Category: 201138-91-2

Application of 201138-91-2, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 201138-91-2, name is 4,6-Dibromodibenzo[b,d]furan, This compound has unique chemical properties. The synthetic route is as follows.

0.1 mol of 4,6-dibromodibenzofuran was dissolved in 320 ml of 1,4-dioxane solvent.Stirring with nitrogen,Add 0.09 mol of [4-(triphenylsilyl)phenyl]boronic acid,0.25 mol of potassium carbonate,0.0001 mol of tetrakis(triphenylphosphine)palladium,Warming up to reflux reaction,After 5 hours, the basic reaction of the raw materials was determined by HPLC.The reaction solution was dried under reduced pressure.The residue was subjected to column chromatography to give Intermediate 1-9-1. (Yield: 63%)

The chemical industry reduces the impact on the environment during synthesis 4,6-Dibromodibenzo[b,d]furan. I believe this compound will play a more active role in future production and life.

Reference:
Patent; Beijing Lv Ren Science And Technology Co., Ltd.; Lv Yao; Jia Xueyi; (19 pag.)CN108424420; (2018); A;,
Bromide – Wikipedia,
bromide – Wiktionary

Application of 201138-91-2, The chemical industry reduces the impact on the environment during synthesis 201138-91-2, name is 4,6-Dibromodibenzo[b,d]furan, I believe this compound will play a more active role in future production and life.

General procedure: The triolborate, dibromides (0.2 mmol), and palladium acetate (10 mol %) were placed in a flask under an atmosphere of nitrogen. DMF/H2O (4/1; 10 mL) was added, and the reaction mixture was stirred at room temperature for 16 h. The mixture was extracted with dichloromethane, dried over MgSO4, and then purified by chromatography on sili

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 4,6-Dibromodibenzo[b,d]furan, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Li, Gao-Qiang; Yamamoto, Yasunori; Miyaura, Norio; Tetrahedron; vol. 67; 36; (2011); p. 6804 – 6811;,
Bromide – Wikipedia,
bromide – Wiktionary

Reference of 201138-91-2,Some common heterocyclic compound, 201138-91-2, name is 4,6-Dibromodibenzo[b,d]furan, molecular formula is C12H6Br2O, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Under an argon atmosphere, to a 1,000 ml Erlenmeyer flask, 4,6-dibromodibenzofuran (16.3 g, 50 mmol), phenylboronic acid (6.71 g, 55 mmol), K2CO3 (20.7 g, 150 mmol), Pd(PPh3)4(2.89 g, 2.5 mmol), 500 ml of a mixture solution of toluene/EtOH/H2O (4/2/1) were added in order, followed by heating and refluxing at a temperature of about 80 C. for about 5 hours. Then, the reaction mixture was cooled to room temperature, and toluene was added thereto. An aqueous layer was removed, and an organic layer was washed with a saline solution and dried with MgSO4. MgSO4 was filtered and separated, and an organic layer was concentrated. The crude product thus obtained was separated by silica gel column chromatography (using a mixture solvent of hexane/toluene) and recrystallized to obtain Intermediate A as a white solid (12.1 g, yield 75%). The structure of the product was identified using FAB-MS (m/z=323).

The synthetic route of 201138-91-2 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Samsung Display Co., Ltd.; UNO, Takuya; (209 pag.)US2019/165285; (2019); A1;,
Bromide – Wikipedia,
bromide – Wiktionary

Synthetic Route of 201138-91-2, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 201138-91-2, name is 4,6-Dibromodibenzo[b,d]furan belongs to bromides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

i. Weigh 32.6 mg of 4,6-dibromobenzofuran and 121 mg of the compound of formula (8) and add it to a mixed solvent containing toluene and ethanol (the volume ratio is toluene: ethanol = 12: 1),Protected by nitrogen, heated to 80 C, and reacted for 20 minutes.Then add 2mg of tris (dibenzylideneacetone) dipalladium,13 mg of bis (2-diphenylphosphine) phenyl ether and 1 ml of potassium carbonate aqueous solution (2 mol / L), heated to 95 C, and reacted for 10 hours.Stop the reaction, extract, collect the organic phase, evaporate the organic solvent under reduced pressure to obtain the crude product, and purify by column chromatography to obtain the compound of formula (VII).The eluent was a mixed solvent of chloroform and n-hexane (the volume ratio was chloroform: n-hexane = 1: 2).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 4,6-Dibromodibenzo[b,d]furan, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; China Petroleum University (East China); Liu Heyuan; Yan Xinyu; Li Xiyou; (8 pag.)CN110256384; (2019); A;,
Bromide – Wikipedia,
bromide – Wiktionary

Related Products of 201138-91-2,Some common heterocyclic compound, 201138-91-2, name is 4,6-Dibromodibenzo[b,d]furan, molecular formula is C12H6Br2O, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

13.4 g phenyl boric acid and 32.6 g 4,6-dibromo-dibenzofuran were added into a 2 L three-neck flask, followed by adding 700 mL toluene and 150 mL ethanol to dissolve. The reaction mixture was aerated with nitrogen gas for 15 minutes, then 150 mL aqueous K2CO3 solution (6.0 eq., 2M) and 2.3 g Pd(PPh3)4 (2 mol %) were sequentially added. The reaction mixture was heated up to 110 C. and reacted overnight. After the reaction finished, the residual was absorbed by the added activated carbon, filtered by suction filtration and removed with solvent by rotary evaporation, then followed by drying and recrystallization with a mixture of toluene and ethanol, to produce 28.1 g Intermediate (11) at a yield of 87%.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 4,6-Dibromodibenzo[b,d]furan, its application will become more common.

Reference:
Patent; NANJING TOPTO MATERIALS CO.,LTD.; KIM, JIN WOO; QIAN, CHAO; GAO, PENGHUI; WANG, XIAOWEI; (157 pag.)US2018/105534; (2018); A1;,
Bromide – Wikipedia,
bromide – Wiktionary

Electric Literature of 201138-91-2, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 201138-91-2, name is 4,6-Dibromodibenzo[b,d]furan, This compound has unique chemical properties. The synthetic route is as follows.

0.1 mol of 4,6-dibromodibenzofuran was dissolved in 320 ml of 1,4-dioxane solvent.Stirring with nitrogen,Add 0.09 mol of [4-(triphenylsilyl)phenyl]boronic acid,0.25 mol of potassium carbonate,0.0001 mol of tetrakis(triphenylphosphine)palladium,Warming up to reflux reaction,After 5 hours, the basic reaction of the raw materials was determined by HPLC.The reaction solution was dried under reduced pressure.The residue was subjected to column chromatography to give Intermediate 1-9-1. (Yield: 63%)

The chemical industry reduces the impact on the environment during synthesis 4,6-Dibromodibenzo[b,d]furan. I believe this compound will play a more active role in future production and life.

Reference:
Patent; Beijing Lv Ren Science And Technology Co., Ltd.; Lv Yao; Jia Xueyi; (19 pag.)CN108424420; (2018); A;,
Bromide – Wikipedia,
bromide – Wiktionary

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 201138-91-2, name is 4,6-Dibromodibenzo[b,d]furan, A new synthetic method of this compound is introduced below., name: 4,6-Dibromodibenzo[b,d]furan

26.9 g Intermediate (22) and 37.8 g 4,6-dibromo dibenzofuran were added into a dry 2 L three-neck flask, followed by adding 800 mL dry and degassed toluene to dissolve. Then, 33.4 g sodium tert-butoxide (3.0 eq.), 0.52 g catalyst palladium diacetate (2% mol) and 2.9 g 1,1?-binaphthyl-2,2?-bis(diphenylphosphino) (BINAP, 4% mol) ligand were added. The reaction mixture was heated up to 110 C. and reacted overnight. After the reaction finished and the reaction mixture was cooled down to room temperature. The residual was absorbed by the added activated carbon, filtered by suction filtration and removed with solvent by rotary evaporation, followed by recrystallization with a mixture of toluene and ethanol, to produce 47.6 g Intermediate (23) at a yield of 90%.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; NANJING TOPTO MATERIALS CO.,LTD.; KIM, JIN WOO; QIAN, CHAO; GAO, PENGHUI; WANG, XIAOWEI; (157 pag.)US2018/105534; (2018); A1;,
Bromide – Wikipedia,
bromide – Wiktionary

Synthetic Route of 201138-91-2, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 201138-91-2 as follows.

In a nitrogen environment 9H-carbazole(100 g, 598 mmol) was dissolved in 2,000 mL of toluene, where the 4,6-dibromodibenzofuran(292 g, 897 mmol), tris(diphenoquinone alkylpiperidinyl) dipalladium (o) (5.48 g, 5.98 mmol), tris-tertbutylphosphine(6.05 g, 29.9 mmol) and sodium tertbutoxide(69.0 g, 718 mmol) sequentially into during heating by and it refluxed 100 C at 35 hours . After the reaction was completed, the reaction solution into water and extracted with dichloromethane (DCM) and then water was removed with anhydrous MgSO4, filter and was concentrated under reduced pressure. In this way, the resulting residue was purified by flash column chromatography to obtain the compound I-15(93.7 g,38%).

According to the analysis of related databases, 201138-91-2, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Cheil Industries Co., Ltd; Lee, Han Ir; Yu, Uhn Sun; Kang, Dong Min; Kang, Uii Soo; Yang, Yong Tak; Oh, Jae Jin; Yu, Dong Gyu; Lee, Sang Sin; Jang, Yuna; Jung, Su Young; Han, Su Jin; Hong, Jin Suk; (59 pag.)KR2015/6758; (2015); A;,
Bromide – Wikipedia,
bromide – Wiktionary

Related Products of 201138-91-2, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 201138-91-2, name is 4,6-Dibromodibenzo[b,d]furan belongs to bromides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

The 80g (245 mmole) of 4,6-dibromo-dibenzofuran been dissolved by heating in a dry flask 500ml of dry THF. The reaction mixture was cooled to -78 . At this temperature was slowly added dropwise 57ml of n-phenyl lithiumDibutyl ether (115 mmol) of 1.9M solution. The batch was stirred for another hour at -73 deg.] C. Then 65g of 2-chloro-4,6-diphenyl-1,3,5-triazine (245 mmol) was dissolved in 150ml of THF and added dropwise at -70 deg.] C. When the addition was complete, the reaction mixture was slowly warmed to room temperature and stirred at room temperature overnight, quenched with water and then evaporated in a rotary evaporator, during which a white solid precipitated. The batch was then cooled to room temperature, filtered off by suction and has precipitated solid was rinsed with methanol. The yield was 40g (84 mmole), corresponding to 34% of the theoretical.

The synthetic route of 4,6-Dibromodibenzo[b,d]furan has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Merck Patent GmbH; Parham, Amir Hossain; Martynova, Irina; Jatsch, Anja; Eberle, Thomas; Kroeber, Jonas Valentin; Pflumm, Christof; (94 pag.)CN105636959; (2016); A;,
Bromide – Wikipedia,
bromide – Wiktionary

Electric Literature of 201138-91-2, A common heterocyclic compound, 201138-91-2, name is 4,6-Dibromodibenzo[b,d]furan, molecular formula is C12H6Br2O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

10.43 g (32 mmol) of B-(9-phenyl-9H-carbazole-3-yl)boronic acid, 8.9 g (31.6 mmol) of 4,6-dibromodibenzofuran and 31 mL (63 mmol) of Na2CO3 (2 M solution) was then suspended in 120 mL of toluene and 120 mL ethanol. To this suspension, it was added 0.73 g (0.63 mmol) of Pd(PPh3)4 and heat the reaction mixture for 16 hours under reflux. After cooling, remove the organic phase, after filtration, washed three times with 200 mL through silica gel, and concentrated until dry. Recrystallization of the residue from toluene. The yield for the 73% of theory, 11.4 g

The synthetic route of 201138-91-2 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Merck patent GmbH; Hussain, Farham Amir; Martinopa, Irina; Yachi, Anya; Avelluley, Thomas; Kuriba, JonasFallentine; (111 pag.)KR2016/38006; (2016); A;,
Bromide – Wikipedia,
bromide – Wiktionary