy features a practical enantioselective reduction of a ketone and a diastereospecific iridium-catalyzed C-H silylation. Further transformations were explored, including controllable regioselective ring-opening reactions. In addition, this strategy was utilized for the synthesis of three natural products, phyllostoxin (proposed structure), grandisol and fragranol.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary