Category: 202865-77-8

Adding a certain compound to certain chemical reactions, such as: 202865-77-8, name is 2-Bromo-4-fluoro-6-methylaniline, belongs to bromides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 202865-77-8, Safety of 2-Bromo-4-fluoro-6-methylaniline

Referential Example 10 Synthesis of 2-Bromo-5-fluoro-4-methylaniline Iron powder (18.5 g) was added to a solution of 5-bromo-2-fluoro-4-nitrotoluene (9.7 g) in acetic acid (30 ml), and the mixture was stirred at 70 C. for 3 hours. The catalyst was removed by filtration through Celite, and the filtrate was washed with chloroform. The solvent and the like in the filtrate were distilled off under reduced pressure. The residue was subjected to column chromatography on silica gel to conduct elution with chloroform, thereby obtaining the title compound (7.9 g) as a red oil. 1 H-NMR (CDCl3) delta: 2.13(s,3H), 6.46(d,J=11 Hz,1H), 7.20(d,J=8 Hz,1H).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2-Bromo-4-fluoro-6-methylaniline, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Wakunaga Pharmaceutical Co., Ltd.; US6136823; (2000); A;,
Bromide – Wikipedia,
bromide – Wiktionary

These common heterocyclic compound, 202865-77-8, name is 2-Bromo-4-fluoro-6-methylaniline, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Recommanded Product: 202865-77-8

Step b2-Bromo-4-fluoro-6-methylbenzonitrileA solution of potassium cyanide (16.25 g, 0.25 mol) in 20 mL of water was added to a suspension of freshly prepared copper(l) chloride (9.5 g, 0.096 mol) in 40 mL of water, copper(l) chloride was observed to dissolve initially and then a minute amount of precipitate was formed. Toluene (30 mL) was added and the mixture was chilled to 0 0C in the fridge. 2-Bromo-4-fluoro-6-methylaniline (15.7 g, 0.077 mol) was added to a mixture of 16.5 mL of 36% aqueous hydrochloric acid and 40 mL of water. The resulting suspension was heated until a solution formed. The solution was chilled to 2 0C with an ice bath and the amine hydrochloride precipitated. A solution of sodium nitrite (5.34 g, 0.078 mol) in 15 mL of water was slowly added keeping the reaction mixture temperature below 5 0C (ice bath). A powder of sodium carbonate decahydrate was added in small portions to adjust the pH of the reaction mixture to about 7.A solution of the diazonium salt was slowly added to the cyanocuprate reagent keeping the reaction temperature below 5 0C. A bright red-orange precipitate formed. The reaction mixture was allowed to warm to 20 0C, kept at this temperature for 14 hours. Then it was slowly heated to 70 0C and kept at this temperature for 1 hour. The precipitate dissolved almost completely. The reaction mixture was allowed to cool to 20 0C and filtered. Organic phase was separated and the aqueous phase was extracted with toluene (3 x 70 mL). The combined organic layers were washed with water (2 x 100 mL), brine (2 x 100 mL), dried with sodium sulfate, filtered and concentrated. The crude nitrile (13.9 g, 84 %) obtained was used without further purification.1H NMR (400 MHz, DMSO-de) delta ppm 7.73 (dd, 3JH-F = 8.2 Hz, 4JH-H = 2.1 Hz, 1H, Ar), 7.44 (dd, 3JH-F = 9.4 Hz, 4JH-H =2.0 Hz, 1H, Ar), 2.52 (s, 3H, CH3). 13C NMR (300 MHz, dbeta-DMSO) delta 163.5 (d, 1Jc-F = 257 Hz), 147.8 (d, 3Jc-F = 11Hz), 126.1 (d, 3Jc-F = 11 Hz), 118.4 (d, 2Jc-F = 27 Hz), 117 (d, 2Jc-F = 23 Hz), 115.8, 112.7 (d, 4Jc-F = 3 Hz).

The synthetic route of 2-Bromo-4-fluoro-6-methylaniline has been constantly updated, and we look forward to future research findings.

Reference:
Patent; NERVIANO MEDICAL SCIENCES S.R.L.; PAPEO, Gianluca Mariano Enrico; ANATOLIEVNA BUSEL, Alina; CASALE, Elena; KHVAT, Alexander; KRASAVIN, Mikhail Yurievitch; ORSINI, Paolo; POSTERI, Helena; SCOLARO, Alessandra; WO2011/6803; (2011); A1;,
Bromide – Wikipedia,
bromide – Wiktionary

Application of 202865-77-8, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 202865-77-8, name is 2-Bromo-4-fluoro-6-methylaniline belongs to bromides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

To a suspension of 2-bromo-4-fluoro-6-methylaniline (5 g, 24.51 mmol) in hydrochloric acid (8 M, 22 mL, 176 mmol) at 0 C. was added a solution of sodium nitrite (1.78 g, 25.7 mmol) in water (ca. 5.5 mL) dropwise. After 10 min, the resulting solution was neutralized (pH 4-5) by addition of solid sodium acetate. The resulting solution was added to a solution of 2-methyl-2-propanethiol (2.76 mL, 24.5 mmol) in ethanol (57 mL) at 0 C. The resulting mixture was stirred at 0 C. for 30 min. The resulting mixture was poured onto ice and the resulting mixture was extracted into diethyl ether (2×). The ethereal was washed with water, then brine, dried over magnesium sulfate, and concentrated. The resulting residue was dissolved in dimethylsulfoxide (14 mL) and transferred to a solution of potassium tert-butoxide (22 g, 196 mmol) in dimethylsulfoxide (140 mL) in a cool water bath (ca. 10 C.) via canula. The bath was removed and stirring continued for 30 min. The reaction mixture was poured onto ice/concentrated hydrochloric acid. The resulting mixture was extracted with dichloromethane (2×), washed with water (3×), then brine, dried over magnesium sulfate and concentrated. Prep HPLC gave 1.66 g (31.5%) as a pale solid. LC/MS (HPLC method 3): tR=2.337 min, 215.01(MH)-.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2-Bromo-4-fluoro-6-methylaniline, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Bristol-Myers Squibb Company; US2009/18132; (2009); A1;,
Bromide – Wikipedia,
bromide – Wiktionary