Category: 201138-91-2

In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 201138-91-2 as follows. Recommanded Product: 4,6-Dibromodibenzo[b,d]furan

6.48 g (20 ml) of 4,6-dibromodibenzo[b,d]furan was dissolved in 100 ml of THF, and 8 ml (2.5 M in hexane) of normal butyllithium was added thereto at about -78 C. After one hour, 1.36 ml (10 mmol) of dichlorophenylphosphine was slowly added dropwisely and stirred for about 3 hours. The temperature was increased to room temperature, water was added, and then, the solution was washed with ethyl acetate (30 ml) three times. The washed ethyl acetate layer was dried with magnesium sulfate (MgSO4) and dried at a reduced pressured to produce a crude product. The crude product thus obtained was separated by silica gel column chromatography to obtain 4.19 g of Intermediate I-23(yield 70%). The product thus obtained was identified by LC-MS (C30H17Br2O2P: M+1 598.0).

According to the analysis of related databases, 201138-91-2, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Samsung Display Co., Ltd.; PARK, Junha; SIM, Mun-ki; LEE, Hyoyoung; JEONG, Eunjae; KIM, Youngkook; HWANG, Seokhwan; (71 pag.)US2018/166639; (2018); A1;,
Bromide – Wikipedia,
bromide – Wiktionary

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 201138-91-2, name is 4,6-Dibromodibenzo[b,d]furan, A new synthetic method of this compound is introduced below., Safety of 4,6-Dibromodibenzo[b,d]furan

A mixture of 13 g (40 mmol) of 4,6-dibromobenzofuran, 11.3 g (40 mmol) of bis(4-tert-butylphenyl)amine, 0.9 g (0.8 mmol) of Pd2(dba)3, 1.2 g (0.6 mmol) of tri-tert-butylphosphine, 5.0 g (52 mmol) of sodium tert-butoxide, and 150 ml of toluene was placed under nitrogen, and then heated and stirred at 70 C. for 24 hrs. After the reaction finished, the mixture was allowed to cool to room temperature. The solution was extracted with 100 ml of ethyl acetate and 300 ml of water. The organic layer was dried with anhydrous magnesium sulfate and the solvent was evaporated under reduced pressure. The residue was purified by column chromatography on silica to give product (16 g, 30.4 mmol, 76%).

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; LUMINESCENCE TECHNOLOGY CORPORATION; Yen, Feng-Wen; Chuang, Li-Chieh; Huang, Tsun-Yuan; (76 pag.)US2019/348609; (2019); A1;,
Bromide – Wikipedia,
bromide – Wiktionary

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 201138-91-2, name is 4,6-Dibromodibenzo[b,d]furan belongs to bromides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. category: bromides-buliding-blocks

13.6 g of phenylboronic acid and 32.6 g of 4.6-dibromo-dibenzofuran were added to a 2 L three-necked flask and 700 mL was added thereto.Dissolve toluene and 150 mL of ethanol, purge with nitrogen for 15 minutes, add 150 mL of K2CO3 (3.0 eq., 2M) in water, and finally add2.3g Pd(PPh3)4 (2mol%). The temperature was raised to 110C and the reaction was completed overnight. Add activated carbon adsorption, suction filtration, remove solvent, dryDrying, recrystallization from toluene and ethanol gave 29.7 g of intermediate AB with a yield of 92%.

The synthetic route of 201138-91-2 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Nanjing Gao Guang Semiconductor Materials Co., Ltd.; Jin Zhenyu; Qian Chao; Shen Nan; Wang Xiaowei; (87 pag.)CN107880055; (2018); A;,
Bromide – Wikipedia,
bromide – Wiktionary

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 201138-91-2, name is 4,6-Dibromodibenzo[b,d]furan belongs to bromides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. category: bromides-buliding-blocks

General procedure: The triolborate, dibromides (0.2 mmol), palladium acetate (10 mol %), BIPHEP (11 mol), and CuCl (0.4 equiv) were placed in a flask under an atmosphere of nitrogen. DMF (15 mL) was added, and heated at 80 C for 14 h. After cooling to room temperature, 15 mL water was added, extracted with dichloromethane, dried over MgSO4, and then purified by chromatography on silica gel.

The synthetic route of 201138-91-2 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Li, Gao-Qiang; Yamamoto, Yasunori; Miyaura, Norio; Tetrahedron; vol. 67; 36; (2011); p. 6804 – 6811;,
Bromide – Wikipedia,
bromide – Wiktionary

Reference of 201138-91-2,Some common heterocyclic compound, 201138-91-2, name is 4,6-Dibromodibenzo[b,d]furan, molecular formula is C12H6Br2O, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

34.5 g Intermediate (18) and 39.1 g 4,6-dibromo dibenzofuran were added into a dry 2 L three-neck flask, followed by adding 800 mL dry and degassed toluene to dissolve. Then, 34.6 g sodium tert-butoxide (3.0 eq.), 0.554 g catalyst palladium diacetate (2% mol) and 3.0 g 1,1?-binaphthyl-2,2?-bis(diphenylphosphino) (BINAP, 4% mol) ligand were added. The reaction mixture was heated up to 110 C. and reacted overnight. After the reaction finished and the reaction mixture was cooled down to room temperature. The residual was absorbed by the added activated carbon, filtered by suction filtration and removed with solvent by rotary evaporation, followed by recrystallization with a mixture of toluene and ethanol, to produce 52.8 g Intermediate (19) at a yield of 87%.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 4,6-Dibromodibenzo[b,d]furan, its application will become more common.

Reference:
Patent; NANJING TOPTO MATERIALS CO.,LTD.; KIM, JIN WOO; QIAN, CHAO; GAO, PENGHUI; WANG, XIAOWEI; (157 pag.)US2018/105534; (2018); A1;,
Bromide – Wikipedia,
bromide – Wiktionary

201138-91-2, Adding some certain compound to certain chemical reactions, such as: 201138-91-2, name is 4,6-Dibromodibenzo[b,d]furan, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 201138-91-2.

In a innert atmoshphere pubchem (http://pubchem.ncbi.nlm.nih.gov/) 4,6-dibromodibenzofuran(4,6-dibromodibenzofuran) 100g (307mmol) in dimethylformamide (DMF) and then dissolved in 0.9 L, here bis(pinacolato)diboron (bis (pinacolato)diboron) 78.0g (307 mmol) and (1,1′-bis (diphenylphosphine) ferrocene) palladium dichloride (II) (1,1′-bis (diphenylphosphine) ferrocene) dichloropalladium (II)), 2.51g (3.07 mmol), potassium acetate and 90.4g (921 put mmol) was heated to reflux at 100 for 3 hours. After the reaction was completed, the reaction solution into water and then filter the mixture, and dried in a vacuum oven. Thus the resulting residue was separated and purified by flash column chromatography gave Compound I-2 56.1g (49%)

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 201138-91-2.

Reference:
Patent; Cheil Industries Co., Ltd.; Lee, Han Ir; Sin, Ji Hun; Yu, Dong Gyu; Gyu, Uhn Sun; Han, Su Jin; Hong, Jin Suk; (33 pag.)KR2015/83385; (2015); A;,
Bromide – Wikipedia,
bromide – Wiktionary

Some common heterocyclic compound, 201138-91-2, name is 4,6-Dibromodibenzo[b,d]furan, molecular formula is C12H6Br2O, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. 201138-91-2

General procedure: The triolborate, dibromides (0.2 mmol), Pd(PPh3)4 (10 mol %), and K2CO3 (2 equiv) were placed in flask under an atmosphere of nitrogen. DMF (15 mL) was added, and heated at 80 C for 14 h. After cooling to room temperature, 15 mL water was added, extracted with dichloromethane, dried over MgSO4, and then purified by chromatography on silica gel.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 201138-91-2, its application will become more common.

Reference:
Article; Li, Gao-Qiang; Yamamoto, Yasunori; Miyaura, Norio; Tetrahedron; vol. 67; 36; (2011); p. 6804 – 6811;,
Bromide – Wikipedia,
bromide – Wiktionary

201138-91-2, The chemical industry reduces the impact on the environment during synthesis 201138-91-2, name is 4,6-Dibromodibenzo[b,d]furan, I believe this compound will play a more active role in future production and life.

Add 32.4g (100mmol) 4,6-dibromodibenzothiophene and 112.8g (300mmol) 2-formylbenzeneboronic acid to a freshly dried 3000mL two-necked bottle, add 62.1g (450mmol) under nitrogen protection Anhydrous potassium carbonate, 6.9 g (6 mmol) of tetratriphenylphosphine palladium, and 225 mL of water and 1500 mL of 1,4-dioxane. After the reaction, the temperature was lowered to room temperature, and the solvent of the reaction system was distilled off under reduced pressure. The crude product was dissolved in 500 mL of dichloromethane and washed with a large amount of water. The organic phase was dried over anhydrous sodium sulfate and concentrated. Dichloromethane: petroleum ether = 1: 1 was used as the eluent for column chromatography to obtain 30 g of off-white solid with a yield of 80%.

The chemical industry reduces the impact on the environment during synthesis 4,6-Dibromodibenzo[b,d]furan. I believe this compound will play a more active role in future production and life.

Reference:
Patent; Beijing Dingcai Technology Co., Ltd.; Wei Jinbei; Li Guomeng; Gao Wenzheng; Sun Lei; (35 pag.)CN110878054; (2020); A;,
Bromide – Wikipedia,
bromide – Wiktionary

201138-91-2, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 201138-91-2, name is 4,6-Dibromodibenzo[b,d]furan, A new synthetic method of this compound is introduced below.

40.0 g (4-(9-phenyl-9H-carbazole-3-)phenyl) boric acid and 32.6 g 4,6-dibromo-dibenzofuran were added into a 2 L three-neck flask, followed by adding 700 mL toluene and 150 mL ethanol to dissolve. The reaction mixture was aerated with nitrogen gas for 15 minutes, then 150 mL aqueous K2CO3 solution (3.0 eq., 2M) and 2.3 g Pd(PPh3)4 (2 mol %) were sequentially added. The reaction mixture was heated up to 110 C. and reacted overnight. After the reaction finished, the residual was absorbed by the added activated carbon, filtered by suction filtration and removed with solvent by rotary evaporation, followed by drying and recrystallization with a mixture of toluene and ethanol, to produce 48.0 g Intermediate (52) at a yield of 85%.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; NANJING TOPTO MATERIALS CO.,LTD.; KIM, JIN WOO; QIAN, CHAO; GAO, PENGHUI; WANG, XIAOWEI; (157 pag.)US2018/105534; (2018); A1;,
Bromide – Wikipedia,
bromide – Wiktionary