Category: 20099-90-5

Li, Chengbin; Li, He; Li, Chunzhi; Ren, Xiaomin; Yang, Qihua published the artcile< One-pot synthesis of mesosilica/nano covalent organic polymer composites and their synergistic effect in photocatalysis>, Synthetic Route of 20099-90-5, the main research area is mesosilica organic polymer composite photocatalysis synergistic effect.

Organic-inorganic hybrid materials provide a desirable platform for the development of novel functional materials. Here, we report the one-pot synthesis of mesoporous hybrid nanospheres by the in-situ sol-gel condensation of tetraethoxysilane around surfactant micelle-confined nano covalent organic polymer (nanoCOP) colloids. The hybrid nanospheres containing nanoCOPs uniformly distributed in the mesosilica network, inherited the visible light responsive properties of the nanoCOPs. The turnover frequency of the hybrid nanospheres is almost 12 times that of its corresponding bulk COP counterpart for the photocatalytic reductive dehalogenation of α-bromoacetophenone, which is attributed to activation of the Hantzsch ester reductant by the hydroxyl group. The existence of a volcano relationship between the activity and nanoCOP/mesosilica ratio confirmed the synergistic effect between nanoCOP and mesosilica. Our preliminary results suggest that hybridization of semiconductors and reactant-activating materials is an efficient strategy for enhancing the activity of a catalyst for photocatalysis.

Chinese Journal of Catalysis published new progress about Colloids. 20099-90-5 belongs to class bromides-buliding-blocks, and the molecular formula is C9H7BrO3, Synthetic Route of 20099-90-5.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Liang, Tao; Zhou, Yi; Elhassan, Reham M.; Hou, Xuben; Yang, Xinying; Fang, Hao published the artcile< HDAC-Bax Multiple Ligands Enhance Bax-Dependent Apoptosis in HeLa Cells>, Category: bromides-buliding-blocks, the main research area is solid tumors HDAC Bax apoptosis antiproliferative cytotoxicity conformational activation.

Inspired by the synergistic effect of BTSA1 (a Bax activator) and SAHA (a histone deacetylase (HDAC) inhibitor) in HeLa cell growth suppression, a series of novel HDAC-Bax multiple ligands were designed rationally. Compound 23, which possesses similar HDAC inhibitory activity relative to SAHA and Bax affinity comparable to BTSA1, exhibits a superior growth suppression against HeLa cells, and its antiproliferative activities are 15-fold and 3-fold higher than BTSA1 and SAHA, resp. The better antiproliferative activity and lower cytotoxicity of compound 23(I) indicated that our HDAC-Bax multiple ligand design strategy achieved success. Further studies suggested that compound 23 could enhance Bax-dependent apoptosis by upregulating Bax, followed by inducing the conformational activation of Bax. To our knowledge, we first report HDAC-Bax multiple ligands and demonstrate a new paradigm for the treatment of solid tumors by enhancing Bax-dependent apoptosis.

Journal of Medicinal Chemistry published new progress about Antitumor agents. 20099-90-5 belongs to class bromides-buliding-blocks, and the molecular formula is C9H7BrO3, Category: bromides-buliding-blocks.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Amaradhi, Radhika; Mohammed, Shabber; Banik, Avijit; Franklin, Ronald; Dingledine, Raymond; Ganesh, Thota published the artcile< Second-Generation Prostaglandin Receptor EP2 Antagonist, TG8-260, with High Potency, Selectivity, Oral Bioavailability, and Anti-Inflammatory Properties>, Formula: C9H7BrO3, the main research area is inflammation antiinflammatory lead optimization pharmacokinetics CYP450 inhibition competitive antagonism.

EP2, a G-protein-coupled prostaglandin-E2 receptor, has emerged as a seminal biol. target for drug discovery. EP2 receptor activation is typically proinflammatory; therefore, the development of EP2 antagonists to mitigate the severity and disease pathol. in a variety of inflammation-driven central nervous system and peripheral disorders would be a novel strategy. We have recently developed a second-generation EP2 antagonist TG8-260 and shown that it reduces hippocampal neuroinflammation and gliosis after pilocarpine-induced status epilepticus in rats. Here, we present details of synthesis, lead optimization on earlier leads that resulted in TG8-260 (I), potency and selectivity evaluations using cAMP-driven time-resolved fluorescence resonance energy-transfer (TR-FRET) assays and [H3]-PGE2-binding assays, absorption, distribution, metabolism, and excretion (ADME), and pharmacokinetics. TG8-260 (2f) showed Schild KB = 13.2 nM (3.6-fold more potent than the previous lead TG8-69 (1c)) and 500-fold selectivity to EP2 against other prostanoid receptors. Pharmacokinetic data indicated that TG8-260 has a plasma half-life of 2.14 h (PO) and excellent oral bioavailability (77.3%). Extensive ADME tests indicated that TG8-260 is a potent inhibitor of CYP450 enzymes. Further, we show that TG8-260 displays antagonistic activity on the induction of EP2 receptor-mediated inflammatory gene expression in microglia BV2-hEP2 cells; therefore, it can serve as a tool for investigating anti-inflammatory pathways in peripheral inflammatory disease animal models.

ACS Pharmacology & Translational Science published new progress about 5-HT2A receptors Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 20099-90-5 belongs to class bromides-buliding-blocks, and the molecular formula is C9H7BrO3, Formula: C9H7BrO3.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Mori, Mattia; Dasso Lang, Maria Chiara; Saladini, Francesco; Palombi, Nastasja; Kovalenko, Lesia; De Forni, Davide; Poddesu, Barbara; Friggeri, Laura; Giannini, Alessia; Malancona, Savina; Summa, Vincenzo; Zazzi, Maurizio; Mely, Yves; Botta, Maurizio published the artcile< Synthesis and Evaluation of Bifunctional Aminothiazoles as Antiretrovirals Targeting the HIV-1 Nucleocapsid Protein>, Application In Synthesis of 20099-90-5, the main research area is aminothiazole preparation antiretroviral HIV 1 nucleocapsid protein inhibitor; structure activity aminothiazole antiretroviral nucleocapsid protein inhibitor.

Small mol. inhibitors of the HIV-1 nucleocapsid protein (NC) are considered as promising agents in the treatment of HIV/AIDS. In an effort to exploit the privileged 2-amino-4-phenylthiazole moiety in NC inhibition, here we conceived, synthesized, and tested in vitro 18 NC inhibitors (NCIs) bearing a double functionalization. In these NCIs, one part of the mol. is designed to interact noncovalently with the NC hydrophobic pocket, while the second portion is designed to interact with the N-terminal domain of NC. This binding hypothesis was verified by mol. dynamics simulations, while the linkage between these two pharmacophores was found to enhance antiretroviral activity both on the wild-type virus and on HIV-1 strains with resistance to currently licensed drugs. The two most interesting compounds, I and II, showed no cytotoxicity, thus becoming valuable leads for further investigations.

ACS Medicinal Chemistry Letters published new progress about Anti-HIV agents. 20099-90-5 belongs to class bromides-buliding-blocks, and the molecular formula is C9H7BrO3, Application In Synthesis of 20099-90-5.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Mathew, Bini; Ruiz, Pedro; Dutta, Shilpa; Entrekin, Jordan T.; Zhang, Sixue; Patel, Kaval D.; Simmons, Micah S.; Augelli-Szafran, Corinne E.; Cowell, Rita M.; Suto, Mark J. published the artcile< Structure-activity relationship (SAR) studies of N-(3-methylpyridin-2-yl)-4-(pyridin-2-yl)thiazol-2-amine (SRI-22819) as NF-κB activators for the treatment of ALS>, SDS of cas: 20099-90-5, the main research area is amyotrophic lateral sclerosis superoxide dismutase NF kapaB ataluren hybrid; Amyotrophic lateral sclerosis; Ataluren; NF-ҡB; Superoxide dismutase.

ALS is a rare type of progressive neurol. disease with unknown etiol. It results in the gradual degeneration and death of motor neurons responsible for controlling the voluntary muscles. Identification of mutations in the superoxide dismutase (SOD) 1 gene has been the most significant finding in ALS research. SOD1 abnormalities have been associated with both familial as well as sporadic ALS cases. SOD2 is a highly inducible SOD that performs in concurrence with SOD1 to detoxify ROS. Induction of SOD2 can be obtained through activation of NF-κBs. We previously reported that SRI-22819 increases NF-κB expression and activation in vitro, but it has poor ADME properties in general and has no oral bioavailability. Our initial studies were focused on direct modifications of SRI-22819. There were active compounds identified but no improvement in microsomal stability was observed In this context, we focused on making more significant structural changes in the core of the mol. Ataluren, an oxadiazole compound that promotes read-through and expression of dystrophin in patients with Duchenne muscular dystrophy, bears some structural similarity to SRI-22819. Thus, we synthesized a series of SRI-22819 and Ataluren (PTC124) hybrid compounds Several compounds from this series exhibited improved activity, microsomal stability and lower calculated polar surface area (PSA). This manuscript describes the synthesis and biol. evaluation of SRI-22819 analogs and its hybrid combination with Ataluren.

European Journal of Medicinal Chemistry published new progress about Amyotrophic lateral sclerosis. 20099-90-5 belongs to class bromides-buliding-blocks, and the molecular formula is C9H7BrO3, SDS of cas: 20099-90-5.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Tang, Kai-Wei; Hsu, Wen-Li; Chen, Cheng-Ru; Tsai, Ming-Hsien; Yen, Chia-Jung; Tseng, Chih-Hua published the artcile< Discovery of triazolyl thalidomide derivatives as anti-fibrosis agents>, Name: 4-(2-Bromoacetyl)benzoic acid, the main research area is triazolyl thalidomide derivative preparation antifibrosis activity.

Fibrosis with excessive accumulation of extracellular matrix (ECM) often causes progressive organ dysfunction and results in many inflammatory and metabolic diseases, including systemic sclerosis, pulmonary fibrosis, advanced liver disease and advanced kidney disease. The store-operated calcium entry (SOCE) pathway and the related signaling pathway were both found to be the important routes for fibrogenesis. Our aim in this study was to discover novel compounds to inhibit fibrogenesis. A number of triazolyl thalidomide derivatives were synthesized and evaluated for their anti-fibrosis activities. Compounds inhibited intracellular Ca2+ activation and showed no cytotoxicity. Among them, 6-{4-[(3-(1,3-dioxoisoindolin-2-yl)-2,6-dioxopiperidin-1-yl)methyl]-1H-1,2,3-triazol-1-yl}hexanoic acid ( I ) with the most potent inhibitory effect was chosen for further examination The results revealed that compound I, a SOCE inhibitor, reversed the migratory ability of TGF-β1-induced myofibroblasts, dedifferentiated myofibroblasts to fibroblasts due to cytoskeleton remodeling, and restrained myofibroblast activation by targeting Orai1 and TGF-β1/SMAD2/3 signaling pathways. The in silico study indicated that compound I, with the appropriate lipophilic carbon chain and carboxylic acid, showed a good drug-likeness model score. Conclusively, the SOCE inhibitor, compound I, is used as a promising lead compound for the development of a new treatment for fibrosis.

New Journal of Chemistry published new progress about Antifibrotic agents. 20099-90-5 belongs to class bromides-buliding-blocks, and the molecular formula is C9H7BrO3, Name: 4-(2-Bromoacetyl)benzoic acid.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Shrimp, Jonathan H.; Jing, Yihang; Gamage, Supuni Thalalla; Nelson, Kathryn M.; Han, Joseph; Bryson, Keri M.; Montgomery, David C.; Thomas, Justin M.; Nance, Kellie D.; Sharma, Sunny; Fox, Stephen D.; Andressen, Thorkell; Sinclair, Wilson R.; Wu, Hong; Allali-Hassani, Abdellah; Senisterra, Guillermo; Vedadi, Masoud; Lafontaine, Denis; Dahlin, Jayme L.; Marmorstein, Ronen; Walters, Michael A.; Meier, Jordan L. published the artcile< Remodelin Is a Cryptic Assay Interference Chemotype That Does Not Inhibit NAT10-Dependent Cytidine Acetylation>, Computed Properties of 20099-90-5, the main research area is remodelin cryptic assay interference chemotype NAT10 acetylase RNA acetylation.

Remodelin is a putative small mol. inhibitor of the RNA acetyltransferase NAT10 which has shown preclin. efficacy in models of the premature aging disease Hutchinson-Gilford Progeria Syndrome (HGPS). Here we evaluate remodelin’s assay interference characteristics and effects on NAT10-catalyzed RNA cytidine acetylation. We find the remodelin chemotype constitutes a cryptic assay interference compound, which does not react with small mol. thiols but demonstrates protein reactivity in ALARM NMR and proteome-wide affinity profiling assays. Biophys. analyses find no direct evidence for interaction of remodelin with the NAT10 acetyltransferase active site. Cellular studies verify that N4-acetylcytidine (ac4C) is a nonredundant target of NAT10 activity in human cell lines and find that this RNA modification is not affected by remodelin treatment in several orthogonal assays. These studies display the potential for remodelin’s chemotype to interact with multiple protein targets in cells and indicate remodelin should not be applied as a specific chem. inhibitor of NAT10-catalyzed RNA acetylation.

ACS Medicinal Chemistry Letters published new progress about Homo sapiens. 20099-90-5 belongs to class bromides-buliding-blocks, and the molecular formula is C9H7BrO3, Computed Properties of 20099-90-5.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Nian, Si-Yun; Wang, Guo-Ping; Jiang, Zheng-Li; Xiao, Ying; Huang, Mo-Han; Zhou, Yi-Huan; Tan, Xiang-Duan published the artcile< Synthesis and biological evaluation of novel SIPI-7623 derivatives as farnesoid X receptor (FXR) antagonists>, Recommanded Product: 4-(2-Bromoacetyl)benzoic acid, the main research area is hypercholesterolemia farnesoid X receptor antagonist SIPI7623; FXR antagonists; Guggulsterone; Molecular docking; SIPI-7623; Structure activity relationship.

Most of reported steroidal FXR antagonists are restricted due to low potency. We described the design and synthesis of novel nonsteroidal scaffold SIPI-7623 derivatives as FXR antagonists. The most potent compound A-11 (IC50 = 7.8 ± 1.1 μM) showed better activity compared to SIPI-7623 (IC50 = 40.8 ± 1.7 μM) and guggulsterone (IC50 = 45.9 ± 1.1 μM). Docking of A-11 in FXR′s ligand-binding domain was also studied.

Molecular Diversity published new progress about Drug design. 20099-90-5 belongs to class bromides-buliding-blocks, and the molecular formula is C9H7BrO3, Recommanded Product: 4-(2-Bromoacetyl)benzoic acid.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Das, Anupam; Thomas, K. R. Justin published the artcile< Light Promoted Synthesis of Quinoxalines and Imidazo[1,2-a]pyridines via Oxybromination from Alkynes and Alkenes>, Synthetic Route of 20099-90-5, the main research area is quinoxaline preparation green chem; alkyne phenylenediamine photochem heterocyclization; imidazopyridine preparation green chem; alkene aminopyridine photochem heterocyclization.

Light promoted two-step one-pot syntheses of quinoxalines I (R1 = H, Ph; R2 = Me, Cl, CN, etc.) and imidazo[1,2-a]pyridines II (R3 = 4-Me, 2-Br, 4-NO2, etc.) from alkynes 4-R2C6H4CCR1 and alkenes R3C6H4CH=CH2, resp. under mild conditions are described. The conversions occur via the formation of α,α’-dibromo ketones 4-R2C6H4C(O)C(Br)2R1 or α-bromo ketones R3C6H4C(O)CH2Br on irradiation with UV LED fluorescent black light (380-390 nm) in acetonitrile/water mixture This protocol does not require sensitizer or catalyst or additives. This two-step protocol is a new entry of synthetic methods available for quinoxaline derivatives I and imidazopyridine derivatives II and offers wide functional group tolerance.

Asian Journal of Organic Chemistry published new progress about Alkynes, aryl Role: RCT (Reactant), RACT (Reactant or Reagent). 20099-90-5 belongs to class bromides-buliding-blocks, and the molecular formula is C9H7BrO3, Synthetic Route of 20099-90-5.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary